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Öğe Ailesel Hipokalemik periyodik paralizi: olgu sunumu(2010) Korkut, Semih; Kandiş, Hayati; Güneş, Harun; Korkut, EsinAilesel hipokalemik periyodik paralizi, yılda birkaç kez veya her gün ortaya çıkabilen ve birkaç saat veya birkaç gün sürebilen geçici kas güçsüzlüğü atakları ile karakterize otozomal dominant geçişli konjenital bir hastalıktır. Ataklar sırasında potasyumun kas hücrelerine geçmesine bağlı olarak serum potasyum düzeyi düşer ve ataklar arasında normal sınırlardadır. Bu makalede belirgin bir tetikleyici faktör olmaksızın geçirdiği hipokalemik paralizi atağı sırasında acil servise başvuran 21 yaşında bir erkek hasta sunulmaktadır.Öğe Akut Üst Gastrointestinal Kanamalı Olgularımızın Endoskopik Sonuçları(2010) Korkut, Esin; Kandiş, Hayati; Korkut, SemihGiriş ve Amaç: Akut üst gastrointestinal kanamalar (AÜGİK), hastaneye yatan hastalar arasında mortalite ve morbiditenin önemli nedenlerinden biridir. Çalışmamızda üst gastrointestinal kanama ile kliniğimize başvuran hastaların endoskopi sonuçlarını retrospektif inceleyerek sunmayı amaçladık. Gereç ve Yöntem: AÜGİK nedeniyle kliniğimize başvuran 110 vaka retrospektif olarak kanamanın yeri ve laboratuvar özellikleri incelendi. Bulgular: Üst gastrointestinal kanamalı 110 olgunun; %42,7si kadın, %57,2si erkek, yaş ortalaması 60,4 17,3 (yaş aralığı 18-85) idi. Hastaların %96sında ilk 24 saat içinde endoskopi yapıldı. En sık saptanan lezyonlar; eroziv gastrit (%33,5) ve duodenal ülser (%29,0) idi. Olguların 9unda (3 vakada argon plazma koagulasyon, 5 vakada 1/10 000 adrenalin ile skleroterapi, 1 vakada varis band ligasyonu) endoskopik tedavi uygulandı. Bir olgu endoskopi işlemi yapılamadan abondan kanama ile kaybedildi. Sonuç: Eroziv gastrit en sık AÜGİK nedeni olarak tespit edildi. Mortalite oranı %0,9 ile oldukça düşük olarak saptandı. Hızlı etkin tedavi, erken dönemde yapılan gastroskopik girişimler mortalite oranının azalmasında etkindir.Öğe APPLICATION OF ARGON PLASMA COAGULATION AT ENDOSCOPIC MANAGEMENT OF NON VARICEAL UPPER GASTROINTESTINAL BLEEDING CLINICAL RESULTS(Nobel Ilac, 2010) Tamer, Ali; Korkut, Esin; Korkmaz, UğurObjective The cum of this study was to compare the effectiveness and safety of argon plasma coagulation (APC) method that has recently been started to be used to epinephrine injection (sclerotherapy) in the endoscopic management of nonvariceal upper gastrointestinal bleeding (UGIB) Material and Method. Patients (8 female 3 male age 61 15 8) applied with nonvariceal UGIB and treated with APC endoscopically were allocated to the study Patients (20 female 10 male age 62 7 18 3) applied with nonvariceal UGIB and treated with sclerotherapy with endoscopic epinephrine (1/10000) were allocated as a control group Age of the patients gender complaints (hematemesis melena) during application drug use (acetyl salicylic acid warfarin nonsteroidal anti inflammatory drugs (NSAI)) hemoglobin (Hb) level during application and discharge endoscopic diagnosis number of blood transfusion and drug treatment methods were noted Results There was no difference between APC applied patients and the patients treated with sclerotherapy in respect to the age of the patients gender presence of hematemesis and melena complaints during application NSAI drug use acetyl salicylic acid and warfarin use Hb level during application and discharge number of blood transfusion length of hospital stay surgical and mortality rate (p>0 05) APC was applied endoscopically diagnosed as hemorrhagic erosive gastritis in addition to the patients applied for peptic ulcer Conclusion APC application is an effective method in endoscopic treatment of nonvariceal upper GI bleeding The ease of application of procedure in APC applied patients a noncontact and controllable depth of coagulation observation of the cessation of bleeding during application endoscopically applicability in patients with hemorrhagic erosive gastritis are the advantagesÖğe Endoscopic results of our patients with upper gastrointestinal bleeding(2010) Korkut, Esin; Kandiş, Hayati; Korkut, SemihBackground and Aims: Acute upper gastrointestinal bleeding (UGB) is one of the most important causes of mortality and morbidity in hospitalized patients. In this study we aimed to retrospectively analyze the gastrointestinal endoscopy results in patients that refer to our clinic with UGB. Materials and Methods: Patients with UGB admitted to our clinic were retrospectively evaluated for location of bleeding and the laboratory findings. Results: One hundred-ten patients with UGB; of the patients, 42.7% were female, 57.2% were male with average age 60.4± 17.3 (ranged between 18 and 85). Upper endoscopy performed in 96% of patients with in the first 24 hours of bleeding. The most frequently observed endoscopic lesions were erosive gastritis (33.5%) and duodenal ulcus (29.0%). Endoscopic treatment performed in 9 of the patients (in 3 patients argon plasma coagulation, in 5 patient scleroteraphy with 1/10000 adrenalin solution and in 1 patient varices band ligation). One patient death with abondan bleeding. Conclusions: Erosive gastritis has been found to be the most frequent cause of UGB. The mortality rate of 0.9% was very low. The fast, effective treatment and gastroscopic evaluation in the early period was important to reduce mortality rate. © 2010 Düzce Medical Journal.Öğe Portal vein hemodynamics in patients with non-alcoholic fatty liver disease(Tohoku Univ Medical Press, 2008) Erdoğmuş, Beşir; Tamer, Ali; Büyükkaya, Ramazan; Yazıcı, Burhan; Büyükkaya, Ayla; Korkut, Esin; Korkmaz, UğurParalleling the rise in the incidence of obesity and diabetes worldwide, nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as one of the major causes of chronic liver disease. Doppler sonography is used as a diagnostic method in the non-invasive assessment of the hemodynamics of hepatic vascular flow in liver diseases. We investigated the effects of fatty infiltration in the liver on the Doppler flow hemodynamics of the portal vein. Doppler sonography of the liver and portal vein was performed in 60 subjects with NAFLD and 20 healthy volunteers (control). The patients were grouped into mild (grade 1), moderate (grade 2), and severe (grade 3) according to sonographic appearance of hepatosteatosis (n = 20 for each group). The vein pulsatility index (VPI), mean flow velocity (MFV), peak maximum velocity (V-max), and peak minimum velocity (V-min) of the portal vein were significantly lower in patients with NAFLD than those of the controls (p < 0.001). The VPI was 0.20 in the patients and 0.31 in the control. The MFV was 12.3 cm/sec in the patients and 16.5 cm/sec in the control group. The portal vein flow was found to be decreased as the grade of fatty infiltration increased for VPI (r = -0.946, p < 0.001),MFV(r=-0.951,p < 0.001). The alteration in Doppler waveform pattern of portal vein with fatty liver population suggests reduced vascular compliance in the liver.Öğe Servikal özofagusta heterotopik gastrik mukoza "inlet patch": klinik, manometrik ve ph metrik özellikler(Düzce Üniversitesi, 2008) Korkut, Esin; Soykan, İrfanGiriş: Heterotopik gastrik mukoza (HGM), proksimal özofagusta yer alan sarımsı pembe renkte, çevre mukozadan keskin bir sınırla ayrılan renkli adacıklardır.Amaç: Heterotopik gastrik mukoza saptadığımız hastaların klinik özelliklerini, özofagus motor fonksiyonlarını ve pH profillerini araştırmak ve HGM'nin bu parametreler üzerine olan olası etkilerini saptamaktı.Gereç ve Yöntemler: Heterotopik gastrik mukoza saptanan 30 hasta çalışmaya alındı. Hastalar reflü belirti sorgulamasına göre reflü pozitif ve reflü negatif 2 gruba ayrıldı. Tüm hastalara özofagus manometre testi ve çift kanal pH probu ile 24 saat ambulatuvar pH ölçümü uygulandı.Bulgular: Otuz servikal HGM' li hasta reflü belirti sorgulamasına göre 18 (%60)'i reflü pozitif ve 12 (%40)'si reflü negatif olarak değerlendirildi. Hastaların belirti sorgulamalarında: Disfaji (%30), globus histerikus (% 40), ağza acı su gelmesi (%60), kronik öksürük (%26), kısık ses (%10), ağız kokusu (%40), boğazı temizleme hissi (%53), >6 ay devam eden boğaz ağrısı (%20), horlama (%40), dilde yanma (%16), gece apneleri (%0), sabah ses kısıklığı (%33) oranlarında saptandı. Reflü semptomu olan HGM'li vakalarda disfaji (%44.4'e karşılık %8.3; p=0.04), boğaz ağrısı (%33.3'e karşılık 0; p=0.031) ve sabah ses kısıklığı (%50'ye karşılık %8.3; p=0.021) mevcuttu. Olguların 4'ünde distal pH metrede asit reflü bulguları saptandı. Bu 4 olgunun 3 ünde proksimalde asit reflüsü bulgusu mevcuttu. Hiçbir hastada proksimalde, distalden bağımsız asit reflü atağı saptanmadı. Hiçbir hastada özofagus motor fonksiyon bozukluğu izlenmedi.Sonuç: Heterotopik gastrik mukoza birçok olguda gastroözofageal reflü hastalığının supraözofageal bulguları ile ortaya çıkabilmektedir. Heterotopik gastrik mukozanın salgıladığı az miktardaki asidin reflü semptomları üzerinde katkısı yoktur. Heterotopik gastrik mukoza özofagusda motor fonksiyon ve asit reflü parameterleri bozukluğuna yol açmayan iyi huylu bir lezyondur.Öğe TWO CASES OF BARIUM SULFATE ASPIRATION(Nobel Ilac, 2011) Kandiş, Hayati; Korkut, Esin; Bilir, Özlem; Korkut, SemihRadiographic imaging with barium sulfate swallow is a radiological procedure to investigate dysphagia and the sense of food sticking in throat. infrequently, application of the procedure causes barium aspiration. Due to the non-irritant structure of the barium sulfate it does not expected to cause severe lung injury. However there have been reported cases progressed to mortality of the patients. Here, we present two patients following inadvertent aspiration of large amounts of barium dining an upper gastrointestinal radiographic contrast study and presented with different clinical outcomes.Öğe Two cases of barium sulfate aspiration [Baryum sülfat aspi?rasyonu: İki? olgu](2011) Kandiş, Hayati; Korkut, Esin; Bilir, Özlem; Korkut, SemihRadiographic imaging with barium sulfate swallow is a radiological procedure to investigate dysphagia and the sense of food sticking in throat. Infrequently, application of the procedure causes barium aspiration. Due to the non-irritant structure of the barium sulfate it does not expected to cause severe lung injury. However, there have been reported cases progressed to mortality of the patients. Here, we present two patients following inadvertent aspiration of large amounts of barium during an upper gastrointestinal radiographic contrast study and presented with different clinical outcomes.Öğe Two successive pregnancies after ursodeoxycholic acid therapy in a previously infertile woman with anti mitochondrial antibody-negative primary biliary cirrhosis(Elsevier Science Inc, 2005) Korkut, Esin; Kısacık, Bünyamin; Akcan, Yusuf; Belenli, Olcay; Bicik, Zerrin; Yücel, OğuzObjective: To describe the benefit of ursodeoxycholic acid (UDCA) for the initiation and completion of a successful pregnancy in a previously infertile woman with primary biliary cirrhosis. Design: Case report. Setting: A university hospital with relevant departments. Patient(s): A 29-year-old woman with primary biliary cirrhosis and failure to conceive for 6 years. Intervention(s): Establishment of diagnosis with a liver biopsy, pretreatment of patient with UDCA before conception, and continuation of UDCA after first trimester until term. UDCA was used in the second pregnancy again after the first trimester. Main Outcome Measure(S): Achievement of a safe conception and full-term pregnancy. Result(S): Two consecutive successful pregnancies, a healthy 3,250-g male infant and a healthy 3,000-g female infant. The second conception occurred in a period without the use of UDCA, implicating a latent beneficial effect of either UDCA orthe previous pregnancy via some possible immune mechanism. Conclusion(s): Ursodeoxycholic acid could help achieve conception in infertile women with primary biliary cirrhosis. The use of UDCA after the first trimester is shown to be safe in two consecutive pregnancies. Although it cannot be conclusive, the unintentional use of UDCA in the first 20 days after conception did not result in any teratogenicity in the first child. (c) 2005 by American Society for Reproductive Medicine.