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Öğe Comparison of Clinical, Laboratory and Demographic Characteristics of Patients Diagnosed with COVID-19 as Symptomatic and Atypical Symptoms(Clin Lab Publ, 2021) Akpinar, Guleser; Demir, Mehmet C.; Sultanoglu, Hasan; Unlu, Elif N.; Oksuz, SukruBackground: Clinical findings of COVID-19 have been observed with a wide spectrum ranging from asymptomatic disease and mild upper respiratory tract infection to severe viral pneumonia resulting in mortality. While clinical symptoms present in some COVID-19 patients, others have been incidentally identified. The objective of this study was to examine the clinical and laboratory features of patients diagnosed with COVID-19 who were symptomatic or had atypical symptoms and to make a contribution to the literature. Methods: Patients with the likelihood of having COVID-19 pneumonia were evaluated with RT-PCR samples, other laboratory tests, and chest computed tomography. Results: There were significant differences between these groups in terms of age, dyspnea, saturation, and comor-bidities including hypertension [HT] in 19 patients, cerebrovascular events [CVE] that were classified as other diseases in two patients (intracranial mass in one patient and Alzheimer's disease in one patient), and CRP and platelet counts (PLT) among the laboratory parameters (for all p < 0.05). Conclusions: Atypical symptoms have increased due to the progression of the outbreak. Infected people with atypical symptoms can act as sources of the infection. Therefore, the epidemiological history of these patients should be sought in detail, and individuals with atypical symptoms in society should be identified as soon as possible in order to control the spreading of the disease.Öğe Evaluation of Quality Assurance Indicators and Contamination Rate in Blood Culture(Duzce Univ, Fac Medicine, 2021) Oksuz, Sukru; Donmez, Betul; Keskin, Banu Humeyru; Memis, Nagihan; Karamurat, Zeynep Dilara; Caliskan, Emel; Sahin, IdrisObjective: Blood culture are of vital importance in patient follow-up, as they enable the identification and production of sepsis causative microorganisms, initiate antibiotic treatment in a timely manner and reduce mortality and morbidity. In this study, it is aimed to evaluate the microorganisms grown in the automated blood culture in the microbiology laboratory of the hospital in terms of quality indicators. Methods: In this study, microorganisms grown from automated blood culture BACTEC-9120 (Becton Dickinson, USA) system from the blood culture samples sent to Duzce University Medical Microbiology Laboratory were evaluated retrospectively. For this purpose, the rejection and contamination rate of the samples for which blood culture was requested, the result of Gram staining-final identification compliance, the number of samples sent from a single bottle, and the growth times of microorganisms after incubation were determined. Results: 5037 blood culture samples were sent to the laboratory from various clinics. 1.7% of these samples were rejected as inappropriate samples. Gram stain-final identification compatibility of blood cultures was investigated and it was determined as 97.8%. The single bottle number of the samples sent was found to be 511. For the 5037 samples included in the study, growth was detected in 20.7%, of which 10.2% were considered as contaminants In our study, the average breeding time of the factors examined for breeding time was determined to be 30.29 hours. Conclusions: As conclusion, there is no gold standard to distinguish true pathogens from contaminant agents in blood cultures.Öğe Identification of the Gram Positive Bacterial Sepsis Agent with Rapid Genotype Test(Duzce Univ, Fac Medicine, 2021) Erdogan, Ziya; Ozturk, Cihadiye Elif; Cangur, Sengul; Caliskan, Emel; Oksuz, Sukru; Karamurat, Zeynep DilaraObjective: An irreversible process begins when a systemic infection causes sepsis. Therefore, rapid identification of the agent bacteria in sepsis and its antibiotic resistance is crucially important. In this study, it was aimed to investigate the efficiency of rapid genotype test in detecting sepsis agent Gram positive bacteria and important antibiotic resistance. Methods: 2132 blood culture samples sent to the laboratory were examined with an automatic blood culture system (BACTEC, BD, USA) between 2018-2019. Blood culture bottles sent to the laboratory were Growing bacteria was identificated by VITEK (bioMerieux, France) automated bacteria identification / antibiotic susceptibility system. In addition, bacterial species and mecA, vanA, vanB, vanC1, vanC2 / C3 genes in blood cultures with Gram positive bacterial growth were also determined by the Genotype (R) BC Gram-positive (Hain Lifesience, Germany) test. Results: 72 patients with gram-positive bacteria growth in two or more blood culture bottles were included in the study. In 44 of the samples (61%) the same bacterial species were detected with conventional method (bacteria culture) and BC Gram positive test. In 28 of the samples (39%) differences were detected between results of methods regarding bacterial species name or vancomycin/methicillin resistance rate. Although single agent was isolated with culture method in all of the samples, multiple agents were detected in eight samples with rapid genotype test. Also, it was found that in mecA positive samples, ciprofloxacin resistance was higher than mecA negative ones. Conclusions: In the study, it was observed that BC Gram positive test could correctly identify sepsis agent bacteria and their resistance genes within 4-5 hours.Öğe Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination(Assoc Medica Brasileira, 2023) Caliskan, Emel; Ozturk, Cihadiye Elif; Oksuz, Sukru; Ince, Nevin; Yekenkurul, Dilek; Kahraman, Gozde; Duran, PelinOBJECTIVE: Because of the coronavirus disease 19 pandemic, studies on vaccination are being conducted in our country as well as across the world. In this study, the antibody levels in healthcare workers vaccinated with two doses of inactivated vaccine and the factors affecting these levels were investigated. METHODS: Randomly selected volunteers from healthcare workers, who had been vaccinated with two doses of inactivated vaccine in January to February 2021, were included in the study. Blood samples were drawn twice, 1 month and 6 months after the second dose vaccine (CoronaVac:Sinovac Life Science Co, Ltd, Beijing, China). The antibody levels were determined by the chemiluminescence microparticle immunoassay method using kits for quantitative detection of immunoglobulin class G antibodies to severe acute respiratory syndrome coronavirus 2. RESULTS: The mean antibody levels of 129 volunteers were 1232.5 (min: 103 to max: 7151) AU/mL in the first month and 403.5 (min: 23 to max: 4963) AU/mL in the sixth month. According to the survey results, 91 (71%) volunteers had not been diagnosed with coronavirus disease 19 before vaccination. The antibody levels 1 month and 6 months after the second dose of vaccination were significantly higher in those who had been diagnosed with coronavirus disease 19 before vaccination than in those who had not. It was found that age, gender, fast food, or healthy nutrition had no effect on antibody levels. CONCLUSION: Vaccines are very important both to protect against coronavirus disease 19 and to experience only a mild form of the disease. Immunoglobulin class G levels formed after vaccination may be affected by many factors and may decrease over time.Öğe Threat in water for drinking and domestic use: Nontuberculous mycobacteria(Wolters Kluwer Medknow Publications, 2021) Atik, Dursun; Oksuz, Sukru; Ozturk, Elif; Caliskan, Emel; Akar, Nida; Sungur, Mehmet AliObjective: Nontuberculous mycobacteria (NTM) have been recognized as a diverse group of organisms that are ubiquitous in environmental sources. In most regions of the world, NTM are not reportable as a public health disease, so epidemiological data are not easily available. However, data in published studies note increasing trends at the rate of NTM isolation from different geographic regions of the world. Increasing NTM isolation may have important public health implications. The aim of our study is the investigation of NTM from water resources and networks in Duzce, Turkey. Methods: NTM are common in water resources and water networks. They can cause waterborne infections in humans. A total of 120 water samples measured of chlorine and pH levels were decontaminated and filtered. Then, the filters were placed in the culturing media. Statistical Analysis Used: Chi-square and t-test were used for the statistical analysis. Results: NTM were detected in 20 (16.6%) samples. Nine of them (45%) were Mycobacterium fortuitum, three (15%) were Mycobacterium gordonae, three (15%) were Mycobacterium szulgai, two (10%) were Mycobacterium lentiflavum, two (10%) were Mycobacterium chelonae, and one (5%) was Mycobacterium peregrinum. Conclusions: These environmental bacteria can cause serious illnesses in both immunocompetent and especially immunocompromised individuals. For the correct treatment of these patients, it is important to determine NTM in clinical samples. Surveillance is necessary to know the source of NTM infection, to identify and type the strains, and to establish effective control measures such as disinfection, maintenance, and modernization of water systems.
