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    Neuro-Behçet Presenting with Venous Sinus Thrombosis: Case Report
    (Düzce Üniversitesi, 2018) Şimşek, Fatma; Bilge, Nuray
    Behçet disease is an inflammatory disease of unknown etiology with multisystem involvement. Central nervous system (CNS) involvement is rare, but may sometimes been before the other systems involvements. CNS involvement is seen in 5-15% of the cases. Early diagnosis and treatment is critical in terms of prevent the sequellae. CNS involvement could be the first reason of the patient to consult the hospital in the cases that carry the fundamental criteria for Behçet disease diagnosis, but not diagnosed yet. In this report, we presented a neurobehçet case admitted to hospital due to severe headache and diplopia, and detecting cerebral vein thrombosis resulting from Behçet disease in etiology. We found this case worth to present since the etiological reason forms the treatment in venous sinus thrombosis and our patient was diagnosed neuro-behçet before than the Behçet disease.
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    The Relationship of Headache with Inflammatory Serum Parameters and Disease Severity in COVID-19 Patients
    (2020) Alay, Handan; Bilge, Nuray; Can, Fatma Kesmes
    Aim: Most of the coronavirus disease 2019 (COVID-19) patients have respiratory symptoms;however, various neurological symptoms, such as headache, can be seen. Thepathophysiological mechanism of headache in COVID-19 is unknown completely. In ourstudy, we aimed to investigate the relationship between headache and inflammatory markersand disease severity in COVID-19 patients.Material and Methods: Two hundred and three hospitalized patients with a polymerase chainreaction (PCR)-confirmed COVID-19 diagnosis between 15 March and 01 June 2020 wereretrospectively investigated. A total of 62 patients with headache symptoms (n=31) andwithout headache symptoms (n=31), who were age and gender-matched, were included in thestudy. The demographic characteristics, inflammatory serum parameters,neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP)/albumin ratio (CAR),hospitalization times, and disease severity were determined.Results: Of the 203 COVID-19 patients, 36 (17.7%) had a headache, and it was the fourthmost common symptom. Headache accompanied other symptoms in all patients. Of thepatients with headache, 14 (45.2%) were female, 17 (54.8%) were male, and the mean age was37.74±16.65 years. In our COVID-19 patients, the neutrophil count, NLR, CRP, CAR weresignificantly higher, and hospital stay was longer in patients with headache than those withoutheadache (p=0.023, p=0.041, p=0.034, p=0,048 and p=0.049, respectively).Conclusion: As a result, the increased inflammatory response may play a role in thepathogenesis of headache in COVID-19 patients. Our study is the first study that evaluated therelationship between headache symptom and inflammation in COVID-19 patients. Furtherresearch is needed on this subject.
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    The Relationship Between Etiology and Genetic Polymorphism in Adults with Cerebral Venous Thrombosis
    (Düzce Üniversitesi, 2019) Şimşek, Fatma; Ceylan, Mustafa; Bilge, Nuray
    Aim: Cerebral venous thrombosis (CVT) is a rare cause of stroke, and there are many factors in its etiology. At least 1/4 of cases is based on thrombophilia. The most common risk factors for thromboembolism were methyl-tetra-hydro-folate reductase (MTHFR) C677T, factor V (FV) G1691A (Leiden), factor II (FII) GA20210 and their mutations. Its relationship with different genetic polymorphisms and high homocysteine levels were also investigated. In this study, it was aimed to investigate the existence of genetic polymorphism and the role of homocysteine levels in CVT etiology.Material and Methods: Demographic characteristics, clinical, radiological and laboratory data of patients diagnosed with CVT between January 2010 and June 2018 were reviewed retrospectively. Etiologic risk factors for CVT and the role of genetic polymorphism in these risk factors were investigated.Results: In this study, 92 (73 female and 19 male) patients and 52 (44 female and 8 male) control subjects were evaluated. The most frequent admission symptom was headache in patients with CVT. MTFHR, factor 13 (F13) V34L, plasminogen activator inhibitory (PAI) and ?-fibrinogen mutations were higher in control group. No statistically significant difference was found between the two groups in terms of FV Leiden, FII, Glycoprotein 3a mutation and homocysteine level.Conclusion: In this study, in addition to the results consistent with the literature, some different results were determined. MTHFR (C677T, A1289C), FV Leiden, FII G20210, ?-fibrinogen 455 G-A, PAI-1 4G/5G polymorphisms do not pose a risk for CVT. F13 V34L polymorphism has a protective role against CVT.