Yazar "Yaşar, Mehmet" seçeneğine göre listele
Listeleniyor 1 - 20 / 23
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Abdominal pain due to hereditary angioedema: Case Report [Herediter anjiyoödeme ba?li karin a?risi](2012) Turan, Hakan; Beşir, Fahri Halit; Büyükkaya, Ramazan; Yaşar, Mehmet; Doğan, SamiHereditary angioedema is a disease characterized by subcutaneous edema without urticaria, upper airway obstruction, and gastrointestinal symptoms. It results from congenital deficiency of C1 esterase inhibitor. This rarely seen disease is autosomal dominant inherited, and severe forms can be life threatening. Here, we present a case of hereditary angioedema who applied to the emergency room with severe abdominal pain, with low levels of C1 esterase inhibitor and C4 and with specific ultrasound findings, and completely recovered with the application of C1 esterase inhibitor concentrate. Copyright © 2012 by Türkiye Klinikleri.Öğe Acute calculous cholecystitis caused by Candida lusitaniae: an unusual causative organism in a patient without underlying malignancy(Natl Inst Infectious Diseases, 2008) Yıldırım, Mustafa; Özaydın, İsmet; Şahin, İdris; Yaşar, MehmetCandidiasis of the gallbladder is an uncommon cause of acute cholecystitis. Candidal cholecystitis is seen especially in patients with malignancies. In the present case, we report that acute calculous cholecystitis was caused by Candida lusitaniae in a 33-year-old patient without underlying malignancy. According to our review of the literature, this is the first report of acute cholecystitis caused by C. lusitaniae.Öğe AEG-1 expression in invasive ductal and lobular breast cancers and its relationship with prognostic parameters(Tubitak Scientific & Technical Research Council Turkey, 2013) Erdem, Havva; Oktay, Murat; Uzunlar, Ali Kemal; Yıldırım, Ümran; Ankaralı, Handan; Yaşar, MehmetAim: The astrocyte-elevated gene-1 (AEG-1, also known as metadherin) is associated with various aspects of tumour malignancy; however, little knowledge is available related to the role of AEG-1 in ductal and lobular carcinomas. The aim of this study was to investigate the relationship of AEG-1 with the prognostic parameters in invasive ductal and lobular carcinomas. Materials and methods: This study was conducted on a total of 72 paraffin-embedded breast tumour samples. They consisted of 61 ductal and 11 lobular carcinomas. Breast tumour samples were stained for AEG-1. The prognostic parameters were compared with the results of AEG-1 stains. Results: We observed that more ductal carcinoma types than lobular carcinoma types resulted in high AEG-1 staining, whereas low AEG-1 staining occurred more in lobular carcinomas than in ductal carcinomas (P = 0.05). A significant negative correlation was also found between HER-2 (r = -0.30, P = 0.019) and AEG-1 (r = -0.804, P = 0.003) in lobular carcinomas. A significant relationship was found between increasing numbers of positive lymph nodes and AEG-1 in ductal carcinoma cases (P = 0.05). Conclusion: These results are consistent with previous reports of the role of AEG-1 in tumour progression. AEG-1 could be a useful marker for the development of new treatments and resistant hormonal therapy.Öğe Apendico-ileal fistula in an acute ileus patient(2012) Yaşar, Mehmet; Aslaner, Arif; Bat, OrhanAppendiko-ileal fistül akut ileus tablosu ile nadir görülür. Bu yazıda mekanik barsak tıkanıklığı nedeni ile laparatomi uygulanan apendikoileal fistüllü 46 yaşında erkek olgu sunuldu. Cerrahi sırasında apendiks lümeni ile terminal ileum arasında bir fistül olduğu gözlendi. Ayrıca proksimal ileal ve jejunal ansların gergin olduğu da saptandı. Apendektomi, segmental ileum rezeksiyonu ve uçuca anastomoz cerrahi işlem olarak uygulandı. İnce barsak tıkanıklığı ile akut ileus tablosu gelişen hastalarda, apendiko-ileal fistülün akılda bulunması gerektiğini düşünmekteyiz.Öğe Appendico-ileal fistula in an acute ileus patient [Bİr Akut İleus Olgusunda Apendİko-İleal Fİstül](2012) Yaşar, Mehmet; Aslaner, Arif; Bat, OrhanAppendico-ileal fistula is a rare condition with acute ileus. We report a case of appendico-ileal fistule in a 46-year-old man patient who has undergone laparatomy for intestinal mechanical obstruction. Intraoperatively, an appendix with a lumen was found with a fistula to the terminal ileum. It has been observed that proximal ileal and jejunal intestinal anses were distended. Appendectomy, segmental ileum resection and end-to-end anastomoses were performed as a surgical procedure. This case describes an elderly man with acute ileus presenting with small bowel obstruction. We conclude that, appendico-ileal fistula should be kept in mind in cases with acute ileus presenting with small bowel obstruction.Öğe Batı Karadeniz Bölgesindeki akut pankreatitli hastaların retrospektif analizi(2010) Yaşar, Mehmet; Taşkın, Ali Kemal; Özaydın, İsmet; Demiraran, YavuzGiriş: Bu çalışma ile kliniğimizde akut pankreatit tanısıyla takip edilen hastaların etiyoloji, tanı ve tedavi yöntemleri, morbidite, mortalite ve Ranson kriterlerinin prognoza etkisi retrospektif olarak analiz edildi. Gereç ve Yöntem: Düzce Üniversitesi Genel Cerrahi Anabilim Dalı’nda 2003–2008 yıllarında 44’ ü (%70.9) ) hafif, 18’ i (%29.1) şiddetli toplam 62 Akut Pankreatit (AP) vakası retrospektif olarak analiz edilmiştir. Bulgular: Akut pankreatitin etiyolojik nedenlerden safra taşı 40 (%64,5), idiyopatik 11 ( % 17.7), hiperlipidemi 4 (% 6.4), alkol-hiperlipidemi 3 (%4.8), alkol 2 (%3,2), ERCP sonrası 2 (%3.2) idi. Akut pankreatit tanısıyla takip edilen hastaların ortalama yaşı 59.6 (18 – 84) olup, 23 (%37)'si erkek, 39 (% 63) 'sı da kadın idi. Biliyer pankreatitli 40 hastanın 14'üne Endoskopik Retrograd Kolanjiopankreatografi (ERCP) uygulandı. Biliyer pankreatitli hastaların, 2 sine de persistan biliyer pankreatit nedeniyle, 6 sına da kolesistit eşlik ettiği için ilk 48 saat içinde, 23 hastaya da akut atak sonrası kolesistektomi uygulanmıştır. Bilier pankreatitli İlk 6 vakanın 3’ üne laporoskopik kolesistektomi yapılırken açığa geçildi. Lokal anestezi altında 2 hastaya peritoneal lavaj, 4’üne tanısal diyagnostik laparoskopi, 2 ‘sine de nekroz eksizyonu yapıldı. Ortalama hastanede kalış süresi hafif olgular için 9.8, ağır olgular için 11.2 gündü. Şiddetli gruptan etiyolojisi idiyopatik olan 3 ( % 4,8) hasta exitus olmuştur. Sonuç: Akut pankreatit mortalitesi yüksek seyredebilen bir hastalıktır. Akut pankreatit etiyolojisinde en sık biliyer nedenler rol oynamaktadır. İdiyopatik AP ikinci sıklıkta rol oynadığı, alkol oranının oldukça düşük olduğu izlenmiştir. Biliyer pankreatitli olguların tedavisinde ilk aşamada ERCP faydalı bir yöntemdir. Mortalitenin genelde Şiddetli AP’ li hastalarda gözlendiği gibi tanı,tedavi ve takip bu hastalarda önem arz etmiştir.Öğe Correlation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasms(Medknow Publications & Media Pvt Ltd, 2015) Erdem, Havva; Gündoğdu, Betül; Ankaralı, Handan; Yaşar, Mehmet; Şener, Ebru; Oktay, Murat; Şahiner, CemBackground: Breast cancer is the second most frequent cancer in the world. Although it is widely accepted that the etiology of breast cancer includes both genetic and environmental factors, the molecular mechanism of its development and progression remains poorly understood, and thus far, no specific signature of breast cancer gene expression has been reported to allow for patient-tailored therapy strategies. Hence, it is of great clinical value to further understand the molecular mechanisms underlying the progression of breast cancer and to identify effective early markers for the diagnosis and prognosis of the disease as well as novel therapeutic targets. Materials and Methods: This study was conducted on a total of 90 paraffin-embedded breast tumor samples. Immunohistochemical stains for astrocyte elevated gene-1 (AEG-1), basic-fibroblast growth factor (b-FGF), beta-catenin, Ki-67, tumor necrosis factor- (TNF-) were performed on tissue microarray using standard procedures. Each patient age, grade, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) status, size, lymphovascular invasion, metastasis of lymph node (LNM), nipple and ductal hyperplasia areas were assessed. Results: We observed significant relationship between the age and LNM or FGF (P = 0.018, 0.035, respectively). The relationship between histological and nuclear grade, LNM, ER, PR, HER-2 and prognostic parameters was evaluated in cases of ductal carcinomas (DC). There was a significant positive correlation between TNF-, size, LNM (P % 0.0001, 0.002, 0.005). We found that significant relationship between AEG-1 and TNF-. There was a significant positive correlation between FGF and Ki-67 and negative correlation AEG-1. Although, FGF, TNF-, AEG-1 staining in DC were observed higher than ductal intraepithelial neoplasms, this observation could not statistically (P >= 0.05). Conclusions: The present work aims to investigate the relationship between the expression of AEG-1, b-FGF, beta-catenin, Ki-67, TNF- other prognostic parameters in DC and ductal intraepithelial neoplasm. We found a relationship between these factors.Öğe DOĞAL VE KİMYASAL EMPRENYE MADDELERİ İLE EMPRENYE EDİLEN SEDİR (Cedrus libani A.Rich.) ODUNUNUN DİRENÇ ÖZELLİKLERİNİN TESPİTİ(Düzce Üniversitesi, 2017) Yaşar, Mehmet; Yaşar, Ş.şadiye; Fidan, M.said; Ertaş, Murat; Altınok, MustafaAhşap malzemenin daha uzun ömürlüolması istenildiğinde çoğu zaman koruyucu maddelerle kaplanarak veya emprenyeedilerek sağlanmaktadır. Bu nedenle, bu çalışmada, sedir odununun doğal vekimyasal emprenye maddeleri ile emprenye edilerek bu emprenye maddelerininfiziksel ve mekanik yönden karşılaştırılmasının yapılması amaçlanmıştır. Bumakalede odun numunesi olarak sedir (Cedruslibani A.Rich.) kullanılmıştır. Kimyasal emprenye maddesi olarak imersolaqua ve timber care aqua, doğal emprenye maddesi olarak ise çam taneni ve meşepalamudu kullanılmıştır. Emprenye işlemi daldırma metodu ile 2 saat süre ilegerçekleştirilmiştir. Emprenye edilen malzemeler, nbsp; açık hava koşullarında bir yıl süreylebekletilmiştir. Emprenye edilen örneklere ait tam kuru yoğunluk, hava kurusuyoğunluk, rutubet miktarı, eğilme direnci, elastikiyet modülü, liflere paralelyönde basınç ve yapışma dirençleri ve vida tutma dirençlerinin testleri yapılmıştır.Sonuç olarak; doğal emprenye maddeleri ile emprenye edilen odun numunelerininhava kurusu yoğunluk, rutubet miktarı, liflere paralel yapışma ve vida tutmadirenç değerleri kimyasal emprenye maddeleri ile emprenye edilen odunnumunelerinden daha yüksek değerlerde çıktığı tespit edilmiştir. Bununlabirlikte, eğilme direnci, elastikiyet modülü ve liflere paralel basınç dirençdeğerlerinin ise daha düşük değerlerde çıktığı saptanmıştır. nbsp; nbsp;Öğe The early anti-inflammatory effect of Kefir in experimental corrosive esophagitis(Edizioni Luigi Pozzi, 2013) Yaşar, Mehmet; Taşkın, Ali Kemal; Kaya, Bülent; Aydın, Metin; Özaydın, İsmet; İskender, Abdülkadir; Kandiş, HayatiAim: Corrosive esophageal burns are still an important problem. The aim of this study was to evaluate the effect of kefir in an experimental corrosive esophagitis model. MATERIAL AND METHOD: Twenty-four male wistar albino rats were used in this experimental study. The rats were randomized into three groups according to the procedure and treatment type (each group has eight rats). Group I: (Control group), Group II: (Induction of corrosive esophagitis with 5 % NaOH without any treatment) and Group III: (Corrosive esophagitis treated with kefir). The rats were sacrificed on the first and seventh days. Mediastinum and abdominal cavity of rats were explorated. Approximately 1.5 cm of esophagus was removed for histopathological examination. Inflammation, injury in the muscularis mucosa and collagen deposition were evaluated. RESULTS: Histopathological results on the first day after caustic injury; inflammation was detected in three rats in Group II and there were no inflammation in rats in Group III. This difference was statistically significant (p<0.05). Injury in muscularis mucosa was detected in three rats in Group II and in one rat in Group III. Histopathological results on the seventh days after caustic injury; Inflammation was positive in four rats in Group II and three rats in Group III. Injury in muscularis mucosa was equal in two groups (three rats each). Collagen deposition with high grade (Grade 2) was detected in two rats in Group II and in four rats in Group III (p<0.05). CONCLUSION: Kefir has anti-inflammatory effect specially in early phase of caustic injury. It has also some beneficial effect in wound healing.Öğe Effects of Erdosteine on Experimental Acute Pancreatitis Model(Coll Physicians & Surgeons Pakistan, 2017) Karapolat, Banu; Karapolat, Sami; Gürleyik, Emin; Yaşar, MehmetObjective: To create acute pancreatitis condition experimentally in rats using cerulein, and to reveal histopathological effects in pancreatic tissue with erdosteine. Study Design: An experimental study. Place and Duration of Study: Department of General Surgery, Duzce University, Turkey, from June to October 2014. Methodology: Thirty male Wistar albino rats were divided into three groups. No procedures were applied to Group 1. The rats in Group 2 and Group 3 were injected cerulein, to establish an experimental pancreatitis model and the blood amylase and lipase values were examined. The rats in Group 3 were given 10 mg/kg erdosteine. This treatment was continued for another 2 days and the rats were sacrificed. The pancreatic tissues were examined histopathologically for edema, inflammation, acinar necrosis, fat necrosis, and vacuolization. Results: The lipase and amylase values and the histopathological examination of pancreatic tissues evidenced that the experimental acute pancreatitis model was established and edema, inflammation, acinar necrosis, fat necrosis, and vacuolization were observed in the pancreatic tissues. The statistical results suggest that erdosteine can decrease the edema, inflammation, acinar necrosis, fat necrosis and vacuolization scores in the tissues. Conclusion: The severity of acute pancreatitis, induced by cerulein in rats, is reduced with the use of erdosteine.Öğe Gastrointestinal Bezoarlar(Kocaeli Derince Eğitim ve Araştırma Hastanesi, 2013) Kaya, Bülent; Yaşar, MehmetBezoarlar sindirilmemiş besinler, ilaçlar, saç gibi maddelerin alınması sonucu oluşan yabancı maddelerdir. Gastrointestinal sistemde en sık midede görülürler. Bezoarların büyük bir kısmı çocuklarda ve genç bayanlarda tespit edilir. Bu hastalarda psikiyatrik bozukluklar görülebilir. Temel olarak 4 farklı bezoar tipi tanımlanmıştır. Bunlar; Fitobezoar, trikobezoar, farmakobezoar ve laktobezoar olarak adlandırılmıştır. Ağrı, erken doygunluk hissi, karında şişkinlik gibi şikayetler esas semptomlardır ve kanama, intestinal obstrüksiyon, perforasyon gibi komplikasyonlara neden olabilirler. Tedavi seçenekleri; medikal ajanlar, endoskopik girişimler, laparoskopik ve konvansiyonel cerrahidir.Öğe The hemostatic effect of calcium alginate in experimental splenic injury model(Turkish Assoc Trauma Emergency Surgery, 2013) Taşkın, Ali Kemal; Yaşar, Mehmet; Özaydın, İsmet; Kaya, Bülent; Bat, Orhan; Ankaralı, Seyit; Aydın, MetinBACKGROUND We evaluated the effect of calcium alginate as a hemostatic agent in a splenic injury model. METHODS Experimental rats (Wistar albino) were divided into four groups. Group I: Laparotomy was not performed. Group II: After laparotomy, the abdomen was closed without any splenic injury. Group III: After laparotomy, splenic injury about 0.5 cm in depth and 0.3 cm in length was created by standard Rochester pean forceps. Physiological serum treated gauze dressing, about 2x2 cm in size, was applied to the injured splenic tissue for 3 minutes. Group IV: After laparotomy, standard splenic injury about 0.5 cm in length and 0.3 cm in depth was created. Calcium alginate wound dressing, 1x1 cm in size, was applied to the splenic wound. In all groups, blood samples for bleeding time and hemogram were taken. Peroperative blood loss, pre- and post-operative hemoglobin and hematocrit values were calculated. RESULTS Comparing hematocrit values and peroperative bleeding in Groups III and IV, Group IV had a lower decline in hematocrit values and lower peroperative bleeding. CONCLUSION Calcium alginate has hemostatic capacity. It may be used in splenic injuries, especially for Grades I and II.Öğe Increased sister chromatid exchanges in patients with gastrointestinal cancers and in their first-degree relatives(TIP ARASTIRMALARI DERNEGI, 2014) Turgut, Taner; Yaşar, Mehmet; Yaykaşlı, Kürşat Oğuz; Ertaş, Ertuğrul; Sılan, FatmaGastrointestinal Cancers (GICs) are the most important causes of mortality and morbidity in industrialized world. Sister chromatid exchange (SCE), as an index of chromosomal instability, involves cancer. The aim of this study is to determine whether SCE frequency is a heritable factor for GIC or not. The study groups consisted of 15 gastrointestinal carcinoma patients, 13 patient relatives and 15 healthy subjects as the control group. After collection of 2 ml peripheral blood, lymphocytes were cultured for 3 days and sister chromatid exchange (SCE), mitotic index, and replication index were analyzed. SCE was significantly increased (p<0.01) in patients (16.06±22.37) and in their relatives (5.23±2.64) compared with controls (3.51±1.58). There was no significant difference between patients' relatives and control group in terms of the incidence of SCE frequency. Mitotic index was significantly decreased (p<0.05, p<0.01) in patients (5.4±3.13) compared with healthy relatives (7.15±2.15) and controls (9.00±2.26). Replication index was also significantly lower (p<0.01) in patients (1.39±0.35) and in their relatives (1.7±0.21) compared with controls (2.04±1.13). The results of this study indicate that SCE is a heritable factor for GICs. Increased SCE reflects genomic instability, which is an important factor in carcinogenesis. Although the most putative factors causing genomic instability are epigenetics marks, further studies in combination with epigenetic modifications are needed using more subjects.Öğe Inflammatory fibrosarcoma: A rare tumor involving retroperitoneum, ileum and colon(2007) Yaşar, Mehmet; Aslaner, Arif; Zengin, Ahmet; Turgut, TanerAn inflammatory fibrosarcoma is a rare tumor with a varied biological behavior, from benign to locally aggressive and occasionally malignant. It generally involves mesentery and retroperitoneal structures, but it rarely can involve the hollow viscera and commonly affects children and young adults. We report a case of inflammatory fibrosarcoma affecting an unusual age group, involving the ileum and descending colon (a rare site) causing subacute intestinal obstruction. We also discuss its surgical management, differential diagnosis and review of current literature.Öğe İnsizyon Hattında Glomus Tümörü: Olgu Sunumu(Düzce Üniversitesi, 2011) Erdem, Havva; Yıldırım, Ümran; Uzunlar, Ali; Şahiner, Cem; Yaşar, MehmetGlomus t uuml;m ouml;rleri ,glomus h uuml;creleri denilen, modifiye d uuml;z kas h uuml;crelerinden farklılaşan, nispeten nadir, benign t uuml;m ouml;rlerdir. Soliter glomus t uuml;m ouml;rleri ve glomanjiyom veya glomulovenous malformasyon olarak ta bilinen multipl glomus t uuml;m ouml;rleri olarak iki tipi belitilmiştir. Her varyantın farklı klinik ve histopatolojik ouml;zellikleri vardır. Bu t uuml;m ouml;rleren sık distal ekstremite yerleşimli,en sık subungual yerleşimlidir. Histolojik olarak, glomus t uuml;m ouml;r uuml; basık endotel h uuml;creleri tek bir tabaka ile kaplı ccedil;ok sayıda k uuml; ccedil; uuml;k, vask uuml;lerlumina g ouml;sterir. Vask uuml;ler alanlar, ccedil;evreye doğru, soluk eozinofilik sitoplazmalı ve b uuml;y uuml;k, soluk ccedil;ekirdek ile karakterize h uuml;cre k uuml;meleri tarafından kuşatılmasıyla karakterizedir. Biz, 51 yaşında, erkek hastanın gastrektomiden sonra insizyon hattı uuml;zerinde oluşmuş, kırmızımsı ağrılı nod uuml;l oluşturmuş soliter glomus t uuml;m ouml;r olgusu sunmak istedik.Öğe Intraabdominal hemorrage due to acute pancreatitis: Case report(Duzce University Medical School, 2018) Yekenkurul, Erman; Yaşar, Mehmet; Yekenkurul, Dilek; İskender, AbdulkadirAcute pancreatitis is acute inflammation of pancreatic cells that may presents with non-specific findings such as abdominal pain and vomiting. Haemorrhage is a rare complication of acute pancreatitis, while complications such as pseudocyst, abscess, necrosis may also occur. Here, we present a case of 39-years-old male patient with intraabdominal bleeding due to idiopathic acute pancreatitis. Patient presented to emergency department with abdominal pain and lack of appetite; as a result of history, findings and investigations acute pancreatitis were considered. Oral feeding was stopped and nutritional support was given by vascular access and pain control was achieved. Due to decrease in hemoglobin and hemotacrit level diagnostic laparoscopy were performed. On exploration fragile and hemorrhagic pancreas was observed. Bleeding control was achieved; after symptomatic treatment abdominal pain regressed. Laboratory findings were completely recovered and patient was discharged. As a result; should also be noted that the rare complications of acute pancreatitis, such as hemorrhage,can be seen, so considering the patient's symptoms can mislead us further investigations should be made. © 2018, Duzce University Medical School. All rights reserved.Öğe Karın Ön Duvar Defektlerinin Kapatılmasında Prolen Mesh Ve Strech Film Kullanımının Yapışıklık Üzerine Etkisi: Deneysel Çalışma(Kocaeli Derince Eğitim ve Araştırma Hastanesi, 2012) Yaşar, Mehmet; İlçe, Zekeriya; Özaydın, İsmetAmaç: Karın ameliyatları sonrası barsak yapışıklıkları ciddi morbidite ve mortaliteye neden olmaktadır. Çalışmamızda insizyonel hernilerde defektin kapatılmasında kullanılan primer kapama, Poliprolen mesh, Prolen mesh - strech filmin adhezyon etkileri karşılaştırıldı. Gereç ve Yöntem: Çalışmada 10 aylık 250–300 gram beyaz Wistar Albina cinsi 30 adet sıçan kullanıldı. Grup I; Primer tamir, Grup II; Prolen mesh, Grup III; Prolen mesh - strech film kullanıldı. Denekler 20 mg/kg Ketamin Hidroklorür (Ketalar) ile uyutuldu. Karın duvarınada yarıçapı 1cm olan defekt oluşturuldu. Defekt Grup I’de primer olarak 3/0 prolen ile tek tek, Grup II’de poliprolen mesh, Grup III’te prolen mesh - strech film ile kapatıldı. Denekler 21. gün sakrifiye edildi. Yapışıklıklar Makromorfolojik ve histopatolojik olarak değerlendirildi. Bulgular: Makromorfolojik evrelendirme kriterlerine göre elde edilen yapışıklık skorları Grup I’de ortalama 1.3 ( 0-3), Grup II’de ortalama 3.4 (2-4), Grup III’de ise ortalama 0.9 (0- 2) idi. Yapışıklıklar arasındaki fark istatistiksel olarak değerlendirildiğinde Grup I ile II ve Grup II ile III arasında anlamlı fark saptandı (P<0.05). Histopatolojik incelemede Mezotel gelişimi, Vasküler proliferasyon, Kollojen oluşumu, Dev hücre oluşumu, Granülasyon oluşumu, İtihabi hücre oluşumu, ve fibroblast proliferasyonu Grup II’de en yüksek, Grup III’te ise en düşük saptandı. Sonuç: Strech film prolen mesh ile karın duvarı defektlerinde yapışıklığı önlemek amacı ile kullanılabilir, sentetik bir materyaldir.Öğe The preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in rats(Comenius Univ, 2018) Yaşar, Mehmet; Erdi, I.; Kaya, B.AIM: We investigated the effects of atorvastatin and N-acetyl cysteine in decreasing ischemia-reperfusion damage after detorsion of a volvulus of the cecum and ascending colon. METHODS: Wistar albino rats (250-300 g) were divided into four groups. A cecal-ascending colon volvulus was created by the intestinal clockwise 720 degrees rotation. At the end of one hour, the bowel was detorsioned. Group I (n = 7) was the sham (laparotomy) group, Group II (n = 7) the control (no treatment, volvulus or detorsion), Group III (n = 7) (N-acetyl cysteine administered), and Group IV (n = 7) (atorvastatin administered) group. Blood samples were collected from each group via peripheral veins and centrifuged one hour after detorsion. The parameters of ischemia including malondialdehyde, glutathione peroxidase, catalase, and superoxide dismutase were then observed in the serous fluid. RESULTS: Malondialdehyde and superoxide dismutase increased in the control group, whereas they were reduced in the Group III and Group IV (p = 0.005; p = 0.008, respectively). The glutathione peroxidase levels revealed no significant differences (p > 0.05), whereas the catalase levels of the group III was higher than in each of the other three groups (p < 0.001). Histopathological evaluation detected reduced lesioning of the organ in the groups which were given atorvastatin and N-acetyl cysteine. CONCLUSION: Atorvastatin and of N-acetyl cysteine have a similar preventive effect in experimental ischemia-reperfusion injury (Tab. 8, Fig. 6, Ref. 24). Text in PDF www.elis.sk.Öğe Primer mezenter hidatid kist rüptürü(2011) Öztürk, Hülya; Yaşar, Mehmet; Küçük, Adem; Öztürk, HayrettinPrimer olarak karaciğer dışında hidatid kistin barsak mezenterine yerleşimi nadirdir. Burada nadir görülen ve akut karın tablosu bulunan ince barsak primer mezenter hidatid kist olgusu sunulmaktadır. Laparotomide kistin rüptüre olduğu görülmüş ve total olarak çıkarılmıştır. Ameliyat sonrası dönemde herhangi bir problem gelişmemiştir.Öğe Retrospective Analyses Of The Acute Pancreatitis With Patients In The West Black Sea(Düzce Üniversitesi, 2010) Taşkın, Ali Kemal; Özaydın, İsmet; Demiraran, Yavuz; Yaşar, MehmetIntroduction: In these study patients who were our clinic with an etiology, diagnosis and treatment methods, morbidity, mortality and effect of Ranson criteria to prognosis were examined retrospectively. Material and Method: In the study 44 mild and 18 severe total 62 AP cases among 2003-2008 at the General Surgery of Duzce University were analyzed retrospectively. Results: A etiologic factor was 40 (66,7 %), gallstone 11 (17, 7%) idiopathic, 4 (6,4 %) hyperlipidemia, 3 (4,8%) alchol-hyperlipidemia, 2 (3,2 %) alcohol, 2 (3,2 %) after ERCP complications. Patients were followed up with a diagnosis of acute pancreatitis, the average age of 59.6 and 23 (37%) were man, 39 (63%) were woman. ERCP were performed to 14 patients with billiary pancreatitis 2 patients for the persistent billiary pancreatitis and for the 6 patients cholecystitis accompanied pancreatitis in the first 48 hours period, 23 patients following the acute pancreatitis attack were performed cholecystectomy. Acute pancreatitis patients first 6 cases of biliary 3 reputations have been switched to laparoscopic open cholecystectomy is being performed. 3 patients peritoneal lavage under local anesthesia, 4 patients’ diagnostic laparoscopy and 2 patients nerosectomy were performed. Mean hospitalization times were 9.8 days for mild and 11.2 days severe. In the severe group idiopathic a etiology 3 (4.8 %) patients were exitus. Conclusion: Acute pancreatitis is a disease that can watch a high mortality rate. Biliary factors were the most common etiological factor. Idiopathic AP played a role in second place and we have observed that the effect of alcohol is quite low. In biliary acute pancreatitis ERCP is a useful method in the first stage. Overall mortality in severe AP, as observed in patients with the diagnosis, treatment and follow-up was important in these patients
