Yazar "Sevmezler, Sedat" seçeneğine göre listele

Listeleniyor 1 - 1 / 1
  • Küçük Resim
    Öğe
    Evaluation of new chalcone derivatives as polyphenol oxidase inhibitors
    (Pergamon-Elsevier Science Ltd, 2011) Sönmez, Fatih; Sevmezler, Sedat; Atahan, Alparslan; Ceylan, Mustafa; Demir, Dudu; Gencer, Nahit; Küçükislamoğlu, Mustafa
    A newly series of 4-(phenylurenyl) chalcone (4a-j) and 4'-(phenylurenyl/thiourenyl)chalcone (9a-l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-L-tyrosine-p-aminobenzoic acid. The result showed that 4a-j inhibited the PPO enzyme activity. Conversely, 9a-h and 9i-l showed activator effect on tyrosinase enzyme activity. (C) 2011 Elsevier Ltd. All rights reserved.