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Öğe Antibiotic usage in hospitalized patients: a one-day point prevalence study(Taylor & Francis Ltd, 2020) Karabay, Oguz; Ince, Nevin; Aypak, Adalet; Gude, Ertugrul; Bodur, HurremMeasurements are one of the most important means of evaluating the quality of antibiotic consumption. This study has evaluated the antibiotic consumption using one-day point prevalence study data collected from different hospitals in Turkey. This research was planned as a multicenter point surveillance study which aimed demonstrating the use of antibiotics among inpatients in Turkey. On the day of surveillance, demographic data from 21,920 inpatients, names of antibiotics used by the inpatients, number of antibiotics approved by infectious disease specialist (IDS), and the length of antibiotic use were recorded. These results showed that 30.3% of patients were using antibiotics and 57.7% of those were IDS-approved. The rate of IDS-approved antibiotic consumption was higher for internal medicine wards and in intensive care units, whereas non-IDS-approved antibiotics were used among inpatients of surgical wards.Öğe Autoimmune Hemolytic Anemia Developing Secondary to Epstein-Barr Virus Infection: A case report(2020) Ince, Nevin; Çelik, F. Elif; Öneç, Birgül; Uyanık, Hilal ŞöhretInfectious mononucleosis (EM) is a disease characterized by irradiation of the Epstein-Barr virus (EBV). The clinical manifestation is characterized by tonsillopharyngitis, lym-phadenopathy and atypical lymphocytosis. We describe a young patient developing hemolytic anemia during follow-up in our clinic due to tonsillopharyngitis secondary to EBV and general condition disorder.Öğe A Case of Hantavirus Renal Syndrome Detected in the COVID-19 Pandemic(Duzce Univ, Fac Medicine, 2022) Cakir, Yasemin; Ince, NevinHantaviruses are enveloped RNA viruses in the Bunyaviridae family that cause rodent -borne zoonotic infections. They cause two separate diseases, hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS), as a result of transmission to humans through contact with rodent excrements and inhalation. The form seen more common in T & uuml;rkiye is HFRS, which progresses with acute kidney injury and thrombocytopenia. Coronavirus disease 2019 (COVID-19) is an infectious disease that ranges from asymptomatic infection to pneumonia, respiratory failure, and death. Because of symptoms such as fever, weakness, and flu -like clinical findings in the early days, it can be confused with many infectious diseases. In this case report, a case of hantavirus renal syndrome admitted with fever, weakness, and flu -like symptoms during the COVID-19 pandemic was presented.Öğe A Case Report of Varicella Pneumonia in an Immunocompetent Adult(Erciyes Univ Sch Medicine, 2021) Ince, Nevin; Kilincel, Ozge; Tanisman, Isilay; Gurbuz, Ali RizaBackground: Chickenpox is a mild, highly infectious viral disease seen in childhood. However, the course tends to be severe in adults and immunosuppressive individuals. Case Report: A 40-year-old man with no known history of chronic disease presented to our hospital emergency department with widespread eruptions over the entire body and cough. Varicella pneumonia was diagnosed based on the patient being in contact with his children who had shortly previously contracted chickenpox, typical cutaneous lesions, and the clinical and thoracic computerized tomography findings. The patient was treated with acyclovir and antibiotics in terms of secondary bacterial infection. Complete healing was achieved after 7 days of treatment. Conclusion: This case is presented to draw attention to pneumonia, a severe complication of chickenpox.Öğe COVID-19 Enfeksiyonunda Ağırlaştırıcı Risk Faktörlerinin Araştırılması(2023) Yekenkurul, Dilek; Ince, Nevin; Yıldırım, Mustafa; Sungur, Mehmet Ali; Escan, Elif; Davran, Fatih; Altınsoy, Hasan BakiAmaç: Koronavirüs hastalığı-2019, yaklaşık iki yıl önce Çin'de başlayan ancak tüm dünyayı etkisi altına alan bir salgına neden olmuştur. Koronavirüs hastalığı-2019 enfeksiyonu ile takip edilen hastaların değerlendirilmesi, ciddi enfeksiyon için risk faktörlerinin ve göstergelerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Koronavirüs hastalığı-2019 enfeksiyonu ile 15 Mart- 01 Haziran 2020 tarihleri arasında yatarak tedavi gören hastalar araştırıldı. Hastalar oksijen satürasyonlarına göre iki gruba ayrıldı; oksijen satürasyonu % 90'ın üzerinde olan hastalar grup 1, % 90 ve altı olan hastalar grup 2 olarak belirlendi. Bu iki grup ağırlaştırıcı risk faktörleri açısından karşılaştırıldı. Bulgular: Bu çalışmaya 90 hasta (46 kadın, 44 erkek) dahil edildi. Bilgisayarlı toraks tomografisinde orta-şiddetli pnömonik tutulum (p=0,002) ve yüksek ateş (pÖğe COVID-19 Olası/Kesin Tanılı Hastalarda Serbest Radikal Ve Antioksidan Enzim Düzeylerinin Değerlendirilmesi(2023) Davran, Fatih; Hacıoğlu, Ceyhan; Alpay, Merve; Yıldız Gülhan, Pınar; Öztürk, C. Elif; Ince, Nevin; Unlu, Elif NisaAmaç: Koronavirüs hastalığı 2019 (COVID-19), küresel halk sağlığını tehdit eden ve bir pandemiye yol açan karmaşık bir hastalık olmasına rağmen, hastalığın patogenezinde yer alan pro-oksidan/oksidan dengesizliğinin katkıları yeterince araştırılmamıştır. Bu nedenle, bu çalışmanın amacı, COVID-19 hastalarında sigara kullanımının oksidatif stres ve antioksidan savunma sistemi biyobelirteçleri üzerindeki etkilerini değerlendirmektir. Gereç ve Yöntemler: Çalışmaya katılan kişiler 4 gruba ayrıldı: (Kontrol grubu) COVID-19 tanısı olmayan ve sigara kullanmayan 45 sağlıklı birey, (Grup 2) COVID-19 tanısı olmayan ve sigara kullanan 45 birey, (Grup 3) COVID-19 tanılı ve sigara kullanmayan 45 hasta, (Grup 4) COVID-19 tanılı ve sigara kullanan 45 hasta. Katılımcıların serumlarındaki D-dimer, nitrik oksit (NO), glutatyon redüktaz (GR), süperoksit dismutaz (SOD), katalaz (CAT), malondialdehid (MDA), total antioksidan seviyeleri (TAS) ve total oksidan seviyeleri (TOS) seviyelerini ticari kitler kullanarak ELİSA yöntemine göre analiz edildi. Bulgular: COVID-19 tanısı alan kişilerdeki D-dimer seviyelerinde anlamlı bir artış söz konusudur (pÖğe Düzce İlinde Son Bir Yılda Görülen Yurt Dışı Kaynaklı Dört Sıtma Olgusu(2020) Keskin, Banu Hümeyra; Tunca, Bekir; Ince, Nevin; Öztürk, Cihadiye Elif; Gökçe, Özlem; Dönmez, BetülSıtma, dünyada tropikal ve subtropikal bölgelerde endemik olarak görülmektedir. Son yıllarda seyahatler ve göçlernedeniyle endemik olmayan bölgelerde de dış kaynaklı sıtma olgularıyla karşılaşılmaktadır. Bu olgu sunumundailimizde son bir yılda görülen yurt dışı kaynaklı dört olgu irdelenmiştir. Olguların hepsinin Afrika’ya seyahat öyküsüolup, ikisinin sıtma profilaksisi almadığı öğrenilmiştir. Tüm olgularda tanı; ince yayma ve kalın damla preparatlarınınincelemelerinde plazmodyum görülmesi ile konulmuştur. İki olguda yapılan PCR testinin sadece birinde pozitifliksaptanmıştır. Etken, iki olguda Plasmodium falciparum, diğer iki olguda ise Plasmodium vivax olarak belirlenmiştir. P.falciparum sıtması olan bir olgu derin anemi nedeniyle yoğun bakımda takip edilmiş ve tüm olgular şifa ile taburcuedilmiştir. Bu olgu sunumunda endemik olmayan bir bölgede görülmüş olan yurt dışı kaynaklı sıtma vakalarınınözellikleri toplu olarak incelenmiştir. Hastanelere ateş nedeniyle başvuran hastalarda sıtmanın endemik olduğubölgelere seyahat sorgulanmalı ve anamnezinde seyahat öyküsü olan ateşli hastalarda ayırıcı tanıda sıtmadüşünülmelidir.Anahtar KelimelÖğe Endogenous Carboxyhemoglobin Concentrations in Predicting Prognosis of Patients with COVID-19 Pneumonia(Clin Lab Publ, 2021) Demir, Mehmet C.; Akpinar, Guleser; Sultanoglu, Hasan; Yildiz-Gulhan, Pinar; Caliskan, Emel; Guclu, Derya; Ince, NevinBackground: The coronavirus disease 2019 (COVID-19) outbreak has caused great difficulties in providing healthcare services worldwide. Accurate and useful indicators are needed for the effective use of resources. Carbon monoxide (CO) is also produced endogenously without exogenous exposure. Studies confirm that endogenous CO increases in conditions such as pneumonia, sepsis, and trauma. This study aimed to compare patients diagnosed with COVID-19 pneumonia and healthy people to reveal whether endogenous carboxyhemoglobin (COHb) levels differ. It was also to determine whether it could be a helpful indicator for the clinician in predicting disease severity in combating the COVID-19 pandemic. Methods: The study included 72 patients admitted to the hospital during the COVID-19 pandemic and diagnosed with COVID-19 pneumonia and a control group of 75 healthy people. The research data was collected retrospectively in a tertiary emergency department. The patients' demographic data, pneumonia severity index (PSI) score, CURB-65 score, 30-day mortality, hospitalization, need for mechanical ventilation (MV), and COHb levels were recorded. Results: While the COHb level was 0.9% (min-max, 0.1 - 4.0) in patients with COVID-19 pneumonia, it was 1% (min-max, 0.1 - 2.6) in the control group. No significant difference was found between the patients and the control group in terms of COHb levels (p = 0.341). Also, there was no correlation between COHb levels and PSI and CURB-65 scores. No significant difference was detected between COHb levels and patients diagnosed with COVID-19 pneumonia in terms of mortality, need for MV, or hospitalization (p > 0.05). Conclusions: We concluded that COHb levels alone could not be used to diagnose COVID-19 pneumonia or predict disease severity. Besides, in COVID-19 pneumonia, the COHb level was not a useful indicator of mortality, need for MV, or hospitalization decision. Further studies are needed to find useful indicators to assist clinicians in their decision-making process in tackling the COVID-19 pandemic.Öğe The evaluation of both the expression and serum protein levels of Caspase-3 gene in patients with different degrees of SARS-CoV2 infection(Wiley, 2021) Gulhan, Pinar Yildiz; Eroz, Recep; Ataoglu, Ozlem; Ince, Nevin; Davran, Fatih; Ozturk, Cihadiye Elif; Balbay, Oner AbidinTo evaluate the effects of Caspase-3 (CASP3) gene expression and serum levels on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A total of 41 individuals (male: 21; female: 20) with SARS-CoV-2 infection were included in the current study. Hemograms were examined from patient blood samples, and CASP3 gene expression levels were detected. Also, human CASP3 levels were determined from the serum samples of patients. The mean age of patients was 56.220 +/- 18.937 years. Significant differences were detected among all groups for CASP3 2-Delta Delta Ct (p = 0.014) and CASP3 concentration (p = 0.024). The relationship between CASP3 2-Delta Delta Ct levels and hemoglobin (p = 0.023), between CASP3 2-Delta Delta Ct levels and C-reactive protein (CRP) (p = 0.001), between CASP3 2-Delta Delta Ct levels and ferritin (p = 0.003), between CASP3 2-Delta Delta Ctlevels and lactate dehydrogenase (p = 0.001), and between CASP3 2-Delta Delta Ct levels and SpO(2) (p = 0.006) were statistically significant. Also, the relationship between CASP3 concentration levels and SpO(2) was statistically significant (p < 0.046). The CASP3 gene and/or its products have an important function to prevent injury caused by SARS-CoV-2 infection. They play crucial roles in maintaining cellular homeostasis and viability. Perhaps CASP3 levels may provide information about the severity of the disease.Öğe Evaluation of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio in patients with cellulitis(Assoc Medica Brasileira, 2020) Ince, Nevin; Guclu, Ertugrul; Sungur, MMehrnet Ali; Karabay, OguzOBJECTIVE: Cellulite infection is a non-necrotizing inflammation of the skin and subcutaneous tissue and is one of the most common reasons for admission to hospital. This retrospective study aimed to investigate the Neutrophil to Lymphocyte Ratio (NLR), Platelet to Lymphocyte Ratio (PLR), and Lymphocyte to Monocyte Ratio (LMR) in patients with cellulitis. METHODS: In our study, we retrospectively analyzed 96 patients with cellulitis and 98 age- and sex-matched healthy controls. The study and control groups were compared regarding NLR, PLR, and LMR. RESULTS: The PLR and NLR of the cellulitis group were significantly higher than those of the control group (p < 0.001). When patients with cellulitis were divided into two groups, i.e., >= 65 years and <65 years, a statistically significant difference was noted in the NLR and LMR values (p < 0.05). In the ROC curve analysis, NLR had the highest discriminative power in distinguishing between cellulitis and healthy controls (AUC = 0.950, 95% CI: 0.920-0.979, p <0.001; 91.6% sensitivity and 89.8% specificity). CONCLUSION: NLR was significantly higher in differentiating cellulite and in patients older than 65 years. Larger, prospective studies are required to determine its usefulness in assessing differential diagnosis and prognosis in cellulitis patients.Öğe AN EVALUATION OF PATIENTS WITH TULAREMIA IN DUZCE PROVINCE IN THE WESTERN BLACK SEA REGION OF TURKEY(Parlar Scientific Publications (P S P), 2020) Ince, Nevin; Cetinkaya, Ozlem; Tunca, Bekir; Cakir, YaseminTularemia is a zoonotic infectious disease caused by Francisella tularensis. The aim of our study was to examine the epidemiological and demographical characteristics, laboratory findings, treatment methods, and treatment results of 68 tularaemia cases reported from Duzce, Western Black Sea region of Turkey, between 2016-2019. Clinical diagnosis was confirmed by micro-agglutination test (>= 1/160 titres). A total of 68 patients (35 females, 33 males) were diagnosed with tularemia. The most common symptoms among the patients in the study were swelling in the neck in 88.2% patients, sore throat in 73.5% patients and tonsillopharyngitis in 72.8% of the patients. Lymph node surgery was performed on 29.4% of patients despite receipt of antibiotherapy. The rate of ciprofloxacin use among patients not requiring lymph node surgery(46%) was significantly higher than that in patients requiring such surgery (20%) (p=0.046). No difference in lymph node surgery was observed among patients receiving combination antibiotherapy (p>0.05).Öğe An evaluation of six-year Stenotrophomonas maltophilia infections in a university hospital(Makerere Univ, Fac Med, 2020) Ince, Nevin; Yekenkurul, Dilek; Danis, Ayse; Caliskan, Emel; Akkas, IdrisBackground: Stenotrophomonas maltophilia is a Gram-negative bacillus and opportunistic emergent pathogen causing hospital-acquired infections (HAIs). Due to risk factors such as prolonged intensive care unit stay and invasive procedures, it has become one of the leading causes of HAIs. Objective: The aim of this study was to evaluate the epidemiology of S.maltophilia infections over a six-year period at D & uuml;zce University Hospital, Turkey. Methods: The incidence, clinical characteristics, antimicrobial susceptibility and outcomes of nosocomial S. maltophilia in-fections during this period were retrospectively analyzed. Results: During the study period, 67 samples obtained from 61 patients were identified. Pneumonias (82%) were the most common HAIs, followed by bloodstream infections (10.5%), urinary tract infections (3%), skin and soft tissue infections (3%) and surgical site infection (1.5%). Admission to intensive care, hospitalization exceeding 30 days, and previous use of broad-spectrum antibiotics constituted risk factors. Resistance to cotrimoxazole (6%) was lower than that to levofloxacin (18%). Conclusion: The most important risk factors for S.maltophilia infection in patients are previous exposure to antibiotics, prolonged hospitalization and invasive procedures such as mechanic ventilation. Discharging patients as early as possible with the rational use of antibiotics may be effective in reducing S. maltophilia infections and resistance rates.Öğe An evaluation of suspected cases of Hantavirus infection admitted to a tertiary care university hospital in Duzce, Turkey, between 2012 and 2018(Tubitak Scientific & Technical Research Council Turkey, 2021) Ince, Nevin; Onec, Kursad; Sav, Tansu; Sungur, Mehmet Ali; Menemenlioglu, DilekBackground/aim: Hantavirus is a rodent borne zoonosis caused by the members of the virus family Bunyaviridae, genus Hantavirus. In this study, we aimed to determine the role of peripheral blood leukocyte ratio in differential diagnosis of Hantavirus disease. Materials and methods: The medical records of patients at the Duzce University Medical Faculty were examined retrospectively. A total of 20 patients diagnosed with hantavirus infection confirmed by serologic tests were included in the study (Group 1). The other group consisted of 30 patients suspected of hantavirus infection but found negative (Group 2). Demographic, clinical and laboratory characteristics, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and lymphocyte/monocyte (LMR) ratios of both groups were compared. Results: As a result of the istatistics analysis, no difference was found between the groups' age, sex, and clinical complaints except lethargy-weakness (P = 0.004) and diarrhea (P < 0.001). Hemogram analysis showed a significant difference between the groups in terms of leukocyte, hemoglobin, hematocrit, platelet, mean platelet volume (P < 0.05) and PLR (P = 0.001) and LMR (P = 0.003) values from peripheral blood leukocyte ratios. Conclusion: In conclusion, NLR, PLR, and LMR ratios may be useful for clinicians in differential diagnosis of Hantavirus in patients presenting with similar symptoms of Hantavirus disease.Öğe Factors Affecting Cervical Lymph Node Suppuration in Oropharyngeal Tularemia Cases(Coll Physicians & Surgeons Pakistan, 2021) Ince, Nevin; Gozdas, Hasan TahsinObjective: To determine the factors associated with cervical lymph node suppuration in oropharyngeal tularemia. Study Design: Observational study. Place and Duration of Study: Departments of Infectious Diseases and Clinical Microbiology, Faculties of Medicine, Duzce University and Bolu Abant Izzet Baysal University Turkey, between January 2016 and August 2019. Methodology: Tularemia was diagnosed in clinically compatible cases by micro-agglutination test (>= 1/ 160 titres). Positive cases were divided into two groups according to development of suppurated and discharging lymph nodes. If the cases did not develop suppuration and discharge lymph nodes, they were defined as completely healed. If they did, they were defined as suppurated and drained lymph node group. Demographic and clinical characteristics and acute phase reactants of these groups were compared as to investigate any significant difference between the groups. Results: There were 88 tularemia cases in the current study. Of these, 60 cases were completely healed (68.2%) and 28 cases had suppurated and drained lymph nodes (31.8%). Tonsillopharyngitis was found significantly lower in suppurated and drained lymph node group compared to the completely healed group (p= 0.016). However, late presentation (>14 days) was found significantly more frequent in suppurated and drained lymph node group compared to the completely healed group (p=0.033). Conclusion: In order to prevent suppurative lymphadenitis in oropharyngeal tularemia, it is advisable to start appropriate antimicrobials within 14 days after the appearance of symptoms.Öğe Investigation of the Factors Associated with Mortality in Catheter-Related Bloodstream Infections: Five-Year Observation(2020) Ince, Nevin; Yekenkurul, Dilek; Çalışkan, Emel; Gürbüz, Ali Rıza; Yener, SelviAim: Intravenous catheter use can cause various infections ranging from infection at the siteof catheter entry to bacteremia and colonization. The purpose of this study was to identify thecausative micro-organisms, and effects on morbidity-mortality of catheter-related bloodstreaminfections developing over the last five years.Material and Methods: Data for 194 patients who underwent central intravenous catheterinsertion in our hospital’s intensive care unit and other departments between November 2014and August 2019 were analyzed retrospectively. Blood samples taken from the catheter or thecatheter tip, and blood samples collected simultaneously from the peripheral vein wereincluded in the study, and culture results were recorded. Patients’ demographic data and theeffects of the factors identified on morbidity and mortality were subjected to statisticalanalysis.Results: Ninety-two (47.4%) of the 194 patients included in the study were female and 102(52.6%) were male, and mortality rate was 62.4% (n=121). The frequency of underlyingmedical conditions such as asthma, congestive heart failure, and cerebrovascular event, andreceiving treatments such as immunosuppression, transfusion, tracheostomy, nasogastric tube,and mechanical ventilation were higher in mortal cases than non-mortal cases. A total of twohundred and forty microorganisms were detected in 194 patients, 121 (50.4%) of which wereGram negative bacteria, while 68 (28.3%) were Gram positive bacteria, and 51 (21.3%) wereCandida species.Conclusion: As a result, it was observed that the advanced age, underlying diseases andpresence of resistant microorganisms were higher in mortal cases.Öğe Monitoring of antibody levels in healthcare workers after inactivated coronavirus disease 19 vaccination(Assoc Medica Brasileira, 2023) Caliskan, Emel; Ozturk, Cihadiye Elif; Oksuz, Sukru; Ince, Nevin; Yekenkurul, Dilek; Kahraman, Gozde; Duran, PelinOBJECTIVE: Because of the coronavirus disease 19 pandemic, studies on vaccination are being conducted in our country as well as across the world. In this study, the antibody levels in healthcare workers vaccinated with two doses of inactivated vaccine and the factors affecting these levels were investigated. METHODS: Randomly selected volunteers from healthcare workers, who had been vaccinated with two doses of inactivated vaccine in January to February 2021, were included in the study. Blood samples were drawn twice, 1 month and 6 months after the second dose vaccine (CoronaVac:Sinovac Life Science Co, Ltd, Beijing, China). The antibody levels were determined by the chemiluminescence microparticle immunoassay method using kits for quantitative detection of immunoglobulin class G antibodies to severe acute respiratory syndrome coronavirus 2. RESULTS: The mean antibody levels of 129 volunteers were 1232.5 (min: 103 to max: 7151) AU/mL in the first month and 403.5 (min: 23 to max: 4963) AU/mL in the sixth month. According to the survey results, 91 (71%) volunteers had not been diagnosed with coronavirus disease 19 before vaccination. The antibody levels 1 month and 6 months after the second dose of vaccination were significantly higher in those who had been diagnosed with coronavirus disease 19 before vaccination than in those who had not. It was found that age, gender, fast food, or healthy nutrition had no effect on antibody levels. CONCLUSION: Vaccines are very important both to protect against coronavirus disease 19 and to experience only a mild form of the disease. Immunoglobulin class G levels formed after vaccination may be affected by many factors and may decrease over time.Öğe Serum trace element and heavy metal levels in patients with sepsis(Taylor & Francis Ltd, 2020) Akkas, Idris; Ince, Nevin; Sungur, Mehmet AliBackground and objectives: Sepsis is defined as a life-threatening organ dysfunction syndrome, which occurs when the body's immune response to infection is impaired. The aim of the present study was to investigate serum Iron, Copper, Zinco, Cobalt, Chromium, Selenium, Vanadium, Nickel, Cadmium, and Aliminium levels in patients with sepsis. Materials and methods: This prospective and observational study was conducted at a tertiary care university hospital of Turkey from 2015 to 2016, and comprised patients with sepsis. Serum concentrations of 10 elements were analyzed using inductively coupled plasma mass spectrometry. Analyses were performed at the laboratory of Duzce University Scientific and Technological Research Application and Research Center. A total of 87 participants (52 men, 35 women; average age, 74.11 +/- 14.26) were enrolled. Results: When evaluated in terms of trace elements, a significant difference was noted between the sepsis and control groups in terms of the levels of the five elements. Chromium, Iron, Nickel, Copper, and Cadmium levels were significantly higher in the sepsis group. Conclusion: Our study indicated in particular, Iron, Copper, Chromium, Nickel, and Cadmium levels were elevated in patients with sepsis.Öğe Use of complementary and alternative medicine in patients with chronic viral hepatitis in Turkey(Churchill Livingstone, 2020) Ince, Nevin; Kaya, Safak; Yildiz, Ilknur Esen; Parlak, Emine; Bayar, BelkisIntroduction: The global use of complementary and alternative medicine (CAM) is growing. The purpose of this study was to determine the prevalence of CAM use in patients in Turkey with CVH, the types of therapy, and patients' sociodemographic characteristics. Methods: The study was designed as a questionnaire-based, cross-sectional analysis. An infectious diseases outpatient follow-up questionnaire was administered to patients at face-to-face interviews. The data obtained were analyzed using SPSS 17 software. Results: This study included 588 patients, of whom 27% used CAM. No differences in sociodemographic characteristics were determined between patients using CAM and those not using it. Herbal methods were used by 63.6% of patients and cupping techniques by 25.4%. Education level was significantly correlated with herbal methods (p = 0.043). CAM use also increased in line with disease duration (p < 0.05). No difference in CAM use was determined between CHB patients using oral antiviral therapy and those not using it (p = 0.162). Conclusion: CAM use, particularly herbal products, is prevalent among Turkish adults with CVH. In case of use of herbal products in chronic viral hepatitis patients, toxicity and liver failure may develop as a result of herbal product-drug interactions. Physicians in the field of hepatology should, therefore, be aware of potential toxicity of CAM, especially in patients with chronic hepatitis liver diseases.
