THE EFFECT OF CALCIUM DOBESILATE ON THE PREVENTION OF INTRAABDOMINAL ADHESIONS: AN EXPERIMENTAL STUDY

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dc.contributor.authorKılıçoğlu, Bülent
dc.contributor.authorKısmet, Kemal
dc.contributor.authorHücümenoğlu, Sema
dc.contributor.authorKüçük, Berkay
dc.contributor.authorErtaş, Ertuğrul
dc.contributor.authorAydın, Osman
dc.contributor.authorÜnal, Yılmaz
dc.date.accessioned2023-07-26T11:51:04Z
dc.date.available2023-07-26T11:51:04Z
dc.date.issued2020
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalıen_US
dc.description.abstractAIM: It was aimed to demonstrate the efficacy of Calcium Dobesilate (Ca-Dob) in preventing postoperative intra-abdominal adhesion formation in an experimental cecal abrasion model. MATERIALS AND METHODS: Thirty female Wistar Albino rats used in the study were randomized into 3 groups. Laparotomy was performed in the sham group, the cecum was removed from the abdomen and replaced without any further processing. In the control group, after cecal abrasion and peritoneal resection no processing was applied. In the Ca-Dob group, abdomen was closed after cecal abrasion and peritoneal resection, then 100 mg/kg/day Ca-Dob was administered orogastrically for 21 days only this group. All rats were sacrificed on 21st day. The adhesions were evaluated. Tissue samples taken from the peritoneum and intestines were sent for histopathological examination to determine the degree of inflammation and fibrosis. Tissue and blood samples were taken for biochemical analysis. RESULTS: Statistically, inflammation, microscopic adhesions and fibrosis scores were found to be significantly lower in the Ca-Dob administered rats compared to the control group (p < 0.05). Tissue Malondialdehyde (MDA), Fluorescent Oxidation Products (FOP) and Total Oxidation Status (TOS) values were found to be significantly lower statistically compared to the control group (p = 0.001). Tissue Total Sulfhydryl (Total SH) values were found to be statistically significantly higher (p < 0.05) in the sham group compared with the control group. Finally; serum MDA and serum TOS values in the CaDob group, was statistically significantly lower (p < 0.05) compared to control group. CONCLUSION: Ca-Dob was found to be efficacious in preventing the formation of adhesions. In addition to the demonstrated antiinflammatory effect histopathologically, the effect of antioxidant effect demonstrated biochemically was concluded to participate to the adhesion preventive efficacy of Ca-Dob. Nevertheless, there is a need for further studies to assess the precise mechanism of the preventing of abdominal adhesions of Ca-Dob.en_US
dc.identifier.doi10.20492/aeahtd.459184
dc.identifier.endpage214en_US
dc.identifier.issn1304-6187
dc.identifier.issue3en_US
dc.identifier.startpage209en_US
dc.identifier.trdizinid463852en_US
dc.identifier.urihttp://doi.org/10.20492/aeahtd.459184
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/463852
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12486
dc.identifier.volume53en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorErtaş, Ertuğrul
dc.language.isoenen_US
dc.relation.ispartofAnkara Eğitim ve Araştırma Hastanesi Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.titleTHE EFFECT OF CALCIUM DOBESILATE ON THE PREVENTION OF INTRAABDOMINAL ADHESIONS: AN EXPERIMENTAL STUDYen_US
dc.typeArticleen_US

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