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    Hypervitaminosis D rarely causes hypercalcemia: new concept subclinical intoxication
    (Düzce Üniversitesi, 2018) Pekkolay, Zafer; Kılınç, Faruk; Altun Tuzcu, Şadiye; Tuzcu, Alpaslan Kemal
    Aim: D vitamins have beenused by physicians and the public more often than usual in recent years. Dvitamin intoxication 25 OH vitamin D level gt; 150 ?g / L calcium level gt;10.5 mg / dl is defined as. In clinical practice, hypercalcemia may not beobserved at very high 25 OH vitamin D levels. The reason for this is unknown. The purpose of this  study is toinvestigate  the percentageof hypercalcemia in patients with very high 25 OH D levels.Material-Methods: BetweenJanuary 1, 2016 and October 31, 2017, 22996 patients who were referred tohospital and examined 25 OH vitamin D levels from all patients were screened atthe Dicle University Medical Faculty Hospital. Patients with 25 OH vitamin Dlevels gt; 150 ?g / L were included in the study. The calcium, phosphorus,creatinine, albumin and parathormone values of these patients, if any, were checked.Rates of hypercalcemia in patients with hypervitaminosis D were evaluated. Thevitamin D preparations they used were recorded. Vitamin D was measured by HPLCmethod. Ethical committee opinion was taken for the study.Results: The number of patientswith vitamine D gt; 150 ?g / L was approximately 1/1000 (0.0013%). Age 56 ± 20(24-90). More frequent in females 21 K 6 E (78/12%). 25 OH Vitamin D 184.81 ±35.37 (150.51-279.64) ?g /L, and D vitamine levels after replacement weremeasured after 2.10 ± 1.58 months. Calcium 9.48 ± 0.52 (8.4-10.9) mg /dL.Percentage of hypercalcemia in patients with vitamin D gt; 150 ?g /L was 3.70.Conclusion: As aresult, very high levels of vitamin D do not show toxicity. When vitamin Dlevel is above the level of toxicity, calcium and phosphorus control should beperformed. Very high vitamin D levels are often attributed to too much ampoule use. Close follow-up and appropriate dose treatment of thepatients will solve this problem. There is a need for studies involving a largenumber of patients with randomized controlled, multicenter, genetic andmetabolic parameters for the correct definition of vitamin D toxicity.