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Öğe Further Evidence for the Role of Nitric Oxide in Maternal Aggression: Effects of L-NAME on Maternal Aggression towards Female Intruders in Wistar Rats(Acad Sciences Czech Republic, Inst Physiology, 2009) Ankaralı, Seyit; Ankaralı, Handan; Marangoz, CaferIt has been shown that nitric oxide (NO) increases aggression in male mice, whereas it decreases aggression in lactating female mice and prairie voles. It is also known that aggression can be exhibited at different levels in rodent species, strain or subtypes. The aims of this study were to investigate the proportion of aggressiveness in Wistar rats, the effect of intraperitoneally administered nonspecific nitric oxide synthase (NOS) inhibitor L-NAME (N-G-nitro L-arginine methyl ester) on maternal aggression towards female intruders, and whether these effects are due to NO production or not. Rats were given saline intraperitoneally on the postpartum Day 2 and aggression levels were recorded. The same rats were given 60 mg/kg L-NAME or D-NAME (N-G-nitro D-arginine methyl ester) on the postpartum Day 3 and their effects on aggression levels were compared to saline. While L-NAME administration did not cause any differences in the total number of aggressive behavior, aggression duration and aggression intensity, it reduced the proportion of animals showing aggressive behavior. In addition, the latency of the first aggression was significantly increased by L-NAME. In the D-NAME group, however, no significant change was found. Our results have shown that L-NAME reduces maternal aggression towards female intruders in Wistar rats through inhibition of NO production. These results suggest that the role of NO in offensive and defensive maternal aggression shares neural mechanisms.Öğe The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats(Nencki Inst Experimental Biology, 2011) Yıldırım, Mehmet; Marangoz, Abdullah H.; Ayyıldız, Mustafa; Ankaralı, Seyit; Marangoz, CaferIn this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 mu g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 mu g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 mu g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 mu g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine.Öğe The interactions of nitric oxide and adenosine on penicillininduced epileptiform activity in rats(2011) Yıldırım, Mehmet; Marangoz, Abdullah H.; Ayyıldız, Mustafa; Ankaralı, Seyit; Marangoz, CaferIn this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 ?g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 ?g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 ?g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 ?g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine. © 2011 by Polish Neuroscience Society.