Yazar "Baba, Dursun" seçeneğine göre listele
Listeleniyor 1 - 20 / 21
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Adolesan Varikosele Güncel Yaklaşımlar(2019) Baba, Dursun; Kayıkçı, Muhammet AliVarikosel, adolesan yaş grubunda da erişkin yaş grubuna benzer sıklıkta görülmektedir. İnfertiliteye neden olabileceği için tanı ve tedavisinde dikkatli ve titiz olunmalıdır. Genel olarak adolesan varikosellerinde fertiliteyi korumak ve testis fonksiyonlarının korunması için yüksek derecede varikosel ya da testis volümünde % 20 azalma cerrahi endikasyon olarak kabul görmektedir. Bu nedenle adolesan varikoseli olan hastaların testis volümleri seri ultrason ölçümleri ve muayene ile yakından takip edilmelidir. Ergenlik döneminden sonra spermiyogram takibi de seri ultrason ölçümleri takipte önemli katkılar sağlar. Cerrahi tedaviden elde edilen başarı nedeniyle bu yaş grubunda tanısı oldukça önemlidir. Bu çalışma da adolesan varikosel tanı ve tedavisi incelenmiştir.Öğe ANOMALİ BÖBREKLERDE FLEKSİBLE ÜRETEROSKOPİ (f-URS) DENEYİMLERİMİZ(2021) Bozkurt, İbrahim Halil; Şahan, Murat; Polat, Salih; Deyirmenci, Özgür; Koraş, Ömer; Baba, Dursun; Gökalp, FatihGiriş: Anomalili böbreklerde böbrek ve proksimal üreter taşı hastaları için uyguladığımız fleksibl-URS ( f-URS) başarısını, komplikasyonlarını ve postopertif sonuçları sunmayı amaçladık. Gereç ve Yöntem: Nisan 2010 ile Haziran 2020 y ılları arasında anomali böbreği olan f-URS uygulanan 69 hastanın dosyaları retrospektif olarak tarandı. Hastalar ın dermografik özellikleri, operasyon süresi,skopi süresi, taşsızlık oranları, komplikasyon oranları kaydedildi. Final taşsızlık (FSFR); postoperastif birinci ayda yapılan ultrasonografi ve radiografik de ğerlendirilerek ta şın yoklu ğu veya bilgisayarlı tomografide 2mm den büyük ta ş fragmanı görülmemesi olarak tanımlandı. Bulgular: Toplam 69 hastanın; parsiyel nefrektomili üç, bifid pelvisli dört, atnalı böbrekli 14, ektopik böbrekli 15, rotasyon anomalilisekiz, duplike üreterli 12 ve kaliksiyel divertikül 13 hastaya f-URS yapıldı. Ortalama taş boyutu 15.1±7.7 mm 2 ve ortalama taş dansitesi (HU) 983±242 olarak saptandı. Tek seansta hastaların %78.2’sinde taşsızlık sağlanmışken ek gişim ile final taşszılık%85,5 olarak saptandı. Sonuç: Anormal böbrekli hastalarda f-URS teknik olarak zorlayıcı olabilse de endoürolojik tekniklerdeki ilerlemeler onu güvenli ve etkili bir prosedür haline getirmiştir. f-URS; daha az invaziv yap ısıve kabul edilebilir komplikasyon oranları nedeniyle anormal böbreklerdeki çoğu taş için çok etkili bir tedavi yöntemidir.Öğe Case report: HIV negative isolated scrotal Kaposi's sarcoma(Elsevier Ltd, 2014) Özmen, Hamid; Baba, Dursun; Kaçağan, Coşkun; Kayıkçı, Ali; Çam, KamilDISCUSSION The pathogenesis of KS has still not been clearly elucidated. However, it is known that all forms of KS are associated with HHV-8 infections. A defect in immune system was almost always necessary. Therefore, KS is usually associated with HIV infection. KS of the penis has been reported in HIV negative patients. Very few cases of scrotal KS have been presented. In a recent review, only 1 patient had scrotal KS out of 32 cases with HIV negative KS. In our case, the patient received a cycle of chemotherapy that might affect his immune system. The lymphangioma-like type is a common morphological sub-type. While lymph edemas are commonly observed in this sub-type, no edema in the lymphs was present in our case.CONCLUSION Classical KS is generally observed in the lower extremities, it can rarely affect scrotal skin as isolated lesions. Therefore, a careful physical examination should also include scrotum for these patients.INTRODUCTION Kaposi's sarcoma (KS) is a rare angioproliferative disorder of the vascular endothelium. The development of KS requires Human Herpes Virus 8 (HHV-8) infection. An associated HIV infection is usually seen. Isolated scrotal KS has rarely been reported. In this article, we present a case of KS that primarily involved the scrotum in a HIV negative patient.PRESENTATION OF CASE A 71-year old male patient admitted to the outpatient department due to nodular lesions on the scrotum. The patient declared that these lesions were present for nearly 5 years. Past medical history revealed that he underwent left thoracotomy and upper lobectomy in 2006 for adenosquamous lung carcinoma. Then, he received a single cycle of adjuvant chemotherapy consisted of docetaxel and cisplatin. Physical examination revealed 3 black small nodules on the scrotum. The anti-HIV test was negative. All scrotal lesions were surgically excised. The pathological investigation revealed KS of the lymphangioma-like type. © 2014 Elsevier B.V. All rights reserved.Öğe Comparison of Early Versus Late Urethral Catheter Removal After Transurethral Resection of the Prostate in Patients with Benign Prostate Hyperplasia(Duzce Univ, Fac Medicine, 2023) Senoglu, Yusuf; Tekin, Ali; Yildirim, Olcay; Baba, Dursun; Yuksel, AlpaslanObjective: Transurethral resection of the prostate (TURP) is considered the standard in the surgical therapy of lower urinary tract symptoms related to benign prostate hyperplasia (BPH). However, there is no consensus on the timing of catheter removal. In this study, we aimed to compare the long-term effects of early and delayed removal of urethral catheters who underwent TURP.Methods: We prospectively analyzed a total of 91 patients who underwent TURP. Patients were randomized into two groups; the early (postop 1st-2nd days) and delayed (7th day) removal of the urethral catheter. After the surgery in 1, 3, and 6th months, we evaluated all patients regarding treatment success. In addition, international prostate symptom score (IPSS), quality of life (QoL), maximum flow rate, postvoid residual urine volume, and morbidities (hematuria, infection, urethral stricture, irritative symptoms, need for re-operation) were assessed at all visits.Results: After TURP, there was no statistical difference in urodynamic parameters, complications, IPSS, and QoL in both groups. Only in the 3rd-month, the maximum flow rate was higher in favor of the early group. Despite similar results in both groups, strictures occurred earlier in the early group than delayed group (respectively 1 and 3 months).Conclusions: These results suggest that there are no differences in efficacy and complications in groups of early or delayed urethral catheter removal after TURP. The results of long-term studies with large series should be awaited to reach a more definite conclusion. We have tried to shed light on a topic without consensus on the time of urethral catheterization after TURP.Öğe The Comparison of Magnetic Resonance Imaging/Transrectal Ultrasound Fusion Biopsies with Conventional Transrectal Biopsies in Prostate Cancer Detection(Galenos Yayincilik, 2021) Baba, Dursun; Balık, Ahmet Yıldırım; Yüksel, Alpaslan; Şenoğlu, YusufObjective: The conventional technique for histological prostate cancer diagnosis is transrectal ultrasound (TRUS)-guided random sampling of the peripheral prostate zone. However, due to method insufficiency and recent developments in prostate imaging, new biopsy methods were introduced. This study aimed to evaluate prostate cancer detection rates by the standard and magnetic resonance (MR) fusion biopsy methods. The main purpose of our study is to mutually evaluate prostate cancer detection rates and results of standard and cognitive MR fusion biopsy methods and share our experiences in this process. Materials and Methods: Patients, who underwent prostate biopsy due to elevated serum prostate-specific antigen levels (>4ng/mL) and/or suspicious rectal examination, were retrospectively evaluated. A total of 160 patients were included in the study between January 2018 and January 2021. Patients were divided into two groups according to the applied method, as standard biopsy (SB) and MR fusion biopsy. Results: Prostate cancer was reported in 25 (31.3%) of 80 patients who underwent SB, wherein 20 (25%) were determined with clinically significant cancer. Prostate cancer was reported in 30 (37.5%) of 80 patients who underwent MR fusion biopsy, wherein 25 (31%) were reported as clinically significant cancer. A statistically significant difference was found in detecting prostate cancer and clinically significant prostate cancer when the prostate imaging-Reporting and Data System (3,4,5) scores were compared with each other (p<0.05, p=0.00). The additional SB to MR-targeted fusion biopsy was statistically significant in prostate cancer diagnosis (p=0.01, p<0.05). Conclusion: The additional SB to targeted biopsy increased the detection rate of clinically significant prostate cancer. Larger randomized studies are needed to reach a consensus on the ideal biopsy technique.Öğe Comparison of Preoperative Urine Culture and Intraoperative Renal Pelvis Culture in Patients Who Underwent Flexible Ureterorenoscopy(Galenos Publ House, 2022) Gökalp, Fatih; Koras, Ömer; Polat, Salih; Sahan, Murat; Baba, Dursun; Bozkurt, İbrahim Halil; Eker, AnilObjective: There is no correlation between the preoperative bladder urine culture (PBUC) sensitivity test and the results of the renal pelvic urine culture (RPUC) test. Materials and Methods: A total of 129 patients who underwent f-URS included the study. Preoperatively, PBUC was collected in all cases, and RPUC was taken when starting the surgery. Results: In PBUC, there was growth in 25 (19.4%) patients and in RPUC, there were only in 35 (27.1%) cases. Preoperative tomographic urine density at the renal pelvis [odds ratio (OR): 0.848, p<0.001], grade >= 2 hydronephrosis (OR: 18.970, p=0.001), and lower calyceal stone location (OR: 0.033, p=0.017) were determined as independent predictive factors for RPUC growth. The ability of tomographic urine density to foresee positive RPUC positivity was determined to be 0.858 (0.780-0.936). The tomographic urine density threshold for RPUC positivity prediction was 4.5, with 80% sensitivity and 77.7% specificity. Conclusion: PBUCs do not necessarily mean accurate colonization. Obtaining renal pelvis urine samples is important for managing postoperative infectious complications. Patients that have preoperative hydronephrosis and nominal tomographic urine density could develop RPUC even if the preoperative bladder urine samples are negative.Öğe Comparison of Systematic, Targeted and Combined Prostate Biopsy: Our Clinical Outcomes(2022) Şenoglu, Yusuf; Taşkıran, Arda Taşkın; Yüksel, Alpaslan; Baba, DursunObjective: Our aim was to compare the diagnostic efficacy of the standard systematic, targeted and combined prostate biopsy methods in prostate cancer. Materials and Methods: Total of 161 patients who underwent prostate biopsy combined with magnetic resonance imaging-ultrasonography fusion method between August 2018 and March 2021 was evaluated retrospectively. Clinically important and insignificant cancer detection rates of biopsy results between standard, targeted and combined biopsy (CB) methods were compared. Changes in the results were also evaluated in terms of Prostate Imaging-Reporting and Data System (PIRADS) scores. Results: Prostate cancer was diagnosed in 46 (28.6%) patients by CB. Fourteen (8.7%) patients were interpreted as a clinically insignificant disease. Prostate cancer and clinically significant disease detection rates were statistically significant in favor of CB compared to targeted biopsy (TB). There was no statistically significant difference between systematic biopsy and TB results. Additionally, it was observed that cancer detection rates were higher in PIRADS ?4 lesions compared to PIRADS 3 lesions in all biopsy methods. Conclusions: Our results have shown that combined prostate biopsy led to higher detection of prostate cancer and provides increased detection of clinically significant disease. High rates of clinically significant cancer, especially in patients with PIRADS ?4 lesions, suggest that the PIRADS scoring is a high-level guide in detecting malignancy.Öğe Comparison of Systematic, Targeted and Combined Prostate Biopsy: Our Clinical Outcomes(Galenos Yayincilik, 2022) Şenoğlu, Yusuf; Taşkıran, Arda Taşkın; Yüksel, Alpaslan; Baba, DursunObjective: Our aim was to compare the diagnostic efficacy of the standard systematic, targeted and combined prostate biopsy methods in prostate cancer. Materials and Methods: Total of 161 patients who underwent prostate biopsy combined with magnetic resonance imaging-ultrasonography fusion method between August 2018 and March 2021 was evaluated retrospectively. Clinically important and insignificant cancer detection rates of biopsy results between standard, targeted and combined biopsy (CB) methods were compared. Changes in the results were also evaluated in terms of Prostate Imaging-Reporting and Data System (PIRADS) scores. Results: Prostate cancer was diagnosed in 46 (28.6%) patients by CB. Fourteen (8.7%) patients were interpreted as a clinically insignificant disease. Prostate cancer and clinically significant disease detection rates were statistically significant in favor of CB compared to targeted biopsy (TB). There was no statistically significant difference between systematic biopsy and TB results. Additionally, it was observed that cancer detection rates were higher in PIRADS o4 lesions compared to PIRADS 3 lesions in all biopsy methods. Conclusions: Our results have shown that combined prostate biopsy led to higher detection of prostate cancer and provides increased detection of clinically significant disease. High rates of clinically significant cancer, especially in patients with PIRADS o4 lesions, suggest that the PIRADS scoring is a high-level guide in detecting malignancy.Öğe The Current Approach for Small Adrenal Masses(Galenos Publ House, 2022) Şenoğlu, Yusuf; Balık, Ahmet Yıldırım; Ediz, Emre; Yüksel, Alpaslan; Baba, DursunAdrenal tumors originate from the medulla or cortex of the adrenal gland and may be benign or malignant, functional or non-functional. Adrenal tumors discovered during imaging for non-adrenal indications are called incidentalomas and are more common than non-incidental masses. Most incidentalomas are hormonally inactive and benign. Adrenal masses are approximately 30-35 mm in diameter at the time of diagnosis. While masses less than 4 cm are generally considered to be small masses, they are at lower risk for malignancy than adrenal masses larger than 4 cm. An incidentally detected adrenal mass should be investigated for malignancy and functional activity. Hormonal activity or malignancy of the adrenal mass are indications for surgery. Laparoscopic surgery for adrenal adenomas is the gold standard. Evaluation is important to determine the treatment and follow-up process. Although the frequency of benign small adrenal masses increase with age, even if the mass size is <4 cm in young patients, because of their rarity at this age, a closer follow-up is required. The ideal follow-up schedule for these small masses <4 cm in diameter has not been precisely defined. However, clinical guidelines recommend clinical and hormonal follow-up for at least 4 years, and follow-up imaging [computed tomography (CT), magnetic resonance imaging] 6-12-24 months after the first CT. If the size increase in a followed mass is >0.8 cm/ year, surgery is recommended, but the malignancy rate is low in these masses.Öğe The Current Approach for Small Adrenal Masses(2022) Şenoglu, Yusuf; Balık, Ahmet Yıldırım; Ediz, Emre; Yüksel, Alpaslan; Baba, DursunAdrenal tumors originate from the medulla or cortex of the adrenal gland and may be benign or malignant, functional or non-functional. Adrenal tumors discovered during imaging for non-adrenal indications are called incidentalomas and are more common than non-incidental masses. Most incidentalomas are hormonally inactive and benign. Adrenal masses are approximately 30-35 mm in diameter at the time of diagnosis. While masses less than 4 cm are generally considered to be small masses, they are at lower risk for malignancy than adrenal masses larger than 4 cm. An incidentally detected adrenal mass should be investigated for malignancy and functional activity. Hormonal activity or malignancy of the adrenal mass are indications for surgery. Laparoscopic surgery for adrenal adenomas is the gold standard. Evaluation is important to determine the treatment and follow-up process. Although the frequency of benign small adrenal masses increase with age, even if the mass size is <4 cm in young patients, because of their rarity at this age, a closer follow-up is required. The ideal follow-up schedule for these small masses <4 cm in diameter has not been precisely defined. However, clinical guidelines recommend clinical and hormonal follow-up for at least 4 years, and follow-up imaging [computed tomography (CT), magnetic resonance imaging] 6-12-24 months after the first CT. If the size increase in a followed mass is >0.8 cm/ year, surgery is recommended, but the malignancy rate is low in these masses.Öğe The Efficacy of N-acetylcysteine Against Renal Oxidative Stress After Extracorporeal Shock Wave Treatment: An Experimental Rat Model(2020) Baba, Dursun; Çam, H. Kamil; Şenoğlu, Yusuf; Yüksel, Alpaslan; Erdem, Havva; Başaran, EkremObjective: To evaluate effects of renal extracorporeal shock wave lithotripsy (SWL) on plasma Oxidative Stress index (OSI) and to observehistopathological alterations in an experimental model. Secondly, protective role of N-acetylcysteine (NAC) was investigated.Materials and Methods: A total of 24 rats were randomly divided into 3 groups as control (group 1), SWL + saline (group 2), and SWL + NAC(group 3). Study groups were further divided into two subgroups as short-term and long-term. In groups 2 and 3, 2000 shock waves were applied.Intraperitoneal saline was administered in group 2, and intraperitoneal NAC was given to group 3. No treatment was administered to group 1.Blood samples and nephrectomy specimens were obtained for biochemical and histopathological examinations, respectively. OSI was calculatedby measuring plasma total antioxidant status (TAS) and total oxidant status (TOS). Acute and chronic histopathological damage were evaluated bylight microscopy.Results: SWL caused a remarkable increase in oxidative stress. Strikingly, TOS levels were significantly lower (p=0.027) and TAS levels weresignificantly higher (p=0.006) in rats with SWL + NAC (group 3). As a result, OSI was lower (p=0.013). This effect was particularly significant in theshort-term subgroup. It was also concluded that tubular damage and interstitial inflammation were higher in the SWL group (p=0.022). These acutehistological alterations were slighter in rats with NAC.Conclusion: The current study demonstrated that SWL can cause severe oxidative stress and acute renal damage by increasing free oxygen radicalproduction. NAC was effective in decreasing SWL-induced oxidative stress and preventing certain histological alterations to some extent.Öğe Investigation of Factors Affecting the Stone-Free Rate in Elderly Patients with Urinary Stones After Shock Wave Lithotripsy(Duzce University Medical School, 2021) Yüksel, Alpaslan; Baba, Dursun; Şenoğlu, Yusuf; Taşkıran, A.T.Aim: Urinary stone disease is an important disease seen in all age groups, including elderly patients. It can cause kidney failure and urinary infection problems. Shock wave therapy, which is the minimal invasive among the different treatment alternatives, is preferred for kidney and proximal ureteral stones smaller than 2 cm. Studies on the efficacy and safety of this treatment in elderly patients are limited. This study aimed to investigate the factors affecting the stone-free rate (SFR) in elderly patients with urinary stones after shock wave lithotripsy. Material and Methods: The data of 120 patients in the Urology department of Duzce University Faculty of Medicine between 2010 and 2018 over 65 years old who underwent extracorporeal shock wave lithotripsy (ESWL) for urinary system stone disease were evaluated retrospectively. The data obtained from these patients included sex, age, location of the stone (upper, middle, or lower calyx, renal pelvis, ureter), number of shock waves, stone size, and the need for the auxiliary procedure were analyzed. Results: Of the 120 patients, 82 (68.3%) were male and 38 (31.7%) were female. Comorbidity was present in 49 patients. An overall SFR of 65.8% (n=79) was found. The highest SFR was found in middle calyx stones with 79.3% (23 of the 29 patients). Post-ESWL auxiliary procedures were needed in 36 (30%) patients. Two patients developed subcapsular renal hematoma and pyelonephritis. Conclusion: ESWL is an appropriate even the first option for elder male with favorable stone size. Furthermore, ESWL caused acceptable morbidity in older patients. © 2021, Duzce University Medical School. All rights reserved.Öğe Investigation of the Relationship of Two-Glass Test with Prostate Biopsy and Presence and Grade of Asymptomatic Prostate Inflammation in Men with Serum Prostate-Specific Antigen Level Between 2.5-10 ng/ml(Duzce Univ, Fac Medicine, 2024) Yuksel, Alpaslan; Tekin, Ali; Senoglu, Yusuf; Baba, Dursun; Gamsizkan, MehmetObjective: Prostate-specific antigen (PSA) is utilized as a marker to detect prostate cancer. Elevated PSA levels often lead to prostate biopsy to assess the potential presence of cancer. However, PSA elevation is not specific to cancer and can be caused by various conditions, including benign prostatic hyperplasia (BPH), urinary tract infections, and chronic prostatitis. Notably, approximately 66% of patients undergoing biopsy do not have prostate cancer, leading to unnecessary procedures and associated complications. Chronic prostatitis is detected in around 40% of these biopsies. The two-glass test involves examining urine before and after a rectal examination to diagnose chronic prostatitis. This study aims to investigate the effectiveness of the two-glass test in predicting prostatitis and inflammation in patients with PSA levels between 2.5-10 ng/ml who have undergone prostate needle biopsy. Materials and Methods: The study included fifty-two male patients aged between 50 and 78 years with PSA levels between 2.5 and 10 ng/ml who presented to our clinic. All patients underwent the EPS-two-glass test and prostate biopsy. EPS (expressed prostatic secretion) is obtained by collecting fluid from the urethra after prostate massage, while VB-3 (voided bladder-3) is urine collected after a massage. These samples are used to detect prostate infection. Prostate inflammation was deemed significant if >= 10 leukocytes were observed under the microscope. Patients were categorized into three groups based on pathology results: prostate cancer, BPH, and chronic prostatitis. The chronic prostatitis group was further classified based on histopathological calcification described by Nickel. Results: Chronic prostatitis was detected in 38% of the study participants. VB3 positivity was significantly higher in the chronic prostatitis group compared to the other groups (p = 0.028). Although no significant difference was observed in the prevalence of inflammation and PSA elevation, PSA levels were higher in the multifocal inflammation subgroup compared to the focal inflammation group. Conclusions: The relationship between chronic prostatitis and PSA elevation remains unclear. Although this study did not find a statistical relationship between inflammation and PSA elevation, the significant correlation between chronic prostatitis and VB3 positivity suggests a potential link. These findings can serve as a foundation for further research aimed at reducing unnecessary biopsies.Öğe Mesanenin nadir benign neoplazmı: Mesane leiomyomu(Duzce University Medical School, 2019) Baba, Dursun; Başaran, Ekrem; Kayıkçı, Muhammet AliMesanenin benign mezenşimal lezyonları oldukça nadirdir ve tüm mesane tümörlerinin %1-5’inin oluştururlar. Bunların içinde de en sık leiomyoma saptanmaktadır. Benign lezyonlar radyolojik olarak maling kitleleri taklit etmesi nedeniyle klinik öneme sahiptir. Tanı radyolojik tetkiklerle kitlenin saptanması ve sonrasında yapılan cerrahi eksizyon ya da biyopsi ile histopatolojik olarak konulmaktadır. Ekstravezikal ve intramural form sistoskopik olarak saptanamayabilirken intravezikal leiomyomlar sistoskopi ile saptanabilir. Sistoskopi sırasında mesane içinde protrüde, kısmen düzgün sınırlı ve yüzeyi mesane mukozası ile kaplı lezyonlar görüldüğünde mesane leiomyomu ayırıcı tanıda düşünülmelidir. 44 yaşında kliniğimize irridatif semptomlarla tarafımıza başvuran ve mikroskopik hematüri saptanan erkek hastada mesanede 2x2 cm kitle saptandı. Minimal invaziv tedavi (TUR-mesane) sonrasında leiomyoma tanısı konulan vaka sunulmaktadır. Anahtar kelimeler: Leiomyom; mesane.Öğe Penil fraktür ve eşlik eden üretral travma: Tam idrar tahlili rutinde yapılmalı mıdır?(2013) Kayıkçı, Ali; Kaçağan, Coşkun; Baba, Dursun; Çam, Haydar KamilPenil fraktür erekte olan peniste, korpus kavernosum ve/veya korpus spongiosumların yırtılmasından kaynakla nmaktadır. Bu duruma üretral rüptür, dorsal sinir ve damar yaralanmaları da eşlik edebilmektedir. Penil fraktürün s ebe pleri arasında, seksüel ilişki, mastürbasyon, zorlayıcı penil manüpulasyon bulunmaktadır. Yaklaşık %40 varan oranlarda üretral yaralanma da görülmektedir. Bu vakada penil fraktüre eşlik eden üretra travması olgusu tartışılmıştır. Tam idrar tahlilinde mikroskopik hematüri saptanması üretra travm asını düşündürmüştür. Dolayısıyla her vakada üretral travma eşlik edebilir. Bu sebeple tüm hastalarda işemeyle ilgili y akınması olmasa da tam idrar tahlili yapılmalıdır Özellikle de mikroskopik hematüri saptananlarda cerrahi ekspolarasyo nda üretral dokunun bütünlüğü kontrol edilmelidir.Öğe Ratlarda ESWL sonrası böbrekte oluşan oksidatif stres hasarında N-asetil sisteinin koruyucu etkisinin araştırılması(Düzce Üniversitesi, 2015) Baba, Dursun; Çam, Haydar Kamil; Tekin, AliAmaç: Bu çalışmada ratlarda böbreğe Ekstrakorporeal Şok Dalga Litotripsi (ESWL) uygulanmasının, oksidatif stresin bir göstergesi olan plazma oksidatif stres indeksine (OSİ) olası etkisinin ve böbrekte oluşturduğu histopatolojik değişikliklerin değerlendirilmesi amaçlanmıştır. Ayrıca koruyucu olarak N-Asetil Sistein (NAC)' in etkinliğinin araştırılması planlanmıştır. Gereç ve Yöntem: Çalışmada kontrol grubu (grup I, n: 6 ), ESWL grubu (Grup II, n: 9) ve ESWL+NAC grubu (Grup III, n: 9) olarak toplam 24 adet adet rat kullanıldı. Tüm grublar; erken dönem ve geç dönem olarak 2 alt gruba ayrıldı. Grup II ve III' deki ratlara anestezi altında ratların kuyruk venine yerleştirilen intravenöz kateterden kontrast madde verilerek floroskopi altında toplayıcı sistemin görüntülenmesi sağlandı. Sol böbreklerine 18 kV şiddetinde, 60 SW/dakika toplam 2000 şok dalgası uygulandı. Grup I deki ratlara herhangibir sistemik tedavi verilmedi, Grup II deki ratlara ESWL sonrası 1. günden başlanarak 1cc/kg/gün dozunda interaperitoneal salin, grup III deki ratlara ESWL sonrası 1. günden başlanarak 300 mg/kg/gün dozunda interaperitoneal N-asetil sistein verildi. Erken dönem alt gruplara ESWL sonrası 14. günde, geç dönem alt gruplara ise 28. günde kan alma ve sol nefrektomi yapılarak biyokimyasal analiz ve spesimenler histopatolojik olarak incelendi. Çalışmada akut ve kronik hasar ayrı ayrı değerlendirildi. Histopatolojik hasar değerlendirilmesi için tübüler hasar, interstisyel inflamasyon ve kanama, glomerüler ve vasküler yapılarda dilatasyon – konjesyon, inflamatuar hücre artışı, tubüler atrofi ve interstisyel fibrozis incelenirken, plazmadan total antioksidan kapasite (TAS) ve total oksidan kapasite (TOS) ölçümü yapılarak oksidatif stres indexi (OSİ) hesaplandı. Bulgular: ESWL uygulaması sonrası NAC verilen grupta (grup III), TOS düzeyi anlamlı derecede daha düşük bulunurken (p = 0,027), TAS seviyesinin anlamlı derecede daha yüksek olduğu saptanmıştır (p =0,006). Bunun sonucu olarak OSİ anlamlı derecede daha düşük bulunmuştur (p =0,013). Bu etki özellikle erken dönemde daha belirgindir. Tübüler hasarın ESWL grubunda daha yüksek olduğu sonucuna varılmıştır (p=0,022). Gruplar arasında intertisyel inflamasyon, konjesyon, inflamatuar hücre artışı, fibrozis ve atrofi değişkenleri ortancaları bakımından anlamlı bir farklılığa rastlanmamıştır. Sonuç: Bu çalışmada, böbreğe ESWL uygulamasının serbest oksijen radikal oluşumunu artırıp, oksidatif strese yol açabileceği ve tübüler hasara sebep olabileceği göstermiştir. ESWL'ye bağlı oksidatif stresin ve tübüler hasarın azaltılmasında NAC etkili bulunmuştur.Öğe Revascularization in Erectile Dysfunction due to Pelvic Trauma(2019) Yüksel, Alpaslan; Karaca, Okay Güven; Baba, Dursun; Şenoglu, Yusuf; Tekin, AliErectile dysfunction is defined as the inability to achieve penile erection necessary for sexualintercourse or to sustain erection sufficiently. Although the treatment options for erectiledysfunction are limited, the most common surgical treatment is penile prosthesis implantation.In addition, penile revascularization of the penis is very effective in the treatment of erectiledysfunction due to different vasculogenic reasons, especially pudendal artery occlusion, afterperineal trauma. Modified Furlow Fisher technique including anastomosis of the inferiorepigastric artery to the penile dorsal vein is a successful treatment option among therevascularization techniques. Despite invasive preliminary evaluations such as duplex Dopplerultrasound, dynamic cavernosometry, selective internal pudendal arteriography, and the longand difficult surgical procedure, it is highly effective in particularly selected young patients.Öğe The role of N-acetylcysteine in preventing hepatic injury associated with systemic oxidative stress after extracorporeal shock wave treatment(Wroclaw Medical Univ, 2020) Cam, Sebahat; Baba, Dursun; Senoglu, Yusuf; Yuksel, Alpaslan; Erdem, HavvaBackground. Systemic oxidative stress may cause detrimental consequences for the liver, leading to hepatic fibrogenesis. Objectives. To investigate histopathological changes in liver tissues due to the increased systemic oxidative stress associated with rat extracorporeal shock wave lithotripsy (SWL) model and to document the consequences of N-acetylcysteine (NAC) administration. Material and methods. In this experimental SWL model, 18 Wistar albino rats were randomly assigned into 3 groups. The control group (group I) had no intervention. Group II underwent SWL treatment with intraperitonea I saline injection. Group III also had SWL with intra peritoneal NAC and was divided into short-term (group III-14 days) and long-term (group III-28 days) subgroup. Hepatectomy was performed for histopathological examinations. Histopathological alterations were evaluated with light microscopy. Immunohistological staining for p53 and myeloperoxidase was also performed. Results. Blood samples revealed a significant increase in plasma oxidative stress index (OSI) after plasma total antioxidant status (TAS) and total oxidant status (TOS) had been measured. It was shown that this increased systemic oxidative stress adversely affected liver tissues. Predominantly, sinusoidal dilatation was remarkably observed in rats with significantly high 051 values (p = 0.043). Similarly, periportal necrosis significantly increased in rats with high OSI values (p = 0.033). p53 positivity was also remarkable in rats with systemic oxidative stress (p = 0.049). N-acetylcysteine administration provided a significant decrease in OSI. N-acetylcysteine also improved all these alterations, including p53 staining. Particularly, sinusoidal dilatation was significantly protected in the long-term NAC group (group III-28 days). Conclusions. We demonstrated that SWL-induced systemic oxidative stress causes histological alterations in liver tissues. Increased p53 and myeloperoxidase staining as markers of oxidative damage were also detected. N-acetylcysteine may protect from these histological and ultra-structural alterations related to oxidative stress.Öğe Squamous Cell Carcinoma of Bladder(Galenos Publ House, 2022) Taşkıran, Arda Taşkın; Baba, DursunSquamous cell carcinoma (SCC) of the bladder is a malignant neoplasm of a pure squamous phenotype originating from the bladder urothelium. SCC of the bladder is a relatively rare tumor with no specific diagnostic test. The diagnosis is usually made at an advanced stage; therefore, the prognosis is poor and most cases result in mortality. Inflammation and infection leading to the metaplasia of epithelial cells are implicated in its etiology. SCC of the bladder is divided into two groups depending on whether it is due to bilharzial infections, and these two groups have different epidemiological, pathogenetic and clinicopathological features. SCC of the bladder accounts for the vast majority (approximately 75%) of bladder cancers in areas where Schistosoma haematobium infection is endemic. The European Association of Urology guidelines classify bladder cancer with any variant histology as high-risk bladder cancer. Because of the rarity and heterogeneity of non-urothelial tumors, treatments described are mostly based on retrospective series and small studies. Radical cystectomy is recommended as the first treatment in patients presenting with non-metastatic bladder SCC. Neoadjuvant radiation therapy (RT) is considered to play a role in schistosomal bladder cancer. However, there are not enough high-quality studies to indicate the role of RT or chemotherapy as adjuvant therapy. Due to the rarity of the disease, there are also no high-evidence guidelines for managing SCC. There is a need for further high-volume and prospective studies to review literature data and developments.Öğe Squamous Cell Carcinoma of Bladder(2022) Taşkıran, Arda Taşkın; Baba, DursunSquamous cell carcinoma (SCC) of the bladder is a malignant neoplasm of a pure squamous phenotype originating from the bladder urothelium. SCC of the bladder is a relatively rare tumor with no specific diagnostic test. The diagnosis is usually made at an advanced stage; therefore, the prognosis is poor and most cases result in mortality. Inflammation and infection leading to the metaplasia of epithelial cells are implicated in its etiology. SCC of the bladder is divided into two groups depending on whether it is due to bilharzial infections, and these two groups have different epidemiological, pathogenetic and clinicopathological features. SCC of the bladder accounts for the vast majority (approximately 75%) of bladder cancers in areas where Schistosoma haematobium infection is endemic. The European Association of Urology guidelines classify bladder cancer with any variant histology as high-risk bladder cancer. Because of the rarity and heterogeneity of non- urothelial tumors, treatments described are mostly based on retrospective series and small studies. Radical cystectomy is recommended as the first treatment in patients presenting with non-metastatic bladder SCC. Neoadjuvant radiation therapy (RT) is considered to play a role in schistosomal bladder cancer. However, there are not enough high-quality studies to indicate the role of RT or chemotherapy as adjuvant therapy. Due to the rarity of the disease, there are also no high-evidence guidelines for managing SCC. There is a need for further high-volume and prospective studies to review literature data and developments.
