Yazar "Zengin, Nurullah" seçeneğine göre listele

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    Adjuvant chemotherapy outcomes in patients over 65 years with early stage colorectal carcinoma
    (Imprimatur Publications, 2014) Civelek, Burak; Aksoy, Sercan; Şendur, Mehmet Ali Nahit; Yazıcı, Ozan; Kanmaz, Hüseyin; Köş, Fahriye Tuğba; Zengin, Nurullah
    Purpose: To evaluate the clinicopathological characteristics and the outcomes of adjuvant chemotherapy of patients with colorectal cancer aged >= 65 years. Methods: Between March 2003 and December 2010, the medical files of 562.colorectal cancer patients >= 65 years of age who were under follow-up in Ankara Numune Educational Hospital, Department of Medical Oncology, were retrospectively analyzed. Only 210 patients with non-metastatic disease at the time of diagnosis and those who had undergone surgical resection were included in the study. Results: The patient median age was 71 years (range 65-87). Of the patients, 115 (54.8%) were males and 95 (45.2%) females. The most common involvement site was the rectum (41.4%), followed by sigmoid colon (21.9%). According to the TNM staging, 12.4% patients had stage I, 48.6% stage II, and 39% stage III disease. At the time of diagnosis 19 patients (9%) had ECOG PS 0, 112 (53.3%) ECOG PS 1, 61(29%) ECOG PS 2, and 16 (7.7%) ECOG PS 3. Of the patients, 141 (66.5%) were administered adjuvant chemotherapy, whereas 69 patients (33%) were not. Thirty nine (18.6%) patients with adjuvant chemotherapy received fluorouracil/folinic acid (PUPA) weekly, 59 (28%) received FUFA infusion, and 43 (21%) received oxaliplatin, folinic acid and 5-fluorouracil (FOLFOX-4) regimen. The median follow-up was 27 months (range 1-116). Disease free survival (DFS) was not reached during the follow-up period. The estimated overall survival (OS) was 68.8 months (range 48.5-73.0). Sixty six (31%) patients died during follow-up. Conclusion: Elderly patients with high risk for recurrence of colorectal cancer must receive adjuvant chemotherapy after curative surgery. Infusional PUPA seems more effective than other regimens.
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    Assessment of prognostic value of "neutrophil to lymphocyte ratio" and "prognostic nutritional index" as a sytemic inflammatory marker in non-small cell lung cancer
    (Asian Pacific Organization for Cancer Prevention, 2015) Köş, Fahriye Tuğba; Hocazade, Cemil; Köş, Mehmet; Uncu, Doğan; Karakaş, Esra; Doğan, Mutlu; Zengin, Nurullah
    Background: Systemic inflammatory response was shown to play an important role in development and progression of many cancer types and different inflammation-based indices were used for determining prognosis. We aimed to investigate the prognostic effects of neutrophil to lymphocyte ratio (NLR) and prognostic nutritional index (PNI) in patients with non-small cell lung cancer (NSCLC). Materials and Methods: NSCLC patients diagnosed in our institution were retrospectively reviewed. Demographic and clinicopathologic characteristics were recorded. NLR and PNI was calculated before the application of any treatment. Results: A total of 138 patients were included in the study. Patients were divided into two groups according to NLR (<3.24 or ? 3.24) and PNI (<49.5 or ? 49.5). While median overall survival was 37.0 (95% CI 17.5-56.5) months in the group with low NLR, it was calculated as 10.0 (95%CI 5.0-15.0) months in the group with high NLR (p<0.0001). While median overall survival was 7.0 (95%CI 3.5-10.5) months in the group with low PNI, it was calculated as 33.0 (95% CI 15.5-50.4) months in the group with high PNI (p<0.0001). Stage, NLR and PNI levels were evaluated as independent risk factors for overall survival for all patients in multivariate analysis (p<0.0001, p=0.04 and p<0.001, respectively). Conclusions: NLR (?3.24) and PNI (<49.5) at diagnosis is an independent marker of poor outcome in patients with NSCLC. NLR and PNI is an easily measured, reproducible prognostic tests that could be considered in NSCLC patients.
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    ASSOCIATION BETWEEN BLOOD UREA NITROGEN/ALBUMIN RATIO AND PROGNOSIS IN NON-SMALL CELL LUNG CANCER
    (Carbone Editore, 2015) Köş, Mehmet; Hocazade, Cemil; Köş, Fahriye Tuğba; Uncu, Doğan; Karakaş, Esra; Doğan, Mutlu; Zengin, Nurullah
    Introduction: Prognostic value of easily available and reproducible laboratory parameters is investigated for non-small cell lung cancer (NSCLC) of which mortality is still high. We aimed to determine the prognostic value of blood urea nitrogen/albumin (BUN/albumin) ratio. Methods: ClinicoPathological characteristics with treatment modalities and laboratory values of NSCLC patients at our center evaluated retrospectively. A total of 142 patients were included to the study. Results: Median age was 57 (range 26-83). Receiver operating characteristic (ROC) curves for overall survival prediction were plotted to verify, the optimum cut-off point for BUN/albumin ratio. The recommended cut-off values for BUN/albumin ratio was 0.80 with a sensitivity of 60.0% and a specificity of 60.0%. While median overall survival was 26.0 (95% CI: 14.2-37.7) months in the group with low BUN/albumin ratio (<0.80), it was Calculated as 10.0 (95% CI: 5.2-14.8) months in the group with high BUN/albumin ratio (>= 0.80). The difference between groups was statistically significant (p=0.005). Conclusion: BUN/albumin ratio seems to be a significant prognostic index in NSCLC. It is not only simple but also inexpensive and reproducible. However, it needs further prospective trials with large number of patients.
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    Evaluation of the effects of red blood cell distribution width on survival in lung cancer patients
    (Termedia Publishing House Ltd, 2016) Köş, Mehmet; Hocazade, Cemil; Köş, Fahriye Tuğba; Uncu, Doğan; Karakaş, Esra; Doğan, Mutlu; Zengin, Nurullah
    Aim of the study: Data are available indicating that red blood cell distribution width (RDW) is higher in cancer patients compared to healthy individuals or benign events. In our study, we aimed to investigate the influence of different RDW levels on survival in lung cancer patients. Material and methods: Clinical and laboratory data from 146 patients with lung cancer and 40 healthy subjects were retrospectively studied. RDW was recorded before the application of any treatment. Patients were categorised according to four different RDW cut-off values (median RDW, RDW determined by ROC curve analysis, the upper limit at the automatic blood count device, and RDW cut of value which used in previous studies). Kaplan-Meier survival analysis was used to examine the effect of RDW on survival for each cut-off level. Results: The median age of patients was 56.5 years (range: 26-83 years). The difference in median RDW between patients and the control group was statistically significant (14.0 and 13.8, respectively, p = 0.04). There was no difference with regard to overall survival when patients with RDW = 14.0 were compared to those with RDW < 14.0 (p = 0.70); however, overall survival was 3.0 months shorter in low values of its own group in each of the following cut-off values: >= 14.2 (p = 0.34), >= 14.5 (p = 0.25), >= 15 (p = 0.59), although no results were statistically significant. Discussion: We consider that the difference between low and high RDW values according to certain cut-off values may reflect the statistics of larger studies although there is a statistically negative correlation between RDW level and survival.
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    Intraabdominal desmoplastic small round cell tumor mimicking renal cell cancer: A case report and review of the literature
    (2008) Tuncel, Altuğ; Aslan, Yılmaz; Yıldırım, Ümran; Zengin, Nurullah; Atan, Ali
    Introduction: A 25 year-old woman admitted to our clinic due to left lomber pain, weakness and abdominal mass. On computerized tomography, 140×110×50 mm in diameter solid mass was detected in upper pole of the left kidney on computerized tomography (CT). The patient underwent left radical nephrectomy and histopathological examination of the specimen was reported as pyelonephritis. Six months after the operation, the patient admitted to our clinic with huge intraabdominal mass. It was defined as hematoma or abcess on CT. One thousand cc necrotic clot like material was evacuated in exploration. Histopathological examination of this material indicated desmoplastic small round cell tumor.
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    Prognostic role of pretreatment platelet/lymphocyte ratio in patients with non-small cell lung cancer
    (Springer Wien, 2016) Köş, Mehmet; Hocazade, Cemil; Köş, Fahriye Tuğba; Uncu, Doğan; Karakaş, Esra; Doğan, Mutlu; Zengin, Nurullah
    It was reported that hematological markers of systemic inflammatory response might be prognostic in various cancer types. We aimed to evaluate the platelet/lymphocyte ratio (PLR) as a prognostic factor and its effect on overall survival in non-small cell lung cancer (NSCLC). Clinicopathological characteristics and basal (pretreatment) PLR of 145 patients with NSCLC were evaluated retrospectively. The preoperative or pretreatment blood count data were obtained from the recorded computerized database. PLR was defined as the absolute platelet count divided by the absolute lymphocyte count. A total of 145 patients were enrolled. Median age was 57 years(range 26-83). Receiver operating characteristic curves for overall survival prediction were plotted to verify the optimum cut-off point for PLR. The recommended cut-off values for PLR was 198.2 with a sensitivity of 65.0 % and a specificity of 71.4 %. Median overall survival was 34.0 (95 % confidence interval (CI) 14.7-53.3) months in the group with low PLR (< 198.2), while it was 11.0 (95 % CI 5.6-16.3) months in the group with high PLR (aeyen 198.2). The difference between the groups was statistically significant (p < 0.0001). Our study supports the view that a high basal PLR is a poor prognostic factor in NSCLC. However, the validity of the cut-off values for PLR identified in our study needs further prospective trials.