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Öğe ASSESSMENT OF CAROTID INTIMA-MEDIA THICKNESS IN ANKYLOSING SPONDYLITIS PATIENTS(Carbone Editore, 2013) Özşahin, Mustafa; Büyükkaya, Ramazan; Beşir, Fahri Halit; Uslu, Mustafa; Demirin, Hilmi; Baltacı, Davut; Erdoğmuş, BeşirBackground and aim: Measurement of the intima media thickness (IMT) of the common carotid artery has been a useful index to identify premature atherosclerosis. In the present study, we aimed to compare the carotid IMT of ankylosing spondylitis (AS) patients with that of controls matched for age and sex. We also evaluated the risk factors for atherosclerosis related to AS. Patients and methods: Fifty-five patients with AS and 55 healthy controls were included in the study. All of the patients underwent a clinical evaluation that included the following: Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI). Bath AS Patient Global Score (BAS-G), chest expansion, and modified Schober test. The same radiologist performed IMT measurements. Results: The mean carotid IMT was 0.59 +/- 0.15 mm in patients and 0.50 +/- 0.10 nun in controls (p=0.001). Disease duration, Schober index, and chest expansion were correlated with risk of atherosclerosis in the patients with AS (r=0.301, r=-0.369, and r=0.511, respectively). Otherwise, BASDAI, BASFI, BAS-G, ESR, hsCRP and treatment seemed to have no effect on CIMT. Conclusion: Our study shows that CIMT was significantly greater in the AS patients than in the controls paired for age and sex.Öğe Effect of smoking intensity on thyroid volume, thyroid nodularity and thyroid function: the Melen study(Edizioni Minerva Medica, 2011) Aydın, Leyla Yılmaz; Aydın, Yusuf; Beşir, Fahri Halit; Demirin, Hilmi; Yıldırım, H.; Önder, Elif; Celbek, GökhanAim. The purpose of our study was to determine the association between smoking habit, goiter, thyroid functions and ultrasonographic nodularity in moderately iodine deficient area. Methods. The MELEN study is a prospectively designed survey on the prevalence of thyroid diseases in Turkish adults. A total of 2298 subjects with a mean age of 50 (age range 18 to 92) were interviewed. Smoking habits were registered from questionnaires and subsequent interviews with a physician. Thyroid ultrasonography was performed and interpreted by the same experienced physician, using the same equipment. After an overnight fast, blood samples were collected from all the study subjects for the determination of serum free thyroxine, thyroid stimulating hormone (TSH) were measured. Results. Mean thyroid volumes of current smokers were significantly lower than either former or never smokers (P=0.014). There were no difference according to smoking habits on goiter and established multinodularity in current smokers (P<0.05). Heavy smokers (>20 pack/year) had higher thyroid volumes, higher goiter and multinodular goiter (MNG) prevalence than moderate smokers (P<0.001). Thyrotoxicosis (TSH<0.35) cases were more frequent among heavy smokers than moderate smokers (14.1% versus 8.2%, P<0.001; respectively). Heavy smoking independently predicted goiter (odds ratio: 1.459 [95% confidence interval: 1.029 and 2.068]; P=0.034). Conclusion. Heavy smoking was associated with increased prevalence of thyroid multinodularity and goiter in respect to moderate smoking. No association was found between smoking habit and thyroid dysfunction.Öğe Efficiency of radioactive I-131 therapy in geriatric patients with toxic nodular goiter(Springer, 2012) Erkan, Melih Engin; Demirin, Hilmi; Aşık, Muhammed; Celbek, Gökhan; Yıldırım, Mustafa; Aydın, Yusuf; Doğan, Ahmet SemihBackground and aims: The success of I-131 therapy in geriatric patients who were referred to an endocrinology clinic with toxic nodular goiter and who lived in iodine-deficiency regions was studied. Materials and methods: Patients older than 60 years who received I-131 therapy were included via retrospective data analyses. Fifty-nine patients between 60 and 82 years of age were enrolled in the study. The patients received an oral capsular form of I-131 (10-25 mCi) and were followed up for 1 year with clinical and laboratory results. Euthyroid or hypothyroid status at the end of the year after treatment was deemed to be a response to treatment. Results: Of the 21 (36%) male and 38 (64%) female patients, 29 (49%) had a solitary toxic nodule and 30 (5 1%) had toxic multinodular goiter. Twenty-nine (49%) of the patients received propylthiouracil therapy. At the end of the year, 38 (64%) patients were euthyroid, 11 (19%) were hypothyroid, and 10 (17%) were thyrotoxic. Forty-nine (83%) patients who were euthyroid and hypothyroid were considered responders. Conclusion: Geriatric patients with toxic nodular goiter were shown to have a high response rate to I-131 therapy. Thus, we suggest that radioactive iodine treatment should be the first-line treatment in these patients. (C) 2012, Editrice KurtisÖğe Evaluation of Elderly Patients at Check-Up Polyclinics for Anemia, Serum Folate and Cobalamin Levels(Walter De Gruyter Gmbh, 2010) Kara, İsmail Hamdi; Kandiş, Hayati; Bahçebaşı, Talat; Köylü, Oya Kıreker; Sayın, Sultan; Demirin, Hilmi; Memişoğulları, RamazanIntroduction: It was aimed to evaluate CBC analyses (HCT, MCV, MCH, MCHC, RDW and PLT), folic acid, cobalamin, serum iron and serum iron binding capacity and make a comparison according to gender in patients >50 years applied to check-up outpatients' clinic. Material and Method: 20 male and 35 female, total 55, consecutive patients who have median age 59.0 (50-85) yrs, applied to check-up polyclinic were included. Result: While median B12 vitamin and folic acid levels in men as follows: 170 (1501000) pg/mL and 6.4 (6.3-7.7) ng/mL; these values for women as follows: 261 (1501000) pg/mL and 9.3 (1.8-17.7) ng/mL (P<0.01 and P<0.01), consecutively. Cobalamin deficiency is common in both of gender. It was determined that cobalamin deficiency in male was 70%, and in female, 45.7%, (P=0.07), consecutively. Folic acid level is found in only one female case as <2 ng/mL. TSI% is lower in female (in male as 26.6% vs. in female as 18.1%; P<0.0001). MCV in eight (14.5%) cases was below 80 fL and MCV in nine (16.4%) cases was above 90 fL; however, MCV in none of cases was above 100 fL. Conclusion: In periodical examination of elderly, a high level of cobalamin deficiency could be determined; also the prevalence of cobalamin deficiency could be changed with accepted cut-off level. Present study showed it is important to consider cobalamin and iron deficiency in periodical examination of elderly.Öğe Have the reference ranges of anemia parameters like iron, ferritin, vitamin B-12 and folate been correctly settled in Turkish adults living in western Black Sea Region?(Walter De Gruyter Gmbh, 2012) Demirin, Hilmi; Memişoğulları, Ramazan; Uçgun, Taner; Yıldırım, Hayriye Ak; Çeler, Ahmet; Bulur, Şule; Güneş, CemalettinObjective: Widespread causes of anemia are the deficiencies of iron, vitamin B-12 and folate. The exact diagnosis is based on the laboratory data determined according to the appropriate reference ranges along with clinical symptoms. International Federation of Clinical Chemistry (IFCC) and Clinical and Laboratory Standards Institute (CLSI) have suggested that each laboratory should determine their own reference values. In this study, we aim to determine reference intervals of anemia parameters in a large cohort of Turkish adults and to investigate whether these values confirm with data sheets of commercial kits. Methods: Healthy 1251 subjects were included in the study. Subjects were divided into six groups according to their ages. Levels of serum iron, unsaturated iron binding capacity (UIBC), ferritin, vitamin B-12 and folate, and complete blood counts of all participants were determined. Results: There were significant differences between genders in terms of serum iron, ferritin, UIBC, folate levels and mean corpuscular volume (MCV). While levels of iron, UIBC, ferritin, and MCV were higher in males, vitamin B-12 and folate levels were higher in females. MCV, folate and vitamin B-12 levels were higher in middle aged adults, and lower in the young and elderly. Conclusion: There wasn't much difference between our results and previous studies and manufacturers' ranges except the ferritin and iron levels. Therefore, reference ranges are not required to be determined again. It was concluded that, high upper limits of serum iron and ferritin levels may be caused by inflammation so that these levels is not appropriate as a reference range unless evaluated together with inflammatory markers such as CRP, but lower levels may be valuable.Öğe Heart rate variability and heart rate recovery in patients with type 1 diabetes mellitus(Taylor & Francis Ltd, 2013) Türker, Yasin; Aslantaş, Yusuf; Aydın, Yusuf; Demirin, Hilmi; Kutlucan, Ali; Tibilli, Hakan; Özhan, HakanObjective Patients with diabetes mellitus (DM) are at an increased risk of sudden cardiac death (SCD) partly explained by cardiac autonomic neuropathy (CAN). There have been fewer studies to evaluate CAN using heart rate variability (HRV) and heart rate recovery (HRR) in patients with type 2 DM. To our knowledge, there has been no study to investigate the association between HRR, HRV and type 1 DM. The purpose of this study was to examine the changes in HRR and HRV measurements in type 1 diabetic patients. Methods The study population consisted of 35 consecutive patients with type 1 diabetes and 35 sex- and age-matched non-diabetic controls. We performed electrocardiography, echocardiography, Holter analysis, exercise stress test, routine biochemical tests including haemoglobin A1c, high-sensitivity C-reactive protein and evaluated the clinical characteristics. HRR was calculated by subtracting the heart rate values at the first minute of the recovery phase from the peak heart rate. Abnormal HRR was defined as HRR <= 18 beats. The HRV analysis was performed in both time domain and frequency domain. Results In HRV analysis, type 1 diabetic patients had significantly lower time domain [SDNN (P=0.041), SDANN (P=0.016), r-MSSD (P<0.001), pNN50 (P<0.001)] and frequency domain [total power (P=0.002), VLF (P<0.001), LF (P<0.001), HF (P=0.001), LF/HF (P=0.034)] HRV parameters as compared to controls. In logistic regression analysis, the HRR (OR 0.927, 95% Cl 0.872 to 0.985, P=0.014), METs (OR 0.562, 95% Cl 0.355 to 0.890, P=0.014), pNN50 (OR 0.729, 95% Cl 0.566 to 0.941, P=0.015) and HF (OR 0.952, 95% Cl 0.911 to 0.994, P=0.027) were independently associated with type 1 DM. Conclusion The results of this study showed that HRV parameters and HRR were significantly reduced in patients with type 1 versus healthy controls. We found that HRV parameters correlated with HRR in type 1 diabetic patients. There is a relationship between CAN and inflammation and also, there may be a relationship between CAN and intensive glycaemic control according to this study.Öğe High sensitive CRP and sICAM-1 can predict Major Adverse Cardiovascular Events: MELEN Study: A Large Turkish Population Based Study(Duzce Univ, 2016) Türker, Yasin; Kayapınar, Osman; Demirin, Hilmi; Eröz, Recep; Kutlucan, Ali; Türker, Yasemin; Baltacı, DavutObjective: We aimed to evaluate the predictors of major adverse cardiovascular events (MACE) in a prospective population based study. Methods: This study included 153 participants aged>40 years with high and very high cardiovascular risk, and 50 participants aged>40 years with low cardiovascular risk according to the SCORE risk assessment. All the participants underwent a doppler ultrasound examination of carotid intima media thickness (CIMT), echocardiographic examination, ECG recording and various biochemical analyses. High-sensitivity C-reactive protein (hsCRP) was measured with chemiluminescent immunometric assay, serum amyloid-A (SAA) protein, soluble intercellular adhesion molecule-1 (sICAM), apolipoprotein-B (ApoB) were measured with ELISA method. eNOS single-nucleotide polymorphism was detected using polymerase chain reaction and restriction fragment length polymorphism methods. The follow-up was done 36 months after the baseline admission. MACE was defined as cardiovascular mortality or myocardial infarction or stroke. Results: Frequency of MACE was higher in high and very high risk group according to low risk group. There were no significant differences in eNOS gene polymorphisms between the risk groups and control subjects, and no significant association between eNOS gene polymorphisms and MACE was detected. Age, ejection fraction (EF), CIMT, hsCRP, ApoB, sICAM-1, and SAA protein levels were all significantly associated with MACE in univariate logistic regression analyses. Multivariate analyses revealed that age (OR: 1.08, CI: 1.02-1.15, p=0.013), EF (OR: 0.94, CI: 0.89-0.99, p=0.016), hsCRP (OR: 1.36, CI: 1.12-1.67, p=0.003) and sICAM-1 (OR: 81.0, CI: 1.04-6320, p=0.048) levels were the only independent predictors of MACE. Conclusion: Higher age, hsCRP and sICAM-1 levels and lower EF were independent predictors of MACE.Öğe Hla-G Ve Kanser İlişkisi(2012) Memişoğulları, Ramazan; Özcan, M. Engin; Uçgun, Taner; Demirin, HilmiHLA antijenlerinin doku uyumu ve immünite açısından önemi bilinmektedir. HLA sınıf 1 antijenlerinden non-klasik gruba dâhil olan HLA-Gnin kanser immunitesindeki baskılayıcı rolü son zamanlarda yapılan çalışmalarda daha da açığa çıkarılmıştır. HLA-G normal durumlarda çok kısıtlı dokularda bulunmaktadır. Trofoblastlar gibi fetal dokularda, timik medulla, kornea, pankreatik adacıklarda ve eritroid ve endotelial hücre prekürsörlerinde bulunmaktadır. HLA-G ekspresyonu bu fizyolojik durumların dışında kanserler, transplantasyon, multiple scleroz, inflamatuar hastalıklar ve viral enfeksiyonlar gibi patolojik durumlarda da artmış seviyelerdedir. Bu derlemede HLA sistemi hakkında kısaca bilgi verilerek HLA-G ile kanser ilişkisini vurgulayan farklı kanser türleri üzerinde yapılmış çalışmaları ortaya koymak amaçlanmıştır.Öğe Maternal Serum Soluble HLA-G Levels in Missed Abortions(Mdpi, 2013) Keskin, Fatih; Karataş, Ahmet; Albayrak, Mustafa; Bıyık, İsmail; Erkan, Müşerref; Demirin, Hilmi; Dilbaz, SerdarBackground and Objective. It is unclear how immune tolerance develops to a semiallograft fetus in pregnancy. Human leukocyte antigen G (HLA-G) expressed by extravascular trophoblasts plays an important role in the recognition of the gestational tissues as self and the development of immune tolerance against the gestational tissues by the maternal immune system. The soluble form of the HLA-G (sHLA-G) molecule in the maternal serum is also reported to contribute to the prevention of rejection during pregnancy. The aim of the study was to compare the maternal serum sHLA-G levels of the women with missed abortions and control subjects with uncomplicated pregnancies. Material and Methods. The prospective cross-sectional study involving 40 with missed abortions and 40 control women, matched by age, gestational age, and body mass index, was carried out. The study group consisted of the women with singleton pregnancies, who were diagnosed with a missed abortion. Only the patients who were confirmed to have an uncomplicated term delivery during follow-up were included in the control group. The serum sHLA-G level was compared between the groups. Results. There was no significant difference in the mean serum sHLA-G levels in terms of gravidity (P=0.761) and a history of abortion (P=0.379) in the control group. The median serum sHLA-G level in the missed abortion group was significantly lower compared with the control group (16.8 [8.5-35.8] vs. 26 [11-135] U/mL, P<0.001). All the women in the control group had uncomplicated term deliveries. Conclusion. Our results showed that the women with missed abortions had significantly lower serum sHLA-G levels compared with the healthy pregnant controls, which may have potentially played a role in the impairment of physiological immunological tolerance during pregnancy. However, the determination of the exact role and the potential clinical utility of maternal serum sHLA-G for the detection/ prediction of a missed abortion risk requires further detailed studies.Öğe Neutrophil - lymphocyte ratio in patients with ankylosing spondylitis(2014) Özşahin, Mustafa; Demirin, Hilmi; Uçgun, Taner; Ermiş, Fatih; Admış, Özlem; Ataoğlu, SafinazAmaç: Bu çalışmanın amacı, ankilozan spondilit (AS) hastalarındaki inflamasyon ile nötrofil -lenfosit oranı (NLO) arasındaki ilişkiyi belirlemektir. Yöntem: Ankilozan spondilit tanılı 40 hasta ve 30 sağlıklı gönüllü çalışmaya dahil edildi. Tüm veriler yatan ve poliklinik hasta kayıt veritabanından elde edildi. Tüm olguların Bath Ankilozan Spondilit Hastalık Aktivite İndeksi (BA S- DAI), tam kan sayımı (TKS), CRP ve ESHı da kapsıyan ayrı ntılı fizik muayene ve laboratuvar bulguları kaydedildi. Lenfosit ve nötrofil sayısı otomatik TKSnin bir parçası olarak ölçüldü. Bulgular : Akut-faz reaktanı olan CRP ve ESH kontrol gr ubuna göre hasta grubunda anlamlı olarak daha yüksekti (p 0.05). Sonuç : Bu çalışmada NLO düzeylerinin AS hastalarında sağlıklı bireylere göre anlamlı olarak yüksek olmadığı görüldü. Bu sonuç NLOnun AS hastalarında sistemik in flamasyonu değerlendirmede uygun bir ölçü birimi olmad ığını götermektedir. Bizim elde ettiğimiz bu ön sonuçların daha ileri çalışmalarla tamamlanması gerektiğine inanıyoruz.Öğe Normal range of mean platelet volume in healthy subjects: Insight from a large epidemiologic study(Pergamon-Elsevier Science Ltd, 2011) Demirin, Hilmi; Özhan, Hakan; Uçgun, Taner; Celer, Ahmet; Bulur, Şule; Çil, Habib; Yıldırım, Hayriye AkAim: Mean platelet volume (MPV) in the healthy population has not been studied before. Therefore, the aim of the study was to measure MPV in normal subjects in a large cohort of Turkish adults. Methods: A total of 2298 subjects with a mean age of 50 (age range 18 to 92) were interviewed. Subjects who had smoking habit, diabetes, hypertension, coronary artery disease, dyslipidemia, chronic obstructive pulmonary disease, cancer, chronic use of any drugs including antiplatelets, heavy drinkers, metabolic syndrome, ejection fraction < 55%, creatinine > 1.4 in men and > 1.1 in women, abnormal liver function tests and an abnormal TSH were excluded in a in a stepwise manner. Complete blood counts were done on the same day within 6 hours by a CELL-DYN 3700 SL analyzer (Abbott Diagnostics). Results: Three hundred twenty-six participants (204 females (63%) and 122 males (37%) with a mean age of 41 +/- 16) constituted the final healthy cohort. Mean MPV of the cohort was 8.9 +/- 1.4 fL. There was no significant difference among age groups regarding MPV. Conclusion: Ninety-five percent of the individuals had a MPV between 7.2 and 11.7 fL. A patient having a MPV beyond this range should be evaluated carefully especially for occlusive arterial diseases. (C) 2011 Elsevier Ltd. All rights reserved.Öğe Oxidative Stress and Decrease of Paroxonase Activity in Patients whit Prostate Cancer(Duzce Univ, 2015) Orhan, Nuri; Özcan, Muhammet Engin; Memişoğulları, Ramazan; Uçgun, Taner; Kayıkçı, Muhammet Ali; Demirin, HilmiObjective: Prostate cancer is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to the prostate cancer. The paraoxonase (PON1) is an endogenous antioxidant in the human body. The aim of our study was to determine whether lipid parameters, total oxidant capacity (TOC), total antioxidant capacity (TAC), oxidative stress index (OSG), serum paraoxonase (PON1) and arylesterase (ARE) levels and phenotypes distribution alter new diagnosis in patients with prostate cancer and to compare the values with those of healthy controls. Methods: The study was performed prospective which consist of the prostate cancer group (PC) and healthy control group. Serum PON1, ARE activities, and other parameters were measured in 40 subjects in both groups. The PON1 phenotypes were defined according to the ratio of serum PON1/ARE activity. In statistical evaluation of data was performed by Student t test and Pearson's correlation analysis. Results: TKOL and LDL-K levels were found to be lower in the patients compared to controls (p=0,044; p=0,026). OSI levels in patients was higher than the controls (p=0,029). PON1 and ARE activities were found to be lower in patients compared to the controls (p=0,040; p=0,027). PON1 enzyme activity was determined as three different phenotypes in both groups. In PC group, significant deviation of PON1 phenotype frequencies from Hardy-Weinberg equilibrium was found. Conclusion: The results of our study suggest that oxidative stress, through lipid peroxidation may play an important role for the development of prostate cancer and that PON1, and PON1 phenotyping may be predictive for prostate cancer.Öğe Phosalone Toxicity on Liver and Pancreas: Role of Vitamins E and C(Asian Journal Of Chemistry, 2013) Demirin, Hilmi; Gökalp, Osman; Kaya, Ertuğrul; Büyükvanlı, Bora; Cesur, Gökhan; Özkan, Aybars; Kaya, MuratPhosalone (6-chloro-3-[diethoxyphosphinothioylsulfanylmethyl]-1,3-benzoxazol-2-one) is one of the most commonly used organophosphorus pesticides in the peat control of crops. Subchronic phosalone exposure was evaluated for its effects on the serum activities of some enzymes concerning hepatic and pancreatic damage including aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyltransferase (GGT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), cholinesterase (ChE); and finally protective effects of combination of vitamins E and C in 24 wistar-albino rats. Experimental groups were as follows: control group (n = 8); a group treated with 120 mg/kg body weight phosalone (P group, n = 8); and a group treated with 120 mg/kg body weight phosalone + vitamin E + vitamin C (P+V group, n = 8). The P and P+V groups were treated orally with phosalone on 5 days a week for 4 weeks. The serum activities of the above mentioned enzymes were analyzed. In the samples phosalone significantly increased the activities of ALT, LDH and decreased ChE (p < 0.05). However no significant change was detected for the remainder enzymes (p > 0.05). In the P+V group, ALT and LDH activities were significantly increased and ChE decreased (p < 0.05). It is concluded that subchronic phosalone causes rat liver damage to an extent, which is somewhat reflected on the liver enzymes. Furthermore, a combination of vitamins E and C can reduce the toxic effects of phosalone on liver tissue of rats.Öğe Phototherapy, Hyperbilirubinemia and Genotoxicity in Newborns(Elsevier Science Bv, 2010) Karadağ, Ahmet; Demirin, Hilmi; Doğan, Derya Gümüş; Aslan, Mehmet; Tatlı, Mustafa Mansur…Öğe Prostat Kanserli Hastalarda Oksidatif Stres ve Paraksonaz Aktivite Azalması(2015) Orhan, Nuri; Özcan, Muhammet Engin; Memişoğulları, Ramazan; Uçgun, Taner; Kayıkçı, Muhammet Ali; Demirin, HilmiAmaç: Prostat kanseri, kansere bağlı ölümlerin önemli nedenlerinden biridir. Oksidatif DNA hasarının prostat kanseri gelişmesine katkıda bulunabileceği belirtilmektedir. Paraoksonaz (PON), insan vücudundaki endojen antioksidanlardan biridir. Çalışmamızda yeni tanı almış prostat kanserli hastalarda ve sağlıklı kontrollerde serum örneklerinde lipid parametreleri, total oksidan ve antioksidan kapasite (TOK, TAK), oksidatif stres indeksi (OSİ), paraoksonaz (PON1) ve arilesteraz (ARE) aktiviteleri ve PON1 fenotip dağılımı saptanarak iki grup arasında karşılaştırılması amaçlandı. Yöntem: Çalışma, prostat kanseri grubunda (PK) ve sağlıklı kontrol grubunda prospektif olarak yapıldı. Serum PON1 ve ARE aktiviteleri ile diğer parametreler her iki gruptaki 40 katılımcıda ölçüldü. PON1 fenotip dağılımı PON1/ARE aktivitelerine göre belirlendi. İstatistiksel değerlendirmeler Student t testi ve Pearson korelasyon analizi ile yapıldı. Bulgular: TKOL ve LDL-K düzeyleri PK grubunda kontrol grubuna göre anlamlı olarak yüksek saptandı (p 0,044; p0,026). OSİ değerleri hastalarda kontrollerden yüksekti (p0,029). PON1 ve ARE değerleri hastalarda kontrollerden düşüktü (p0,040; p0,027). PON1 aktivitelerine göre her iki grupta üç fenotip belirlendi. PK grubunda Hardy-Weinberg dağılımından sapma olduğu gözlendi. Sonuç: Sonuçlarımız oksidatif stresin lipid peroksidasyonu aracılığıyla prostat kanserinin gelişiminde önemli rol oynayabileceğini ve PON1 ile PON1 fenotiplemesinin prostat kanseri için prediktif değer taşıyabileceğini göstermektedir.Öğe The relation between Hla-G and cancer(2012) Memişoğulları, Ramazan; Özcan, M. Engin; Uçgun, Taner; Demirin, HilmiThe importance of HLA antigens on immunity and tissue compatibility is known. The suppressor role of a non classical HLA antigen HLA-G is being clearer with the results of last studies. On normal situations its being is restricted in a few type of tissue. It can be found on fetal tissues like trophoblasts, tymic medulla, cornea, pancreatic islets and precursors of erithroid and endothelial cells. The expression of HLA-g is increased in the situations like malignities, transplantation, multiple sclerosis, inflammatory diseases and viral infections. In this review it is aimed to give short information on HLA system and to introduce the studies pronouncing the relation of HLA-G and malignities. © 2012 Düzce Medical Journal.Öğe Relationship of maternal serum resistin and visfatin levels with gestational diabetes mellitus(Taylor & Francis Ltd, 2014) Karataş, Ahmet; Işıkkent, Nilüfer Tuncay; Özlü, Tülay; Demirin, HilmiIntroduction: Adiponectin, resistin and visfatin are thought to play role in the pathophysiology of gestational diabetes (GDM). In this study, we aimed to investigate the association of maternal second trimester serum resistin and visfatin levels with GDM. Materials and methods: Screening and diagnosis for GDM was performed between the 24-28th gestational weeks. About 40 women diagnosed with GDM and 40 non-diabetic women constituted the study and control groups, respectively. Groups were compared for second trimester maternal serum resistin, visfatin and HbA1c levels, HOMA-IR and postpartum 75 g OGTT results. Results: Mean serum resistin (p = 0.071) and visfatin (p = 0.194) levels were similar between the groups. However, mean BMI (p = 0.013), HOMA-IR (p = 0.019), HbA1c (p<0.0001) and birth weight (p = 0.037) were significantly higher in GDM group compared to controls. Type 2 diabetes and impaired glucose tolerance were detected in 2 (5%) and 7 (20%) women in the GDM group, respectively, with 75 g OGTT performed at the postpartum 6th week. Resistin levels of patients with GDM and postpartum glucose intolerance were higher than those with GDM but no postpartum glucose intolerance (p = 0.012). Visfatin levels in the GDM group showed a positive correlation with biparietal diameter, head circumference, abdominal circumference and femur length (p<0.05). Conclusion: Maternal serum resistin and visfatin levels are unchanged in GDM. In patients with GDM, second trimester resistin levels may be predictive for postpartum glucose intolerance and second trimester visfatin levels may be related with fetal biometric measurements. Further larger studies are needed.Öğe Serum visfatin and omentin levels in slow coronary flow(Elsevier Doyma Sl, 2014) Uçgun, Taner; Başar, Cengiz; Memişoğulları, Ramazan; Demirin, Hilmi; Türker, Yasin; Aslantaş, YusufObjective: The adipocytokines visfatin and omentin have a direct effect on inflammation and endothelial injury. The expression of visfatin is closely associated with the expression of proin-flam matory cytokines. Omentin has an anti-inflammatory effect and is inversely associated with coronary artery disease (CAD). The slow coronary flow phenomenon is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease. The pathophysiology of SCF has not been clearly identified, although multiple abnormalities including endothelial dysfunction, atherothrombosis and inflammation have been reported. However, the relationship between visfatin, omentin and SCF is still unknown. In this study, we aimed to investigate the relationship of these adipocytokines with SCF. Methods: The study included slow coronary flow (n=45) and normal coronary flow (n=55) subjects, according to the corrected TIMI frame count, who underwent angiography in the catheterization laboratory of Duzce University. Statistical analyses were performed with SPSS version 12. Results: Visfatin levels were significantly higher in patients with SCF than in controls (p<0.001). Plasma omentin levels were lower in the SCF group than in controls, although without statistical significance. Visfatin, gender and platelet count were significant predictors of SCF in multivariate logistic regression analysis (OR 0.748, 95% CI 0.632-0.886, p=0.01; OR 30.016, 95% CI 4.355-206.8, p=0.01; OR1.028, 95% CI 1.006-1.050, p=0.011, respectively). Conclusion: Adipocytokines such as visfatin and omentin may play a role in the pathogenesis of coronary slow flow. (C) 2014 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.
