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Öğe Comparison of peripheral nerve repair using ethylcyanoacrylate and conventional suture technique in a rat sciatic nerve injury model(2020) Atam, Camettin; Orhan, Zafer; Toplu, Gaye; Serin, Merdan; Karaduman, Zekeriya Okan; Öztürk, AyhanObjective: The aim of this study was to compare the outcomes of primary nerve repair using either ethyl-cyanoacrylate orconventional microsuture technique in a rat peripheral nerve injury model.Methods: In this study, a total of 30 Wistar Albino rats weighing between 220 and 275 g were used. The rats were randomlydivided into three groups (10 in each), including one control (group 1) and two experimental groups (group 2, conventionalmicrosuture repair; group 3, cyanoacrylate repair). In each group, the sciatic nerve was identified and transected. No furtherintervention was performed in group 1. The nerve was repaired using the epineural technique with a 10/0 atraumaticnylon in group 2 and synthetic cyanoacrylate adhesive in group 3. At the fifth postoperative week, needle electromyography(EMG) was performed to measure distal latency, combined muscle action potential (CMAP), and motor nerve conductionvelocity (MNCV). Following the EMG recordings, animals were euthanized. Nerve samples were collected to evaluate vacuolardegeneration, fibrosis, and foreign body reaction histopathologically.Results: In the EMG analysis, mean distal latency was significantly shorter in group 1 (0.85±0.09 ms) than in groups 2(1.17±0.25 ms) (p=0.0052) and 3 (1.14±0.14 ms) (p=0.0026) while no significant differences existed between groups 2 and3 (p>0.9999). The mean CMAP was greater in group 1 (10.5±0.35 mV) than in groups 2 (2.86±1.28 mV) (p=0.011) and 3(2.16±1.34 mV) (p=0.0002), but there was no significant difference between groups 2 and 3 (p>0.9999). The mean MNCVwas 53.5±5.95, 39.62±7.31, and 39.84±4.73 mm/sec in groups 1, 2, and 3, respectively. There was a significant differencebetween groups 1 and 2 (p=0.0052) and between 1 and 3 (p=0.0026), but not between 2 and 3 (p>0.9999). In the histopathologicalevaluation, the mean vacuolar degeneration score was 0, 2.12, and 1.88 in groups 1, 2, and 3, respectively. No obviousdifference was observed between groups 2 and 3 (p=0.743). The mean fibrosis score was 0, 1.62, and 1.77 in groups 1, 2,and 3, respectively. There was no significant difference between groups 2 and 3 (p=0.888). The mean foreign body reactionscore was 0, 2.5, and 2.44 in groups 1, 2, and 3, respectively. No difference was present between groups 2 and 3 (p=0.743).Conclusion: Primary nerve repair using the cyanoacrylate adhesive may provide similar electrophysiological and histopathologicalresults as compared to the conventional microsuture repair.Öğe Does Periosteal Graft Combined With Platelet-Rich Plasma Enhance the Healing of Bone Defect?(Lippincott Williams & Wilkins, 2018) Türkseven, Arzu; Özçelik, Derya; Çalış, Mert; Çelik, Hakan Hamdi; Yılmaz, Fahri; Önbaş, Ömer; Toplu, GayeIntroduction:This study investigated the effect of periosteal graft + platelet-rich plasma (PRP) combination on facial bone defect healing. Methods: Five-millimeter critical sized defects in zygomatic arches of 12 adult New Zealand rabbits were created. Rabbits were randomly divided into 3 groups: First group (control group): bone defects of left zygomatic arches of 6 rabbits were wrapped with a silicone tube. Second group (periosteal graft group): bone defects of left zygomatic arches of 6 rabbits were wrapped with periosteal graft. Third group (experimental group): bone defects of right zygomatic arches of 12 rabbits were wrapped with periosteal graft-PRP combination. New bone formation was evaluated at 8th and 16th weeks. One rabbit was sacrificed at 8th week. Remaining 11 rabbits were imaged with 3-dimensional computed tomography (CT) at 16th week; then, zygomatic arches were removed for micro-CT and histologic examinations. Results: Three-dimensional CT analysis at 16th week revealed no significant difference between groups regarding new bone formation (P = 0.232). Micro-CT analysis of new regenerated bone at 16th week displayed significant differences between groups 1 and 3 regarding mean bone volume (BV, mm(3)) (P = 0.028) and mean bone mineral density (BMD, mm(2)) (P = 0.001). There was no difference between groups 2 and 3 or between groups 1 and 2, regarding BV or BMD. Histological Bone Regeneration Scorings at 16th week displayed significant difference between groups (P = 0.015). Negative correlation between 3-dimensional CT and histologic results (r = 0.120); positive correlations between BV/BMD values in micro-CT and histologic results (r = 0.524 and r = 0.456) were found. Conclusions: By enhancing bone formation capacity of periosteal grafts, periosteal graft-PRP combination provided bone formation having more volume and density comparing with silicone tube application.Öğe Facial Contouring and Rejuvenation with the Use of Fat Injection(2021) Toplu, Gaye; Altınel, DinçerAim: Reversing the effects of facial aging is achieved through a combination of the best techniques. Minimizing theappearance of fine wrinkles is an important part of treatment, which can include skin resurfacing, intradermal fillinginjections, or a combination of the two. The search for the ideal filling material continues, but intradermal fat injectionscan be a cheap and safe alternative to classic intradermal fillers. This study aims to evaluate the feasibility, validity, andreliability of micrograft, nanofat graft, sharp needle intradermal fat grafting (SNIF) technique.Material and Methods: In this retrospective study, the records of 13 consecutive patients treated over 3 years werereviewed to evaluate the results of the technique including panfacial rejuvenation, contouring, augmentation with fatinjection, and its complications.Results: The results were evaluated by clinical examination and patient photographs. Aesthetically good healing wasachieved using microfat graft, nanofat graft, sharp needle emulsified fat with intradermal injection techniques, theresults lasted more than 1 year, which exceeded the expected time for absorbable dermal fillers (typically 3 to 6months). No major complications were encountered; the most common minor complications were bruising andswelling.Conclusion: Microfat and nanofat grafts, SNIF, are a safe and effective alternative to conventional absorbable dermalfillers for patients who can accept minor discomfort from donor site fat harvesting. Fat harvesting and injectiontechniques should be done precisely to achieve proper results and prevent complications.Öğe The Importance of the Trigeminal Cardiac Reflex in Rhinoplasty Surgery(Lippincott Williams & Wilkins, 2015) Özçelik, Derya; Toplu, Gaye; Türkseven, Arzu; Sezen, Gülbin; Ankaralı, HandanBackground Trigeminocardiac reflex (TCR) consists of bradycardia or asystole along with hypotension and apnea coinciding with stimulation of the trigeminal nerve. During rhinoplasty procedures, we noticed that local anesthetic solution (LAS) application to the columellar area results in bradycardia. We planned to conduct a randomized prospective study on 47 patients undergoing rhinoplasty to demonstrate the characteristics of TCR arising from the columella. Method Local anesthetic solution containing 2% prilocaine with 1:80,000 adrenaline was applied under standard general anesthesia protocol. In group 1 (study group, n = 24), 2 mL of LAS was applied to the columella. In group 2 (control group, n = 23), 2 mL of LAS was applied to the nasal dorsum. In group 3 (control group, n = 20), after LAS was applied to nasal dorsum in group 2, we waited for 10 minutes. Then, 2 mL of LAS was applied to the columella. Here, recordings were taken for the columella. Heart rate (HR) and blood pressure (BP) were recorded just before needle insertion (baseline level), at the time of needle insertion (NIT) to the columella or dorsum, and after the 1st, 5th, 10th, 30th, and 60th seconds. Results Transient bradycardia (>= 20% drop in HR) was observed in 33% of the patients in group 1. Decrease in HR compared to the baseline level in group 1 was significantly greater than that of groups 2 and 3 at all times (P <= 0.05). Systolic BP in NIT and in 60th second in group 1, only in NIT in group 2 was significantly lower than that of baseline levels (P <= 0.05). Conclusions We concluded that stimulation of a sensory branch of the trigeminal nerve in the columellar area leads to TCR under general anesthesia by eliciting clinical hypotension with a drop in systolic BP and in HR of more than 20% compared to the baseline level. Knowing the existence of a certain TCR area will be helpful to the surgeon and anesthesiologist to exercise extra vigilance and to make continuous and meticulous monitoring of the electrocardiogram, HR, and BP during which the TCR may be precipitated such as local anesthetic infiltration to the columellar area in rhinoseptoplasty operations.Öğe Lateral facial cleft associated with accessory mandible having teeth, absent parotid gland and peripheral facial weakness(Churchill Livingstone, 2014) Özçelik, Derya; Toplu, Gaye; Türkseven, Arzu; Şenses, Dursun Ali; Yiğit, BüşraTransverse facial cleft is a very rare malformation. The Tessier no. 7 cleft is a lateral facial cleft which emanates from oral cavity and extends towards the tragus, involving both soft tissue and skeletal components. Here, we present a case having transverse facial cleft, accessory mandible having teeth, absent parotid gland and ipsilateral peripheral facial nerve weakness. After surgical repair of the cleft in 2-month of age, improvement of the facial nerve function was detected in 3-year of age. Resection of the accessory mandible was planned in 5-6 years of age. (C) 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.Öğe Lefort 1 Osteotomy Study of Maxillary Bone in Caprine Skull Model: Comparison of Different Osteotomy Techniques (Piezo Versus Lindemann Bur Versus Manual Chisel)(Lippincott Williams & Wilkins, 2024) Serin, Merdan; Altinel, Dincer; Toplu, Gaye; Rakici, Ibrahim Taskin; Toplu, Selcuk GokselObjective:In this study, we aimed to compare the efficiency of different osteotomy techniques for Lefort 1 osteotomy in an experimental caprine skull model. Methods:Twelve caprine skulls were used for the study. Skulls were divided into 3 groups: (1) manual chisel group, (2) Lindemann bur group, and (3) piezo osteotomy group. Bilateral osteotomies were performed on each skull. Results were evaluated with three-dimensional computerized tomography scans and macroscopic observations of the mucosal tears and soft tissue. Results:The mean length of the bone gap in the manual, Lindemann, and piezo groups was 4.8 (+/- 0.7), 3.38 (+/- 1.49), and 1.39 (+/- 0.3) mm, respectively (P < 0.05). The mean number of comminuted fractures in the manual, Lindemann, and piezo groups was 5.5 (+/- 1.4), 1.6 (+/- 0.3), and 0.6 (+/- 0.5), respectively (P < 0.05). Mucosal tearing and soft tissue damage based on subjective inspection observations were negligible in the piezo technique. Soft tissue and mucosal damage were observed significantly more in the manual chisel osteotomy method compared with the other 2 techniques. Conclusion:We anticipate that piezo, which has started to be used in new application areas besides rhinoplasty, will continue to be used more widely, especially in reconstructive orthognathic surgery, due to the minimal damage it causes to tissues. With the long-term results, much healthier interpretations can be made.Öğe Long-term objective results of proximal phalanx fracture treatment(Turkish Assoc Trauma Emergency Surgery, 2011) Özçelik, Derya; Toplu, Gaye; Ünveren, Toygar; Kaçağan, Fatma; Şenyuva, Cemal Tahsin GökhürBACKGROUND Proximal phalanx fractures are common. In this study, our preferred methods regarding the treatment of proximal phalanx fractures and their long-term objective results are presented. METHODS Between October 2001 and March 2010, in the Plastic Reconstructive and Aesthetic Surgery Department of Duzce Medical Faculty, we treated 23 patients with 32 proximal phalanx fractures. Stable fractures (n=5) were treated with splints, while unstable fractures (n=27) were stabilized with 1.0 mm percutaneous intramedullary Kirschner wires following open reduction. RESULTS At follow-ups, ranging from 3 months to 9 years, patients were evaluated with radiologic efficiency, range of motion (ROM), total active movements (TAM), and grip power of the digit. TAM scores of 20 fingers were perfect (>= 220 degrees for D2-5, >= 150 degrees for D1), for 7 fingers were good (180-220 degrees for D2-5, 120-150 degrees for D1), and for 5 fingers were either moderate or poor. No difference was observed between grip strength of broken fingers and that of healthy fingers. As a major complication, non-union occurred in one finger. CONCLUSION We concluded that Kirschner wire fixation is a reliable and simple method of treating unstable proximal phalangeal fractures, and excellent long-term results can be obtained in suitable cases. In stable proximal phalanx fractures, splints provide sufficient treatment.Öğe Posttraumatic giant proliferating trichilemmal cysts on the parietal region of the scalp(Wolters Kluwer Medknow Publications, 2011) Erdem, Havva; Yıldırım, Ümran; Uzunlar, Ali Kemal; Şahiner, Cem; Özçelik, Derya; Toplu, GayeProliferating trichilemmal (pilar) cysts, also known as pilar tumors, are most commonly found on the scalp of elderly women. Proliferating trichilemmal cysts are rare, slowly growing, lobular masses inherited autosomal dominantly and localized on scalps, and believed to arise due to a complication of a trauma and inflammation, and 5-10% of people are reported to be effected. Herein, we present the case of a 70-year-old woman with a 23-year history of multiple enlarging scalp masses. Clinically, squamous cell carcinoma was considered in the differential diagnosis, and the lesion was totally excised. Our case emphasizes the necessity for detailed clinical and pathological correlation for differential diagnosis.Öğe Ratlarda kritik büyüklükteki zigoma kemik defektinde adipoz kaynaklı mezenkimal kök hücrelerin kemik iyileşmesi üzerindeki etkileri(Düzce Üniversitesi, 2012) Toplu, Gaye; Özçelik, DeryaKemik defektlerinin tedavisinde halen en geçerli yöntem kortiko-kansellöz (bazenvaskülarize) kemik greftlerinin kullanımı olmasına rağmen, hücre bazlı stratejilerin önemi gün geçtikçe artmaktadır. Bu amaçla farklılaşmamış (kök hücre) veya farklılaşmış (osteoblast) hücreler, birtakım büyüme faktörleri ile veya tek başına kullanılmaktadır.Bu çalışmanın amacı: ratlarda zigoma kritik büyüklükteki membranöz kemik defektinde, adipoz doku kaynaklı mezenkimal kök hücrelerin etkilerini göstermek ve osteojenik potansiyelleri arasındaki farkları ortaya koymaktır.15 aylıktan büyük 18 adet erkek wistar albino rat kullanılarak, lateral insizyonlar ile sağ ve sol zigomatik arklar ortaya konulacak Ratların bilateral zigomatik arklarında (36 zigoma) standart olarak 3mm kemik defekt oluşturulacak. 1.Grup deney grubu olarak, inguinal yağ yastıkçığı alanlarından alınacak olan yağ dokularına santrifüj işlemi uygulandıktan sonra oluşacak kök hücrelerin sağ zigoma kemik defektinin bulunduğu alana enjekte edilecek, 2. grup kontrol grubu olarak sol zigomada 3mm lik kritik kemik defekti oluşturularak kendi halinde iyileşmeye bırakılacak. 10. ve 20. haftalarda kemik defektlerinin iyileşme alanları 3 boyutlu tomografi ile değerlendirilecek ve sonrasında denekler sakrifiye edilerek kemik iyileşmesi histolojik olarak incelenecektirTemin edilmesi kolay olan adipoz kökenli kök hücrelerin yeni oluşan membranöz kemik dokusuna entegre olduğu ve yeni kemik oluşumunun istatistiksel olarak anlamlı derecede hızlandırdığı ve oluşan kemiğin kalitesinin arttığı histopatolojik, radyolojik incelemelerle kanıtlanacaktır.Öğe Subtotal ear amputation with a very narrow pedicle: a case report and review of the literature(Turkish Assoc Trauma Emergency Surgery, 2009) Özçelik, Derya; Ünveren, Toygar; Toplu, GayeTotal ear amputation is common, and management can necessitate different procedures, especially microsurgical anastomosis. Partial ear amputations supplied by narrow pedicles. however, have been reported rarely. In a subtotally amputated auricle, the chance of survival depends on the vascularization within the pedicle. In our case, the right ear of a 36-year-old mate patient was subtotally amputated following a traffic accident, leaving only a 6-mm skin pedicle on the cranial side. The subtotally amputated segment was bleeding from the wound margins. The ear was reattached with primary suture without using microsurgical techniques after optimal debridement. Postoperatively, we administrated dextran 40 for 5 days to improve the microcirculation and increase blood volume and antibiotic to control the infection. No signs of edema, venous congestion or arterial insufficiency were observed immediately after the operation or subsequently. The replanted auricle healed completely with 100% survival, resulting in an essentially normal contour and appearance. This successful result without microvascular anastomoses also points Out the anatomical features of the auricular vascular networks.Öğe Vertical Mammaplasty for Gigantomastia(Springer, 2009) Özçelik, Derya; Ünveren, Toygar; Toplu, Gaye; Bilgen, Fatma; İskender, Abdülkadir; Şenyuva, CemalA 48-year-old female patient presented with gigantomastia. The sternal notch-nipple distance was 55 cm for the right breast and 50 cm for the left. Vertical mammaplasty based on the superior pedicle was performed. The resected tissue weighed 3400 g for the right breast and 2800 g for the left breast. The outcome was excellent with respect to symmetry, shape, size, residual scars, and sensitivity of the nipple-areola complex. Longer pedicles or larger resections were not found in the literature on vertical mammaplasty applications. In our opinion, by using the vertical mammaplasty technique in gigantomastia it is possible to achieve a well-projecting shape and preserve NAC sensitivity.
