Yazar "Akdeniz, Necmettin" seçeneğine göre listele
Listeleniyor 1 - 9 / 9
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Alteration of tissue expression of human beta defensin-1 and human beta defensin-2 in psoriasis vulgaris following phototherapy(Taylor & Francis Ltd, 2019) Uzunçakmak, Tuğba Kevser; Karadağ, Ayşe Serap; Özkanlı, Şeyma; Akbulak, Özge; Özlü, Emin; Akdeniz, Necmettin; Oğuztüzün, SerpilWe compared the expression profiles of antimicrobial peptides (AMPs) in psoriatic skin before and after narrow band ultraviolet B (nb-UVB) phototherapy and compared the levels to healthy controls. We studied 15 male and 12 female patients with psoriasis vulgaris, and 11 female and nine male control individuals. The patient group was treated with 24-36 sessions of nb-UVB phototherapy. Immunohistochemical staining for human beta defensin 1 (hBD-1) and human beta defensin 2 (hBD-2) expression of lesioned and control skin was performed prior to and following phototherapy. After phototherapy, the psoriatic area and severity index (PASI) decreased significantly in the treated patients compared to controls. The hBD-1 level was significantly higher in psoriasis patients than healthy controls. We found no statistically significant difference in hBD-1 and hBD 2 levels before and after phototherapy in the patient group. Although hBD-1 plays a role in psoriasis, levels of human beta defensin 1 and 2 are not affected significantly by phototherapy.Öğe Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study(Kare Publ, 2018) Özlü, Emin; Uzunçakmak, Tuğba Kevser; Takır, Mümtaz; Akdeniz, Necmettin; Karadağ, Ayşe SerapOBJECTIVE: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group. METHODS: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. The number of diabetic obese patients was 138 (30%), whereas that of nondiabetic obese patients was 312 (70%). A detailed dermatological examination was performed for each case, and accompanying dermatoses were compared. RESULTS: The mean body mass index (BMI) in the obese patients and control group was 37.22 kg/m(2) and 22.23 kg/m(2), respectively. The most common dermatoses in the obese patients were, according to their frequency: striae distensae (291 patients, 64.7%), acrochordon (236 patients, 52.4%), acanthosis nigricans (213 patients, 47.3%), plantar hyperkeratosis (209 patients, 46.4%), and venous insufficiency (202 patients, 44.9%). Although hirsutism was more frequently observed in the nondiabetic obese group than in the diabetic obese group, stasis dermatitis was less frequently observed (p<0.05). CONCLUSION: We found that many dermatoses are more frequently observed in the obese patients than in the controls. We observed that the effect of obesity on skin is different from that of diabetes mellitus and that cutaneous manifestations of obesity occur more frequently. More extensive, comprehensive, and advanced studies on this subject are required.Öğe Effect of pulse corticosteroids and low dose methotrexate in cases of treatment-resistant lichen sclerosus(Elsevier Taiwan, 2018) Karadağ, Ayşe Serap; Akdeniz, Necmettin; Özlü, Emin; Süslü, Hülya; Uzunçakmak, Tuğba Kevser; Bozdağ, Halenur; Kavala, Mukaddes…Öğe Melanocytes as the source of the increased melanisation in pigmented epithelial tumours: a holistic approach(Tubitak Scientific & Technical Research Council Turkey, 2022) Kilitci, Asuman; Elmas, Ömer Faruk; Akdeniz, Necmettin; Gamsızkan, MehmetBackground/aim: We aimed to elucidate the causes of the increased melanisation in basal cell carcinoma (BCC) and seborrheic keratosis (SK), and the role of melanocytes in this process. Materials and methods: This study was a retrospective-cohort study conducted in the pathology department of a university hospital between January 2019 and October 2020. Forty-nine SK and 30 pigmented BCC were included in our study. SRY-box transcription factor 10 (SOX10), CD68, and Masson???Fontana staining was used for analysis in all samples. A representative section of each specimen was photographed under ??400 magnification to facilitate the assessments of the morphology of the melanocytes and their following morphometric parameters: density, nuclear diameter, and distribution. The density of pigmented keratinocytes in the lesional epidermis was scored. The nuclear diameters of melanocytes located in the nonlesional epidermis, the density of the melanophages, and the presence or absence of ulceration and solar elastosis were also recorded. Results: The morphometric findings confirmed a statistically significant increase in melanocyte density in the BCC group compared with that in the SK group (p < 0.001). Moreover, the nuclear minor diameters in the melanocytes of the BCC sections were significantly higher than those in the SK specimens (p < 0.001). The epidermal melanocytes were distributed diffusely in almost all BCC specimens (96.7%), whereas they were mainly limited to the basal layer in the majority of the SK sections (59.2%). The number of epidermal melanised keratinocytes with a score of 3 was significantly higher in the SK group (n = 31; 63.2%) than in the BCC group (n = 6; 20%) (p = 0.001), and they were the main cells representing the pigmented appearance of the tumours. No significant difference was found between both tumour groups in terms of their melanophage density scores (p = 0.206). Conclusion: This study is the first step towards an objective quantification of the melanocytes in pigmented epithelial tumours and may provide a morphological background for future studies on these skin lesions.Öğe Morphea secondary to interferon betai B injection: A case and review of the literature(Dermatology Online Journal, 2019) Özlü, Emin; Karadağ, Ayşe Serap; Akdeniz, Necmettin; Uzunçakmak, Tuğba Kevser; Zemheri, Ebru; Özkanlı, ŞeymaInterferon beta (IFNß) is a drug used successfully in the treatment of multiple sclerosis (MS). Although IFNß is a safe and well-tolerated drug, dermatological side effects are common. The most common dermatological adverse effect is a local reaction at the injection site. It may also cause inflammatory and immune-mediated dermatological side effects. However, morphea induced by IFNßlb injection is very rare. © 2019, Dermatology Online Journal. All rights reserved.Öğe Novel PTCH1 Gene Mutation in a Patient with Gorlin-Goltz Syndrome(Korean Dermatological Assoc, 2019) Özlü, Emin; Karadağ, Ayşe Serap; Akalın, İbrahim; Yeşil, Gözde; Yılmaz, Sarenur; Zindancı, İlkin; Akdeniz, Necmettin…Öğe Plantar fibromatosis in a mentally challenged man treated with intralesional corticosteroids(Pulse Marketing and Communications LLC, 2017) Karadağ, Ayşe Serap; Özlü, Emin; Ceyran, Ayşe Bahar; Şimşek, Mehmet; Uzunçakmak, Tuğba Kevser; Zindancı, İlkin; Akdeniz, NecmettinA 21-year-old mentally challenged man presented with a fixed plaque lesion on the right foot, which had been present for 10 years. Dermatologic examination revealed an erythematous, painful, firm, fixed plaque-nodular lesion on the plantar aspect of the right foot (Figure 1A). Nothing of distinction was noted from his family history or his laboratory tests. An incisional biopsy revealed parallel, regular bundles composed of uniform, plump spindle cells. Thin collagen fibers were seen in contact with and located between the spindle cells. This mass was separated from the surrounding soft tissue by an irregular, unclear border (Figure 2A). İmmunohistochemically, the spindle cells showed diffuse, strong reactivity to vimentin (Figure 2B) and smooth muscle actin (Figure 2C). © 2017 Pulse Marketing & Communications, LLC.Öğe A Psoralen and Ultraviolet A?Aggravated Dermatosis: Grover’s Disease(2020) Ozlu, Emin; Karadag, Ayse Serap; Uzuncakmak, Tugba Kevser; Ozkanlı, Seyma; Erdem, Aysegul; Akdeniz, NecmettinGrover’s disease (GD) is an acquired dermatosis called transient acantholytic dermatosis. The exact cause is unknown, but the factors blamed for the etiology include ultraviolet (UV), sweating, temperature rise, radiation, medications, and malignancies. Topical corticosteroids, topical retinoids, and topical calcipotriol are usually sufficient for treatment, and systemic retinoids, systemic steroids, phototherapy, and methotrexate are rarely used. The current report describes the case of GD in a female patient, which was aggravated by the psoralen and UVA phototherapy.Öğe Tissue expression of glutathione S transferase isoenzymes in vitiligo(Taylor & Francis Ltd, 2021) Uzuncakmak, Tugba Kevser; Ozkanli, Seyma; Kocdogan, Arzu Kaya; Oguztuzun, Serpil; Karadag, Ayse Serap; Ozlu, Emin; Akdeniz, NecmettinThe association of glutathione S-transferase (GST) enzymes with vitiligo is inconclusive. To evaluate tissue expressions of GST isoenzymes in vitiligo patients and to compare these expressions with healthy controls, we used 26 active depigmented patches on the trunk of vitiligo patients and 20 healthy sex and age matched controls. Punch biopsies were taken from the lesioned or normal skin. Tissue expression of GST isoenzymes were analyzed immunohistochemically. Tissue expression of GSTT1, GSTA1 and GSTP1 was significantly higher in the patient group than controls. Tissue expression of GSTM1 was not significantly different between the two groups. The increased tissue expression of GSTT1, GSTA1 and GSTP1 may represent a response to excess free radical formation in vitiligo and may support the role of oxidative stress in the pathogenesis of vitiligo.
