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    45,X[75]/46,Xdel(X)(p11.2)[25] Karyotipine sahip unikornuat uteruslu olgu
    (2019) Eröz, Recep; Köksal, Mehmet; Doğan, Mustafa; Yüce, Hüseyin; Başbuğ, Alper
    Turner sendromu, önemli bir infertilite nedenidir ancak mozaik veya X delesyonu taşıyan hastalarda eğer puberteye spontan olarakgirilmişse gebelik gerçekleşebilmektedir. Unikornuat uterus ise gebelik kaybına yol açabilen ve çok nadir rastlanılan bir uterusanomalisidir. Şu anki olgu, nadir görülmesi ve Turner sendromlu hastalarda gebelik kayıplarının bir nedenin ortaya konması gibiyönleriyle literatüre katkı sağlamak amacıyla sunulmuştur.
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    Assessment of Central Corneal Thickness, Intraocular Pressure and Retinal Nerve Fiber Layer Thickness at Women with Polycystic Ovary Syndrome
    (Duzce Univ, 2017) Teberik, Kuddusi; Sağlam, Hakan; Başbuğ, Alper; Karaaslan, Musa; Kaya, Murat; Sungur, Mehmet Ali
    Objective: To compare intraocular pressure, central cornea thickness, anterior chamber depth, axial length and thickness of retina nerve fiber layer between women with polycystic ovary syndrome and healthy at the same age segment. Methods: Between August 2015-January 2016, 46 women who have polycystic ovary syndrome and 53 healthy women have been included to the study. After a complete ophthalmologic examination, intraocular pressure, central cornea thickness, anterior chamber depth, axial length and retinal nerve fiber layer thickness were investigated. In the statistical analysis of the data, Independent Samples t test was utilized to compare the groups. Results: While mean age was 23.4 +/- 4.5 (16-35) in the group with polycystic ovary syndrome, average age level was found as 24.0 +/- 6.1 (18-54) among the controls (P=0.549). Intraocular pressure values were measured and determined as 17.7 +/- 2.6 mmHg in the group with polycystic ovary syndrome, while the values were 15.2 +/- 2.4 mmHg in the controls (P <0,001). Although it was 79.4 +/- 10.2 mu m in the group with polycystic ovary syndrome, retinal nerve fiber layer thickness in the nasal quadrant was found to be 73.8 +/- 10.9 mu m among the controls (P <0.001). Conclusion: We found that the increased levels seen in intraocular pressure and retinal nerve fiber layer thickness in the nasal quadrants of the patients with polycystic ovary syndrome were statistically significance. Hence, we recommend that the patients with polycystic ovary syndrome should be specially analyzed as to eye assessment.
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    Association of serum and follicular fluid leptin and ghrelin levels with in vitro fertilization success
    (Via Medica, 2017) Akarsu, Süleyman; Büke, Barış; Göde, Funda; Dirican, Kerem Enver; Başbuğ, Alper; Ceyhan, Seyit Temel; Işık, Ahmet Zeki
    Objectives: The aim of this study was to evaluate the relationship between in vitro fertilization (IVF) cycle outcomes, serum and follicular fluid (FF) levels of leptin and ghrelin. Material and methods: Forty-four women who underwent intracytoplasmic sperm injection cycles (ICSI) were enrolled in the study. On the third day (D3) of the menstrual cycle, venous blood samples were drawn for serum measurements of leptin and ghrelin. The follicular fluid (FF) and the corresponding oocyte were obtained from a single dominant preovulatory follicle at the time of oocyte pick-up. The FF and D3 serum leptin and ghrelin concentrations were measured by enzyme-linked immunosorbent assay. The relationship between pregnancy rate and serum, follicular fluid levels of leptin and ghrelin were analyzed. Results: Of the 44 cases included, nineteen achieved clinical pregnancy (43.18%). Follicular fluid ghrelin levels were significantly lower in the pregnant group than non-pregnant group (p < 0.05) With respect to FF leptin, there was no statistically significant differences between the pregnant and non-pregnant women (p > 0.05). There was no statistically significant difference in D3 serum ghrelin between pregnant and non-pregnant groups (p > 0.05). However, D3 serum leptin levels were significantly lower in pregnant women than non-pregnant women (p < 0.05). Conclusions: Lower ghrelin levels in the follicular fluid were associated with higher pregnancy rates. Also, D3 serum leptin levels were inversely correlated with clinical pregnancy rates. These findings support the potential role of these molecules on IVF outcomes.
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    Coexistence of uterine smooth muscle tumors of uncertain malignant potential (Stump) and subserosal leiomyoma: A rare cause of postmenopausal bleeding [Malign potansiyeli belirsiz uterus düz kas tümörü (Stump) ve subserozal leiomyoma birlikteliği: postmenopozal kanamanin nadir bir nedeni]
    (Gunes Kitap Kirtasiye, 2015) Başbuğ, Alper; Başbuğ, Derya; Çağlar, Mete; Yavuzcan, Ali; Baştan, Merve; Yılmaz, Mehmet; Başar, Feyza
    Information about the clinical behaviour and risk factors of Uterine Smooth Muscle Tumors of Uncertain Malignant Potential (STUMPs) is extremely limited. Most of the patients with STUMP are at reproductive age. Postmenopausal bleeding (PMB) can occur about 10% of patients after menopause. An uterine leiomyosarcoma may be the cause of PMB in some cases but STUMPs are not a common cause of PMB. We reported here a 51-year-old woman presenting with PMB having STUMP and multiple bening subserosal leiomyomas. © 2017 Gunes Kitap Kirtasiye. All rights reserved.
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    A comparison of emergency and therapeutic modified Shirodkar cerclage: an analysis of 38 consecutive cases
    (Galenos Yayincilik, 2019) Başbuğ, Alper; Doğan, Ozan
    Objective: To compare the maternal and neonatal outcomes of patients with emergency versus therapeutic cerclage. Materials and Methods: The study included 38 female patients who underwent cervical cerclage using the modified Shirodkar method in the Obstetrics and Gynecology Clinics of Duzce University Medical Faculty Hospital and Duzce Ataturk State Hospital. Results: The operating time for the emergency cerclage group was significantly longer than that of the therapeutic group (30.40 minutes vs 19.85 minutes, p=0.001). Following the cerclage procedure, the cervical length was longer in the therapeutic cerclage group [29.90 millimeters (mm) vs. 22.45 mm, p=0.001]. The cerclage to birth interval was also longer in the therapeutic group (91 vs. 138 days). Conclusion: In comparison with therapeutic cerclage, the total duration of pregnancy after emergency cerclage is shorter, and newborns have a greater need for intensive care. Both methods, however, protect against advanced prematurity, which causes neonatal loss.
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    Comparison of ICSI and Spontaneous Pregnancy Outcomes in Women with Unexplained Infertility
    (Düzce Üniversitesi, 2024) Başbuğ, Alper; Yurtçu, Engin; Keyif, Betül; Düzenli, Fatma Nur
    Aim: This study aimed to investigate whether there is a difference between the results of intracytoplasmic sperm injection (ICSI) pregnancies and subsequent spontaneous pregnancies with a diagnosis of unexplained infertility.Material and Methods: In this retrospective study, a total of 48 women who first conceived with ICSI and then achieved spontaneous pregnancy were included. Duration and causes of infertility, time to spontaneous conception, pregnancy outcomes, and maternal and neonatal complications were evaluated.Results: Maternal age was older in the spontaneous pregnancy group compared to the ICSI group (p=0.029). The gestational age at delivery was found similar in both groups. Although birth weight was higher in the spontaneous pregnancy group, the difference between the groups was not statistically significant (p=0.382). The time to achieve pregnancy was shorter in the spontaneous pregnancy group (p=0.001). Gestational diabetes was significantly higher in the spontaneous pregnancy group (p=0.001), while amniotic fluid abnormality, gestational hypertension (p=0.001), and preterm delivery (p=0.001) were significantly higher in the ICSI group. While the number of babies with the 1st-minute low Apgar score was higher in the ICSI group (%4.16 vs 2.08%, p=0.001), the 5th-minute Apgar score was similar.Conclusion: Even if couples are evaluated as infertile, it should be taken into consideration that they can achieve spontaneous pregnancy. It may be rational to wait for spontaneous pregnancy in eligible couples with unexplained infertility and not to refer the patient for early assisted reproductive techniques.
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    A Comparison of Triple and Double Sperm Washing for Density Gradient Preparation in Intrauterine Insemination Cycles when Overnight Incubation of Specimens Occurred: A Retrospective Cohort
    (Imr Press, 2022) Soyer-Çalışkan, Canan; Hatirnaz, Kaan; Çelik, Samettin; Başbuğ, Alper; Hatirnaz, Ebru S.; Hatırnaz, Şafak; Dahan, Michael H.
    Background: The number of sperm washes to maximize outcomes for intra-uterine insemination has not been well investigated. Therefore, we undertook to compare the pregnancy and live birth rates of triple sperm washing and double sperm washing for density gradient preparation for intrauterine insemination (IUI) cycles. Methods: A retrospective cohort study including 279 couples (136 couples with triple sperm washing and 143 couples with double sperm washing) with a diagnosis of unexplained infertility and mild male subfertility who had IUI cycles between April 2015 and April 2017 were evaluated. After overnight incubation of the sperm, subjects underwent either traditional double sperm washing or Triple sperm washing which consists of use of a third gradient and spinning procedure to the conventional double gradient sperm washing in order to obtain a higher quantity of motile sperm. Results: Total sperm count after triple washing was higher than double sperm washing (98.25 +/- 62.06 vs. 81.08 +/- 31.57; p = 0.003). Positive beta-hCG test and live birth per cycle were higher in triple sperm washing (25.8% vs. 13.3%, p = 0.009; 18.4% vs. 9.8%, p = 0.039; respectively) than in the double sperm washing group. Conclusions: The use of motile sperms obtained from triple sperm washing may increase the rates of pregnancy and live birth in IUI cycles of women with unexplained and mild male factor infertility. A prospective randomized study should be undertaken to confirm the results.
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    Determination Of The Age Of Onset To The Osteoporosis Screening Program And Frequency Of Osteoporosis: Duzce University Training And Research Hospital Sampling
    (Duzce Univ, 2017) Mehmet, Yılmaz; Başbuğ, Alper; Kaya, Aşkı Ellibeş; Çağlar, Mete; Özkara, Atilla; Sungur, Mehmet Ali; Ataoğlu, Safinaz
    Aim: In our study, we aimed to determine the age of onset to the osteoporosis screening program and frequency of osteoporosis in the who admitted Duzce University Training and Research Hospital Material and Methods: Between the dates 01.01.2015 and 31.12.2015, 400 women between the ages of 40 and 70, who applied to Duzce University Training and Research Hospital, Departments of Physical Therapy and Rehabilitation, Gynecology and Obstetrics, and Orthopedics, and had got their femoral neck and L1-L4 anterior vertebra BMD (Bone Mineral Density) measured with DXA method, were included in our research. With the FRAX trial questionnaire have conducted to determine major osteoporotic fracture risk, patient data were recorded via asking questions to patients. Statistics: In the statistical analysis, Independent Samples T-test was evaluated for group comparison of continuous variables, Pearson's chi-square test was used for the analysis of relations between categorical variables, and Pearson's correlation analysis was used to review the relations between continuous variables. Results: In our study, we determined the mean age of osteoporosis group as 60.6 while the frequency was demonstrated as 11.8%. Conclusion: For our region, we determined the age of onset for osteoporosis screening as 60 for women without a major osteoporotic fracture risk factor.
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    Diagnosis and Treatment Approaches in Vaginal Agenesis
    (Düzce Üniversitesi, 2024) Başbuğ, Alper
    The development of the female genital system is a complex process that depends on a series of events involving cellular differentiation, migration, fusion, and recanalization. Failure of any of these processes results in congenital anomalies. Developmental anomalies can occur at various stages, resulting in conditions that impact both the urinary and reproductive systems. In younger patients, such malformations can significantly affect their overall health and quality of life, including aspects such as fertility, sexual function, and psychological well-being. The psychosexual effects of vaginal agenesis should not be overlooked, and clinical care primarily involves comprehensive counseling and support through open communication with the patient. For adult patients, treatment for vaginal agenesis typically starts with therapeutic counseling and education, with non-invasive vaginal dilation being recommended as the first-line approach, or surgery if necessary. Consequently, managing these issues often requires a multidisciplinary approach, engaging specialists such as urologists, gynecologists, endocrinologists, and geneticists, among others. Early detection and timely intervention can greatly enhance the outlook for individuals with these conditions. Besides considering the patient's expectations, the surgeon's experience plays a crucial role in selecting the appropriate surgical technique. This is because the success of the initial surgery is critical to the effectiveness of any subsequent procedures if required. In this review, the evaluation and treatment of vaginal agenesis, which constitutes an important part of congenital anomalies of the vagina, were discussed.
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    Discriminating Performance of Early Uterine and Cervical Artery Pulsatility and Resistivity In Pre-Invasive Cervical Lesions
    (Yerkure Tanitim Yayincilik Hizmetleri As, 2018) Doğan, Ozan; Pulatoğlu, Çiğdem; Başbuğ, Alper; Kaya, Aşkı Ellibeş; Yassa, Murat
    Objectives: The aim of the present study was to investigate the diagnostic effectiveness of uterine and cervical vascularity alone or in combination with human papillomavirus (HPV) DNA testing and with cytology. Methods: Data were prospectively collected from 129 patients in an outpatient clinic of a secondary setting. Routine liquid-based cervical cytology and HPV-DNA testing were obtained. An abnormal result of any of these high-risk types was viewed as positive. Pulsatility (PI) and resistance (RI) indices of uterine (UA) and cervical (CA) arteries were assessed by Doppler sonography. Pathological diagnosis was considered as the gold standard for assessment. Diagnostic efficiency of alone and joint screening of the three indices for discriminating cervical intraepithelial neoplasia (CIN-I) or above from below was assessed. Results: UA-RI and CA-RI were significantly lower in the HPV (+) group than in the controls (p=0.02 and p=0.03, respectively). In subsequent sub-analysis among patients with positive HPV-DNA, UA-PI was significantly higher in the HPV-16 (+) group than in the HPV-18 (+) group (p=0.04). High-risk HPV (Hr-HPV) testing had the highest sensitivity compared with Doppler and cytology (76.5%, 64.7%, and 58.5%, respectively). Combining CA-RI with cytology or Hr-HPV significantly reduced the sensitivity (23.5% and 29.4, respectively) but improved the specificity from 54.4% to 69.8% and 40.9% to 70.7%, respectively. Combining UA-PI with Hr-HPV slightly increased the positive predictivity when compared with testing Hr-HPV alone (36.1% vs. 33.3%). Conclusion: The potential of the Doppler indices of UA and CA was doubtful in discriminating CIN-I or above lesions in the early period. In addition, RI of UA and CA differed with regard to the presence of HPV infection, whereas CA-RI differed in high-risk HPV cases.
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    Do external female genital measurements affect genital perception and sexual function and orgasm?
    (2020) Kaya, Aşkı Ellibeş; Doğan, Ozan; Yassa, Murat; Başbuğ, Alper; Özcan, Canan; Çalışkan, Eray
    Objective: To provide baseline data for the anatomy of the external female genitalia and to investigate the correlation between those measurements and sexual function and genital perception.Materials and Methods: This prospective cohort study consisted of 208 healthy premenopausal women. The Female Sexual Function index (FSFI) and the Female Genital Self-image scale (FGSIS) questionnaires were administered. Participants were divided into two groups according to their female sexual dysfunction (FSD) status. External genital measurements and anterior and posterior vaginal length were measured.Results: The external female genital measurements were (cm, mean ± standard deviation): clitoral prepuce length 2.05±0.48; clitoral glans length 0.87±0.21; clitoral glans width 0.60±0.15; clitoris to urethra 2.24±0.55; anterior fornix depth 7.75±0.92; posterior fornix depth 9.25±0.75; labia minora width, right 2.12±0.86, left 2.20±0.96. A weak negative correlation was found between total FGSIS scores and clitoral prepuce length (p=0.01, r=-0.17), whereas a weak positive correlation was seen between total FGSIS scores and anterior-posterior vaginal lengths (p=0.04, r=0.13; p=0.02, r=0.15, respectively). No statistically significant difference was found between the genital measurements of participants with FSD (n=82, 39.4%) and those without FSD (n=126, 60.6%), and the total FSFI scores and orgasm subdomain scores.Conclusion: The female genital measurements were found to be distributed over a wide range. Although the relationship between genital measurements and genital perception varied, no significant relationship was found between genital measurements and sexual functions or orgasm. These findings suggest that a more cautious approach should be taken towards genital surgeries for cosmetic purposes.
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    Does pregnancy interval after laparoscopic sleeve gastrectomy affect maternal and perinatal outcomes?
    (Taylor & Francis Ltd, 2019) Başbuğ, Alper; Kaya, Aşkı Ellibeş; Doğan, Sami; Pehlivan, Mevlüt; Göynümer, Gökhan
    Background: Obesity is a global health epidemic and is associated with many maternal and neonatal complications. Laparoscopic sleeve gastrectomy (LSG) is among the surgical treatments for obesity. The appropriate timing of pregnancy following LSG remains controversial and few studies have evaluated this public health issue. Objective: To evaluate the effect of pregnancy timing after LSG on maternal and perinatal outcomes. Study design: We performed a retrospective observational study of 23 pregnant women who underwent LSG at a tertiary hospital in Turkey. Women who became pregnant within 18 months of undergoing LSG were included in the early pregnancy after LSG group, and those who became pregnant after 18 months were included the late pregnancy after LSG group. Maternal and perinatal outcomes were evaluated, including gestational diabetes mellitus (GDM), pregnancy-associated hypertensive disorders, preterm birth, mode of delivery, small and large for gestational age births (small for gestational age (SGA), large for gestational age (LGA)), birth injury, and congenital malformations. Results: Body mass index (BMI) at conception was higher in the early pregnancy after LSG group than in the late pregnancy after LSG group (30.48 versus 27.25, respectively; p = .03). Pregnancy interval after LSG did not impact maternal-fetal complications or mode of delivery. After a 75 g oral glucose tolerance test (OGTT) for GDM, 75% (n = 6) of the early pregnancy group presented with early dumping syndrome, compared to only 13.3% (n = 2) of the late pregnancy after LSG group (p = .009). Conclusions: LSG may reduce obesity-related gestational complications, such as GDM and LGA. The interval between LSG and conception did not impact maternal or neonatal outcomes. Screening for GDM can result in dumping syndrome in pregnancies after LSG.
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    Does Suture Material Affect Uterine Scar Healing After Cesarean Section? Results from a Randomized Controlled Trial
    (Taylor & Francis Inc, 2019) Başbuğ, Alper; Doğan, Ozan; Kaya, Aşkı Ellibeş; Pulatoğlu, Çiğdem; Çağlar, Mete
    Background: Impaired healing of the uterine scar after cesarean has been associated with adverse gynecological and obstetric outcomes. Although a large number of studies have been conducted on the events leading to this, information obtained from prospective randomized studies examining the role of suture material in the formation of cesarean scar defect (CSD) is lacking. Objective: To evaluate the effects of synthetic suture materials on CSD formation. Study design: We performed a two-arm 1:1 randomized study in women with singleton pregnancies undergoing elective primary cesarean delivery after the 38th week of gestation. Uterine scar closure was performed using synthetic absorbable monofilament and multifilament sutures. The primary outcome was residual myometrial thickness (RMT) in the area of the scar, measured by transvaginal ultrasound 6-9 months after birth. Secondary outcomes included differences in mean operative time, mean estimated blood loss at the time of surgery, and the rates of postoperative gynecological sequelae. Results: Complete follow-up was obtained from 94 (88%) of 107 participants. RMT was thicker in the monofilament compared to the multifilament suture group (5.5 +/- 2.24 vs. 4.18 +/- 1.76, p = 0.01). Hemoglobin delta was higher in the monofilament suture group (1.59 +/- 0.96 vs. 1.25 +/- 0.60, p = 0.04). There was no statistically significant difference between the monofilament suture and multifilament suture groups in terms of gynecological sequelae. Conclusion: Closure of the uterine scar with monofilament suture has a positive effect on scar healing and increases RMT thickness.
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    Dual oocyte retrieval and embryo transfer in the same cycle for women with premature ovarian insufficiency
    (Wiley, 2019) Hatırnaz, Şafak; Ata, Barış; Hatırnaz, Ebru; Başbuğ, Alper; Tannus, Samer
    Objective To compare dual oocyte retrieval with minimal ovarian stimulation and embryo transfer in the same menstrual cycle versus conventional ovarian stimulation among women with premature ovarian insufficiency (POI). Methods A retrospective study of 51 women with POI attending a reproductive center in Turkey between 2013 and 2015. Women with an ovarian follicle of 12 mm or larger early in the follicular phase who underwent oocyte retrieval followed by an immediate cycle of ovarian stimulation (group 1, n=14) were compared with those who received conventional ovarian stimulation (group 2, n=37). Both groups underwent subsequent ovarian stimulation cycles to obtain optimally two embryos for transfer. Results The groups had similar baseline parameters. Serum estradiol was higher in group 1 (P<0.001); total number of oocyte retrievals was higher in group 2 (P<0.001); and total number of oocytes retrieved was similar (P=0.192). Group 1 had more higher-quality embryos (P=0.031). There was a non-significant trend toward higher live birth rates in the dual trigger group (28% vs 8%, P=0.08). Conclusion Rescuing growing follicles early in the follicular phase combined with subsequent ovarian stimulation and embryo transfer in the same cycle resulted in fewer oocyte retrieval cycles and might potentially improve reproductive outcomes.
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    The effect of adenomyosis on the outcomes of laparoscopic hysterectomy
    (Aves, 2016) Yavuzcan, Ali; Başbuğ, Alper; Bastan, Merve; Çağlar, Mete; Özdemir, İsmail
    Objective: The presence of adenomyosis (ADS) may increase complication rates associated with laparoscopic hysterectomy (LH) due to an increased weight of the uterus, increased vascularization of the uterus, impaired myometrial tissue, and presence of additional gynecological pathologies such as leiomyoma or endometriosis. The aim of the present study was to evaluate perioperative and early postoperative parameters in patients with or without adenomyotic lesions. Material and Methods: The study included patients who underwent LH in a university hospital. Patient data were retrieved from the hospital records and reviewed retrospectively. Sixty-one patients (85.9%) without adenomyotic lesions comprised the control group. Ten patients with adenomyotic lesions (14.1%) were regarded as the study group. Results: In this study, the mean age of the patients was 50.93+/-9.39 years. The mean uterus size was significantly higher in patients with ADS (p=0.02). There was no statistically significant difference in perioperative variables such as delta hemoglobin (Hb), insertion of pelvic drainage catheter, and invasive assessment of the urinary tract between both the groups (p=0.27, p=1.0, and p=0.67, respectively). The difference between the groups in terms of postoperative blood transfusion was not statistically significant (p=0.25). There was no statistically significant difference in the postoperative maximum body temperature, length of hospital stay, and duration of urinary catheterization between both the groups (p=0.77, p=0.36, and p=0.75, respectively). Conclusion: LH appears to be a safe alternative for patients with ADS. Large-scale, prospective, and randomized trials are required in order to suggest the routine use of LH in patients preoperatively diagnosed with ADS.
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    Endometrial Örnekleme Yapılan Hastaların Sonografik Bulgularının ve Histopatolojik Sonuçlarının Değerlendirilmesi
    (Duzce Univ, 2018) Özbilgeç, Sıtkı; Kaya, Aşkı Ellibeş; Başbuğ, Alper
    Amaç: Bu çalışmanın amacı, endometrial örnekleme yapılan olgularda histopatolojik sonuçlar ve sonografik veriler arasındaki ilişkinin araştırılmasıdır. Gereç ve Yöntem: Düzce Üniversitesi Tıp Fakültesi Hastanesi‘nde Ocak 2015 - Ocak 2017 yılları arasında endometrial örnekleme yapılan hastaların sonuçları retrospektif olarak hastane otomasyon sisteminden ve hasta dosyalarından incelenerek değerlendirildi. Hastalar menopozal durumlarına göre premenopoz ve postmenopoz olarak sınıflandırılarak, hasta gruplarındaki sonuçlar istatistiksel olarak karşılaştırıldı. Bulgular: Hastaların 231‘i premenopozal, 202‘si postmenopozal dönemde idi. Premenopozal hastaların ortalama endometrial kalınlıkları 10,42 ± 6,75 (mm, mean±SD) iken, postmenopozal hastaların endometrial kalınlık ortalamaları 10,01 ± 7,26 (mm, mean±SD) bulundu. Premalign lezyonların görülme oranı, her iki grupta benzer bulundu (p=0,87, p=0,54). Postmenopozal 10 hastada malignite tanısı konuldu, bu hastaların tümünün ilk başvuru şikayeti postmenopozal kanamaydı. Yapılan ROC analiz ile malignite için endometrial kalınlık sınır değeri; 8,5 mm olarak bulundu. Premenopozal dönemde, endometrial polip % 22,1 (n=51) oranında izlenirken, postmenopozal dönemde %16,3 (n=33) oranında izlendi (p=0,014). Tamoksifen kullanan 8 hastanın patoloji sonucu %75 (n=6) benign, %12,5 (n=1) premalign, %12,5 (n=1) malign olarak raporlandı. Sonuç: Postmenopozal kanamalı hastalarda endometrial örnekleme malignite ekartasyonu açısından hayatidir.
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    Endometrial pipelle scratching may decrease abortion rates rather than increasing pregnancy rates in intrauterine insemination cycles
    (Ondokuz Mayıs Üniversitesi, 2018) Çelik, Samettin; Hatırnaz, Şafak; Çalışkan, Canan Soyer; Hatırnaz, Ebru Saynur; Başbuğ, Alper; Çelik, Handan
    To assess the efficacy of endometrial pipelle scratching (EPS) preceding in- trauterine insemination (IUI) cycles. A total of 348 patients with unexplained infertility were enrolled into the study. 117 women with EPS were compared with 231 women without EPS and IUI. Livebirth and pregnancy rates and abor- tion rates were the primary outcomes. There were no difference in age, duration of infertility, basal hormone and total gonadotropin dose used throughout the cycle and endometrial thickness. In terms of pregnancy outcomes, pregnancy and livebirth rates in EPS group were17.1% and 15.7% respectively, while preg- nancy and livebirth rates in Non EPS group were 23.8% and 16% respectively. Spontaneous abortion rate in EPS group was significantly lower than Non EPS group (1.7% vs. 7.8%) which was statistically significant (p = 0.021). EPS did not improve pregnancy and livebirth rates. However, abortion rates were signifi- cantly lower in EPS patients. EPS may not have any impact on the embryonic implantation but may improve the proper development of implanted embryos by modulating the local factors. 
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    Evaluation of Anterior Segment Parameters and Retinal Nerve Fiber Layer Thickness According to Pregnancy Trimester
    (Duzce Univ, 2018) Teberik, Kuddusi; Başbuğ, Alper; Sağlam, Hakan; Karaaslan, Musa; Kaya, Murat
    Objective: To analyze the effects of pregnancy on anterior segment parameters and retinal nerve fiber layer (RNFL) thickness. Methods: The study designed prospectively conducted among 122 singleton pregnant women and 49 non-pregnant women. Intraocular pressure (IOP) was measured via the Goldman applanation tonometry. Central corneal thickness (CCT), axial lenght (AxL) and anterior chamber depth (ACD) measurement were performed with Echoscan US 500. For investigating the thickness of RNFL in detail, the optical coherence tomography was used. One Way ANOVA test was used to make a comparison between normal distribution groups. Results: There was no statistically significant difference regarding age. The IOP were 16.0 mmHg in the 1st trimester, 14.6 mmHg in the 2nd trimester, 13.6 mmHg in the 3rd trimester and 15.56 mmHg in the non-pregnant. Statistically, the findings of the 2nd and the 3rd trimester were significantly different from that of the 1st trimester (p = 0.033, p = 0.001, respectively). CCT averages were 554 mu m, 564 mu m and 552 mu m, respectively, according to the trimester, while it was 542 mu m in non-pregnant women. The difference between CCT averages between pregnancies in the 2nd and 3rd trimesters and non-pregnant women was statistically significant (p = 0.022, p = 0.041, respectively). The comparison of average thickness of four RNFL showed no difference between the pregnant and non-pregnant. Conclusions: During gestation, there was an increase in CCT with a decrease in IOP. We also determined that the ACD, AxL, and RNFL thickness measurements do not change with pregnancy.
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    Evaluation of sleep in women with menopause: results of the Pittsburg Sleep Quality Index and polysomnography
    (Galenos Yayincilik, 2015) Ağan, Kağan; Özmerdivenli, Recep; Değirmenci, Yıldız; Çağlar, Mete; Başbuğ, Alper; Balbay, Ege Güleç; Sungur, Mehmet Ali
    Objective: To investigate subjective sleep quality among women in the menopausal period and to confirm and diagnose the possible sleep disturbances with polysomnographic (PSG) evaluation objectively. Material and Methods: Sixty-seven women with menopause were enrolled in the study. Sociodemographic characteristics and the features of menopause were recorded. We assessed subjective sleep quality with Pittsburg Sleep Quality Index (PSQI). To confirm sleep disturbances and further diagnose the underlying cause, PSG evaluation was performed to women with PSQI scores of >5 who gave their approval. Results: Mean PSQI score of women with normal PSG evaluation was 12.00 +/- 3.16, while it was 11.00 +/- 2.32 in women with abnormal PSG evaluation (p=0.466); 59.7% (n=40) of women had poor sleep quality. Among these, 11 (64.7%) had abnormal results in the PSG evaluation and were diagnosed with obstructive sleep apnea syndrome (OSAS); 54.5% had mild OSAS, 27.3% had moderate, and 18.2% had severe OSAS. Conclusion: PSQI and PSG evaluations would give a chance to demonstrate sleep problems and shed a light on treatment options according to the underlying causes of sleep disturbances in menopause.
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    An Evaluation of the Association of Reproductive History and Multiple Births during Adolescence with Postmenopausal Osteoporosis
    (Georg Thieme Verlag Kg, 2019) Kaya, Aşkı Ellibeş; Doğan, Ozan; Başbuğ, Alper; Sönmez, Cemil Işık; Sungur, Mehmet Ali; Ataoğlu, Safinaz
    Introduction Osteoporosis is the most common metabolic bone disease characterized by low bone mass. Reproductive factors are known to affect bone mineral density (BMD). Calcium loss from maternal bone and decreased BMD have been observed especially during pregnancy and lactation, although this loss has been reported to recover within 6-12 months. There is no consensus on whether the effect of reproductive factors on the bone is positive or negative. The adolescent period is important for total bone mass, and total bone mass is significant in osteoporosis. The aim of this study was to investigate the effect of first gestational age, multiple births during adolescence, interpregnancy interval and reproductive history such as duration of breastfeeding on bone mineral density in postmenopausal women. Materials and Methods BMD was measured in a total of 196 postmenopausal patients and in accordance with the results, analysis was made of three groups as normal, osteopenia and osteoporosis. Dual Energy X-Ray Absorptiometry (DEXA) was used to take the lumbar, femoral and total bone BMD measurements. Results No statistically significant difference was determined between the groups in respect of total breastfeeding time (p = 0.596). It was detected that an increased interpregnancy interval decreased the risk of osteoporosis. In patients with osteoporosis, the mean interpregnancy interval was 1.4 +/- 0.73 years, while it was longer in patients with osteopenia (1.92 +/- 1.20) and normal BMD (2.45 +/- 1.77) (p = 0.005). While no effect was determined of the first gestational age on BMD, in the univariate logistic regression analysis, multiple births in the adolescent period were seen to increase the risk of osteoporosis 6.833-fold (p = 0.001, OR = 6.833, 95% CI = 2.131-21.908; p = 0.001). The increase in the age of menopause was determined to decrease the risk of osteoporosis (OR = 0.911, 95% CI = 0.843-0.985; p = 0.019). Conclusion Having frequent births throughout the whole reproductive age and having more than one child in adolescence has an adverse effect on postmenopausal bone mineral densities.