A comparison of plasma nitrite, nitrate and asymmetric dimethylarginine levels in major depression patients before and after escitalopram treatment

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dc.contributor.authorHisarvant, Arzu
dc.contributor.authorAtaoğlu, Ahmet
dc.contributor.authorÖzçetin, Adnan
dc.contributor.authorKılıç, Osman
dc.contributor.authorÖlmez, Safiye Bahar
dc.contributor.authorKuduban, Ali Kemal
dc.date.accessioned2020-04-30T13:32:03Z
dc.date.available2020-04-30T13:32:03Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractObjective: Asymmetric dimethyl arginine (ADMA) function, which is an intracellular repressor of nitric oxide (NO) and NO, examined and revealed in many mental disorders. In this study, we compared the simultaneous levels of plasma nitrite (NO2), nitrate (NO3) and ADMA before and after escitalopram treatment at Major Depression Disorder (MDD) patients and healthy controls. Material and Method: 40 patients with MDD according to DSM-IV-R and 40 heathy controls was included in this study. The Montgomery-Åsberg Depression Rating Scale was used to determine the severity of illness. Plasma NO2, NO3 and ADMA levels were measured in the MDD and the control groups. Results: Pretreatment plasma NO2, NO3 and ADMA levels in MDD group were significantly lower (but ADMA levels were higher) than in the control group. After the treatment NO levels of MDD group were close to control group, ADMA levels were statistically lower than the control group. Conclusion: Our study can contribute to the understanding of the role of NO and ADMA and relationship between complicated neurotransmitter systems at MDD etiopathogenesis. © 2018, Nobelmedicus. All rights reserved.en_US
dc.identifier.endpage30en_US
dc.identifier.issn1305-2381
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/23
dc.identifier.volume14en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherNobelmedicusen_US
dc.relation.ispartofNobel Medicusen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsymmetric dimetilarginin; Depressive disorder; Escitalopram; Nitrat; Nitriteen_US
dc.titleA comparison of plasma nitrite, nitrate and asymmetric dimethylarginine levels in major depression patients before and after escitalopram treatmenten_US
dc.title.alternativeMajor depresyon hastalarinda essitalopram tedavisi öncesi ve sonrasi plazma nitrit, nitrat ve asimetrik dimetilarjinin düzeylerinin karşilaştirilmasien_US
dc.typeArticleen_US

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