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    Erdosteine protects rat testis tissue from hypoxic injury by reducing apoptotic cell death
    (Wiley, 2014) Güven, Aysel; İçkin, Meletm; Uzun, O.; Bakar, Coşkun; Balbay, Ege Güleç; Balbay, O.
    The purpose of this study was to examine the effects of hypobaric hypoxia on testis morphology and the effects of erdosteine on testis tissue. Caspase-3 and hypoxia-inducible factor 1 expressions were detected by immunohistochemistry. Adult male Wistar rats were placed in a hypobaric hypoxic chamber. Rats in the erdosteine group were exposed to the same conditions and treated orally with erdosteine (20mgkg(-1) daily) at the same time from the first day of hypoxic exposure for 2weeks. The normoxia group was evaluated as the control. The hypoxia group showed decreased height of spermatogenic epithelium in some seminiferous tubules, vacuolisation in spermatogenic epithelial cells, deterioration and gaps in the basal membrane and an increase in blood vessels in the interstitial area. The erdosteine group showed amelioration of both epithelial cell vacuolisation and basal membrane deterioration. Numbers of hypoxia-inducible factor 1-immunostained Sertoli and Leydig cells were significantly higher in the hypoxia group than in the erdosteine group. The number of seminiferous tubules with caspase-3-immunostained germ cells was highest in the hypoxia group and decreased in the erdosteine and normoxia groups respectively. Based on these observations, erdosteine protects testis tissue from hypoxic injury by reducing apoptotic cell death.
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    Interpretation of Landscape Sensitivity and River Habitat Assessment Approaches Based on Cultural Landscape Elements: The Edirne Sarayiçi Case
    (Peter Lang Publishing Group, 2023) Keleş, E.; Uzun, O.
    Edirne is an important historical and cultural urban center since it has been the home of several civilizations throughout history. Edirne is a border town with cultural diversity. Furthermore, the Maritsa, Tunca and Arda rivers that divide the city are also significant natural landscape elements. These rivers are international waters and have been important factors in urban structure and serve as a natural corridor around the urban center. In recent years, the city has experienced problems such as population growth, urbanization, tourism, increase in impervious surfaces, damage to natural corridors, and urban or rural floods. Thus, planning and management of these areas are quite important to ensure sustainability. The present study aims to determine the landscape sensitivity in Edirne Sarayiçi region that includes various natural, historical and cultural assets. Thus, landscape function analyzes (water function, habitat, erosion function and cultural status) were conducted and the landscape sensitivity was determined by ovarlay the maps. The condition of the river habitats was analyzed with field work in and around the Tunca river. The analysis of the Sarayiçi region landscapes revealed that the landscape sensitivity was low; however, the presence of historical and cultural assets in the area and frequent floods damaged the river habitats and increased landscape sensitivity. Thus, recommendations for the restoration and conservation of the landscape are presented to preserve natural and cultural components and ensure the sustainability of historical assets © 2023 Peter Lang GmbH, Internationaler Verlag der Wissenschaften.
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    Rural development oriented ecotourism planning on catchment basin scale: The case of pabuçdere and kazandere catchment basins
    (Tarbiat Modares University, 2017) Kiper, Tuğba; Uzun, O.; Topel, T. Üstün
    This study was based on the hypothesis that "Ecotourism is an important instrument in sustainable rural development and ecologically-based landscape planning approaches which take the objectives of socio-economic development and nature conservation have an effective role in this issue". For this purpose, the necessity of ecologically-based landscape planning approaches in the planning and implementation of ecotourism activities and the importance of the views of related stakeholders in decision-making process have been established in this study. The field of study was grounded on subbasin and micro basin boundaries which take natural thresholds into consideration instead of administrative boundaries which contrast with natural thresholds. A total of 31 micro basins, consisting of 20 basins in the Kazandere basin of a total of 293 km2 in the northwest of Turkey and 11 basin in the Pabuçdere basin, have been assessed. A 3-phased method was followed in the study. Firstly, the inventory and data base of the field were created on Geographic Information Systems medium and micro basins were determined. In the second phase, suitability analyses were carried out on the basis of the Ecotourism Opportunity Spectrum (ECOS) according to 6 basic components, 15 assessment factors, and 24 subcriteria. In the third phase, the micro basins suitable for ecotourism potential were determined by creating a synthesis sheet on the field of study as a result of related analyses and assessments, and ecotourism oriented development strategies were developed by utilizing the rapid rural appraisal conducted in the area and visitor questionnaires as well. © 2017, Tarbiat Modares University. All rights reserved.
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    Rural Development Oriented Ecotourism Planning on Catchment Basin Scale: The Case of Pabucdere and Kazandere Catchment Basins
    (Tarbiat Modares Univ, 2017) Kiper, Tuğba; Uzun, O.; Topel, T. Üstün
    This study was based on the hypothesis that "Ecotourism is an important instrument in sustainable rural development and ecologically-based landscape planning approaches which take the objectives of socio-economic development and nature conservation have an effective role in this issue". For this purpose, the necessity of ecologically-based landscape planning approaches in the planning and implementation of ecotourism activities and the importance of the views of related stakeholders in decision-making process have been established in this study. The field of study was grounded on subbasin and micro basin boundaries which take natural thresholds into consideration instead of administrative boundaries which contrast with natural thresholds. A total of 31 micro basins, consisting of 20 basins in the Kazandere basin of a total of 293 km(2) in the northwest of Turkey and 11 basin in the Pabucdere basin, have been assessed. A 3-phased method was followed in the study. Firstly, the inventory and data base of the field were created on Geographic Information Systems medium and micro basins were determined. In the second phase, suitability analyses were carried out on the basis of the Ecotourism Opportunity Spectrum (ECOS) according to 6 basic components, 15 assessment factors, and 24 subcriteria. In the third phase, the micro basins suitable for ecotourism potential were determined by creating a synthesis sheet on the field of study as a result of related analyses and assessments, and ecotourism oriented development strategies were developed by utilizing the rapid rural appraisal conducted in the area and visitor questionnaires as well.