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    Evaluation of Quality Assurance Indicators and Contamination Rate in Blood Culture
    (Duzce Univ, Fac Medicine, 2021) Oksuz, Sukru; Donmez, Betul; Keskin, Banu Humeyru; Memis, Nagihan; Karamurat, Zeynep Dilara; Caliskan, Emel; Sahin, Idris
    Objective: Blood culture are of vital importance in patient follow-up, as they enable the identification and production of sepsis causative microorganisms, initiate antibiotic treatment in a timely manner and reduce mortality and morbidity. In this study, it is aimed to evaluate the microorganisms grown in the automated blood culture in the microbiology laboratory of the hospital in terms of quality indicators. Methods: In this study, microorganisms grown from automated blood culture BACTEC-9120 (Becton Dickinson, USA) system from the blood culture samples sent to Duzce University Medical Microbiology Laboratory were evaluated retrospectively. For this purpose, the rejection and contamination rate of the samples for which blood culture was requested, the result of Gram staining-final identification compliance, the number of samples sent from a single bottle, and the growth times of microorganisms after incubation were determined. Results: 5037 blood culture samples were sent to the laboratory from various clinics. 1.7% of these samples were rejected as inappropriate samples. Gram stain-final identification compatibility of blood cultures was investigated and it was determined as 97.8%. The single bottle number of the samples sent was found to be 511. For the 5037 samples included in the study, growth was detected in 20.7%, of which 10.2% were considered as contaminants In our study, the average breeding time of the factors examined for breeding time was determined to be 30.29 hours. Conclusions: As conclusion, there is no gold standard to distinguish true pathogens from contaminant agents in blood cultures.
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    Experiences of the Department of Medical Faculty in the Pandemia Process
    (Duzce Univ, 2020) Buken, Bora; Kayikci, Muhammet Ali; Sahin, Idris; Cakar, Nigar Demircan
    Regarding Covid-19 pandemic, the preparatory works were carried out by the Rector's Office, the Dean of the Faculty of Medicine and the Chief Physician of the Hospital. Staff assignments were made and service started with the circular signed by Ministry of Health dated March 17, 2020. Gradual transition was planned by monitoring the rate of increase in the incidence of cases seen in our city. In accordance with the instructions of the Presidency, the Ministry of Health Scientific Committee and the Higher Education Institution (YOK), pandemic tent, pandemic service, pandemic intensive care units were opened and research assistants and lecturers were assigned to these units with decision taken by full harmonic work of the Hospital Administrative Board. Physicians from all branches were appointed with rotation in the pandemic outpatient clinic. The global epidemic caused by Covid-19 (corona virus) brought about serious changes in both education and exam applications in the last period of 2019-2020 academic year. The departments that require applied training, especially the Faculty of Medicine, were more affected from this process. All infrastructure facilities of our university were integrated into the system in a very short time in order to conduct online exams and the exams were successfully applied. Dear Rector, Professor Dr. Nigar Demican Cakar played the most important role in the effective functioning of the process with her directional decisions, administrative audits and continuously supports to the other transactions throughout the whole process.
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    Investigation of Isoniazid, Rifampicin and Second Generation Antibiotic Resistance Genes in Rifampicin-Resistant Mycobacterium tuberculosis Complex Strains Isolated at Düzce University Between 2004-2021
    (Duzce Univ, Fac Medicine, 2025) Akbas, Emel; Ege, Nagihan; Atik, Dursun; Caliskan, Emel; Oksuz, Sukru; Sahin, Idris; Ozturk, Elif Cihadiye
    Objective: To determine the gene patterns causing antibiotic resistance in M. Methods: Nineteen rifampicin-resistant MTBC strains isolated between 2004 and 2021 were included. The species of these strains with MTBC genotype and the gene pattern causing rifampicin resistance with MTBDR plus genotype were analysed. Results: Nineteen of the isolates were identified as M. tuberculosis/canetti by the MTBC genotype method. Seven of these isolates were genotypically resistant to rifampicin. One of the resistant isolates had deletion in WT8 and WT6 bands, one had deletion in WT8 band, one had deletion in WT7 band and rpoBMUT2A mutation, and four had deletion in WT8 band and rpoBMUT3 mutation. Seven of the resistant isolates were genotypically INH resistant. Five of them had katGMUT1 mutation with deletion in katGWT band and two of them had only INH AMUT3B mutation. Of the 10 multidrug-resistant MTBC isolates, nine were genotypically resistant to none of the second-generation drugs using the GenoType MTBDR sl ver 2.0 method. However, one isolate could not be evaluated with this assay. Conclusions: The presence of MDR-TB and RR-TB is an important challenge especially in TB control, which increases the need for molecular methods. Although it still has not replaced culture, there is a need for the use and development of new molecular methods that will benefit us in TB treatment and control.