Yazar "Zengin, Mustafa" seçeneğine göre listele

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    Employing of 2-Acetylpyridine Based Chalcone as Hg2+ Sensing Material: Experimental and Theoretical Examination
    (Düzce Üniversitesi, 2022) Musatat, Ahmad Badreddin; Atahan, Alparslan; Aksu, Mecit; Zengin, Mustafa
    This study reports the evaluation of 2-acetylpyridine based chalcone structure as a useful sensing material for Hg2+ ion detection by the means of UV-visible spectroscopy. In this context, firstly, the most common twenty metal ions were treated by the chalcone structure which was synthesized from 2-acetylpyridine and 4-diphenylaminobenzaldehyde according to the known procedures. As result, the studied chalcone compound exhibited good sensing activity towards Hg2+ ion in acetonitrile/water medium with significant red-shift phenomenon. In addition, some photophysical/electronic parameters of the chalcone and its Hg2+ complex were determined experimentally and theoretically. B3LYP, PBE0 methods and SVP, TVZP, and TVZPP basis sets were used for theoretical calculations in acetonitrile media. Finally, experimental results were explained and the proposed sensing mechanism was supported via density functional theory (DFT) outputs.
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    Synthesis, characterization and electrochemical behavior of some Ni(II), Cu(II), Co(II) and Cd(II) complexes of ONS type tridentate Schiff base ligand
    (Pergamon-Elsevier Science Ltd, 2011) Durmuş, Sefa; Atahan, Alparslan; Zengin, Mustafa
    Tridentate Schiff base (H2L) ligand was synthesized via condensation of o-hydroxybenzaldehyde and 2-aminothiophenol. The metal complexes were prepared from reaction of the ligand with corresponding metal salts presence of substituted pyridine in two different solvents (MeOH or MeCN). The ligand and metal complexes were then characterized by using FTIR, TGA, H-1 NMR and C-13 NMR spectroscopies. The FTIR spectra showed that H2L was coordinated to the metal ions in tridentate manner with ONS donor sites of the azomethine N, deprotonated phenolic-OH and phenolic-SH. Furthermore, substituted pyridine was coordinated to the central metal atoms. The thermal behavior of the complexes was investigated by using TGA method and dissociations indicated that substituted pyridine and ligand were leaved from coordination. This coordination of the metal complexes was correlated by H-1 NMR and C-13 NMR. Finally, electrochemical behavior of the ligand and a Ni(II) complex were investigated. (C) 2011 Elsevier B.V. All rights reserved.
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    Synthesis, enzyme inhibition, and molecular docking studies of a novel chalcone series bearing benzothiazole scaffold
    (Wiley, 2023) Musatat, Ahmad Badreddin; Atahan, Alparslan; Ergün, Adem; Çıkrıkçı, Kübra; Gençer, Nahit; Arslan, Oktay; Zengin, Mustafa
    This study reports the facile synthesis of a novel series of benzothiazole-chalcones, in addition to their inhibitory profile on important metabolic enzymes including human carbonic anhydrases (hCA-I, hCA-II) and paraoxonase (PON-1). The inhibition parameters, IC50 (concentration for 50% inhibition) and Ki (dissociation constant) values, toward the title enzymes were determined for the studied compounds. As a result, IC50 values of hydratase activity were in the range 4.15-5.47 and 2.56-4.58 mu M for hCA-I and hCA-II, respectively. At the same time, IC50 values of esterase activity were in the range 24.91-104.00 and 35.25-97.00 mu M, while Ki values were in the range 14.43-59.66 and 26.65-73.34 mu M for hCA-I and hCA-II, respectively. In addition, PON-1 enzyme inhibition results showed interesting inhibitory effects, with IC50 values between 13.28 and 16.68 mu M. Finally, a comprehensive approach was established for the synthesized compounds based on theoretical calculations, which have been done using B3LYP, PBE0 theories and SVP, TVZP, TVZPP basis sets, followed by docking studies by which the outputs proved the harmonically flows with the experimental results.