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Öğe Antioxidant and Apoptotic Effect of Edaravone on Cisplatin-Induced Brain Injury in Rats(Neurological Society R.O.C (Taiwan), 2024) Kara, O.; Kilitci, A.Purpose: This study aims to investigate the effect of edaravone in preventing cisplatin-induced brain damage. Methods: Forty female Wistar albino rats were included in the study. 4 groups were created. In group 1 (control group) (n=10), neither any drugs were given nor anything was performed. Group 2 (cisplatin group) (n=10), single dose 7.5 mg/kg cisplatin was given. In group 3 (edaravone group) (n=10), single dose 1 mg/kg edaravone was administered. Group 4 (cisplatin+ edaravone group) (n=10), single dose 7.5 mg/kg cisplatin and 1 mg/kg edaravone were given. Brain tissue was removed in all rats after 3 days. Blood samples taken from heart tissue were examined for malondialdehyde (MDA) and nitric oxide (NO) levels. Brain tissue was evaluated for damage with p53, GFAP and Ki 67. Results: Edaravone reduced cisplatin-induced brain damage. MDA and NO levels in the cisplatin group were significantly higher than the other groups (p< 0.05). Likewise, tissue damage in the cisplatin group was significantly higher than in the other groups (p< 0.05). The immunohistochemical staining which was done by using p53, GFAP and Ki 67 was shown that tissue damage was higher in cisplatin group than cisplatin+ edaravone group and this difference was found to be statistically significant (p< 0.05). Conclusion: The findings of our study suggest that edaravone therapy may be effective in the prevention and treatment of cisplatin-induced brain injury. © 2024, Neurological Society R.O.C (Taiwan). All rights reserved.Öğe Morphological and Molecular Analysis of Incidental Neoplasia in Explanted Lungs with UIP/IPF: A Single Centre Experience(Elsevier Science Inc, 2023) Lunardi, F.; Verzeletti, V.; Pezzuto, F.; De Chellis, C.; Tauro, V.; Fortarezza, F.; Kilitci, A.[No abstract available]Öğe Rat brain and testicular tissue effects of radiofrequency radiation exposure: Histopathological, DNA damage of brain and qRT-PCR analysis(Ijrr-Iranian Journal Radiation Res, 2024) Yavas, M. C.; Kilitci, A.; Celik, E.; Yegin, K.; Sirav, B.; Varol, S.Background: : The Background: We evaluate the effects of radiofrequency electromagnetic field (RF-EMF) on rat brain and testicular tissue using histopathology, comet assay, and real-time quantitative PCR techniques. Materials and Methods: Two equal groups of fourteen rats one for sham-control and the other for exposure (n = seven) were created. For a duration of 14 days, the exposure group (2100 MHz, testicular tissue SAR values of 163 mW/kg for 10 g, brain tissue SAR values of 292 mW/ kg on average) was subjected to five hours of exposure per day. Evaluations were conducted on tissue gene expression levels, histopathology, and DNA damage to brain tissue. Results: The histological examination of brain tissue from the exposed group revealed vascular alterations and significant edema (p < 0.05). It was determined that RF radiation-induced much more cellular damage in the exposed group (18.26% tail DNA) than in the control group (4.06% tail DNA). Signs of deterioration in spermatogenic cells in the testicular tissue of the exposed group also changed significantly (p < 0.05). The Bax and bcl-2 genes showed a significant difference (p < 0.05) in the mRNA level data, whereas the p53 genes showed no significant change (p > 0.05). Conclusion: These findings suggest that it may cause some histopathological and cellular damage in brain and testis tissue.
