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Öğe Behcet's disease as a causative factor of cerebral venous sinus thrombosis: subgroup analysis of data from the VENOST study(Oxford Univ Press, 2019) Uludüz, Derya; Midi, Ipek; Duman, Taşkın; Çolakoğlu, Sena; Tüfekçi, Ahmet; Bakar, Mustafa; Aluçlu, UfukObjective This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behcet's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 2).Öğe Burden of Chronic Migraine in Tertiary Headache Outpatient Clinics: Experience of 10 years a Multicenter Study(Sage Publications Ltd, 2017) Yalın, Osman Özgür; Uludüz, Derya; Sungur, Mehmet Ali; Özge, Aynur…Öğe Cerebral Venous Sinus Thrombosis as a Rare Complication of Systemic Lupus Erythematosus: Subgroup Analysis of the VENOST Study(Elsevier, 2019) Duman, Taşkın; Demirci, Seden; Uludüz, Derya; Kozak, Hasan Hüseyin; Demir, Serkan; Mısırlı, Cemile Handan; Göksan, BakiAim: Systemic lupus erythematosus (SLE) is an unusual risk factor for cerebral venous sinus thrombosis (CVST). As few CVST patients with SLE have been reported, little is known regarding its frequency as an underlying etiology, clinical characteristics, or long-term outcome. We evaluated a large cohort of CVST patients with SLE in a multicenter study of cerebral venous thrombosis, the VENOST study, and their clinical characteristics. Material and Method: Among the 1144 CVST patients in the VENOST cohort, patients diagnosed with SLE were studied. Their demographic and clinical characteristics, etiological risk factors, venous involvement status, and outcomes were recorded. Results: In total, 15 (1.31%) of 1144 CVST patients had SLE. The mean age of these patients was 39.9 +/- 12.1 years and 13 (86.7%) were female. Presenting symptoms included headache (73.3%), visual field defects (40.0%), and altered consciousness (26.7%). The main sinuses involved were the transverse (60.0%), sagittal (40.0%), and sigmoid (20.0%) sinuses. Parenchymal involvement was not seen in 73.3% of the patients. On the modified Rankin scale, 92.9% of the patients scored 0-1 at the 1-month follow-up and 90.9% scored 0-1 at the 1-year follow-up. Conclusions: SLE was found in 1.31% of the CVST patients, most frequently in young women. Headache was the most common symptom and the CVST onset was chronic in the majority of cases. The patient outcomes were favorable. CVST should be suspected in SLE patients, even in those with isolated chronic headache symptoms with or without other neurological findings.Öğe Characteristics of Isolated Headache patients in Cerebral Venous Sinus Thrombosis (CVST): The Results of VENOST - national survey(Springeropen, 2018) Uludüz, Derya; Yalın, Osman Özgür; Duman, Taşkın; Domaç, Füsun Mayda; Öztürk, Şerefnur; Yayla, Vildan; Sungur, Mehmet Ali…Öğe Hashimoto tiroiditi hastalarında primer baş ağrısının sıklığı ve ilişkili faktörler(2022) Gözübatık Çelik, R. Gökçen; Uludüz, Derya; Hatipoğlu, Esra; Hacıoğlu, Yalçın; Türk, Bengi Gül; Sungur, Mehmet Ali; Göksan, BakiAmaç: Bu çalışmanın amacı, Hashimoto tiroiditi tanısı alan hastalarda primer baş ağrısı insidansını ve potansiyel biyobelirteçleri değerlendirmektir. Gereç ve Yöntem: Endokrinoloji polikliniğine başvuran Hashimoto tiroiditi olan hastalar çalışmaya dahil edildi. Demografik veriler, tiroid fonksiyon test sonuçları ve otoantikor titreleri kaydedildi. Baş ağrısının klinik özellikleri de belirlendi. Aynı araştırmacı, tüm hastalarda baş ağrısı şiddeti derecelendirmesi için görsel analog ölçeği (VAS) kullandı. Bulgular: Primer baş ağrısı olan 95 (%61,3) hastadan 20’si (%21,1) migren, 17’si (%17,9) gerilim tipi baş ağrısı (TTH) ve 20’si (%21,1) yeni günlük kalıcı baş ağrısı (NDPH) tanısı aldı. Yüz elli beş kişiden 38’inde (%24,5) hipotiroidizme bağlı baş ağrısı (HRH) tespit edildi. Baş ağrısı tipi ile yüksek kan antikor düzeyi (anti-TPO) arasında istatistiksel olarak anlamlı ilişki bulunmazken (p=0,135), tiroid uyarıcı hormon (TSH) ile pozitif korelasyon saptandı (p<0,001). Migrenli Hashimoto hastalarında (n=14, %70,0) daha yüksek kan antikor düzeyleri bulunurken, bu oranlar HRH’de %86,8 (n=33), TTH hastalarında %76,5 (n=13), NDPH hastalarında %60,0 (n=12) olarak saptandı. Elli yedi hasta Hashimoto tanısı aldıktan sonra yeni bir baş ağrısı tanımlarken, hormon tedavisi sonrası baş ağrısı devam eden hasta sayısı 48 idi. Bu da primer baş ağrısı ve Hashimoto hastalığı komorbiditeyi göstermekteydi. Sonuç: Baş ağrısı ile ilişkili tek faktörün TSH düzeyi olması patofizyolojide farklı mekanizmaların rol oynadığını düşündürdü. Primer baş ağrısı tanısında tedavi edilebilen sekonder nedenlerin detaylı araştırılması önem taşımaktadır.Öğe Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study(2021) Duman, Taşkın; Çınar, Nilgün; Uludüz, Derya; Domaç, Füsun Mayda; Öztürk, Şerefnur; Yayla, Vildan; Demir, SerkanObjectives: Headache is the most common complaint in cerebral venous sinus thrombosis (CVST) and it may sometimes bethe only symptom in these patients. This retrospective and prospective study was an investigation of any differences in termsof clinical risk factors, radiological findings, or prognosis in patients with CVST who presented with isolated headache (IH) andcases with other concomitant findings (non-isolated headache [NIH]).Methods: A total of 1144 patients from a multicenter study of cerebral venous sinus thrombosis (VENOST study) were enrolled inthis research. The demographic, biochemical, clinical, and radiological aspects of 287 IH cases and 857 NIH cases were compared.Results: There were twice as many women as men in the study group. In the IH group, when gender distribution was evaluated byage group, no statistically significant difference was found. The onset of headache was frequently subacute and chronic in the IHgroup, but an acute onset was more common in the NIH group. Other neurological findings were observed in 29% of the IH groupduring follow-up. A previous history of deep, cerebral, or other venous thromboembolism was less common in the IH group thanin the NIH group. Transverse sinus involvement was greater in the IH group, whereas sagittal sinus involvement was greater in theNIH group. The presence of a plasminogen activator inhibitor (PAI) mutation was significantly greater in the IH group.Conclusion: IH and CVST should be kept in mind if a patient has subacute or chronic headache. PAI, which has an importantrole in thrombolytic events, may be a risk factor in CVST. Detailed hematological investigations should be considered. Additional studies are needed.Öğe Identification of Allodynic Migraine Patients with the Turkish Version of the Allodynia Symptom Checklist: Reliability and Consistency Study(Aves, 2017) Özgür, Osman; Uludüz, Derya; Sungur, Mehmet Ali; Sart, Hande; Özge, AynurIntroduction: Cutaneous allodynia is regarded as an expression of central sensitization in migraine. Although the gold standard is quantitative sensory testing, several practical assessment questionnaires have been developed to assess allodynia in migraine. We aimed to establish the first valid Turkish allodynia assessment questionnaire based on a 12-item allodynia symptom checklist and to evaluate the associated factors. Methods: The first part of the study included the translation and cultural adaptation of a Turkish version of the checklist. The Turkish version of the questionnaire was administered to 344 episodic and chronic migraine patients, who were chosen according to the International Classification of Headache Disorders -III beta criteria. Results: The total checklist score showed excellent test-retest reliability (r= 0.821). The internal consistency of the checklist was assessed using Cronbach alpha values and was found to be acceptable (Cronbach alpha for the checklist= 0.767). Data analysis revealed that 10 items of the questionnaire adequately identified allodynic subjects. Cutaneous allodynia was present in 218 (63.4%) migraine patients. Allodynia was more prominent in patients experiencing migraine with aura (p= 0.008) and in females (p< 0.001). Multiple logistic regression analysis found that female gender, aura existence, longer headache duration, and higher attack frequency were the major determinants of cutaneous allodynia. Conclusion: Allodynia is common and has clinical significance in migraine; therefore, establishing a validated Turkish questionnaire for the assessment of allodynia was necessary. In this study, a Turkish version of the allodynia symptom checklist was validated and found to be convenient for the identification of allodynia in migraine patients.Öğe One-year incidence of Chronic Migraine in Tertiary Headache Outpatient Clinics: A multi-center study(Springeropen, 2018) Özge, Aynur; Uludüz, Derya; Yalın, Osman Özgür; Demirci, Seden; Selekler, Macit; Akyol, Ali; Siva, Aksel…Öğe Phenotypic features of chronic migraine(Bmc, 2016) Yalın, Osman Özgür; Uludüz, Derya; Özge, Aynur; Sungur, Mehmet Ali; Selekler, Macit; Siva, AkselBackground: Chronic migraine is a disabling, under-recognized, and undertreated disorder that increases health burdens. The aim of this study was to evaluate phenotypic features and the relevance of accompanying symptoms of migraine attacks in chronic migraine. Method: This study was conducted as part of an ongoing Turkish Headache Database Study investigating the clinical characteristics and outcomes of headache syndromes in the Turkish population. The electronic database was examined retrospectively, and 835 patients with chronic migraine were included. Results: Patient group consisted of 710 women and 125 men (85 and 15 %, respectively). Mean patient age was 36.8 +/- 13.5 years, median value of migraine onset was 60 months (18-120), median headache frequency was 25 days per month (16-30), median of attack duration was 12 h (4-24), and median of intensity was eight (7-9). Increasing headache days per month were inversely related with the presence of nausea, vomiting, phonophobia, and photophobia. Longer duration of headache (months) and higher visual analog scale (VAS) for headache intensity were associated with all accompanying symptoms. Phonophobia, nausea, photophobia, and vomiting were the most frequent accompanying symptoms (experienced by 80.2, 77.6, 71.2, and 40.9 % of patients, respectively). Osmophobia was also frequent in chronic migraine patients (53.4 %) and was closely associated with other accompanying symptoms. Vertigo and dizziness were observed less frequently, and they were not associated with accompanying symptoms. Conclusion: Phenotype of chronic migraine may be associated with the course of chronification. Duration of illness and attack intensity were closely related with the presence of accompanying symptoms, although headache frequency was found to be inversely related to the presence of accompanying symptoms. Osmophobia was also a frequent symptom and was closely related with other accompanied symptoms, unlike vertigo and dizziness. Inclusion of osmophobia into the diagnostic criteria might improve accurate diagnosis of chronic migraine.Öğe The relevance of associated symptoms of migraine according to migraine subtypes: A Clinical study(Springeropen, 2018) Özge, Aynur; Yalın, Osman Özgür; Uludüz, Derya; Mercan, Özlem; Sungur, Mehmet Ali; Siva, Aksel…
