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    In vitro Antiradical, Antimicrobial and Antiproliferative Activities and Phytochemical Compositions of Endemic Alcea calvertii (Boiss) Boiss. Flowers
    (2020) Keser, Serhat; Keser, Fatma; Tekin, Suat; Kaygılı, Ömer; Turkoglu, Ismail; Demır, Ersin; Turkoglu, Semra
    Alcea calvertii (Boiss) Boiss. is belonged to Malvaceae family, and it is a perennial herbaceous endemic plant.Alcea genus plants are grown as ornamental plants in the gardens. In the present study, the antiproliferative,antimicrobial, antiradical activities and phytochemical compositions of ethanol, water, methanol and acet oneextracts of A. calvertii flowers were examined. A. calvertii flowers water, ethanol, methanol and acetone extractsare lower scavenged DPPH, ABTS and OH radicals than standard antioxidant trolox. A. calvertii flowers containvitamins, sterols, flavonoids and phenolic acids, dominated by vanillic acid, gallic acid, catechin, ?-tocopherol,ergosterol and vitamin D. A. calvertii flowers water extract showed better antiproliferative activities than otherextracts against to MCF-7 and HCT-116 cell lines. A. calvertii flowers methanol extract showed higherantiproliferative effect against to LNCaP cell lines.
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    In Vitro Biological Evaluation and Phytochemical Contents of Three Centaurea L. Species Growing from Eastern Anatolia in Turkey
    (2020) Keser, Serhat; Keser, Fatma; Turkoglu, Ismail; Kaygılı, Ömer; Tekin, Suat; Demır, Ersin; Turkoglu, Semra
    Centaurea L. species were used as medicinal plants among thepeople for treatment of the common cold, abscesses, peptic ulcers,hemorrhoid and diabetes etc.. In the present study, antiradicalproperties, phytochemical contents, antimicrobial andantiproliferative activities of three Centaurea species wereinvestigated. Centaurea saligna (K.Koch) Wagenitz methanol(99.94%), Centaurea virgata Lam. methanol (98.23%) and water(98.10%) extracts were showed higher ABTS scavenging than trolox(96.79%). Centaurea kurdica Reichardt extracts showed loweractivity than trolox for all the antiradical assays. Centaurea extractsexhibited antimicrobial activity against to some microorganisms. Itwas determined that these Centaurea species contain high amount oftotal flavonoid, phenolic and proanthocyanidin, phenolic acids,phytosterols and unsaturated fatty acids. Also, three Centaureaextracts showed very high antiproliferative property on LNCaP,HCT-116, MCF-7 cancer cell lines.