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Öğe Abdominal Ateşli Silah Yaralanması Nedeniyle Opere Edilen Çocuk Hastaların Klinik Özellikleri: Bir Somali Deneyimi(2022) Abdi, Abdishakur Mohamed; Küçük, Adem; Ali, Abdullahi Yusuf; Adam, Mesut Kayse; Mohamed, Shukri SaidAmaç: Ateşli silah yaralanmaları dünya genelinde önemli bir morbidite ve mortalite nedenidir. Bu çalışmada Somali'deki tek çocuk cerrahisi kliniğinde abdominal ateşli silah yaralanması nedeniyle opere edilen hastaların klinik özellikleri incelendi. Gereç ve Yöntemler: Bu çalışmada,Somali'deki tek çocuk cerrahisi kliniğine Mayıs 2019 - Temmuz 2021 tarihleri arasında abdominal ateşli silah yaralanması ile getirilen ve opere edilen 42 çocuk hastanınkayıtları retrospektif olarak incelendi. Hastalar yaş, cinsiyet, yaralanma nedeni (ateşli silah veya bombalanma), tedavi, ameliyat bulguları, yaralanan organlar, hastanede kalış süresi ve komplikasyonlar açısından değerlendirildi. Bulgular: Yaşları 3 - 16 arasında değişen (ortanca 10 yıl), 28 (%67) erkek ve 14 (%33) kadın hastaların 30’u (%71) bombalanma, 12’si ise (%29) kurşunlanma sonucu yaralanmıştı. Vakaların 21’inde (%50) tek, 21’inde (%50) birden fazla organ yaralanması saptandı. En sık hasar gören organlar sırasıyla ince bağırsak (n=24), kolon (n=14), karaciğer (n=10) ve böbrekti (n=7). Ortanca yatış süresi yedi gün olarak saptandı. Vakaların 36’sı (%86) serviste, altısı (%14) yoğun bakım ünitesinde takip edildi. Yoğun bakımda takip edilen iki hastanın seyri mortalite ile sonuçlandı. Sonuç: Çalışmamızın sonuçları, Somali’de tek bir çocuk cerrahisi kliniğinde kısa bir zaman dilimi içinde elde ettiğimiz verilerin, çocukların ciddi oranda abdominal ateşli silah yaralanmalarına maruz kaldıklarını ve önemli bir morbidite ve mortalite ile karşı karşıya olduklarını ortaya koymaktadır.Öğe The assessment of bupivacaine-tramadol and levobupivacaine-tramadol combinations for preemptive caudal anaesthesia in children: a randomized, double-blind, prospective study(E-Century Publishing Corp, 2014) Sezen, Gülbin; Demiraran, Yavuz; Karagöz, İbrahim; Küçük, AdemCaudal block is the regional anesthetic technique that is used most frequently in pediatric surgery and bupivacaine and levobupivacaine are widely utilized in this technique. Opioid drugs have been added to local anesthetic solutions to prolong duration of analgesia but ideal combination were not found. We compared the postoperative analgesic efficacy of equal concentrations of bupivacaine or levobupivacaine plus tramadol in pediatric patients. Sixty eight children aged 2 to 7 years who were undergoing inguinal herniorrhaphies or orchidopexies received bupivacaine 0.25% plus tramadol 2 mg/kg (1 ml/kg) (BT group) or levobupivacaine 0.25% plus tramadol 2 mg/kg (1 ml/kg) (LT group) by the caudal route after laryngeal mask anesthesia. The primary outcome of the study was to compare the duration and quality of postoperative analgesia. The postoperative pain relief was evaluated by the Children and Infants Postoperative Pain Scale (CHIPPS) at 2, 4, 6, 12, and 24 h postoperatively. In addition, the time of first analgesic requirement was noted. The CHIPPS scores were not statistically different between the groups. The duration of analgesia and requirements for rescue analgesia was similar. Urinary retention was observed more often in the BT group. There were no significant differences between groups for arterial pressures and heart rate values after caudal block and during the operation. Caudal bupivacaine plus tramadol and levobupivacaine plus tramadol have similar postoperative analgesic efficacy. But the use of bupivacaine plus tramadol may cause a greater frequency of urinary retention.Öğe A Case of Bronchogenic Cyst Mimicking Foreign Body Aspiration(Lippincott Williams & Wilkins, 2013) Özkan, Aybars; Okur, Mesut; Kaya, Murat; Küçük, AdemBronchogenic cysts (BCs) can be life threatening if they compress vital structures in infants and small children. In particular, subcarinal cysts can be life-threatening and compromise the airways. In infants, the initial presentation may be respiratory distress. We report a case of mediastinal cystic mass compressing the main left bronchus. The case was an 18-month-old boy who had been admitted with acute respiratory distress. Chest x-ray showed overdistension of the left lung and a mediastinal shift. Foreign body aspiration was diagnosed. Magnetic resonance imaging was performed, which has shown a mediastinal cystic mass; therefore, the patient underwent thoracotomy. Surgical intervention revealed a subcarinal extrapulmonary BC that compresses the left main bronchus. The diagnosis of BC was confirmed with pathological investigation. In this report, we present a case of BC with the emphasis on the differential diagnosis with foreign body aspiration.Öğe A child with deep face burn caused by chafing fuel(Kare Publishing, 2013) Özkan, Aybars; Katrancı, Ali Osman; Okur, Mesut; Kaya, Murat; Küçük, Adem[No abstract available]Öğe CONGENITAL IMPERFORATE HYMEN WITH BILATERAL HYDRONEPHROSIS, POLYDACTYLY AND LARYNGOCELE: A Rare Neonatal Presentation(Taylor & Francis Inc, 2010) Öztürk, Hülya; Yazıcı, Burhan; Küçük, Adem; Şenses, Dursun AliImperforate hymen is a rare congenital malformation to present with symptoms in the neonatal period. We present a case of a 5-day-old neonate with a marked interlabial swelling causing urinary retention. Imaging revealed hydrometrocolpos, hydrosalpinx, and bilateral hydronephrosis. Additionally, our patient had polydactyly of both feet and hands, and laryngocele that have not been previously described in literature. Hymenectomy is the mainstay of management to prevent the development of hematocolpos, pain, and possible retrograde menstruation.Öğe Correlation of ischemia-modified albumin levels and histopathologic findings in experimental ovarian torsion(Kare Publ, 2016) Yıldırım, Ahmet; Yıldırım, Şule; Topaloğlu, Naci; Tekin, Mustafa; Küçük, Adem; Erdem, Havva; Çakır, Dilek ÜlkerObjectives: Ischemia modified albumin (IMA) levels significantly increased and may be used as a diagnostic marker in ovarian torsion. The aim of this study is to investigate whether there was any correlation between IMA levels and histopathologic changes in experimental ovarian torsion. Material and methods: Fourteen Sprague-Dawley rats, each weighing 220-250 g were divided randomly into 2 groups; in Group 1, the control group (n = 7), only laparotomy was performed and in Group 2, the experimental group (n = 7), ovarian torsion was performed. Ischemia was performed for 3 h; following the ischemia period, the torsion was relieved by detwisting the adnexa and then the ovarian I/R protocol was applied for 3 h. Blood samples were taken from all of the rats to measure the IMA levels and the ovaries were surgically removed for histologic examination. A blinded pathologist examined and scored the samples. Results: The median (minimum-maximum) IMA values were 921.00 (870.00-966.00) ABSUs in the ovarian torsion group and 853.00 (782.00-869.00) ABSUs in the control group. The difference was statistically significant. In the correlation analysis, a significant and strong correlationwas found between IMA levels and histopathologic changes (Spearman's rho = vertical bar 0.987, p < 0.001). Conclusion: Positive correlation was found between the IMA levels and the histopathologic severity of the disease. This finding is important for both diagnosis of the disease and patient follow-up. As a new marker in ovarian torsion, IMA may also indicate the severity of the ovarian histopathology. Copyright (C) 2016 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner.Öğe An easy technique for removal of knotted catheter in the bladder: percutaneous suprapubic cystoscopic intervention(E-Century Publishing Corp, 2013) Özkan, Aybars; Okur, Mesut; Kaya, Murat; Büyükkaya, Ramazan; Katrancı, Ali Osman; Küçük, AdemUncontaminated urine samples are indispensable to precisely diagnose urinary tract infections in newborns or infants. Among many clinical interventions for urine collection are described, the most common noninvasive practice is using sterile bags, associated with significant contamination of samples. In children, however, invasive methods i.e. catheterization, are generally needed for reliable urine specimens. Almost always all the inserted catheters are easily drawn back, nevertheless, might not work as expected, and lead to considerable problems that cannot be overcome. Herein, a case of a female newborn treated with a successful percutaneous suprapubic cystoscopic procedure for extracting knotted urinary catheter in the bladder is presented. The least invasive and easiest technic is suggested to be used when catheter is knotted in the bladder, as elaborately stated.Öğe Effect of combined anti-inflammatory and antioxidant therapy on ischemia-reperfusion injury in rat ovary: an experimental study(E-Century Publishing Corp, 2016) Kaya, Murat; Özkan, Aybars; Eröz, Recep; Soyer, Tutku; Kabaklıoğlu, Murat; Oktay, Murat; Küçük, AdemAn experiemental study was performed to evaluate the effect of combined anti-inflammatory and antioxidant theraphy on ischemia-reperfusion injury in rat ovary. Also the results of combined theraphy is aimed to compared with monotherapy. Fifty-four female Wistar rats were randomly divided into 9 equal groups (n=6). In Sham group right ovaries of the rats were sampled without generating ischemia and reperfusion injury via median laparatomy. Ischemia/Reperfusion (I/R) was performed by clamping the vascular supply of right ovary for 3 hours (I/R 1 group) and 6 hours (I/R 2 group), respectively. After one hour reperfusion, rats recieved 20 mg/kg Methylprednisolone (Pred 1; 3 hours ischemia and Pred 2; 6 hours ischemia) and 50 mg/kg Vitamin C (Vit C 1; 3 hours ischemia and Vit C 2; 6 hours ischemia). The combined therapy groups (Pred+Vit C 1 and Pred+Vit C 2) were adminstered same doses of both Methylprednisolone and Vitamin C. Rats were sacrifed after 24 hours of reperfusion and ovarian tissues were sampled for oxidative markers [malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx)] biochemically. Histopathological findings of inflammation (follicular cell degeneration, vascular congestion, hemorrhage and infiltration by inflammatory cells) were also evaluated with an injury score grading normal findings to severe injury (Grade 0 to 3). The results were compared among groups. Mean levels of antioxidant enzymes and histopathologic grades showed significant difference among groups (P<0.05). MDA and CAT levels were lower in Pred+Vit C 1 than Pred 1, Vit C 1 and I/R 1 (P<0.05). SOD and CAT levels were lower in Pred+Vit C 2 than Pred 2 and I/R 2. Total injury scores were lower in Pred+Vit C 1 and Pred+Vit C 2 than I/R 1 and I/R 2 (P<0.05). The combined treatment of anti-oxidant and anti-inflammatory theraphy reduces the biochemical and histopathologic findings of I/R injury in rat ovary. These results are significantly comparable with the effect of monotheraphy.Öğe Effects of tenoxicam in experimental corrosive esophagitis model(Oxford Univ Press Inc, 2015) Erbaş, Mesut; Kiraz, Hasan Ali; Küçük, Adem; Topaloğlu, Naci; Erdem, Havva; Şahin, Hasan Can; Özkan, M. Turgut AlperEsophageal stricture, one of the important complications of corrosive esophagus, develops following edema and granulation tissue that forms during and after the inflammatory reactions. Tenoxicam, a non-steroid anti-inflammatory drug with a long half-life, prevents various leukocyte functions including phagocyte and histamine secretion by inhibiting prostaglandin synthesis and removes various oxygen radicals in the region of inflammation. We designed this as a histopathological study using tenoxicam in rats for which we created a corrosive esophagus model. After necessary authorizations were obtained, the study was performed in Canakkale 18 Mart University experimental animal laboratory. Twenty-four Wistar albino rats, weighing 220-240g, were used for the experiment. Experimental animals were randomized into three groups: tenoxicam group (group T, n:8), control group (group C, n:8), and sham group (group S, n:8). Tenoxicam 0.5mg/kg/day was administered to animals in group T, where esophageal burn was developed experimentally, 5mg/kg 0.9% NaCL was administered i.p. to rats in group C for 15 days, once in 24 hours. No procedure was applied to rats in group S. After 15 days, all animals were sacrificed under general anesthesia and their esophagi were extracted. As a result of histopathological evaluation, inflammation and fibroblast proliferation was not observed in rats in the sham group (group S). Intense inflammation was observed in six rats (6+/2-) in the control group, and fibroblast proliferation was observed as 5+/3-. And in treatment groups, inflammation was evaluated as 3+/5-, and fibroblast proliferation as 3+/5-. In our study, histopathologic damage score was higher in the control group (P < 0.005). We deduce that tenoxicam can be useful in the treatment of caustic esophageal injuries in the acute phase, but think that these drugs require further researches and clinical studies before routine clinical use.Öğe Experimental Esophagitis Model Preventing Tracheal Aspiration(Wroclaw Medical Univ, 2015) Kiraz, Hasan A.; Erbaş, Mesut; Küçük, Adem; Topaloğlu, Naci; Erdem, Havva; Şahin, Hasan; Kiraz, AslıBackground. Corrosive esophagitis injuries are a serious clinical problem with many agents used for diagnosis and treatment. Experimental esophagus burn models use a method described mainly in studies by Gehanno and Guedon, and modified by Liu and Richardson. Objectives. The aim of this study was to describe a new esophagitis model that prevents tracheal aspiration. Material and Methods. In this study we used 16 Wistar albino rats weighing between 220-240 g. The experimental animals were randomly divided into two groups: the model group (group M, n: 8) and control group (group C, n: 8). The necessary anesthesia was administered. Passing through a median laparotomy incision, the abdomen was entered and in group M and C the esophagus was freed and held by a suture at the gastroesophageal junction. After this procedure, about 1 cm proximal to the gastroesophageal junction, the esophagus was suspended by a suture. The esophagus segment between the two sutures was exposed to 0.1 mL 10% NaOH in group M and 0.1 mL saline in group C for 20 s. Ten days later all experimental animals were sacrificed and their esophagus removed. After dying with hematoxylin and eosine trichrome, the histopathological evaluation results for the rats in all groups were investigated with a light microscope. Results. Histopathological examination indicated submucosal collagen increase, damage to muscularis mucosa and tunica muscularis and collagen deposition. In the model group, the rats had high neutrophils and tissue damage accompanied by necrosis. In the control group, the rats had minimal or no tissue damage and fibrosis was not observed. Conclusions. Our procedure is relatively less invasive and easy to apply with corrosive esophagitis only in the required region, and at the same time treatment medications can be easily administered.Öğe Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats(Springer, 2015) Topaloğlu, Naci; Küçük, Adem; Yıldırım, Şule; Tekin, Mustafa; Erdem, Havva; Deniz, MustafaGlucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental ischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue. However, its protective abilities against I/R injury in the liver are unknown. We investigated the potential role of GLP-2 pretreatment on hepatic I/R injury in rats. A total of 24 rats were randomly divided into three groups (n = 8). The first group was the control group; the second group was the vehicle-treated hepatic ischemia/reperfusion (HIR, vehicle saline-treated) group; and the third group was the GLP-2 pretreated I/R (GLP2-IR) group. Each rat in the third group was intraperitoneally administered 5 mu g GLP-2 for 5 d before the procedure. A portal triad was created to induce ischemia with a vascular atraumatic clamp. After 40 min, the clamp was released to initiate hepatic reperfusion for 6 h. Blood samples and tissue specimens from the liver were obtained. Alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels significantly increased in the saline-treated HIR group (P < 0.001), whereas GLP-2 pretreatment significantly decreased their levels (P < 0.01). Our data suggested that GLP-2 pretreatment may have a protective effect on liver I/R injury. However, dose-response studies are necessary to determine the most effective dose.Öğe I Wish, If There Was A Circumcision Pill(Düzce Üniversitesi, 2013) Okur, Mesut; Kaya, Murat; Küçük, Adem; Özkan, Aybars“I wish, if there was a circumcision pill…”This sentence is the wish of a child when his turn forcircumcision comes. Circumcision is a very old, starting with the history of religions, celestial,medical, cultural practice. Of course, yesterday, today, tomorrow will be the most commonlyperformed surgical procedure. I understand that especially in Germany, the prohibition ofcircumcision, again renewed interest in and curiosity about the circumcision. This prohibitionnot only of members of the Muslim and Jewish religious will be at the same time led to effectson circumcision for medical reasons. In our country where a lot of circumcision is performed,a senior research to explain the benefits of circumcision to the whole world, if we had a goodreference work that may be it would not think to ban circumcision. To do this, first and foremostpractitioners of circumcision, universities, health ministry officials and their families haveresponsibility for role. With this review aimed that to expose the complications of circumcisionand following the procedure and to raise awareness in the community about circumcisionÖğe Jel yakıtına bağlı derin yüz yanığı gelişen bir çocuk olgu(2013) Özkan, Aybars; Katrancı, Ali Osman; Okur, Mesut; Kaya, Murat; Küçük, Adem…Öğe Kronik obstruktif sarılık oluşturulan prepubertal sıçanlarda karaciğer hasarı üzerine ursodeoksikolik asit ve selektif siklooksijenaz-2 inhibitörü Selekoksib'in koruyucu etkileri(Düzce Üniversitesi, 2011) Küçük, Adem; Öztürk, HülyaKolestaz karaciğer hücre ölümü, fibrozis, siroz ve sonunda karaciğer yetmezliğine yol açar. Ursodeoksikolik asit (UDKA) kolestatik bozuklukların tedavi için Food and Drug Administration (FDA) tarafından onaylanmış tek ilaçtır. Hepatik siklooksijenaz-2 (COX-2) virüs veya toksinler tarafından neden olunan çeşitli kronik karaciğer hastalıklarında artar. Bu çalışma, safra kanalı ligasyonu (SYL) yoluyla neden olunan kolestaz bir sıçan modelinde inflamasyon ve fibrogenez üzerinde UDKA ve selektif COX-2 inhibitörü selekoksib'in etkilerini araştırmak amacıyla yapılmıştır.21 gün SYL uygulanan 50 Sprague-Dawley sıçan (sham, SYL, SYL sonrası UDKA tedavi grubu, SYL sonrası selekoksib tedavi grubu ve SYL sonrası UDKA ve selekoksib kombinasyonu tedavi grubu) beş tedavi grubuna ayrıldı. 21 gün sonra serum ve karaciğer örnekleri alındı. Fibrozis, duktular proliferasyon ve portal inflamasyon karaciğer örneklerinde skorlandı. Karaciğer fonksiyon testlerinin düzeyleri ölçüldü.Kontrol grubu ile karşılaştırıldığında, SYL grubunda serum biyokimyasal enzimlerinde yükselme ile birlikte duktular reaksiyon, fibrosis, inflamasyon gibi histolojik değişiklikler karaciğer hasarını gösterdi. Bu patofizyolojik değişiklikler UDKA ve selekoksib tedavisi ile azaldı.Bulgularımız UDKA'e selekoksibin eklenmesi karaciğerde inflamasyon ve fibrozisi azaltır ve kolestatik hastalıklar için UDKA ile etkili bir tamamlayıcı tedavi olabileceğini göstermektedir. UDKA ve selekoksibin kombinasyonunun olumlu etkileri sitoprotektif antioksidan ve anti-inflamatuar etkileri ile ilişkili olabilir.Öğe Malrotation-associated cholecystoduodenal fistula(2014) Özkan, Aybars; Özaydın, İsmet; Kaya, Murat; Küçük, Adem; Katrancı, Ali OsmanBackground: Cholecystoduodenal fistula (CDF) is the most common cholecystenteric fistula. It is a late complication of gallbladder disease with calculus and is mainly encountered in the elderly and females. Case Report: We report the case of a teenage patient with cholecystoduodenal fistula and malrotation. Direct plain abdominal x-ray demonstrated air in the biliary system. Computed tomography revealed CDF-associated with an anomaly of intestinal malrotation. She had gallstones (with a few stones in the gallbladder) and cholecystitis. CDF is caused by malrotation, and cholecystitis has not been reported before. In this regard our patient is the first and youngest reported case. Conclusions: We suggest that CDF is probably a consequence of malrotation. The patient's clinical features and operative management are presented and discussed with current literature. © Am J Case Rep, 2014.Öğe Primer mezenter hidatid kist rüptürü(2011) Öztürk, Hülya; Yaşar, Mehmet; Küçük, Adem; Öztürk, HayrettinPrimer olarak karaciğer dışında hidatid kistin barsak mezenterine yerleşimi nadirdir. Burada nadir görülen ve akut karın tablosu bulunan ince barsak primer mezenter hidatid kist olgusu sunulmaktadır. Laparotomide kistin rüptüre olduğu görülmüş ve total olarak çıkarılmıştır. Ameliyat sonrası dönemde herhangi bir problem gelişmemiştir.Öğe Protective effect of glucagon-like peptide-2 in experimental corrosive esophagitis(Oxford Univ Press Inc, 2015) Tekin, Mustafa; Topaloğlu, Naci; Küçük, Adem; Deniz, Mustafa; Yıldırım, Şule; Erdem, HavvaCorrosive esophageal injuries are one of the life-threatening morbidities leading to esophageal stricture and perforation affecting all age groups but especially children due to accidental ingestions in this age group. Glucagon-like peptide-2 (GLP-2) is an intestinal polypeptide with potent anti-inflammatory effects. Its effects are studied in various studies but not in corrosive esophagitis. We aimed to investigate whether it has protective effect in experimental corrosive esophagitis, in the absence of existing studies into possible links. Twenty-four Wistar-albino rats, weighing 220-240 g, were randomized into three groups (n=8 in each). First group is control, second one is sham operated, and the third one is treatment group. Median laparotomy was made in all groups. In sham and treatment groups, esophagus was loosened and suspended from 1cm proximal to the esophageal junction. The esophagus segment between suspenders was exposed to 0.1mL 5% NaOH for 10 seconds. In the treatment group, rats were given GLP-2 for 7 days intraperitoneally. After 7 days, all rats were sacrified and esophagi were totally removed. In the histopathologic examination, esophageal tissues were compared in terms of inflammation, muscularis mucosa injury, and collagen deposition of tunica muscularis. Histopathologic changes in the esophageal tissues of groups were compared. Histopathologic injury in the GLP-2 treated group was significantly less than sham group (P<0.05). There was statistically significant healing in the GLP-2 treatment group. It is concluded that GLP-2 has a preventive effect on inflammation and collagen accumulation in an experimental corrosive esophagitis. In the light of the information that initial lesions in the early phase are predictors of complications, GLP-2 is a promising agent that has an anti-inflammatory effect in caustic injuries.Öğe Protective effects of ursodeoxycholic acid in experimental corrosive esophagitis injury in rats(Edizioni Luigi Pozzi, 2017) Küçük, Adem; Topaloğlu, Naci; Yıldırım, Şule; Tekin, Mustafa; Erbaş, Mesut; Kiraz, Hasan Ali; Özkan, AybarsAccidental caustic ingestions are serious medical problems especially in childhood. Various treatment modalities are being used for the complications of caustic injuries such as stricture formation. The aim of this study is to establish whether ursodeoxycholic acid (UDCA) has protective effects on experimental corrosive esophagitis in rats. Twenty four Wistar-albino rats, weighing 220-240 g, were used in the study. Experimental animals were divided in three groups randomly: UDCA treatment group (Group 7; n:8), control group (Group K n: 8) and sham group (Group S, n: 8). In group T and S corrosive esophagitis was induced. UDCA (5 mg/kg) was performed to the group T for 10 days orally. All animals were sacrificed at the end of procedures and histopathological changes in esophageal tissue were scored by a single investigator who was blind to the groups. In group T inflammation was present in two rats, muscularis mucosa injury in two rats, grade I collagen deposition in six rats and grade 2 in two rats. In comparison with group S these were statistically significant (p value was 0.003, 0.003 and 0.015, respectively). UDCA has protective effect in experimental corrosive esophagitis.Öğe Protective role of Proanthocyanidin in experimental ovarian torsion(Tehran University of Medical Sciences, 2015) Yıldırım, Şule; Topaloğlu, Naci; Tekin, Mustafa; Küçük, Adem; Erdem, Havva; Erbaş, Mesut; Yıldırım, AhmetBackground: Proanthocyanidin is a potent bioactive antioxidant naturally occurring in grape seed and acts as reactive oxygen species (ROS) scavenger. The aim of this study was to investigate the effects of proanthocyanidinin in experimental ovarian torsion injury. Methods: Twenty four rats were randomly divided into three groups (n=8). Group 1: the laparotomy group, group 2: ovarian torsion group, and group 3: intervention group administered proanthocyanidinin of 50 mg/kg before bilateral ovarian ischemia and reperfusion. Histologic examination and scoring was done at the end of the experiment. Statistical analyses were performed using the SPSS v. 19. Results: Ovarian histopathologic findings of all three groups were significantly different in terms of hemorrhage (p<0.001), edema (p=0.001) and vascular dilatation (p<0.001). Pathologic changes induced by I/R were reduced in ovaries of rats administered proanthocyanidin, in particular, hemorrhage, edema and vascular dilatation. Conclusion: Proanthocyanidin, known as free radical scavenger and antioxidant, is protective against tissue damage induced by ischemia and/or ischemia/reperfusion in rat ovaries.Öğe Rectal Foreign-Body Retained by Self-Sexual Stimulation: A Case of a 12 Year-Old Boy(Acil Tıp Uzmanları Derneği, 2013) Okur, Mesut; Küçük, Adem; Özkan, Aybars; Kaya, Murat; Taşkın, Ali KemalAlthough a rectal foreign body (FB) usually occurs in children with iatrogenic causes, it may be seen in older children due to an object used for sexual stimulation. The extraction process of retained rectal FBs can require various interventions including laparotomy. A 12-year-old male was admitted to the emergency department with complaints of abdominal and anal pain. A plain abdominal x-ray revealed a retained rectal FB. The foreign object was extracted manually from the rectum in the emergency intervention room. Initially, the patient said that he had swallowed the FB; however, after a detailed inquiry it was determined that he was using the object for self-satisfaction. In this case report, we emphasized that rectal FBs could also be readily removed by digital rectal manipulation without the need for general anesthesia and this patient was very young with a rectal FB
