Yazar "Karadağ, Ayşe Serap" seçeneğine göre listele
Listeleniyor 1 - 13 / 13
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Alteration of tissue expression of human beta defensin-1 and human beta defensin-2 in psoriasis vulgaris following phototherapy(Taylor & Francis Ltd, 2019) Uzunçakmak, Tuğba Kevser; Karadağ, Ayşe Serap; Özkanlı, Şeyma; Akbulak, Özge; Özlü, Emin; Akdeniz, Necmettin; Oğuztüzün, SerpilWe compared the expression profiles of antimicrobial peptides (AMPs) in psoriatic skin before and after narrow band ultraviolet B (nb-UVB) phototherapy and compared the levels to healthy controls. We studied 15 male and 12 female patients with psoriasis vulgaris, and 11 female and nine male control individuals. The patient group was treated with 24-36 sessions of nb-UVB phototherapy. Immunohistochemical staining for human beta defensin 1 (hBD-1) and human beta defensin 2 (hBD-2) expression of lesioned and control skin was performed prior to and following phototherapy. After phototherapy, the psoriatic area and severity index (PASI) decreased significantly in the treated patients compared to controls. The hBD-1 level was significantly higher in psoriasis patients than healthy controls. We found no statistically significant difference in hBD-1 and hBD 2 levels before and after phototherapy in the patient group. Although hBD-1 plays a role in psoriasis, levels of human beta defensin 1 and 2 are not affected significantly by phototherapy.Öğe Behçet disease: New developments in the etiopathogenesis of an old silk road disease(Pulse Marketing and Communications LLC, 2018) Özlü, Emin; Karadağ, Ayşe SerapBehçet disease (BD) is a systemic inflammatory disorder that affects the skin, mucosa, eyes, joints, blood vessels, brain, and gastrointestinal tract. The etiopathogenesis of BD has not yet been fully elucidated, but disorganized immune responses against the stimuli of environmental triggering factors have been considered to play a major role in the pathogenesis of the disease in individuals with genetic susceptibility. Human leukocyte antigen (HLA)-B*51 is known to be the main factor involved in genetic susceptibility to BD. Among the environmental factors, infectious agents in particular are thought to be important. Immunological abnormalities could thus be the cornerstone in the development of BD. Along with cytokines that play a role in disease pathogenesis, numerous other cytokines have been recently identified or have been the focus of recent studies. This contribution sheds light on the etiopathogenesis and immunology of BD in relation to the current literature. © 2018 Pulse Marketing & Communications, LLC.Öğe Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study(Kare Publ, 2018) Özlü, Emin; Uzunçakmak, Tuğba Kevser; Takır, Mümtaz; Akdeniz, Necmettin; Karadağ, Ayşe SerapOBJECTIVE: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group. METHODS: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. The number of diabetic obese patients was 138 (30%), whereas that of nondiabetic obese patients was 312 (70%). A detailed dermatological examination was performed for each case, and accompanying dermatoses were compared. RESULTS: The mean body mass index (BMI) in the obese patients and control group was 37.22 kg/m(2) and 22.23 kg/m(2), respectively. The most common dermatoses in the obese patients were, according to their frequency: striae distensae (291 patients, 64.7%), acrochordon (236 patients, 52.4%), acanthosis nigricans (213 patients, 47.3%), plantar hyperkeratosis (209 patients, 46.4%), and venous insufficiency (202 patients, 44.9%). Although hirsutism was more frequently observed in the nondiabetic obese group than in the diabetic obese group, stasis dermatitis was less frequently observed (p<0.05). CONCLUSION: We found that many dermatoses are more frequently observed in the obese patients than in the controls. We observed that the effect of obesity on skin is different from that of diabetes mellitus and that cutaneous manifestations of obesity occur more frequently. More extensive, comprehensive, and advanced studies on this subject are required.Öğe Correlation study between clinical classification and disability index in a holistic evaluation of acne severity and impact in Turkey(Edizioni Minerva Medica, 2021) Özlü, Emin; Karadağ, Ayşe Serap; Aksoy, Berna; Bilgili, Serap Güneş; Gönül, Müzeyyen; Yavuz, İbrahim H.; Şenel, EnginBACKGROUND: This study provides a comparison between disease severity observed by inspectors and the disease burden assessed by patients is scanty in acne study. METHODS: In a multicenter prospective hospital-based study, modified Comprehensive Acne Severity Scale (mCASS) and Cardiff Acne Disability Index (CADI) were employed to grade disease severity and to determine the quality of life, respectively. The average of the mCASS and CADI scores, with range at 0-25, was termed as Acne Severity and Impact Grading System (ASIG). RESULTS: In 1331 evaluated patients (mean: 21,51 +/- 4,93 years), including 306 men and 1025 women, an overall significant, positive correlation was found between ASIG and mCASS (r=0.862), or CADI (r=0.686), respectively (P=0.001 each). Adult women with back acne and adolescent with decollete expressed greater concern (higher CADI) than the clinical severity (lower mCASS). The overall prevalence of acne in decollete area, including neck, was 32.3%. CONCLUSIONS: Discrepancies in the acne severity between self-perception and objective evaluation exist in certain subgroups of patients. Decollete acne deserves special attention in clinical assessment. (Cite this article as: Ozlu E, Karadag AS, Aksoy B, Gunes Bilgili S, Gonul M, Yavuz IH, et al. Correlation study between clinical classification and disability index in a holistic evaluation of acne severity and impact in Turkey. Ital J Dermatol Venereol 2021;156:669-74. DOI: 10.23736/S27848671.20.06738-3)Öğe Cutaneous manifestations of diabetes mellitus and the metabolic syndrome(Elsevier Science Inc, 2018) Karadağ, Ayşe Serap; Özlü, Emin; Lavery, Michael JosephMetabolic diseases are commonly encountered in the Western world. Cutaneous manifestations are common in metabolic disorders, such as diabetes mellitus (DM) and the metabolic syndrome (MetS), and metabolic diseases may manifest with specific skin findings. MetS and DM share a common mechanism in their etiopathogenesis. As a result, the skin findings associated with these two diseases partially overlap. Several skin findings in DM and MetS may be the first clinical features of the disease, and early diagnosis facilitates treatment, thereby helping in preventing long-term complications. In this review, MetS and skin manifestations associated with DM are discussed. (C) 2018 Elsevier Inc. All rights reserved.Öğe Effect of low-dose acitretin treatment on pituitary hormones in psoriasis vulgaris: A retrospective study(Wolters Kluwer Medknow Publications, 2019) Karadağ, Ayşe Serap; Özlü, Emin; Köstek, Osman; Bilgili, Serap Güneş; Balaharoğlu, Ragıp; Ertuğrul, Derun TanerBackground: It has been reported that retinoids may lead to hormonal alterations. Aim: In this retrospective study, we aimed to study the effect of acitretin on pituitary hormones in psoriasis patients. Methods: Out of 50 patients intended to be studied, blood samples of 43 patients could be tested before and after 3 months of acitretin therapy (0.2 to 0.5 mg/kg/day). Results: Patients mean +/- standard deviation ages and female/male ratio were 46 +/- 17 years and 19/24, respectively. After treatment with acitretin, gamma-glutamyltransferase, alkaline phosphatase, total cholesterol and triglyceride levels increased significantly (P < 0.05). After treatment, total protein, free thyroxine (T4) levels decreased significantly (P < 0.05). No significant differences were observed between before-after acitretin treatment regarding pituitary hormone levels in psoriasis patients (P > 0.05). Limitations: The retrospective nature of the study, inability to retest blood samples of 7 patients at 3 months post treatment, low dose and short duration of acitretin treatment were limitations of this study. Conclusion: This study showed that pituitary hormones were not affected except free T4 (thyroid hormone) by acitretin treatment. Further experimental and clinical studies are needed to clarify the effect of acitretin on pituitary hormones.Öğe Effect of pulse corticosteroids and low dose methotrexate in cases of treatment-resistant lichen sclerosus(Elsevier Taiwan, 2018) Karadağ, Ayşe Serap; Akdeniz, Necmettin; Özlü, Emin; Süslü, Hülya; Uzunçakmak, Tuğba Kevser; Bozdağ, Halenur; Kavala, Mukaddes…Öğe Effects of Different Doses of Systemic Isotretinoin on Eyes: A Histopathological and Immunohistochemical Study in Rats(NLM (Medline), 2020) Karadağ, Remzi; Karadağ, Ayşe Serap; Özlü, Emin; Oğuztüzün, Serpil; Şimşek, Gülçin; Esmer, Oktay; Bilgili, Serap GüneşPURPOSE: To evaluate ocular side effects associated with systemic isotretinoin histopathologically. METHODS: In this multicenter study, a total of 15 male and 15 female rats were randomly divided into 3 equal groups according to the oral dose of isotretinoin they were administered: 0 mg/kg/d (group A), 7.5 mg/kg/d (group B), and 15 mg/kg/d (group C). Biopsy specimens were taken from the globe conjunctiva, cornea, and eyelid conjunctiva. Expression levels of human beta-defensin-1, human beta-defensin-2, toll-like receptor (TLR)-2, and TLR-4 were evaluated by immunohistochemical methods. RESULTS: The number of goblet cells in eyelid conjunctiva was significantly lower in group B than that in group A and group C (P = 0.002). The sizes of meibomian gland acini were significantly smaller in group B and group C than those in group A (P < 0.001). Fibrosis of eyelid conjunctiva was significantly higher in group C and group B than that in group A (P = 0.002). The levels of staining of TLR-4 in the cornea with group B were significantly lower compared with group C (P = 0.035). CONCLUSIONS: Our study suggests that isotretinoin in the early period affects eyelid conjunctiva and meibomian glands without affecting the globe conjunctiva and cornea. Occurrence of the initial symptoms of isotretinoin on the eyelids, especially on the meibomian glands, suggests that the symptoms of patients occur because of evaporative dry eye.Öğe Effects of Isotretinoin Treatment on Sleep and Quality of Life in Patients with Acne Vulgaris(Duzce Univ, 2018) Özlü, Emin; Ertaş, Ragıp; Özyurt, Kemal; Karaatlı, İsmail; Karadağ, Ayşe SerapObjective: We aimed to investigate the effect of isotretinoin treatment on sleep and quality of life in patients with AV. Methods: 109 total patients who identified as 66 AV patients attended the dermatology outpatient clinic and started isotretinoin treatment, and 43 healthy controls, were enrolled in the study. Pittsburgh Sleep Quality Index (PSQI), short form-36 (SF-36), and Global Acne Grading System (GAGS) were administered to all patients twice; before and two months after the treatment. The results were compared with the healthy control group. Results: The pretreatment physical health scores of the patients were significantly higher than the healthy controls. No significant differences were observed between before-after isotretinoin treatment regarding physical and mental health scores in AV patients. While there were no significant differences between the pretreatment and healthy control group in terms of total PSQI scores; the scores of sleep duration were significantly lower in the pretreatment group. No significant differences were observed between before-after isotretinoin treatment regarding total PSQI and subcomponent scores in AV patients. There was a statistically significant negative correlation between pre- and post-treatment total PSQI scores and physical, mental health scores in patients with AV. Conclusion: Results of the present study suggest that isotretinoin therapy does not affect the sleep quality in patients with AV. The impairment of sleep quality negatively affects the quality of life in patients with AV. More comprehensive studies assessing the effect of isotretinoin treatment on sleep quality are needed.Öğe Morphea secondary to interferon betai B injection: A case and review of the literature(Dermatology Online Journal, 2019) Özlü, Emin; Karadağ, Ayşe Serap; Akdeniz, Necmettin; Uzunçakmak, Tuğba Kevser; Zemheri, Ebru; Özkanlı, ŞeymaInterferon beta (IFNß) is a drug used successfully in the treatment of multiple sclerosis (MS). Although IFNß is a safe and well-tolerated drug, dermatological side effects are common. The most common dermatological adverse effect is a local reaction at the injection site. It may also cause inflammatory and immune-mediated dermatological side effects. However, morphea induced by IFNßlb injection is very rare. © 2019, Dermatology Online Journal. All rights reserved.Öğe Novel PTCH1 Gene Mutation in a Patient with Gorlin-Goltz Syndrome(Korean Dermatological Assoc, 2019) Özlü, Emin; Karadağ, Ayşe Serap; Akalın, İbrahim; Yeşil, Gözde; Yılmaz, Sarenur; Zindancı, İlkin; Akdeniz, Necmettin…Öğe Plantar fibromatosis in a mentally challenged man treated with intralesional corticosteroids(Pulse Marketing and Communications LLC, 2017) Karadağ, Ayşe Serap; Özlü, Emin; Ceyran, Ayşe Bahar; Şimşek, Mehmet; Uzunçakmak, Tuğba Kevser; Zindancı, İlkin; Akdeniz, NecmettinA 21-year-old mentally challenged man presented with a fixed plaque lesion on the right foot, which had been present for 10 years. Dermatologic examination revealed an erythematous, painful, firm, fixed plaque-nodular lesion on the plantar aspect of the right foot (Figure 1A). Nothing of distinction was noted from his family history or his laboratory tests. An incisional biopsy revealed parallel, regular bundles composed of uniform, plump spindle cells. Thin collagen fibers were seen in contact with and located between the spindle cells. This mass was separated from the surrounding soft tissue by an irregular, unclear border (Figure 2A). İmmunohistochemically, the spindle cells showed diffuse, strong reactivity to vimentin (Figure 2B) and smooth muscle actin (Figure 2C). © 2017 Pulse Marketing & Communications, LLC.Öğe The Significance of Scars: Patient and Clinician Perspectives(Nova Science Publishers, Inc., 2019) Özlü, Emin; Karadağ, Ayşe SerapThe formation of a scar represents the extension of regenerative wound repair mechanisms. On the one hand, scar tissue helps in wound closure by supporting wound contracture and reepithelization. There is no doubt that the scar formation developed in response to an injury facilitates the organism’s survival process directly and effectively. On the other hand, the effect of the pathologically developed scarring on the global disease burden has still not been accurately defined. There are three basic subtypes of scars, namely simple, atrophic, and hypertrophic/pathological (hypertrophic scars and keloids), and they have different histopathological features, development, dispersion patterns, and remission phases. There are important consequences when scars’ global and individual effects are considered. Patients with scars face long-term functional and psychological problems. In interpreting scars for both individuals and society, individual, cultural, psychological, and social effects and prejudices play a crucial role. Both the psychosocial and financial aspects of the scars, as well as the effects on the patient and society, should be considered. © 2019 by Nova Science Publishers, Inc.
