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  • Küçük Resim
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    In Vitro Antioxidant and Enzyme Inhibition Activity of Hesperis İsatidea (Boiss.) D.A. German & Al-Shehbaz (Brassicaceae) and its Anatomy
    (2021) Yıılmaz, Gülderen; Ekşi, Gülnur; Eruygur, Nuraniye; Ayaz, Fatma
    Hesperis isatidea (Brassicaceae) is a perennial herbaceous endemic plant known as “Allıgelin”. It has traditional use concerning the cough, wound, cold and vulnerary in the form of decoction and poultice in Eastern Turkey. In this study, the in vitro antioxidant activity (DPPH, ABTS, FRAP, and metal chelating) and enzyme inhibitory activities (anticholinesterase, anti-tyrosinase) of H. isatideae were evaluated. Besides, the transverse sections were taken from the leaf, stem and fruit to determine the morphological and anatomical features of H. isatidea. The characteristic elements of the preparations were determined by Leica CME stereomicroscope and the distinctive features were shown in photographs. The obtained results of in vitro antioxidant and enzyme inhibitory assays suggest that H. isatidea may useful to develop bioactive compounds rich nutraceuticals for health care.
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    Synthesis and Characterization of Copper-Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities
    (Wiley-V C H Verlag Gmbh, 2022) Koca Çalışkan, Ufuk; Dönmez, Ceylan; Eruygur, Nuraniye; Ayaz, Fatma; Altınkaynak, Cevahir; Özdemir, Nalan
    In this study, organic-inorganic hybrid nanoflowers were synthesized using methanolic extracts of the medicinal plants Ajuga chamaepitys subsp. chia var. chia, Achillea wilhelmsii, Bongardia chrysogonum, Malva sylvestris, Phlomis grandiflora var. grandiflora, Verbascum sp. together with copper ions (Cu2+). The synthesized plant extract based-inorganic hybrid nanoflowers (PE-ihNFs) of A. chamaepitys subsp. chia var. chia (Ac-ihNFs), A. wilhelmsii (Aw-ihNfs), B. chrysogonum (Bc-ihNFs), M. sylvestris (Ms-ihNFs) P. grandiflora var. grandiflora (Pg-ihNFs), and Verbascum sp. (Vs-ihNFs) were characterized by Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray (EDX), Fourier transform infrared spectrometry (FTIR), and X-Ray Diffraction (XRD). Also, several enzymes were selected to evaluate the enzyme inhibition activities of the synthesized PE-ihNFs. For the first-time, enzymes, tyrosinase, alpha-amylase and alpha-glucosidase, acetyl and butyryl cholinesterase inhibition activities of the PE-ihNFs with comparison to their plain plant extracts were evaluated in vitro. Results show that the among all the analyzed PE-ihNFs, demonstrated better alpha-glucosidase & alpha-amylase enzyme inhibition activity compared to the plain extracts. These initial studies are promising for the synthesis of these hybrid nanoflowers containing medicinal plant extracts, which might have commercial applications in the pharmaceutical and dermo-cosmetics industries.