Yazar "Buyucek, Seyma" seçeneğine göre listele
Listeleniyor 1 - 3 / 3
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Atypically Located Basal Cell Carcinoma: Three Case Reports(2020) Karagün, Ebru; Gamsızkan, Mehmet; Eyup, Yavuz; Bahcivan, Atike; Özcan, Yunus; Buyucek, SeymaBasal cell carcinoma (BCC) is the most common malignant tumor in humans. It can be seen anywhere in the skin,although more than 80% occurs in areas exposed to the sun, such as the head and neck. Chronic exposure to sunlight is thought to bethe main etiological factor. Although the risk of metastasis in BCC is very low, the tumor may be locally aggressive and cause tissuedestruction. We present three cases of BCC in atypical locations, the waist region, the lateral femoral region, and the perinealregion. No predisposing factor in terms of etiology of BCC was encountered in these patients’ histories. We are presenting ourcases, together with a discussion of the current literature, to emphasize that BCC should be considered even in atypically locatedlesions.Öğe BRAF mutation, TERT promoter mutation, and HER2 amplification in sporadic or neurofibromatosis-related neurofibromas and malignant peripheral nerve sheath tumors: do these molecules have a signature in malignant transformation?(Wiley, 2020) Coskun, Sinem; Gamsizkan, Mehmet; Yilmaz, Ismail; Yalcinkaya, Ulviye; Sungur, Mehmet Ali; Buyucek, Seyma; Onal, BinnurPeripheral nerve sheath tumors may occur sporadically or related to neurofibromatosis (NF). Unless the mechanisms of tumorigenesis in NF related malignant peripheral nerve sheath tumors (MPNST) are better understood, it remained unclear in sporadic cases. We aimed to investigate the genetic route for malignancy in both individuals with NF-1 and sporadic ones to open a way for targeted therapies in the future. We investigated the role of HER2 with Dual ISH DNA Probe Cocktail test, BRAF mutation (exon 15) and TERT promoter mutation frequency with Sanger sequencing method in respectively 25 sporadic neurofibromas, 25 NF-1 related neurofibromas and 25 MPNST cases from two institutes. Categorical data were analyzed and summarized as frequency and percentage. Statistical analysis was done with SPSS v.22 statistical package, and the statistical significance level was considered as 0.05. We identified TERT promoter mutation only in one sporadic MPNST (4%) and no BRAF mutation in any case. HER2 amplification is found in 10/25 (40%) MPNST cases. No mutations or gene amplification detected in neurofibromas (p < 0.001). MPNSTs are sarcomas with poor prognosis and limited treatment options. TERT promoter mutations and HER2 amplification may play a putative role in therapeutic purposes.Öğe The effects of CDP-choline treatment in Amanita phalloides mushroom toxicosis(Pergamon-Elsevier Science Ltd, 2024) Coskun, Nuri Cenk; Buyucek, SeymaAmanita phalloides poisoning is known to be the most fatal case among mushroom poisoning cases. Its main mechanism of toxicity is that it leads to cell death by the irreversible binding of its toxins to the DNA-dependent RNA polymerase II enzyme. This study was planned to analyze the effects of the CDP-choline molecule on Amanita phalloides mushroom poisoning cases. The extract of the Amanita phalloides mushroom was taken and intraperitoneally administered to male Wistar Albino rats at a dose of 0.3 g/kg. In the experiment phase, the rats were divided into three groups of CDP-choline treatment according to the doses of 100 mg/kg, 250 mg/kg, and 500 mg/kg, and one control group was administered a 1 ml/kg dose of 0.9% isotonic NaCl solution. The treatments were then administered intraperitoneally at the 2nd hour, and at the 6th hour, the rats were sacrificed. The degree of damage in the liver and kidney tissues of the rats was evaluated histopathologically. It was concluded that CDP-choline reduced or prevented the damage that occurred in the liver significantly and dose-dependently in the toxicosis picture caused by Amanita phalloides , and it showed a tendency to lower or prevent the damage in the kidney, albeit not significantly.