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  • Küçük Resim
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    Effect of Ginkgo biloba on brain volume after carotid artery occlusion in rats: a stereological and histopathological study
    (Tubitak Scientific & Technical Research Council Turkey, 2014) Aktürk, Zeynep; Odacı, Ersan; İkinci, Ayşe; Baş, Orhan; Canpolat, Sinan; Çolakoğlu, Serdar; Sönmez, Osman Fikret
    Background/aim: This study investigated the effect of Ginkgo biloba (GB) on brain volume in cerebral ischemia induced by stopping carotid artery blood flow. Materials and methods: Twenty-four adult male rats were divided into 4 groups of 6 rats each. No procedure was performed on the control group. Ischemia was applied to the rats in the ischemia and ischemia + GB groups by clamping the arteria carotis communis for 30 min. The rats in the ischemia + GB group were given 100 mg/kg drops (Tebokan Fort Drop, Abdi Ibrahim Ilac Sanayi A.S., Turkey) containing dry GB leaf extract orally, every day for 14 days from the day of ischemia. In the sham group, surgical stress alone was applied by performing a skin incision. On the 14th day, brain tissues were extracted and evaluated stereologically and histopathologically. Results: The only statistically significant difference was observed between the sham and control groups. Conclusion: This result may be interpreted as surgical stress, established by cutaneous incision, having an adverse effect on brain volume. Additionally, the absence of any difference in terms of brain volume following 30 min of ischemia between the ischemia and control groups suggests that a probable postischemic rise in brain volume disappears within 14 days.
  • Küçük Resim Yok
    Öğe
    Oxidant-Antioxidant Balance Changes in Adipose Tissues of High Fat Diet-Induced Obese Rats: Depot-Specific Manner and Ineffectiveness of N-Acetylcysteine
    (Kocaeli Üniversitesi, 2019) Kahraman, Cemil; Alver, Ahmet; Bodur, Akın; Akça, İmran İnce; Altay, Diler Us; Canpolat, Sinan
    Objective: The aims of study were to investigate effects of both N-acetylcysteine (NAC, an antioxidant) and high fat diet (HFD) to oxidative stress in differently located adipose tissues and the liver. Methods: Our study is created from control, HFD and NAC groups (n=6). Control group was fed with only standard diet. HFD group was fed with only HFD. NAC group was fed with HFD, and additionally that group received NAC (2 g/L). All groups were fed with designated diets for 85 days. Antioxidant enzyme activities, glutathione, and malondialdehyde were measured in epididymal, perirenal, subcutaneous adipose tissues, and liver.Results: In the HFD group, malondialdehyde (MDA) levels increased in perirenal adipose tissue and liver. In addition, superoxide dismutase (SOD) and catalase activities in the HFD group were lower both epididymal and perirenal adipose tissue, whereas glutathione peroxidase activities were lower in subcutaneous and epididymal adipose tissue. Glutathione was lower in liver tissue alone. In subcutan adipose tissue, the glutathione and SOD activities increased due to NAC administration. Conclusion: The present findings showed that oxidative stress and antioxidant enzyme profiles were variable in localized adipose tissue in different regions. Thought antioxidant enzyme activities in some tissues increased due to NAC application, these increases were insignificant in terms of oxidant-antioxidant balance.