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Öğe Clinical prognostic factors in patients with idiopathic peripheral facial nerve paralysis (Bell’s palsy)(2017) Akcan, Fatih Alper; Dündar, Yusuf; Uluat, Ahmet; Korkmaz, Hakan; Özdek, AliObjectives. The aim of this study was to analyse the clinical prognostic factors that are associated with treatment outcomes in patients with idiopathic peripheral facial nerve paralysis (PFNP). Methods. The study was performed retrospectively with 80 patients in a tertiary medical center. All of the patients were treated and followed for idiopathic PFNP (Bell’s palsy). The patient charts were reviewed for patient demographics and characteristics. The comorbidities (hypertension, diabetes mellitus), the side, grade and duration of palsy, and the acoustic stapedius reflex were analyzed. Results. Forty-three male and 37 female patients were diagnosed with idiopathic PFNP. Sixty-seven of patients had complete, 13 patients had partial recovery. Of the partial recoveries, 12 patients had Grade 2 and one patient Grade 3 PFNP at the end of primary treatment. Patients tended to have incomplete recovery if they have a diagnosis of diabetes mellitus, but the difference between groups was not statistically significant (p0.326). A positive stapedius reflex was associated with complete recovery (p0.023). Patients had much more risk of incomplete recovery if age is more than 40 years (p0.006). Conclusion. A detailed history and complete physical examination are very important in peripheral facial palsy. Co-morbid diseases and demographic features such as high blood pressure, diabetes mellitus and advanced age might influence the treatment outcomes.Öğe Clinical role of vitamin D in prognosis of otitis media with effusion(Elsevier Ireland Ltd, 2018) Akcan, Fatih Alper; Dündar, Yusuf; Akcan, Hümeyra Bayram; Uluat, Ahmet; Cebeci, Derya; Sungur, Mehmet Ali; Ünlü, İlhanObjective: To investigate the clinical role of Vitamin D in prognosis of Otitis media with effusion. Methods: This prospective-controlled study was conducted at otolaryngology department in Duzce University, Turkey. The study group comprised children who were diagnosed with Otitis media with effusion between September 2016 and February 2017. Control group was conducted with children underwent circumcision or inguinal hernia repair operations that confirmed with ENT examination they do not have any sign of otitis media. After 3 months of follow-up without any treatment, unresolved cases who were accepted as chronic otitis media with effusion were operated under general anesthesia for ventilation tube application. Study and control groups were assessed depending on the serum 25(OH)Vitamin D levels at the end of 3 months; <15 ng/mL was accepted as vitamin D deficiency. The results were compared with the control group in terms of vitamin D levels. Also, subgroup analysis was performed addressing to the complete recovery otitis media with effusion and chronic otitis media with effusion. Results: One-hundred-seventy-four children with otitis media with effusion and 80 control patients were included to the study. One-hundred-eight (62%) out of 174 patients with otitis media with effusion was completely recovered after a 3-months follow up. Of those 66 out of 174 children, they had persistent diseases, underwent ventilation tube insertion after a 3-months follow-up. The mean 25(OH)Vitamin D level was 18.98 +/- 10.60 in otitis media with effusion group and 28.07 +/- 14.10 in control group and the difference was statistically significant between the study and control group (p < 0.001). Vitamin D deficiency was observed in 33 out of 66 patients (50.0%) in chronic otitis media with effusion group whilst 35 out of 108 patients (32.4%) in complete recovery otitis media with effusion group (p = 0.021). The rate of 25(OH)Vitamin D deficiency was 25% in control group which was statistically different from chronic otitis media with effusion and recovery chronic otitis media with effusion groups (p = 0.006). Conclusions: This study not only shows the relationship between Vitamin D and otitis media with effusion development, but also demonstrates the effects of Vitamin D on otitis media with effusion prognosis. There is a significant association between 25(OH)Vitamin D deficiency and follow-up outcomes of otitis media with effusion.Öğe Does surgical technique significantly change the rate of post-tonsillectomy hemorrhage?(Duzce University Medical School, 2018) Dündar, Yusuf; Akcan, Hümeyra Bayram; Cebeci, Derya; Uluat, Ahmet; Akcan, Fatih AlperAim: Tonsillectomy is one of the most common surgical procedures in the pediatric population, as well as one of the first operations learned during otolaryngology residency. This study aims to evaluate the effect of surgical technique on the occurrence of post-tonsillectomy hemorrhage. Material and Methods: This prospectively-designed clinical trial was conducted in a tertiary referral center between May 2012 and April 2015. A total of 608 patients had tonsillectomies performed by a single surgeon with three different surgical techniques used during the study period. Patients in group one were operated on using cold dissection; group two comprised patients who underwent bipolar cautery; group three had the posterior pillar mucosal suturing technique performed. Results: 608 patients met inclusion criteria; 165 of them in group one, 274 in group two, and 169 in group three. The median age was 5 (2-14) years old. A total of five patients (0.82%) experienced post-operative bleeding. One of these patients (from group one) experienced primary hemorrhage. The four others were considered secondary hemorrhage; two from each the bipolar cautery and posterior pillar mucosal suturing groups. The rates of post-operative hemorrhage in each group were 0.61%, 0.73% and 1.18%, respectively (p=0.861). Only one of the five patients necessitated a return to the operating room to control the bleeding. Conclusion: Our study findings suggest that the choice of surgical technique does not affect the post-tonsillectomy bleeding rate. There were no significant differences in bleeding rates between subgroups. © 2018, Duzce University Medical School. All rights reserved.Öğe Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency(Springer, 2019) Akcan, Fatih Alper; Dündar, Yusuf; Akcan, Hümeyra Bayram; Uluat, Ahmet; Cebeci, Derya; Ünlü, İlhanObjectivesThe main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency.MethodsA total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency.ResultsThe mean 25(HO)Vitamin-D levels were 14.324.23ng/mL (7-24.6) and 29.38 +/- 7.05ng/mL (25-53.8) in study and control groups, respectively (p<0.001). The mean NMC time was 11.15 +/- 3.05 (6.3-17.6) and 8.40 +/- 2.33 (6-13.2) in study and control groups, respectively (p<0.001). The mean 25(HO)Vitamin-D level after the replacement protocol was 33.38 +/- 10.03 and the mean NMC time was 9.56 +/- 2.54 (p<0.001).Conclusion The mean NMC time was significantly increased in patients with Vitamin-D deficiency which can be corrected after Vitamin-D replacement protocols. The prolonged mucociliary clearance might be one of the pathophysiologic pathways at increased upper respiratory tract infections, and sinonasal and ear infections in patients with Vitamin-D deficiency.Öğe The Histopathological Findings of Adenoid Tissue After Topical Mometasone Furoate Implementation(Duzce Univ, 2018) Akcan, Fatih Alper; Akcan, Hümeyra Bayram; Dündar, Yusuf; Uluat, Ahmet; Karakuş, EsraObjective: Pediatric sleep disordered breathing (SDB) is a common childhood disease with a potential risk of several comorbidities. The most common cause of SDB in childhood is upper airway obstruction due to adenotonsillar hypertrophy and the classical treatment is adenotonsillectomy. However, it carries a risk of many complications and persistent apnea. Topical nasal steroid treatment may be an alternative to surgery in the treatment of pediatric SDB. However, histopathological effects of topical nasal steroids are mostly understudied. Methods: A retrospective controlled clinical study in an academic tertiary referral center. A total of 110 children were involved in the study who underwent adenoidectomy for the treatment of SDB. The study group (51-children) was treated with topical nasal mometasone furoate monohydrate 100 mcg/day. The control group (59-children) was selected randomly and all had no history of topical nasal steroid pre-operatively. Post-operative adenoidectomy specimens were reviewed according to acute/chronic inflammation findings, follicular hyperplasia, goblet cell hyperplasia, squamous metaplasia, fibrosis, atrophy, ulcer and hemorrhage. The findings were scored semiquantitatively for statistical analysis. Results: Chronic inflammation findings, follicular hyperplasia and goblet cell hyperplasia were significantly decreased in the study group in addition fibrosis, atrophy and ulcer findings were significantly increased in the study group. However, there was no statistical difference between the groups according to acute inflammation and hemorrhage. Conclusions: Topical nasal corticosteroids significantly suppress the nasopharyngeal inflammatory process in SDB. This treatment may be an alternative to surgery at least in patients with mild and moderate disease.Öğe Is anemia in children with sleep disordered breathing actually a consequence of chronic disease?(2018) Akcan, Fatih Alper; Dündar, Yusuf; Akcan, Hümeyra Bayram; Uluat, Ahmet; Cebeci, Derya; Sungur, Mehmet AliObjectives. We aimed to investigate iron metabolism and laboratory findings of anemia in children undergoing adenotonsillectomy for sleep disordered breathing. Methods. Consecutive children undergoing adenoidectomy/adenotonsillectomy for sleep disordered breathing between January 2013 and January 2015 were investigated. Routine preoperative blood tests including blood count and iron studies were analyzed. Subgroup analyses were performed addressing to the severity of sleep disordered breathing, age and duration of symptoms. Results were compared between subgroups and normal values. Results. The study included 171 children. The mean age was 5.44 2.62 years. The mean hemoglobin level was 11.87 1.125 gr/dL and 24 (14%) out of 171 patients had anemia ( 11 gr/dL). The mean ferritin levels were 23.23 17.27 µg/L and 21.27 15.44 µg/L in patients with anemia and non-anemic patients, respectively (p 0.572). Ferritin levels decreased in only 8 (33%) out of 24 patients with anemia. The mean age, body mass index, hematocrit, mean corpuscular volume, unsaturated iron binding capacity and serum iron levels decreased in patients with anemia. The rate of anemia significantly increased in children less than or equal to 3 years of age (p 0.020). There was no significant association between hemoglobin levels and sleep disordered breathing clinical score or duration of symptoms. Conclusion. The association between low iron status and sleep disordered breathing has previously published. Unfortunately, the type of anemia is still unclear. Our results supposed that the anemia of chronic disease secondary to chronic inflammatory process might play a role in pathogenesis of anemia in patients with sleep disordered breathing.Öğe Pediatric Tracheotomies: A 5-Year Experience In 152 Children(Deomed Publ, Istanbul, 2018) Akcan, Fatih Alper; Dündar, Yusuf; Uluat, Ahmet; Cebeci, Derya; Sungur, Mehmet Ali; Salman, Nergis; Ünlü, İlhanObjective: To analyze the indications, complications, and outcomes of pediatric tracheotomies. Material and methods: All tracheotomies performed in a tertiary referral center between January 2011 and December 2015 were reviewed retrospectively. Demographic characteristics of patients, types of referral to hospital, tracheotomy indications, preoperative evaluation findings, surgical technique, postoperative care and complications, discharge and follow-up results were analyzed. Results: A total of 152 pediatric patients underwent tracheotomy at our hospital during this five year period. The median age of patients at the time of tracheotomy was 15.8 months, ranging from 24 days to 17 years. Of the 152 patients, 91 had neurological diseases, 38 had cardiopulmonary diseases, 14 had craniofacial abnormalities, seven had upper airway obstruction, and two underwent tracheostomy for trauma. Eleven (7.2%) patients experienced early complications, and 15 (9.8%) experienced late complications. Twenty (13.1%) patients were decannulated during the follow-up period. Unfortunately, 9 patients (5.9%) died of primary disease and 3 patients (1.9%) died of tracheostomy-related complications Conclusions: The majority of procedures were performed for diseases leading to prolonged mechanical ventilator support such as neurological and cardiopulmonary diseases. This study demostrates the importance of tracheotomy indications, which are the main predictors of decannulation rates. The other significant predictor is pulmonary complications that may cause permanent dependence of mechanical ventilator support as a result of pulmonary failure.Öğe A Presentatıon Of Anunusual Nasal Dermoıd Cyst And Its Treatment(2017) Akcan, Fatih Alper; Dündar, Yusuf; Uluat, Ahmet; Salman, Nergis; Ünlü, NisaA nasal dermoid cyst is a rare developmental anomaly seen in children. There are many classification systems of dermoid cysts according to anatomic localisation or extent of the lesions. However, comprehensive classifications have not been reached. We have reported a case of a nasal dermoid cyst located in a bone capsule in the left nasal passage. This is an unusual localisation for these cysts, which usually occur at the anterior skull base. A full endoscopic resection of the left nasal dermoid cyst was successfully performed. There were no peri-operative complications. All classifications describeintraosseous nasal dermoid cysts at the anterior skull base, at the nasal bone. This is the first case report of an intraosseous nasal dermoid cyst located at the posterior nasal passage. The clinical features and successful endoscopic treatment of this unusual patient are presented in the literature.