Dermatological Side-Effects Developing in Patients Using Targeted Chemotherapy Drugs: A Review of the Literature

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dc.authorid
dc.contributor.authorKaragün, Ebru
dc.contributor.authorEşbah, Onur
dc.date.accessioned2021-12-01T18:22:29Z
dc.date.available2021-12-01T18:22:29Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjectives: Numerous dermatological side-effects are reported with the use of targeted therapies. These adverseevents derive from common signaling pathways implicated in malignant behavior and normal homeostatic activity ofboth the epidermis and dermis.Methods: Patients under follow-up at the Oncology Clinic 12 using bevacizumab, five cetuximab, four sunitinib, foursorafenib, three panitumumab, one pazopanib, one trastuzumab, and one using vemurafenib, were included in thestudy. Patients’ cutaneous drug side-effects were assessed at dermatological examinations before starting treatmentand at months 1, 3, and 6 during treatment.Results: The most common finding was xerosis, seen in 54% (17/31) of our patients receiving targeted treatment.Papulopustular eruption was observed in 63% (12/19) of patients using epidermal growth factor receptor inhibitors.The most common finding in the nails was brittleness-tenderness. Dry mouth was prominent among the mucositisfindings. The four patients with nosebleeds were using antiangiogenesis agents. Papulopustular eruptions emergedin the first month, xerosis in the second and third, dry mouth in the third, and pyogenic granuloma, nail findings, andnosebleeds in the fourth to sixth months.Conclusion: Dermatological side-effects can impact on the patient’s quality of life and cause significant morbidity.Dermatologists and oncologists should therefore collaborate closely to manage these side-effects.en_US
dc.identifier.doi10.14744/ejmi.2020.44067
dc.identifier.endpage180en_US
dc.identifier.issn2602-3164
dc.identifier.issn2602-3164
dc.identifier.issue2en_US
dc.identifier.startpage173en_US
dc.identifier.urihttps://doi.org/10.14744/ejmi.2020.44067
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpZME16YzVPUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9493
dc.identifier.volume4en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEurasian Journal of Medical Investigationen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleDermatological Side-Effects Developing in Patients Using Targeted Chemotherapy Drugs: A Review of the Literatureen_US
dc.typeArticleen_US

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