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    Evaluation of tear function tests and corneal thickness in patients with meibomian gland dysfunction
    (2020) Teberik, Kuddusi; İritaş, İlter
    Objectives: To investigate whether central corneal thickness (CCT) and tear function test differ from healthycontrols in the ones suffering meibomian gland dysfunction (MGD).Methods: This prospective study was carried out with 99 individuals in total (50 patients MGD, 49 healthyindividuals). Schirmer-1, tear break-up time (TBUT), the Ocular Surface Disease Index (OSDI) questionnaireand CCT measurmentwas administered to all patients.Results: The average Schirmer 1 measurements were 16.6 ± 3.3 mm for right eyes, 16.4 ± 3.6 mm for lefteyes in the MGD group and 17.1 ± 3.7 mm for right eyes, 17.0 ± 4.4 mm for left eyes in the control group. Themean TBUT values were 10.1 ± 3.6 seconds for right eyes, 10.2 ± 3.4 seconds for left eyes in the MGD groupand 14.7±3.7 seconds for right eyes, 15.8 ± 4.1 seconds for left eyes in the control group (p = 0.001). Themean OSDI score values were 40.3 ± 23.7 in the MGD group and 19.4 ± 8.7 in the control group (p = 0.001).The average CCT in the MGD group was 539.4 ± 30.0 µm and 539.7 ± 33.0 µm (right and left, respectively).The average CCT in the control group was 551.6 ± 32.8 µm and 550.7 ± 32.2 µm (right and left, respectively).The mean CCT measurements in the MGD group were not statistically significant compared to the healthycontrol group (p = 0.059, and p = 0.097, right and left, respectively).Conclusions: The Schirmer test and CCT measurements are not significantly different in patients with MGDcompared to healthy control subjects
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    Keratoconus Could Be Associated With Psoriasis: Novel Findings From a Comparative Study
    (Lippincott Williams & Wilkins, 2019) Akçam, Hanife Tuba; Karagün, Ebru; İritaş, İlter; Eyüp, Yavuz
    Purpose: To explore the relationship between keratoconus (KC) and psoriasis. Methods: One hundred ten eyes of 55 patients with psoriasis (study group, SG) and 110 eyes of age-sex-matched 55 healthy volunteers (control group, CG) were included in the study. All cases underwent a detailed dermatological and ophthalmological examination including corneal topography. Moreover, Psoriasis Area and Severity Index (PAST) scoring of the patients was carried out in the SG. A thorough comparison of pachymetric, aberrometric, and topometric values between the groups was performed, and the results were interpreted. A chi(2) test, Mann-Whitney U test, and Pearson correlation test were used for statistical assessment. Results: Although the average Kmax (44.6 in the SG; 44.5 in the CG; P = 0.613) and Belin/Ambrnsio enhanced ectasia total deviation value (1.34 in SG; 1.20 in CG; P = 0.880) were similar between the groups, the mean index of vertical asymmetry value in the SG (0.14 mm) was significantly higher than that in the CG (0.11 mm) (P = 0.041). Moreover, 28 eyes from 16 patients with psoriasis were found to be associated with KC because 26 of those 28 eyes were KC suspects and 2 of them were definite KC. A positive correlation was found among topometric parameters, especially between duration of the disease and PASI score. A negative correlation was discovered between topometric parameters and the early beginning of psoriasis. Conclusions: Serious changes in topography maps may occur in psoriatic patients. The changes were found to be more evident in the presence of a higher PAST score and the early beginning and longer duration of the disease. The results hinted a potential relationship between psoriasis and KC.