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    Synthesis and antimicrobial evaluation of novel heterocyclic compounds containing thiosemicarbazone
    (Sage Publications Inc, 2025) Macit, Ahsen Zeynep; Nartop, Dilek; Ogutcu, Hatice
    Herein, six novel heterocyclic compounds containing thiosemicarbazone were obtained by the condensation reaction of thiazole with thiosemicarbazide and benzaldehyde derivatives. The structures of newly obtained thiosemicarbazone-based heterocyclic compounds were investigated by spectroscopic methods (element analysis, infrared spectra (IR), proton nuclear magnetic resonance (1H-NMR), high resolution mass spectrometry (HRMS), scanning electron microscopy and energy dispersive X-ray (SEM-EDX). The antimicrobial efficiency of the obtained thiosemicarbazone-based heterocyclic compounds was screened in vitro against some pathogenic bacteria and yeast as potential medicinal agents. New heterocyclic compounds containing thiosemicarbazone were determined to be effective in varying degrees at inhibiting the activity of the tested disease-causing pathogenic strains. The heterocyclic compounds were found to show high or moderate antimicrobial activity. It was found that the synthesized heterocyclic compounds showed high or moderate antimicrobial activity.
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    Synthesis and in Vitro Antimicrobial Evaluation of Novel Potent Bioactive Heterocyclic Compounds
    (Taylor & Francis Ltd, 2023) Macit, Ahsen Zeynep; Hasanoglu Ozkan, Elvan; Ogutcu, Hatice; Nartop, Dilek
    In the present work, the antibacterial and antifungal properties of six new heterocyclic Schiff bases (HSb1, HSb2, HSb3, HSb4, HSb5, HSb6) were evaluated as potential bioactive compounds against the disease-causing pathogenic microorganisms (S.epidermidis, S.aureus, B.cereus RSKK863, E.aerogenes, P.aeroginosa sp., K. pneumonia, S. type H, P.vulgaris, E. coli and (C.albicans Y-1200-NIH). The well-diffusion-method was used to determine the antimicrobial activity. For this purpose, heterocyclic Schiff bases were synthesized by condensation reaction of aldehyde derivatives and thiosemicarbazide derivatives. Spectral analysis techniques (organic elemental analysis, FT-IR,H-1-NMR, HRMS, SEM-EDX) were used to characterize the synthesized compounds. It was determined that all the newly synthesized heterocyclic Schiff bases exhibited sound, high or moderate inhibitory effects on the growth of selected different standard antibiotics. [Graphical Abstract]
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    Tiyazol içeren bazı yeni tiyosemikarbazon bileşiklerinin sentezi
    (Düzce Üniversitesi, 2022) Macit, Ahsen Zeynep; Nartop, Dilek
    Tiyosemikarbazonlar, tiyosemikarbazit bileşikleri ile aldehit veya ketonların reaksiyonu ile oluşan ve biyolojik aktivite özellikleri sebebiyle ilgi gören bileşiklerdir. Çalışma kapsamında, 2-aminotiyazol-5-karboksaldehit, tiyosemikarbazit bileşikleri (4-metil-3-tiyosemikarbazit, 4-feniltiyosemikarbazit) ve benzaldehit türevlerinin (5-floro-2-hidroksibenzaldehit, 5-floro-2-hidroksi-3-metilbenzaldehit, 3-kloro-5-florosalisilaldehit, 5-brom-2-hidroksibenzaldehit, 5-klorsalisilaldehit, 2-hidroksi-5-metilbenzaldehit) kondenzasyon reaksiyonu sonucu 10 (on) adet yeni tiyasemikarbazon bileşiği (MeTSC-CH3, MeTSC-Cl, PhTSC-CH3, PhTSC-Cl, MTSC-Br, MTSC-Cl, MTSC-CH3, FTSC-Br, FTSC-Cl, FTSC-CH3) sentezlendi. Elde edilen tiyazol içeren tiyosemikarbazon bileşiklerinin yapıları spektroskopik yöntemler (element analizi, FTIR, 1H-NMR, SEM-EDX, ve HRMS) ile karakterize edildi.