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    The effects of gallic acid on the acute necrotizing pancreatitis in rats
    (Wiley-Blackwell, 2016) Kural, Birgül; Altay, Diler Us; Kahraman, C.; Alhan, Etem; Şen, T. Mazlum; Ercin, C.; Örem, Asım
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    Investigation of the relationship between oxidative stress and SCUBE1 levels in high fat diet-induced obese rats
    (Tubitak Scientific & Technical Research Council Turkey, 2018) Bodur, Akın; Kahraman, Cemil; Altay, Diler Us; Rendi, Taghi Ahmadi; Menteşe, Ahmet; Alver, Ahmet
    Background/aim: This study aimed to investigate signal peptide-Cub-EGF domain-containing protein 1 (SCUBE1) levels and oxidative stress (OS) in a high fat diet (HFD)-induced obese rat model. Materials and methods: Fourteen rats were randomly divided into two groups. Group 1, the control group, was given a standard diet (10% calories of fat) and Group 2, the obese group, was given a HFD (60% calories of fat), both for 70 days. Rats were then sacrificed and serum samples were collected. Serum glucose and triglyceride concentrations were determined using an autoanalyzer. Serum SCUBE1, adiponectin, and plasminogen activator inhibitor-1 levels were determined using an enzyme-linked immunosorbent assay. Serum malondialdehyde levels and superoxide dismutase and glutathione peroxidase enzyme activities were determined using colorimetric methods. Results: Final body weight was higher in the obese group (P = 0.007). Serum malondialdehyde concentrations were also higher in the obese group (P = 0.021). Serum glutathione peroxidase activities were higher in the control group (P = 0.028). Serum SCUBE1 levels were also higher in the control group (P = 0.038). Conclusion: There may be no connection between the measured OS parameters and SCUBE1. Differences in SCUBE1 levels may therefore be evaluated independently from OS in obesity.
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    Oxidant-Antioxidant Balance Changes in Adipose Tissues of High Fat Diet-Induced Obese Rats: Depot-Specific Manner and Ineffectiveness of N-Acetylcysteine
    (Kocaeli Üniversitesi, 2019) Kahraman, Cemil; Alver, Ahmet; Bodur, Akın; Akça, İmran İnce; Altay, Diler Us; Canpolat, Sinan
    Objective: The aims of study were to investigate effects of both N-acetylcysteine (NAC, an antioxidant) and high fat diet (HFD) to oxidative stress in differently located adipose tissues and the liver. Methods: Our study is created from control, HFD and NAC groups (n=6). Control group was fed with only standard diet. HFD group was fed with only HFD. NAC group was fed with HFD, and additionally that group received NAC (2 g/L). All groups were fed with designated diets for 85 days. Antioxidant enzyme activities, glutathione, and malondialdehyde were measured in epididymal, perirenal, subcutaneous adipose tissues, and liver.Results: In the HFD group, malondialdehyde (MDA) levels increased in perirenal adipose tissue and liver. In addition, superoxide dismutase (SOD) and catalase activities in the HFD group were lower both epididymal and perirenal adipose tissue, whereas glutathione peroxidase activities were lower in subcutaneous and epididymal adipose tissue. Glutathione was lower in liver tissue alone. In subcutan adipose tissue, the glutathione and SOD activities increased due to NAC administration. Conclusion: The present findings showed that oxidative stress and antioxidant enzyme profiles were variable in localized adipose tissue in different regions. Thought antioxidant enzyme activities in some tissues increased due to NAC application, these increases were insignificant in terms of oxidant-antioxidant balance.