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    Effect of ATP-dependent channel modulators on ischemia-induced arrhythmia change depending on age and gender
    (Royal Soc Medicine Press Ltd, 2013) Bozdoğan, Ömer; Kaya, Salih Tunç; Yaşar, Selçuk; Orallar, Hayriye
    The number of ATP-dependent potassium channels in myocardial cells has been previously shown to change depending on gender and age. Different effects of the ATP-dependent potassium channel blocker, glybenclamide and ATP-dependent potassium channel opener, pinacidil on ischemia or reperfusion-induced arrhythmia observed in various research might depend on different ages and genders of the animals used. The aim of this study is to research the effect of ATP-dependent potassium channel modulators on ischemia-induced arrhythmia in animals of different ages and genders. Sprague-Dawley rats of different ages and genders were used in this study. Ischemia was produced by the ligation of the left coronary artery for 30 min. Electrocardiogram (ECG), blood pressure, infarct area and blood glucose were determined during the 30 min of ischemia. An arrhythmia score from an ECG recorded during 30 min of ischemia was determined by examining the duration and type of arrhythmia. Different effects of glybenclamide and pinacidil on the arrhythmias were observed in male and female young and middle-age rats. Pinacidil decreased the infarct zone in younger female rats, but differences in the type and length of ischemia-induced arrhythmias between females and males disappeared in older age. The results of this study showed that the effect of ATP-dependent potassium channel modulators on ischemia-induced arrhythmia changed due to the age and gender of rats.
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    The Effect of Long Termand Acute Administration of Genistein on Ischemia-reperfusion-induced Arrhythmia
    (Wiley-Blackwell, 2016) Ekşioğlu, Didem; Erim, Firdevs; Bozdoğan, Ömer; Özarslan, Oğulcan Talat; Orallar, Hayriye Soytürk; Kaya, Salih Tunç; Yaşar, Selçuk
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    The Effect of Resveratrol and Glibenclamide on Ischemia/Reperfusion Induced Arrhythmias in STZ-induced Diabetic Rats
    (Wiley-Blackwell, 2016) Kaya, Salih Tunç; Özaslan, Oğulcan Talat; Ekşioğlu, Didem; Erim, Firdevs; Yaşar, Selçuk; Bozdoğan, Ömer
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    The effects of ATP-dependent potassium channel opener; pinacidil, and blocker; glibenclamide, on the ischemia induced arrhythmia in partial and complete ligation of coronary artery in rats
    (Mashhad Univ Med Sciences, 2015) Yaşar, Selçuk; Bozdoğan, Ömer; Kaya, Salih Tunç; Orallar, Hayriye Soytürk
    Objective(s): Electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion. The leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias. The aim of this study is to research the effect of ATP-dependent potassium (K-ATP) channel blocker (glibenclamide) and opener (pinacidil) on ischemia induced arrhythmia in the presence of small and large infarct sizes. Materials and Methods: In this study Sprague-Dawley male rats of 8-9 months of age were used. Ischemia was produced by the partial ligation of left coronary artery ramus descending (PL) for smaller infarct and complete ligation of this artery (CL) for larger infarct for 30 min. The arrhythmia score which was calculated from the duration and type of arrhythmia was significantly higher in animals which had a larger infarct area than the animals which had a smaller infarct. Results: Glibenclamide increased the rate of arrhythmia in animals having smaller infarct but not in animals having larger infarct. Pinacidil did not affect the occurrence of arrhythmia in either group. There was a significant difference in the infarct size and risk of infarct zone between animals which had small and large infarct sizes. The effect of glibenclamide and pinacidil on the arrhythmias differed depend on decrease of infarct size. Conclusion: Glibenclamide is not effective to decrease ischemia induced arrhythmia in the presence of small and pinacidil in large ischemic zone.
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    Evaluation of atherosclerotic plaque, coronary stent and coronary by-pass grafts with 128-slice CT and technical optimization: Our single center experiences
    (2012) Kayan, Mustafa; Çetin, Meltem; Türker, Yasin; Yılmaz, Ömer; Munduz, Mehmet; Yaşar, Selçuk; Duymuş, Mahmut
    The purpose of this study was to evaluate the native coronary artery (CA), coronary atherosclerotic plaque, coronary by-pass grafts and coronary stents with 128-slice CT, comparison of findings with literature and technical optimization. In one hundred fifty patients who had undergone coronary computerized tomography angiography using 128-slice CT (CCTA), CAs were examined in terms of visibility, atherosclerotic plaque characteristics, by-pass graft and stent patency. In each case, CAs were divided into fifteen segments according to the American Heart Association (AHA) classification and then evaluated. Out of one hundred and fifty (150) cases, 2250 CA segments were examined according to AHA classification. A total of 1045 segments below 2 mm were examined for visibility. Fifty segments could not be visualized. Soft plaques were observed in 97 cases (4 cases with calcium load = 0). Atherosclerotic plaques were observed in 450 segments. By-pass grafts were observed in ten cases while 28 stents were observed in fifteen cases. In cases with by-pass graft, artifacts due to clips did not hinder the examination. In conjunction with technological advances, CAs can be non-invasively examined using new generation multi-dimensional computerized tomography. Clips artifacts in coronary stents and by-pass grafts do not hinder CA examination due to high spatial and temporal resolution of MDCT devices.
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    Evaluation of coronary artery anomalies using 128-Slice computed tomography
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2012) Kayan, Mustafa; Yavuz, Turhan; Munduz, Mehmet; Türker, Yasin; Yeşildağ, Ahmet; Etli, Mustafa; Yaşar, Selçuk
    Background: In this study, we aimed to investigate the efficacy of a 128-slice computed tomography (CT) device in detecting anatomical variations and anomalies of coronary arteries and to compare the results obtained with literature data. Methods: Totally, 83 patients (58 males, 25 females; mean age 53.7 +/- 10 years; range 31 to 80 years) with suspected or known coronary artery disease who underwent evaluation using the 128-slice CT in our clinic between February 2009 and December 2010 were retrospectively analyzed. All images were evaluated in terms of anatomic variation and anomaly by a radiologist with expertise in cardiovascular radiology. Continuous variables were expressed as arithmetical mean +/- standard deviation (SD), while categorical variables were expressed as percent (%). Statistical analysis was performed using descriptive statistical tests. Results: The rate of right dominance, left dominance and co-dominance was 80.7%, 8.4% and 10.8%, respectively. It was observed that the conus artery originated from the right sinus valsalva at a rate of 16.86% and from the right coronary artery (RCA) at a rate of 83.1%. It was found that sinus node artery (SNA) originated from the RCA at a rate of 77.1%, from the circumflex (Cx) artery at a rate of 18.1%, from the left main coronary artery (LMCA) at a rate of 2.4% and from the right sinus valsalva at a rate of 2.4%. Ramus intermedius was present in 30.12% of the patients. Coronary artery anomaly was observed in 48 patients (57.8%). of them, 1.2% had absence of LMCA, 6% had commissural origin, 1.2% had coronary hypoplasia, 4.8% had anomalous of contralateral sinus origin, and 43.3% had myocardial bridging. Conclusion: The 128-slice CT device is a non-invasive method which provides reliable, detailed and correct information for detecting variations and anomalies of coronary arteries. We believe that the 128-slice CT is of higher value in diagnosis and surgical therapy of coronary artery anomalies.
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    The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial K-ATP channel
    (Taylor & Francis Ltd, 2019) Kaya, Salih Tunç; Bozdoğan, Ömer; Özarslan, Talat O.; Taşkın, Eylem; Eksioğlu, Didem; Erim, Firdevs; Yaşar, Selçuk
    Context: Cardiovascular dysfunctions such as life-threatening arrhythmias are one of the main reasons of mortality and morbidity in diabetic patients Objective: We aimed to investigate the long-term effects of resveratrol, berberine and glibenclamide combinations on the ischemia/reperfusion (I/R) induced arrhythmias in streptozotocin (STZ)-induced diabetic rats and to investigate the role of myocardial K-ATP channel in the possible anti-arrhythmic actions of the treatments. Methods: Two days after induction of diabetes, diabetic rats were treated with resveratrol [5 mg/kg, intraperitoneally (i.p.)], berberine (10 mg/kg, i.p) and glibenclamide (5 mg/kg, i.p) for 6 weeks. On the 43th day, experimental animals were subjected to 6-min ischemia and 6-min reperfusion in vivo. Results: The protein expression of Kir6.2 subunits was downregulated in the diabetic hearts. However, all drug treatments restored the protein expression of Kir6.2 subunits. Resveratrol alone and its combination with glibenclamide decreased the arrhythmia score, the arrhythmic period and the incidence of other types of arrhythmias during the reperfusion period. Conclusions: The combination of resveratrol with glibenclamide may alleviate reperfusion-induced arrhythmias via an underlying mechanism not be only associated with the restoration of the protein expression of Kir6.2 subunits but also associated with the other subunits or ion channels underlying cardiac action potential.
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    Short-term diabetes decreases ischemia reperfusion-induced arrhythmia: the effect of alpha-2 blocker yohimbine and glibenclamide
    (Tubitak Scientific & Technical Research Council Turkey, 2016) Bozdoğan, Ömer; Kaya, Salih Tunç; Yaşar, Selçuk; Baş, Erçin Çağdaş; Özarslan, Oğulcan Talat; Ekşioğlu, Didem; Erim, Firdevs
    This study examined the effect of yohimbine alone and in combination with glibenclamide on ischemia and reperfusion-induced arrhythmias in diabetes. Six minutes of ischemia were produced in 1-week diabetic rats by ligation of the left coronary artery, and 6 min of reperfusion were produced by releasing the artery. A dose of 5 mg/kg of yohimbine and glibenclamide was administered for 7 days prior to the coronary ligation. The blood pressure, heart rate, and arrhythmia were determined from the recorded ECG during the 6 min of ischemia and reperfusion and then compared using a one-way ANOVA statistical program and the chi-square test. The score of arrhythmia calculated from the type and duration of arrhythmia decreased in the diabetic rats (3.5 +/- 1.69 in control, 1.7 +/- 0.81 in diabetes group). The arrhythmia score returned to the control value in the rats that were given a combination of yohimbine and glibenclamide (3 +/- 1.73). Yohimbine is used in the treatment of erectile dysfunction; glibenclamide is used as an antidiabetic drug in diabetic patients and may be a risk factor in the increase of ischemia reperfusion-induced arrhythmias.