Tip 2 diyabetes mellitus hastalarında görülen depresyonun mikrovasküler komplikasyonlarla ilişkisi
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Dosyalar
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Düzce Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş: Tip 2 Diyabetes Mellitus (DM) tüm dünyada sıklığı artan, komplikasyonlarla seyredebilen, morbidite ve mortaliteye sebep olan bir hastalıktır. Tip 2 DM'de depresyon sıklığı artmıştır. DM ve depresyon birlikte saptandığında hastalığa uyum zorlaşmakta ve mortalite artmaktadır. Bu çalışmamızda diyabetik hastalarda depresyon varlığını ve depresyonun demografik veriler, glisemik kontrol ve komplikasyonlarla ilişkisini değerlendirmeyi amaçladık. Yöntem ve Gereçler: Çalışmaya 2 yıl ve üzeri Tip 2 DM tanısı olan 86 hasta alındı. Hastaların demografik özellikleri, anamnez ve muayene bilgileri, ek hastalıkları, aldıkları tedaviler, glisemik kontrol ve laboratuvar parametreleri, mikrovasküler komplikasyonları kaydedildi. Beck depresyon envanteri (BDI) skorlarına göre 3 gruba ve HbA1c değerlerine göre 2 gruba ayrıldı. İstatistiksel değerlendirmelerin tümü PASW 18'de yapıldı ve p<0,05 istatistiksel olarak anlamlı kabul edildi. Bulgular: HbA1c değerleri yüksek olan grupta BDI skoru anlamlı düzeyde yüksek saptandı (p=0.004). Yaş, vücut-kitle indeksi ve diyabet süresi sabitken BDI ile HbA1c arasında anlamlı ilişki bulundu (r=0.396, p<0.001). Yaş, kadın cinsiyet, VKİ, diyabet süresi, ek hastalık, nöropati, retinopati ve nefropati varlığı ile BDI skorları arasında anlamlı ilişki saptandı (p değerleri sırasıyla: 0,001; 0,023; 0,006; <0,001; 0,003; <0,001; <0,001; <0,001). Diğer değişkenlerle BDI skoru arasında anlamlı ilişki saptanmadı. Regresyon analizi yapıldığında nöropati, retinopati ve kadın cinsiyet ile BDI skoru arasında anlamlı ilişki bulundu (p değerleri sırasıyla: 0,023; 0,002; 0,026. Odds Ratio sırasıyla: 5,865; 18,302; 3,920). Sonuç: Çalışmamızda, diyabetik bireylerde depresyonun kötü glisemik kontrol, yüksek HbA1c değerleri, kadın cinsiyet, ileri yaş, ek hastalık varlığı, nöropati, nefropati ve retinopati ile ilişkili olduğu bulundu. Kadın cinsiyet varlığında 3,92, nöropati varlığında 5,865 kat ve retinopati varlığında 18,302 kat artış saptandı.
Introduction: Type 2 Diabetes Mellitus (DM) is a disease, which can be presented with complications and causes morbidity and mortality with incidence increasing all over the world. Depression incidence is increased in Type 2 DM. When DM and depression are detected together, compliance to the disease is increased as well as mortality. Herein, we aimed to evaluate the presence of depression in diabetic patients and the relationship between depression and demographic data, glycemic control and complications. Materials and Method: 86 patients with a diagnosis of type 2 diabetes for 2 years and older are enrolled in the study. Demographic characteristics of the patients with their medical history, physical examination findings, comorbidities, received therapies, glycemic control and laboratory parameters, microvascular complications were recorded. They were divided into 3 groups according to their beck depression inventory (BDI) scores and 2 groups according to their HbA1c levels. All statistical analyzes were performed on PASW 18 and p <0.05 was considered statistically significant. Results: In the group with high HbA1c levels, the BDI scores were found significantly high (p = 0.004). Significant relationship was found between HbA1c and BDI when age, body-mass index and diabetes duration are constant (r = 0.396, p <0.001). Significant correlation between BDI scores and age, female gender, BMI, duration of diabetes, comorbidities, neuropathy, retinopathy and nephropathy was determined (p values as 0,001; 0,023; 0,006; <0.001; 0.003, <0.001, <0.001, <0.001 ). There was no significant relationship between BDI scores and other variables. Regression analysis found significant relationship between BDI scores and neuropathy, retinopathy and female gender. (p values; 0.023; 0.002; 0.026 and Odds Ratio; 5.865; 18.302; 3.920, respectively). Discussion: In our study, depression in diabetics was found to be associated with poor glycemic control, high HbA1c levels, female gender, elderly, presence of concomitant disease, neuropathy, nephropathy and retinopathy. 3.92-fold increase in the presence of female sex, 5.865-fold increase in the presence of neuropathy and 18.302-fold increase in the presence of retinopathy was observed.
Introduction: Type 2 Diabetes Mellitus (DM) is a disease, which can be presented with complications and causes morbidity and mortality with incidence increasing all over the world. Depression incidence is increased in Type 2 DM. When DM and depression are detected together, compliance to the disease is increased as well as mortality. Herein, we aimed to evaluate the presence of depression in diabetic patients and the relationship between depression and demographic data, glycemic control and complications. Materials and Method: 86 patients with a diagnosis of type 2 diabetes for 2 years and older are enrolled in the study. Demographic characteristics of the patients with their medical history, physical examination findings, comorbidities, received therapies, glycemic control and laboratory parameters, microvascular complications were recorded. They were divided into 3 groups according to their beck depression inventory (BDI) scores and 2 groups according to their HbA1c levels. All statistical analyzes were performed on PASW 18 and p <0.05 was considered statistically significant. Results: In the group with high HbA1c levels, the BDI scores were found significantly high (p = 0.004). Significant relationship was found between HbA1c and BDI when age, body-mass index and diabetes duration are constant (r = 0.396, p <0.001). Significant correlation between BDI scores and age, female gender, BMI, duration of diabetes, comorbidities, neuropathy, retinopathy and nephropathy was determined (p values as 0,001; 0,023; 0,006; <0.001; 0.003, <0.001, <0.001, <0.001 ). There was no significant relationship between BDI scores and other variables. Regression analysis found significant relationship between BDI scores and neuropathy, retinopathy and female gender. (p values; 0.023; 0.002; 0.026 and Odds Ratio; 5.865; 18.302; 3.920, respectively). Discussion: In our study, depression in diabetics was found to be associated with poor glycemic control, high HbA1c levels, female gender, elderly, presence of concomitant disease, neuropathy, nephropathy and retinopathy. 3.92-fold increase in the presence of female sex, 5.865-fold increase in the presence of neuropathy and 18.302-fold increase in the presence of retinopathy was observed.
Açıklama
YÖK Tez No: 501317
Anahtar Kelimeler
Endokrinoloji ve Metabolizma Hastalıkları, Endocrinology and Metabolic Diseases
