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  • Küçük Resim
    Öğe
    Antioxidant, Antimicrobial and Phenolic Component Analysis of Some Edge Medicinal Plants
    (2023) Ulger, Sultan; Uğraş, Serpil
    Objective: The plants, which grow wild in the Eastern Anatolia Region and are known as kari (Arum elongatum; Ae) and mende (Chaerophyllum macrospermum; Cm), are used for treatment purposes such as pain reliever and wound healing properties. It is aimed to determine some biological properties of these plants, which are also used medicinally. Material-Method: Firstly, hexane (H), ethanol (E) and acetone (A) extracts of dried plants were prepared and antimicrobial activities of extracts against 13 indicator microorganisms were determined by agar well diffusion method. Antioxidant activities were determined by DPPH and ABTS analyses and the total phenolic component contents were determined by the Folin-Ciocalteu method. Results: The maximum extract yield was obtained in the ethanol extracts of the plants (AeE;10.4011% CmE;2.4898%), the minimum extract yield was obtained in the acetone extracts (AeA;0.8422% CmA;0.3510%). The hexane extract of A. elongatum has no inhibition activity against E. faecalis and L. monocytogenes, but it has inhibition activity against other indicator microorganisms. The other extracts of A. elongatum and all extracts of C. macrospermum were found to have inhibitory activity against all indicator microorganisms. Furthermore, the highest phenolic content was calculated as 54.60±0.486 ?g mL-1 (AeE) and the lowest content as 3.47±0.001 ?g mL-1 (CmA). As a result of the DPPH method the highest IC50 was calculated as 32.4140 ?g mL-1 (CmH) and the lowest IC50 as 12.7876 ?g mL-1 (AeA) and ABTS method the highest IC50 was calculated as 10.3203 ?g mL-1 (CmE), and the lowest IC50 as 0.2744 ?g mL-1 (CmA). Conclusion: These results show that the plant extracts have strong antimicrobial activity and antioxidant activity.
  • Küçük Resim Yok
    Öğe
    Synthesis of magnesium monoperoxyphthalate (MMPP) used as bleach for denim industry, denim fabric applications and some analysis for human health impacts
    (Taylor & Francis Ltd, 2025) Ugras, Serpil; Karagul, Bora; Ulger, Sultan; Akbulut, Derya; Akkurt, Mustafa
    This study aimed to synthesize the eco-friendly organic bleach magnesium bis(monoperoxyphthalate) hexahydrate (MMPP) using a modified method and to develop various chelating agents to enhance its effectiveness. Additionally, the study sought to determine the antimicrobial and cytotoxic properties of MMPP and to compare it with KMnO4, which is actively used in the denim industry. As a result of the studies, a highly efficient molecule that can be used in denim bleaching was synthesized with a new modified method specific to this study. Furthermore, maximum efficiency in bleaching applications was achieved by using C6H6MgO7 (5%) and HEDP (5%) as chelating agents. Furthermore, it was determined that MMPP has high inhibitory activity against pathogenic microorganisms at low doses (MIC values; 312.5-625.0 mu g/mL for bacteria and 4-8 mg/mL for yeast). It was determined that antibacterial dosages were not cytotoxic. MMPP did not show any toxic effect against eukaryotic cells in the range of 1 mu g/mL - 1 mg/mL. These studies were compared with KMnO4, which is used all over the world in bleaching technology and is in the class of very dangerous chemicals. It was determined that MMPP and KMnO4 have similar bleaching effects in fabric applications. KMnO4 does not have antimicrobial activity and its cytotoxic activity results are like MMPP. It can be said that MMPP has a superior feature compared to KMnO4, thanks to its antimicrobial properties. Finally, MMPP differs from existing bleach chemicals in that it has high antimicrobial activity and does not have cytotoxic activity and can be said to be a strong alternative to dangerous bleaches as KMnO4. Compared to other bleaching agents, the most significant advantage of the MMPP molecule is that it does not generate harmful by-products and poses no threat to human health or the environment.