Yazar "Eski, Mehmet Tahir" seçeneğine göre listele
Listeleniyor 1 - 20 / 22
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Association of ABO blood groups and Rh factor with retinal and choroidal thickness(Sage Publications Ltd, 2019) Teberik, Kuddusi; Eski, Mehmet TahirPurpose: To evaluate if ABO blood group and Rh factor have an effect on retinal and choroidal thickness. Methods: This study was designed prospectively. Retinal nerve fiber layer, retinal, and choroidal thicknesses were measured with spectral-domain optical coherence tomography. Retinal and choroidal thickness measurements (one subfoveal, three temporal, and three nasal) were obtained at 500-mu m intervals up to 1500 mu m with the caliper system. Results: In this study, 109 male and 151 female, 260 individuals in total were included. There were 125 subjects in group A, 29 in group B, 34 in group AB, and 72 in group O. Rh factor was positive in 194 subjects and negative in 66. There was no significant difference between the groups regarding age (p = 0.667). The groups did not show any statistical difference in retinal nerve fiber layer thickness. There was significant difference found for mean retinal thickness at temporal 1000 mu m when four groups were compared (p = 0.037). No statistically significant difference was detected for the remaining retinal and choroidal sectoral regions. The groups did not statistically significantly differ concerning Rh factor (p > 0.05). Conclusion: Although we found a significant difference in retinal thickness in the temporal retina between group B with group A and group O, we suggest that both blood group and Rh factor have no effect on retinal and choroidal thickness.Öğe Associations of glycated hemoglobin (HbA1c) level with central corneal and macular thickness in diabetic patients without macular edema(2018) Teberik, Kuddusi; Eski, Mehmet Tahir; Kaya, MuratObjectives: To determine the correlation between central corneal thickness (CCT) and central macularthickness (CMT), and fasting plasma glucose levels and HbA1c levels before diabetic macular edema (DME)in type 2 diabetes mellitus (DM) patients without diabetic retinopathy.Methods: Forty-four eyes of subjects diagnosed with type 2 DM, and 45 healthy control subjects participatedin this study. Detailed ophthalmologic examination was performed with all participants. CMT was measuredin both groups by Spectral-domain optical coherence tomography. CCT measurements were made with anEchoscan US-500 ultrasonic pachymeter. Blood biochemical tests for glycated hemoglobin (HbA1c) and fastingplasma glucose levels were run on all patients.Results: The results of the study showed that the mean CCT was significantly thicker in type 2 DM patients563.84 33.25 ?m than in the controls 550.13 28.41 ?m (p 0.039). The mean of CMT was 231.27 37.74?m in the study group and 225.38 38.33 ?m in the control group (p 0.05). No relationship was foundbetween CCT and CMT and HbA1c level in the study and control groups.Conclusions: The mean CCT was significantly thicker in type 2 DM patients without diabetic retinopathy thanin the controls. The mean CMT is thicker in type 2 DM patients without diabetic retinopathy patients than inthe controls, but this difference was not statistically significant. Optical coherence tomography can be a perfectdetector for early detection of DME.Öğe Changes in the Anterior Segment and Dry Eye Parameters of People Using Oral Tetracycline(Tıbbi Kayıtlar Derneği, 2023) Eski, Mehmet Tahir; Teberik, Kuddusi; Sezer, TahaAim: The purpose of the study is to evaluate the effect of anti-inflammatory efficiency of tetracycline on dry eye and anterior segment parameters. Material and Methods: This prospective study was conducted with 61 people who had been using tetracycline for the past 2 months. Each participant went through a detailed ophthalmological examination where intraocular pressure (IOP), central cornea thickness (CCT), K1 and K2 from keratometry measurements, anterior chamber depth (ACD), axial length (AXL), tear breakup time test (BUT), lissamin green staining (LG), Schirmer’s tear test-1 (ST) and ocular surface disease index (OSDI) score were evaluated. Measurements of the patients who would be using a daily dose of 100 mg doxycycline for 2 months were done prior to the medication as well as 1 month and 2 months after the medication. 3 data sets of the participants were compared at the end of 2 months. Results: When results were compared, it was found that ST and LG parameters gradually increased in the first and second months and this increase was statistically significant (p<0.001 and p=0.018, respectively). On the other hand, BUT and OSDI scores decreased over time but it was not statistically significant. There were no statistically significant differences in terms of other parameters either (p>0.05). When female and male participants were compared in terms of BUT, it was found that the decrease in females at the second month was higher and this was statistically significant (p=0.01). Conclusion: t was concluded that the young individuals using tetracycline displayed an early stage of improvement in dry eye parameters.Öğe Compare of optic coherence tomography parameters in recreational synthetic tetrahydrocannabinol use and healthy control(Taylor & Francis Ltd, 2023) Eski, Mehmet Tahir; Teberik, Kuddusi; Taha, Sezer; Buken, Bora; Sonmez, Feruza TuranPurposeTo evaluate retinal thickness (RT), retinal nerve fiber layer thickness (RNFLT), and choroidal thickness (CT) changes in synthetic cannabinoid (SC) users.MethodsThis prospective study evaluated the RT, RNFLT, and CT values of 56 SC users and 58 healthy controls. The individuals using SCs were referred to us by our hospital's forensic medicine department. Retinal and choroidal images were obtained using spectral-domain optical coherence tomography (OCT). Measurements (one subfoveal, three temporals, three nasal) were taken at 500 & mu;m intervals up to 1500 & mu;m using the caliper system. Only the right eye was used for subsequent analysis.ResultsMean ages were 27.7 & PLUSMN; 5.7 years in the SC-user group and 25.4 & PLUSMN; 6.7 in the control group. Subfoveal Global RNFLT was in the SCs group 102.3 & PLUSMN; 10.5 & mu;m and 105.6 & PLUSMN; 20.2 & mu;m in the control group (p = 0.271). Subfoveal CT was in the SC group mean of 316.1 & PLUSMN; 100.2 & mu;m and in the control group mean 346.4 & PLUSMN; 81.8 & mu;m (p = 0.065). RT, T500 (283.3 & PLUSMN; 36.7 & mu;m, 296.6 & PLUSMN; 20.5 & mu;m, p = 0.011) and N1500 (355.1 & PLUSMN; 14.3 & mu;m, 349.3 & PLUSMN; 18.1 & mu;m, p = 0.049) were significantly higher in the SC group than in the control group, respectively.ConclusionAnalysis of OCT findings of individuals who had been using SC for more than one year revealed no statistically significant difference between RNFLT and CT, although N1500 was significantly higher in RT. Further studies in the field of OCT are important to explore the pathology of SCÖğe Comparison of Anterior Segment Measurements in Obese Children and Healthy Control Group(Duzce Univ, Fac Medicine, 2023) Eski, Mehmet Tahir; Teberik, Kuddusi; Sezer, Taha; Arslanoglu, IlknurOphthalmology, Objective: To evaluate anterior segment parameters in obese children. Methods: Fifty-five obese and 30 control group children subjects participated. All participants and the control group were examined and anthropometric measurements were made. The measurements of fasting blood glucose (FBG), systolic blood pressure (SBP) triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), and insulin values were performed. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Each participant underwent a detailed ophthalmic examination and intraocular pressure (IOP), central corneal thickness (CCT), anterior chamber depth (ACD) and lens thickness (LT) were measured. Results: The gender distribution of the groups was similar (p=0.893). The mean of CCT and LT were significantly higher in the obese group (572.9 & PLUSMN; 14.5 vs. 559.5 & PLUSMN; 10.1 & mu;m, p=0.001; 3.6 & PLUSMN; 0.14 vs. 3.48 & PLUSMN; 0.25 mm, p=0.007). No significant difference was found between the obese and control groups in terms of other parameters. Body mass index (BMI) and waist circumference (WC) had a significant negative correlation with LT control groups. The obese group showed a significant positive correlation between IOP and TG (r=0.276, p=0.042), and a significant negative correlation with HDL-C (r=-0.273, p=0.043). In the control group, there was a significant positive correlation between IOP and BMI (r=0.389, p=0.034), WC (r=0.497, p=0.005), HOMA-IR (r=0.384, p=0.036), Insulin (r=0.407, p=0.026), and a significant negative correlation with TC (r=-0.511, p=0.004). A significantly positive correlation between ACD and LDL-C (r=0.371, p=0.043) and a significantly negative correlation between HOMA-IR in the control group were detected (r=-0.682, p=0.000). Conclusions: The obese group had higher CCT and LT than the control groups.Öğe Comparison of central corneal thickness and intraocular pressure measured with two different tono/pachymeter devices in non-glaucomatouse children(Sage Publications Ltd, 2021) Teberik, Kuddusi; Eski, Mehmet Tahir; Ankarali, HandanPurpose: The goal of this research is to compare the intraocular pressure (IOP) and the mean central corneal thickness (CCT) values obtained from the measurements with Nidek NT-530P and Canon TX-20P devices with the values obtained by ultrasound pachymetry (UP) and Goldmann applanation tonometry (GAT) in children. Methods: This prospective study was conducted with 119 healthy children. The measurements were repeated three times for each eye. The intraclass correlation coefficient (ICC) was used to assess the correlation between the measurements obtained from different devices. The Bland-Altman plot was used to analyze the agreement between two different devices graphically. The measurements were taken in the same order in all subjects: TX-20P, NT-530P, UP, and GAT. Results: The mean age of the children was 10.1 +/- 3.2 (6-17) years. The mean CCT values for the eyes were 568.90 and 569.68 (TX-20P), 571.44 and 566.37 (NT-530P), 564.77 and 564.67 mu m UP, (right and left, respectively). The highest correspondence observed for CCT was between UP and NT-530P devices (ICC, 0.982, the left eye). The mean IOP measurements for Canon TX-20P, NT-530P, and GAT were 16.5 +/- 3.2, 16.3 +/- 3.2, and 16.8 +/- 3.6 mmHg for the right eyes, respectively, while those for the left eyes were 16.6 +/- 3.1, 16.2 +/- 3.3, and 16.8 +/- 3.7 mmHg. The highest correspondence was noted between measurements obtained using GAT and Nidek NT-530P devices (ICC, 0.945, in the left eye). Conclusion: Tono/pachymetry devices in the healthy children are provides significant agreements with the gold standard methods for IOP and CCT measurements. Clinical Trial Registration number: 2016-94Öğe Comparison of central corneal thickness with four different optical devices(Springer, 2018) Teberik, Kuddusi; Eski, Mehmet Tahir; Kaya, Murat; Ankaralı, HandanBackgroundTo compare the consistency between the average scores of the contact central corneal thickness measurements from ultrasound pachymetry devices still gold standard, such as iPac((R)) and Echoscan US-500, and noncontact measurements via Pentacam HR and Sirius topography.MethodsThis prospective study, subsequently admitted to the ophthalmology department, 76 healthy individuals were performed. The measurements were repeated three times for each eye, and average scores were statistically analyzed on the same day and almost at the same time. While measuring the eyes, Pentacam HR, Sirius topography, iPac((R)), and Echoscan US-500 were used, respectively. The inter-rater agreement of measurements from the devices was assessed with intraclass correlation coefficient, and 95% Confidence Interval and p values demonstrating statistically significance were also presented. In the graphical assessment of the agreement, the Bland-Altman graph was used.ResultsAmong 76 study participants, 43 (56.6%) were composed of women, and age level was 38.612.5years, ranging between 18 and 69. It was observed that the highest agreement was between the measurements obtained from Echoscan US-500 and iPac((R)) devices, but the agreement between the measurements of different devices was higher than 0.90. Bland-Altman graphics were also investigated; the results of four different devices were seen to be consistent with one another.ConclusionsTherefore, the devices we compared in the study can be used as alternatives to one another due to the higher consistency between CCT measurements provided with through UP devices of Echoscan US-500 and iPac((R)), and Pentacam HR and Sirius topography devices. p id= Par5 Clinical Trial Registration number: 2016/112Öğe Comparison of the effects of 3 different anti-VEGF drugs on cornea thickness, lens thickness and anterior chamber depth: Case-Control Study(2023) Eski, Mehmet Tahir; Teberik, Kuddusi; Sezer, TahaTo compare the long-term effects of 3 different anti-VEGF molecules on the lens, cornea and anterior chamber in phakic patients who have received consecutive intravitreal injections. 157 patients who did not have corneal pathology but were treated with 1.25mg/0.05ml intravitreal bevacizumab, 0.5mg/0.5ml ranibizumab or 2mg/0.05ml aflibercept injections due to diabetic macular edema were retrospectively analyzed in our clinic. Patients who received three consecutive monthly injections were included to the study. Corneal thickness, lens thickness and anterior chamber depth measurements which were taken before the injections, 1 month after the first injection, 1 month after the second injection, and 1 month after the third injection were used in the study. There was no statistical difference between the bevacizumab, ranibizumab, aflibercept and control group in terms of preoperative specifications such as number of patients, gender and age average. A statistically significant difference was found between the 4 anterior chamber depth measurements in the control group, Ranibizumab drug group, and Bevacizumab and Aflibercept drug groups (p<0.001, p=0.026; p=0.07, p<0.001, respectively). Anterior chamber depth of the Ranibizumab and Bevacizumab patients decreased in the first month and increased in the second and third months. However, anterior chamber depth of the Aflibercept patients increased over time. As a result of our study; we concluded that three different anti- VEGF drug molecules have an effect on the anterior camera.Öğe A Comparison of Three Different Photoscreeners in Children(Slack Inc, 2018) Teberik, Kuddusi; Eski, Mehmet Tahir; Kaya, Murat; Ankaralı, HandanPurpose: To compare the results obtained from three non-cycloplegic handheld photorefractometers with cycloplegic autorefractometry (Topcon KR-8100; Topcon Corporation, Tokyo, Japan) measurement in children. Methods: The refractive status of 238 eyes in 119 healthy children was assessed. The values acquired using photorefraction with the non-cycloplegic PlusoptiX A12 (Plusoptix GmbH, Nuremberg, Germany), Retinomax K-plus 3 (Righton, Tokyo, Japan), and Spot Vision Screener (Welch Allyn, Skaneateles Falls, NY) devices were compared with those obtained from the cycloplegic Topcon KR-8100. The agreement between the measurements was assessed using the intraclass correlation coefficient. Results: The mean age was 10.1 +/- 3.2 years (range: 6 to 17 years). The mean spherical value for the right eyes was 0.38 diopters (D) (range: -4.50 to 6.25 D) for the Plusoptix A12; 0.45 D (range: -4.50 to 6.25 D) for the Spot Vision Screener; -1.15 D (range: -8.75 to 6.50 D) for the Retinomax K-plus 3; and 0.62 (range: -4.50 to 6.00) for the Topcon KR-8100. The mean spherical equivalent value for the right eyes was 0.41 D (range: -4.50 to 7.90 D) for the Plusoptix A12; 0.18 D (range: -4.75 to 6.13 D) for the Spot Vision Screener; -1.30 D (range: -10.50 to 6.38 D) for the Retinomax K-plus 3; and 0.67 D (range: -4.00 to 6.00 D) for the Topcon KR-8100 (for the right eyes). Conclusions: The photorefractometer method was beneficial in the measurement of refractive errors of school-aged children. The PlusoptiX A12 photorefractometer method may eliminate the need for cycloplegia in the detection of refractive errors in children.Öğe The effect of nasal steroids on retinal nerve fiber layer in patients with a family history of glaucoma(2023) Ünlü, İlhan; Eski, Mehmet TahirObjectives: We aimed at analyzing the effect of nasal steroids on intraocular pressure (IOP) and retinal nerve fiber layer thickness (RNFL) in patients with a family history of glaucoma who also use fluticasone propionate (FP group) and mometasone furoate (MF group). Methods: Patients with a family history of glaucoma and suitable for using nasal steroids were included in the study population. IOP, anterior chamber depth (ACD), axial length (AL) and central corneal thickness (CCT) and RNFL thickness measurements of the patients were carried out. Measurements were done on 3 levels, namely, one before starting the medication, the other 1 month after starting the medication and the last one 3 months after the medication. 3 groups were established in our study: patients who are using MF group and FP group and also C group (control group; healthy individuals who have a family history of glaucoma but not using any medication). Results: The average age of patients in our study who were under medication was 33.2 ± 8.9 years. The study consisted of a total of 46 patients, 32 of whom were using nasal steroids and 14 belonging to the C group. It was found that global value in MF group decreased from 100.9 ± 7.7 to 99.6 ± 7.6 in the 3rd month and ACD in MF group decreased from 3.2 ± 0.4 mm to 2.9 ± 0.4 mm in the 1st month, both to be found statistically significant (p = 0.037 and p = 0.001 respectively). During the RNFL thickness measurements of patients, it was found that Temporal (T) segment in FP group decreased from 82.1 ± 13.8 to 81.7 ± 13.3 in the first month and T segment in MF group decreased from 72.8 ± 12.0 to 71.3 ± 10.2 in 3 months, both decreases to be found statistically significant (p = 0.047 and p=0.003 respectively). It was found that IOP in FP group increased from 15.3 ± 3.6 mm Hg to 17.7 ± 4.1 mm Hg in the 3rd month hence found to be statistically significant (p = 0.006). CCT in FP patients was found to be significantly higher in the 3rd month (p = 0.025). Conclusions: As a result of our study, it was found that nasal steroid usage in patients with a family history of glaucoma may cause an increase in IOP and thinning of the RNFL.Öğe The Effects of Long-term Growth Hormone Treatment on Ocular Findings(Georg Thieme Verlag Kg, 2023) Eski, Mehmet Tahir; Teberik, Kuddusi; Bolu, Semih; Ankarali, Handan; Kaya, Murat; Arslanoglu, IlknurPurpose This study aimed to examine the long-term changes in anterior chamber depth (ACD), central corneal thickness (CCT), axial length (AxL), peripapillary retinal nerve fibre layer thickness (RNFLT), peripapillary ganglion cell layer - inner plexiform layer (GCL-IPL) thickness, and peripapillary choroidal thickness (ChT) after rhGH replacement treatment in paediatric patients with IGHD, compared to healthy controls.Methods Twenty-two children with IGHD including 12 girls and 10 boys were enrolled in the study group, and 30 (16 girls, 14 boys) healthy children composed the control group. A detailed ophthalmological examination was performed for each participant. ACD, CCT, AxL, peripapillary RNFLT, GCL-IPL thickness and ChT measurements were performed before the rhGH replacement treatment and in the 12th month of the post-treatment period, as well as the corresponding visits in the control group. AxL ultrasound pachymetry (CCT), peripapillary RNFL thickness, peripapillary RNFLT, GCL-IPL thickness, and peripapillary ChT parameters were measured by spectral-domain optical coherence tomography.Results The mean age of the groups were similar (p = 0.143). 12-month CCT, ACD, and AxL measurements of the study group showed significantly higher results than the pre-treatment measurements (p = 0.005, p = 0.024, and p = 0.002, respectively). Similarly, the mean RNFLT and ChT measurements of the study group obtained from all sectors were significantly higher in the 12th-month visit (p < 0.001 for both) other than the RNFLT, and GCL-IPL thickness measurements (p > 0.05 for all). However, all these parameters were similar at pre- and post-treatment visits in the control group (p > 0.05 for all). The mean pre-treatment values of all these parameters were significantly lower in the study group compared to the control group (p < 0.05 for all), other than the RNFLT, GCL-IPL thickness measurements (p > 0.05 for all), while the mean post-treatment values of all these parameters in both groups were similar at month 12 (p > 0.05 for all).Conclusion GH replacement treatment in childhood may play an important role in the development of the neural retina and can be effective on the anterior segment, RNFLT and ChT measurements.Öğe Effects of Smoking on Pattern Visual Evoked Potentials(Tıbbi Kayıtlar Derneği, 2023) Eski, Mehmet Tahir; Yabalak, Ahmet; Şahan, Halime; Ayaslı, Alper; Sezer, TahaAim: The aim of the study is to get a better understanding of the side effects of smoking by evaluating the effect of recently elevated smoking rate on Visual Evoked Potentials (VEP) and to determine whether it is necessary to use different normals when evaluating the VEP measurements of smoking patients. Material and Methods: The patients who have applied to our ophthalmology and neurology outpatient clinics during 2021-2022 are included to the study. Detailed ophthalmologic examination of the patients as well as their VEP test is completed followed by a dilated fundus examination assessment. The patients with normal results are included to the study. The smoking rate is calculated on pack/year basis. Pattern VEP (PVEP) recording is performed based on Keypoint (Dantec, Denmark) and International Society for Clinical Electrophysiology of Vision (ISCEV) criteria. Data obtained through the study are analyzed by SPSS 21.0 version software. Countable variables with normal distribution between two independent groups are analyzed with Independent Sample T test whereas variables without normal distribution are analyzed with Mann Whitney U test. Chi-square test is used for comparing categorical variables. Results: 71 patients were included to the study where 33 of them were placed in smoking group and 38 in non-smoking group (control group). Smoking group had a yearly cigarette package consumption of 5.20±8.93 (0.2-40). VEP latency and amplitude changes were compared and according to the obtained results; there was P100 latency prolongation in between left and right eye of the patients in the control group and smoking group but it did not have any statistical significance (p=0.910 and p=0.697 respectively). There was no statistically significant difference in either left nor right eye in terms of smoking and P100 and N70 latencies (p=0.707, p=0.838, p=0.717 and p=0.621 respectively). Similarly, there was no significant correlation between yearly package consumption and P100 and N70 latencies and amplitudes of left and right eyes (p=0.503, p=0.410, p=0.776 and p=0.940 respectively). Conclusion: No significant effect of smoking is found on VEP values thus leading us to believe that the same normal intervals can be used in the evaluation of VEP results of both smoking and non-smoking patients.Öğe The effects of subconjunctival bevacizumab, ranibizumab, and aflibercept on corneal neovascularization(Sage Publications Ltd, 2022) Eski, Mehmet Tahir; Teberik, Kuddusi; Oltulu, Pembe; Ankaralı, Handan; Kaya, Murat; Alpay, MervePurpose To investigate the effects of subconjunctival bevacizumab, ranibizumab, and aflibercept in an experimental corneal neovascularization model. Materials and methods The eyes of 24 rats were chemically cauterized and randomly divided into four groups: bevacizumab group (0.05 mL/1.25 mg bevacizumab), ranibizumab group (0.05 mL/0.5 mg ranibizumab), aflibercept group (0.05 mL/1.25 mg aflibercept), and control group (0.05 mL saline solution). Plasma vascular endothelial growth factor (VEGF) levels were among the major measurement outcomes to assess corneal neovascularization. The collected plasmas were analyzed using the SIGMA RAB0511 Rat VEGF Elisa kit. The PCR technique and VEGF amplification procedures were used for molecular analysis. Each cornea was removed and histologically examined on day 21. Corneal images were evaluated by image analyzer software. Results In the post-injection period, the number of major corneal arteries decreased significantly in the injection groups when compared to the control group (p = 0.037), but no statistically significant differences were noted among the injection groups (p > 0.05). The aflibercept group had the lowest area of neovascularization. Immunohistochemical staining revealed substantially lower VEGF percentages in neovascularized arteries of the injection groups than the control group (p = 0.015). In TUNEL staining, the mean TUNEL value (number/1hpf) was substantially greater in the control group than in the injection groups, but the mean TUNEL values were similar between the injection groups (p = 0.019, p > 0.05, respectively). No statistically significant differences were observed between the groups in terms of corneal surface area with increased cellularity, edema, and inflammation (p = 0.263). The mean plasma VEGF concentration in the control group was statistically greater than those in the injection groups (p = 0.001). Conclusion Subconjunctival bevacizumab, ranibizumab, and aflibercept crossed the blood and seemed to be effective in inhibiting corneal neovascularization without causing epitheliopathy in an experimental rat model compared to the controls. However, no significant results were noted between these three anti-VEGF molecules.Öğe Effects of topical azithromycin, moxifloxacin, and povidone iodine on conjunctival bacterial flora in patients undergoing intravitreal injection(Consel Brasil Oftalmologia, 2019) Teberik, Kuddusi; Eski, Mehmet Tahir; Çalışkan, Emel; Kılınçel, Özge; Kaya, Murat; Ankaralı, HandanPurpose: To compare effects of 5% topical povidone iodine with prophylactic topical azithromycin and moxifloxacin on bacterial flora in patients undergoing intravitreal injection. Methods: A total of 132 patients were randomly assigned to receive treatment with azithromycin or moxifloxacin, or no treatment (control group). In total, 528 specimens were obtained at the time of admission, 4 days before intravitreal injection, 4 days after intravitreal injection, and 8 days after intravitreal injection. Samples were immediately sent to the microbiology laboratory for incubation. Results: The microorganism observed most frequently was coagulase-negative Staphylococcus (23.8%). When the results of samples obtained on Day 4 before injection were assessed, growth of coagulase-negative Staphylococcus was significantly lower in the moxifloxacin group, compared with controls (p=0.049). Acinetobacter baumannii continued to grow after administration of azithromycin (p=0.033). When the results of four days after intravitreal injection were evaluated, growth of coagulase-negative Staphylococcus was higher in controls, compared with patients who received azithromycin or moxifloxacin (p=0.004). Eradication rate was significantly higher in the moxifloxacin group than in the control group (p=0.001). Samples obtained on Day 8 after intravitreal injection showed similar levels of bacterial growth in all groups (p=0.217). Conclusion: Moxifloxacin was more effective than 5% povidone iodine in controlling the growth of conjunctival bacterial flora. Use of moxifloxacin in combination with 5% povidone iodine resulted in a synergistic effect.Öğe Evaluation of Intraocular pressure, Corneal thickness, and Retinal nerve fiber layer thickness in patients with Obstructive Sleep Apnea Syndrome(Professional Medical Publications, 2018) Teberik, Kuddusi; Eski, Mehmet Tahir; Balbay, Ege Güleç; Kaya, MuratObjective: To evaluate the intraocular pressure (IOP), central corneal thickness (CCT), and peripapillary retinal nerve fiber layer (RNFL) thickness in Patients with Obstructive Sleep Apnea Syndrome. Methods: In this prospective study, 103 patients with OSAS (study group) and 37 healthy subjects were enrolled. All participants underwent comprehensive ophthalmic examinations. Mean outcome measures were intraocular pressure by Goldmann applanation tonometry, CCT measurement using ultrasound pachymeter and peripapillary RNFL thickness measured by spectral-domain optical coherence tomography. Results: The differences between the mean values of RNFL thickness in all quadrants were similar in both groups and were not statistically significant (p=0.274). The IOP and CCT measurement averages of all patients with OSAS were lower than the control group. However, this difference was not statistically significant. There was no correlation between the apnea-hypopnea index, lowest oxygen saturation (LAST) or Body Mass Index (BMI) and the peripapillary RNFL thickness, IOP or CCT when OSAS group was divided by severity. Conclusions: The study results suggest that peripapillary RNFL thickness, IOP or CCT did not differ significantly between OSAS and control groups. We also found no correlation between apnea severity (AHI), lowest oxygen saturation (LAST) and BMI and RNFL, CCT and IOP.Öğe Evaluation of peripapillary choroidal vascularity index in young smokers(Taylor & Francis Ltd, 2023) Eski, Mehmet Tahir; Sezer, Taha; Bayraktar, Havvanur; Altikardesler, EmirPurpose: This retrospective study aimed to compare the peripapillary choroidal vascularity index (CVI) between young smokers who smoked less than 5 packs/year and non-smokers. Methods: The study included 52 smokers and 67 non-smokers, and comprehensive eye examinations were performed on all participants. Axial lengths (AL) were measured, and peripapillary enhanced depth imaging optical coherence tomography (EDI-OCT) images were obtained and evaluated using the Open Source ImageJ software. The CVI, total choroidal area ( TCA), luminal area (LA), stromal area (SA), and retinal nerve fibre layer (RNFL) quadrants were compared between the two groups. Results: The mean age of the smokers was 23.76 +/- 1.84 years, and for non-smokers, it was 23.98 +/- 2.18 years. The mean peripapillary CVI for smokers was 0.65 +/- 0.08, and for non-smokers, it was 0.67 +/- 0.03. No statistically significant difference in CVI was observed between the two groups. However, statistically significant differences were found in the temporal inferior (TI), temporal superior (TS), nasal inferior (NI), and nasal superior (NS) quadrants of the RNFL between the two groups (p < 0.05). There was no correlation between the number of packs/year and CVI values in the smoking group (r = 0.031, p = 0.826). Conclusion: The study revealed no significant difference in CVI among young smokers who smoked less than 5 packs/year compared to non-smokers. However, there was a statistically significant decrease in the TI, TS, NI, and NS quadrants of the RNFL in early-age smokers.Öğe Ocular abnormalities in morbid obesity(Consel Brasil Oftalmologia, 2019) Teberik, Kuddusi; Eski, Mehmet Tahir; Doğan, Sami; Pehlivan, Mevlüt; Kaya, MuratPurpose:Obesity is associated with eye diseases, but the underlying structural changes and pathogenic mechanisms have not been examined in detail. Here, we assessed the effects of morbid obesity on the morphometric indices of eye disease. Methods: Morbidly obese volunteers (n=101, body mass index [BMI] >= 40) and healthy individuals (n=95, BMI: 18.50-24.99) were examined by Goldman applanation tonometry, pachymetry, and spectral domain optical coherence tomography. Intraocular pressure, anterior chamber depth, axial length, central corneal thickness, retinal nerve fiber layer thickness, central fovea! thickness, and choroidal thickness were compared between groups. Results: Uncorrected intraocular pressure was significantly greater in the morbidly obese group than in the healthy control group (15.5 +/- 2.5 vs. 14.5 +/- 2.6 mmHg, p=0.009), whereas axial length, anterior chamber depth, and central corneal thickness did not differ between the groups. The mean retinal nerve fiber layer thickness at the temporal quadrant was reduced in the morbidly obese group (72.7 +/- 13.6 vs. 85.05 +/- 52.6 mu m, p=0.024). Similarly, the mean retinal thicknesses at nasal and temporal 1500-mu m locations were lower in the morbidly obese group (346.6 +/- 18.2 vs. 353.7 +/- 18.8 mu m, p=0.008; 323.1 +/- 20.3 vs. 330.0 +/- 18.9 mu m, p=0.001). The mean choroidal thickness was also reduced in almost all measurement locations (fovea, temporal 500 and 1000 mu m, and nasal 500, 1000, and 1500 mu m) of the obese group (p <0.05). Weight and BMI were negatively correlated with subfoveal choroidal thickness (r=-0.186, p=0.009; r=-0.173, p=0.015). Conclusion: Morbid obesity is associated with elevated uncorrected intraocular pressure and signs of neuropathy and retinopathy. Obesity may thus increase the risks of glaucoma and glaucomatous optic neuropathy.Öğe Oftalmopatisiz Hipertiroidik Hastalarda Optik Cohorens Tomografi Bulguları(2023) Eski, Mehmet Tahir; Teberik, Kuddusi; Sezer, Taha; Önmez, AttilaAmaç: Bu çalışmada, hipertiroidi tanısı olan ve oftalmopati gelişmemiş hastalardaki koroid, retina ve peripapiller sinir lifi tabakasının kalınlığını ötiroid hasta grubuyla karşılaştırmak amaçlanmıştır. Gereç ve Yöntemler: Hastaların serum tiroid stimülan hormon (TSH), serbest T3 (fT3), serbest T4 (fT4) değerleri incelendi. Hipertiroidi semptomları ile başvuran ve tetkiklerinde TSH; 0,5 mu/L’nin altında saptanan olgular çalışmaya dahil edildi. Spektral domain optik koherens tomografi ile retina kalınlığı (RT), retina sinir lifi tabakası (RSLT) kalınlığı ve koroid kalınlığı (CT) hesaplandı. Bulgular: Çalışmaya 40’ı (%49) hipertiroidi hastası (HT), 42’si (%51) ötiroidik sağlıklı bireyler olmak üzere toplamda 82 kişi dahil edildi. RT ölçümleri açısından T500, T1000, T1500 ve N1500 değerlerinin HT grupta kontrol grubuna göre daha düşük olduğu olduğu ve bunların istatistiksel olarak anlamlı olduğu görüldü (sırasıyla pÖğe Orbital Emphysema andPneumocephalus Caused By Air Gun:Case Report(2017) Teberik, Kuddusi; Eski, Mehmet Tahir; Kaya, MuratOrbital amfizem, direkt veya indirekt travma neticesinde orbitaya hava kaçması sonucu meydana gelen bir durumdur. Oniki yaşında erkek bir çocuk şakalaşma esnasında yüksek basınçlı hava tabancasının sol gözüne sıkılması şikayeti ile kliniğimize başvurdu. Hastanın yapılan of- talmolojik muayenesinde görme düzeyleri her iki gözde 20/20 olarak saptandı. Göz içi basınçları normaldi. Ön segment muayenesinde sol göz çevresinde şişlik, propitozis, krepitasyon, hassasiyet ve ağrı mevcuttu. Kapak ekarte edilerek yapılan biyomikroskopik muayenede yaygın subkon- jonktival amfizem, saat 4-5 hizasında subkonjonktival hemoraji ve aynı bölgedeki forniks kon- jonktivasında yaklaşık 2 mm'lik kesi tespit edildi. Arka segment muayenesinde her iki göz de doğal olarak değerlendirildi. Hastanın fizik muayenesinde yüzünün sol tarafında, şakağında ve kulak üstündeki saçlı deride krepitasyon alınan şişlik mevcuttu. Bilgisayarlı tomografi tetkikinde retroorbital bölgede amfizem ve pnömosefali tespit edildi. Hastaya tarafımızca topikal antibiyotik damla ve pomad ile beyin cerrahisi tarafından profilaktik oral antibiyotik ve antiinflamatuar te- davi verildiÖğe Ratlarda deneysel kornea neovaskülarizasyonunda bevacızumab, ranıbızumab ve afliberceptin karşılaştırılması(Düzce Üniversitesi, 2017) Eski, Mehmet Tahir; Teberik, KuddusiDeneysel kornea neovaskülarizasyonu geliştirilen ratlarda bevacizumab, ranibizumab ve afliberceptin etkinliğinin kontrol grubuyla karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmamızda 24 adet 250-300 gr ağırlığındaki Wistar-Albino türü erkek ratlar kullanıldı. Çalışmadaki 24 rat 4 farklı gruba ayrıldı.Her grup aynı şartlar altında aynı miktarda besin ile, aynı ortam ısısı ve ışığı altında takip edildi. Gruplardaki ratlar 1-6 arası kulak numarasıyla numaralandırıldı. Kornea merkezinde yanık oluşturmak için gümüş nitrat uygulandı, neovaskülarizasyonun gelişmesi için 10 gün beklendi. Ratlarda spontan oluşturulan gruplara bevacizumab,ranibizumab ve aflibercept subkonjonktiva l uygulandı.Düzenli aralıklarla takip edilerek 21 gün sonunda tüm gruplardaki kornealar alındı ve patolojik olarak incelendi. Bulgular: Kontrol grubunda, vasküler endotelyal growth faktör (VEGF) yüzde ortalaması, Tünel boyama (sayı/1hpf),enjeksiyon sonrası knv/tüm alan oranı ve ana damar sayısı bakımından diğer 3 gruptan da anlamlı düzeyde yüksek bulundu ancak gruplar arasında anlamlı farka rastlanılmadı. Eozinofil sayısı kontrol ve ranibizumab grubunda bevacizumab ve aflibercept grubundan anlamlı düzeyde yüksek bulundu. Sonuç: Çalışmamızda sık gördüğümüz kornea neovaskülarizasyonu tedavisinde henüz ruhsatı olmayan anti-VEGF moleküllerinin etkili olduğuna dair sonuçlar elde ettik. Bu sonuçların daha büyük gruplarda,yeni yaklaşımların geliştirilmesi ile ilerde bu tür hastaların tedavisi için alternatif bir yöntem olacağını düşünmekteyiz
