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    Acute Effects of Red Bull Energy Drinks on Atrial Electromechanical Function in Healthy Young Adults
    (Excerpta Medica Inc-Elsevier Science Inc, 2020) Ozde, Cem; Kaya, Adnan; Akbudak, Ismail Hakki; Akture, Gulsah; Kayapinar, Osman
    Energy drinks (EDs) are widely consumed by adolescents and young adults. Almost all kinds of arrhythmias have been reported following EDs consumption, most of which is atrial fibrillation (AF). Atrial conduction time prolongation and heterogeneous sinusal impulses propagation to the atriums are the key electrophysiological mechanisms leading AF. We aimed to evaluate the acute effects of Red Bull ED ingestion on atrial electromechanical conduction times in healthy young adults. After a 12-hour fasting, 54 healthy young adults consumed 330 mL of Red Bull ED. Atrial electromechanical coupling (PA), intra-atrial electromechanical delay (intra-AEMD), and interatrial electromechanical delay (inter-AEMD) were measured at baseline and 2-hour after Red Bull ED ingestion by echocardiographic tissue-Doppler imaging (TDI) method. PA-lateral (49.7 +/- 11.2 vs 54.1 +/- 11.0 msn, p = 0.001) and PA-septal (40.8 +/- 9.1 vs 43.7 +/- 10.5 msn, p = 0.032) times were statistically significantly prolonged after Red Bull ED ingestion. There was also a statistically significant increase in the duration of inter-AEMD (14.4 +/- 10.6 vs 18.1 +/- 8.5 msn, p = 0.010) after ED ingestion. It was showed that even a single can of ED can acutely increase atrial electromechanical conduction times in young adults. These findings may be the cause of ED-associated AF. (C) 2019 Elsevier Inc. All rights reserved.
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    Association Between Plasma Levels of Fibrinogen and the Presence and Severity of Coronary Artery Ectasia
    (2020) Ozde, Cem; Kayapınar, Osman; Afşin, Hamdi
    Objective The aim of this study was to investigate the plasma fibrinogen levels in patients with isolated coronary artery ectasia (CAE).Materialsand MethodsThe study population included 154 patients, of whom 52 had isolated CAE, 52 had stable coronary artery disease (CAD) and 50 had normal coronary arteries (NCA). Theseverity of isolated CAE was determined using the Markis classification. All the subjects underwent complete physical examinations, including a detailed medical history,complete blood count and biochemical parameters. Plasma fibrinogen levels also were measured in all subjects.Results The baseline characteristics of the three groups were similar. Plasma fibrinogen levels were significantly higher in the CAE group and CAD group than in the NCA group(383.3 ± 53.0 mg/dl and 400.8 ± 50.6 mg/dl vs 324.0 ± 56.4 respectively, p < 0.001). No difference was found between the CAE and CAD groups. The fibrinogen level wassignificantly higher in the type 1 Markis subgroup than in the type 2 and type 3 subgroups (P <0.001). In multivariate logistic regression analyses, fibrinogen level wasindependently and significantly associated with isolated CAE. Receiver operating characteristic curve analysis revealed that fibrinogen levels > 325 mg/dl identified patientswith isolated CAE.Conclusions Plasma fibrinogen is an easily measurable systemic inflammatory biomarker that is independently associated with CAE presence and severity. This suggests that fibrinogenmay be involved in the pathophysiology of CAE.
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    Evaluation of Plasma Soluble Cd40 Ligand Levels in Children with Familial Mediterranean Fever and Its Relationship with Carotid Intima-Media Thickness
    (Mdpi, 2025) Ozde, Sukriye; Mehdizade, Cansu; Ali, Ozel Mehmet; Ozde, Cem; Kayapinar, Osman; Erguven, Muferret
    Background/Objectives: It has been suggested that chronic inflammatory diseases may be associated with an increased risk of cardiovascular disease. In this study, we investigated plasma soluble CD40 ligand (sCD40L) levels and their association with carotid intima-media thickness (cIMT) in children with Familial Mediterranean fever (FMF). Methods: The study was designed as a prospective cross-sectional study. The study included 68 asymptomatic children aged 5-18 years with FMF, diagnosed according to Tel Hashomer criteria, who were followed up regularly for at least one year, receiving regular colchicine treatment and not in an acute exacerbation period, along with 65 healthy children with similar demographic characteristics. cIMT was assessed by ultrasound and plasma sCD40L levels were measured by sandwich ELISA in all children. Results: Erythrocyte sedimentation rate, high-sensitivity C-reactive protein and serum amyloid A levels were not significantly different between patients and controls. However, sCD40L (p = 0.004) and fibrinogen (p = 0.011) levels were significantly higher in the FMF group compared to the control group. No significant difference was found between the patient and control groups in terms of carotid intima-media thickness (p = 0.517). Multivariate logistic regression was performed to assess the independent associations of fibrinogen and sCD40L with FMF. The results of this analysis indicated that sCD40L, but not fibrinogen, demonstrated a significant association with FMF (odds ratio [OR]: 1.003, 95% confidence interval [CI]: 1.001-1.006, p = 0.011). To determine the diagnostic performance of sCD40L, a receiver operating characteristic (ROC) curve was generated. This analysis demonstrated that sCD40L levels exceeding 100 pg/mL were predictive of FMF, yielding a sensitivity of 70.6% and a specificity of 62.3%. The positive predictive value and negative predictive value were 55.4% and 64.3%, respectively. The area under the curve for sCD40L was 0.644 (95% CI: 0.549-0.738, p = 0.004), signifying a statistically significant predictive capacity. Plasma sCD40L levels were significantly higher in FMF children with the M694V mutation (p = 0.013). Conclusions: The results of this study suggest that the high plasma sCD40L levels found in children with FMF may be related to the inflammatory activation of the disease rather than to atherosclerosis.
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    Evaluation of Serum Soluble Lectin-like Oxidised Low-Density Lipoprotein Receptor-1 (sLOX-1) Level in Children with Non-Complicated Type-1 Diabetes Mellitus (T1DM) and Its Relationship with Carotid Intima Media Thickness (cIMT)
    (Mdpi, 2025) Ozde, Sukriye; Yavuzyilmaz, Fatma; Ozel, Mehmet Ali; Kayapinar, Osman; Ozde, Cem; Akture, Gulsah; Arslanoglu, Ilknur
    Background: The objective of this study was to evaluate serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) levels in children with type-1 diabetes mellitus (T1DM) without any atherosclerotic complications and to investigate whether there was an association with early atherosclerotic processes in these children. Methods: The study's design entailed a prospective cross-sectional observational study methodology. The patient group consisted of 80 consecutive children aged 8-18 years who had been diagnosed with T1DM for at least ten years and had not developed any chronic clinical complications related to T1DM. The control group consisted of 72 completely healthy children with similar demographic characteristics. Serum levels of sLOX-1 were measured, and carotid intima-media thickness (cIMT) was evaluated using ultrasonography in all subjects. Results: A statistical analysis of the results was conducted. The serum sLOX-1 level was found to be significantly higher in the patient group than in the control group (0.49 +/- 0.11 vs. 0.82 +/- 0.35; p < 0.001). The statistical significance observed was maintained in the multivariable logistic regression analysis (p < 0.001). A significant correlation was identified between cIMT and serum sLOX-1 levels (r = 0.669, p < 0.001). The receiver operating characteristic curve for sLOX-1 indicated that a cutoff value greater than 0.65 ng/mL was associated with T1DM. Conclusions: Serum sLOX-1 levels were markedly elevated in children with T1DM who had not yet manifested chronic complications. These findings suggest that elevated serum sLOX-1 levels may be associated with the progression of atherosclerosis in children with T1DM.
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    Evaluation of the systemic-immune inflammation index (SII) and systemic immune-inflammation response index (SIRI) in children with type 1 diabetes mellitus and its relationship with cumulative glycemic exposure
    (Walter De Gruyter Gmbh, 2024) Ozde, Sukriye; Akture, Gulsah; Ozel, Mehmet Ali; Yavuzyilmaz, Fatma; Arslanoglu, Ilknur; Ozde, Cem; Kayapinar, Osman
    Objectives: In this study, the systemic proinflammatory status was assessed using the systemic immune-inflammation index (SII) and SIRI systemic immune-inflammatory response index (SIRI) in children and adolescents with type 1 diabetes mellitus (T1DM). Methods: The study involved 159 patients aged between 6 and 16 years. The SII and SIRI values were calculated based on the complete blood count. Basic blood biochemistry evaluated, and carotid intima-media thickness (cIMT) was measured and recorded. The cumulative glycemic exposure was calculated by multiplying the value above the normal reference range of the HbA1c value. The sum of all these values obtained from the time of diagnosis to obtain the cumulative glycemic exposure. All findings were compared statistically. All statistically significant parameters were evaluated in the multivariate logistic regression analysis. Results:The analysis revealed that only cIMT (Exp(B)/OR: 0.769, 95 % CI: 0.694-0.853, p<0.001), high-density lipoprotein (Exp(B)/OR: 3.924, 95 % CI: 2.335-6.596, p<0.001), monocyte count (Exp(B)/OR: 1.650, 95 % CI: 1.257-2.178, p<0.001), hematocrit (Exp(B)/OR: 0.675, 95 % CI: 0.523-0.870, p<0.001), and SIRI (Exp(B)/OR: 1.005, 95 % CI: 1.002-1.008, p<0.001) were significantly associated with T1DM. A statistically significant positive association was found between cumulative glycemic exposure and SIRI only (r=0.213, p=0.032). To our knowledge, this is the first study to evaluate SII and SIRI in children with type 1 diabetes. Conclusions: These findings indicate that SIRI could serve as a potential biomarker for detecting early-onset proatherosclerotic processes in diabetic children. However, further clinical studies are required to confirm this.
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    Radial Artery Thrombosis and Associated Risk Factors in Patients Undergoing Radial Coronary Angiography
    (Touch Medical Media Ltd, 2024) Koc, A. Y. Esra; Naldemir, Ibrahim Feyyaz; Ozde, Cem; Akture, Gulsah; Aytekin, Seda; Kayapinar, Osman; Karaca, Gurkan
    Background: Radial access is considered the preferred method for coronary angiography (CAG) and percutaneous coronary intervention. Radial artery thrombosis (RAT) stands out as the primary complication associated with trans- radial access. Our objective was to explore the occurrence of RAT and its associated risk factors. Method: A study encompassing 150 patients who underwent coronary interventions via radial access was conducted. Colour Doppler ultrasonography was used to assess proximal and distal radial flow rates 4-6 hours post- procedure. Patients diagnosed with RAT constituted the study group, while those without RAT were designated as controls. Results: Among the 150 patients, 20 (13.3%) developed RAT, with partial occlusions observed in 2.7% and total occlusions in 10.7%. Univariate analysis identified potential correlations between RAT and variables such as female gender, hypertension (HT), history of coronary artery disease, use of anti- thrombocyte medications, duration of compression, indication for CAG, haematocrit levels, neutrophil count, creatinine levels and estimated glomerular filtration rate. However, only HT showed a statistically significant association. Multivariate analysis confirmed HT, anti- thrombocyte drug use, duration of compression, haematocrit levels and creatinine levels as independent predictors of RAT. Conclusion: HT, anti- thrombocyte drug use, duration of compression, haematocrit levels and creatinine levels are identified as independent predictors of RAT. Standard pulse examination may not adequately detect RAT.
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    The Relationship of Coronary Thrombus Burden and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Score in Patients With ST-Segment Elevation Myocardial Infarction
    (Sage Publications Inc, 2024) Coskun, Goekhan; Ozde, Cem; Kayapinar, Osman; Aktore, Gulsah; Eksi, Ensar; Afsin, Hamdi; Sayin, Ahmet Egemen
    Background: The anticoagulation and risk factors in atrial fibrillation (ATRIA) score is associated with adverse cardiovascular events. However, its relationship with coronary thrombus burden is unclear. Therefore, we aimed to investigate the relationship between the ATRIA score and thrombus burden in patients with ST-segment elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI). Materials and Methods: The study was designed as a prospective cross-sectional observational study. Our study included 319 patients who were prospectively admitted with STEMI between January 2021 and April 2022. Patients were divided into 2 groups with low thrombus burden (LTB) (grade <3) and high thrombus burden (HTB) (grade >= 3). ATRIA score was calculated and recorded for all patients. ATRIA scores of both groups were compared. Results: In our study, 58.9% (n = 188) of patients in the LTB group and 41% (n = 131) of patients in the HTB group. The ATRIA risk score (p < .001) was significantly higher in the HTB group. In multivariate logistic regression analysis, ATRIA score, glomerular filtration rate, hypertens & imath;on, abciximab usage, and no-reflow were found to be independent predictors of HTB in STEMI patients undergoing primary PCI. In receiver operating characteristic analysis, ATRIA score >4 had a sensitivity of 66.2% and specificity of 95.2%, and ATRIA score >8 sensitivity of 98% and specificity of 100% predicted HTB. Conclusion: In this study, we found that thrombus burden may be associated with ATRIA risk score in patients presenting with STEMI.