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    Can Inflammatory Indexes Predict the Severity of Mucosal Inflammation in Ulcerative Colitis?
    (Düzce Üniversitesi, 2024) Küçük, İrfan; Tural, Ersin
    Aim: Inflammatory indexes can relate to disease activity in ulcerative colitis (UC). This study aimed to evaluate whether the inflammatory indexes of neutrophil-lymphocyte ratio (NLR), C-reactive protein (CRP)-albumin ratio (CAR), CRP-lymphocyte ratio (CLR), and systemic immune-inflammation index (SIII) might predict the severity of mucosal inflammation in UC.Material and Methods: This retrospective case-control study included 184 UC patients and 101 healthy controls. The Mayo clinical score and Mayo endoscopic score were used for the clinical and endoscopic features of UC. Truelove and Richards’s method for the severity of mucosal inflammation determined the histological activity index (HAI).Results: The inflammatory index values, were higher in UC patients compared to the control group (p=0.007 for NLR, and p lt;0.001 for the others). The patients having endoscopic, clinic, and histologically active disease had higher inflammatory index values than those in remission (p lt;0.001 for all). UC patients with extensive disease had higher inflammatory index values than the patients who had limited disease (p lt;0.001 for all). The HAI values were positively correlated to all inflammatory indexes, and the correlation was the strongest between the HAI and CLR (rho=0.737, p lt;0.001). Regarding HAI, the diagnostic accuracy of all inflammatory indexes for detecting the clinically active disease was statistically significant, and there was no significant difference between them in terms of diagnostic accuracy.Conclusion: The inflammatory indexes of NLR, CAR, CLR, and SII might predict the severity of histological inflammation in UC.
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    An Examination of the Factors, Which May Affect the Duration of Admission to the Hospital of Panic Diagnosed Patient in Surgical Pathology during and Pre-COVID-19 Pandemic
    (Duzce Univ, Fac Medicine, 2021) Issın, Gizem; Gamsızkan, Mehmet; Tural, Ersin; Çağatay, Diren Vuslat; Çimen, Ferda Keskin
    Objective: This study aimed to determine the duration of hospital admission of the panic diagnosed patients in surgical pathology, examine the factors that may influence hospital admission time, and identify the impact of the COVID-19 pandemic on hospital admission time. Methods: The panic diagnosed patients in surgical pathology between January 2018 and January 2021 were determined. These patients' demographic, clinical, and critical diagnostic form data were documented. The duration of hospital admission of patients during and pre-COVID-19 pandemic period was determined. Results: There were 65 panic diagnosed cases in surgical pathology, of which one patient had leukocytoclastic vasculitis, 10 patients had uterine contents without villi or trophoblasts, and 54 patients had unexpected malignancy. The mean time of admission to the hospital of verbally informed and not verbally informed cases were five days and 156 days, respectively, in the pre-COVID-19 group. All cases in the COVID-19 pandemic group were verbally informed about critical diagnosis and the mean time of admission to the hospital was 18 days (1-40). Admission times were on mean about 13 days longer in verbally informed cases in the COVID-19 pandemic group compared to verbally informed cases in the pre-COVID-19 group. Conclusions: We determined a dramatic decrease in the number of panic diagnosed cases in surgical pathology during the COVID-19 pandemic and patients who are verbally informed admitted to the hospital in a shorter time. The integration of panic diagnosis notification systems to health applications and primary responsible family physician's systems may be useful for preventing unwanted delays.