Yazar "Kiraz, Hasan Ali" seçeneğine göre listele

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  • Küçük Resim
    Öğe
    Bilateral alt ekstremite uzuv kaybı olan geriatrik hastada spinal anestezi: 2 olgu sunumu
    (2013) Erbaş, Mesut; Öztürk, Ömür; Kiraz, Hasan Ali; Toman, Hüseyin; Şahin, Hasan; Demiraran, Yavuz
    Yaşam kalitesinin yükselmesi, yeni teşhis ve tedavi olanaklarının geliştirilmesi ile yaşlı popülasyon tüm dünyada hızla artmaktadır. Yaşlı hasta grubundaki yandaş hastalıklar ve gelişebilecek komplikasyonlar nedeniyle rejyonel anestezi teknikleri genel anesteziye tercih edilmektedir. Spinal anestezinin operasyon sırasında kognitif fonksiyonların ve hava yolu reflekslerinin korunması, postoperatif dönemde etkin analjezinin sağlanması ile birlikte erken mobilizasyon gibi avantajları vardır. Spinal anestezide lokal anesteziğin sefale doğru yayılması ile birlikte preganglionik sempatik liflerde blokaj olması, kardiovasküler yan etkilere yol açabilir. Özellikle geriatrik hastalarda bu hemodinamik instabiliteden kaçınmak için lokal anesteziğin mümkün olan en düşük dozda kullanılması tercih edilmelidir. Biz bu yazıda geriatrik, bilateral alt ekstermite uzuv kaybı olan ve ürolojik girişim geçirecek olan yüksek riskli iki olgumuzda spinal anestezi uygulamamızı ve bilateral uzuv kaybının uyguladığımız lokal anestezik d ozuna etkisini literatür eşliğinde tartışmayı amaçladık.
  • Küçük Resim
    Öğe
    Effects of tenoxicam in experimental corrosive esophagitis model
    (Oxford Univ Press Inc, 2015) Erbaş, Mesut; Kiraz, Hasan Ali; Küçük, Adem; Topaloğlu, Naci; Erdem, Havva; Şahin, Hasan Can; Özkan, M. Turgut Alper
    Esophageal stricture, one of the important complications of corrosive esophagus, develops following edema and granulation tissue that forms during and after the inflammatory reactions. Tenoxicam, a non-steroid anti-inflammatory drug with a long half-life, prevents various leukocyte functions including phagocyte and histamine secretion by inhibiting prostaglandin synthesis and removes various oxygen radicals in the region of inflammation. We designed this as a histopathological study using tenoxicam in rats for which we created a corrosive esophagus model. After necessary authorizations were obtained, the study was performed in Canakkale 18 Mart University experimental animal laboratory. Twenty-four Wistar albino rats, weighing 220-240g, were used for the experiment. Experimental animals were randomized into three groups: tenoxicam group (group T, n:8), control group (group C, n:8), and sham group (group S, n:8). Tenoxicam 0.5mg/kg/day was administered to animals in group T, where esophageal burn was developed experimentally, 5mg/kg 0.9% NaCL was administered i.p. to rats in group C for 15 days, once in 24 hours. No procedure was applied to rats in group S. After 15 days, all animals were sacrificed under general anesthesia and their esophagi were extracted. As a result of histopathological evaluation, inflammation and fibroblast proliferation was not observed in rats in the sham group (group S). Intense inflammation was observed in six rats (6+/2-) in the control group, and fibroblast proliferation was observed as 5+/3-. And in treatment groups, inflammation was evaluated as 3+/5-, and fibroblast proliferation as 3+/5-. In our study, histopathologic damage score was higher in the control group (P < 0.005). We deduce that tenoxicam can be useful in the treatment of caustic esophageal injuries in the acute phase, but think that these drugs require further researches and clinical studies before routine clinical use.
  • Küçük Resim
    Öğe
    Protective effects of ursodeoxycholic acid in experimental corrosive esophagitis injury in rats
    (Edizioni Luigi Pozzi, 2017) Küçük, Adem; Topaloğlu, Naci; Yıldırım, Şule; Tekin, Mustafa; Erbaş, Mesut; Kiraz, Hasan Ali; Özkan, Aybars
    Accidental caustic ingestions are serious medical problems especially in childhood. Various treatment modalities are being used for the complications of caustic injuries such as stricture formation. The aim of this study is to establish whether ursodeoxycholic acid (UDCA) has protective effects on experimental corrosive esophagitis in rats. Twenty four Wistar-albino rats, weighing 220-240 g, were used in the study. Experimental animals were divided in three groups randomly: UDCA treatment group (Group 7; n:8), control group (Group K n: 8) and sham group (Group S, n: 8). In group T and S corrosive esophagitis was induced. UDCA (5 mg/kg) was performed to the group T for 10 days orally. All animals were sacrificed at the end of procedures and histopathological changes in esophageal tissue were scored by a single investigator who was blind to the groups. In group T inflammation was present in two rats, muscularis mucosa injury in two rats, grade I collagen deposition in six rats and grade 2 in two rats. In comparison with group S these were statistically significant (p value was 0.003, 0.003 and 0.015, respectively). UDCA has protective effect in experimental corrosive esophagitis.