Yazar "Tunca, Mustafa" seçeneğine göre listele

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    Anti-TNF agent etanercept augments UV-induced skin cancer development in SKH-1 mice(dagger)
    (Taylor & Francis Ltd, 2019) Çalışkan, Ercan; Gamsızkan, Mehmet; Yürekli, Aslan; Botsalı, Ayşenur; Kabalar, Mehmet Eşref; Demiriz, Murat; Tunca, Mustafa
    Background: Despite being employed in the treatment of inflammatory disorders for more than 20 years all over the world, data regarding photocarcinogenic risks of anti-TNF agents is scarce. Objective: To assess photocarcinogenic potential of anti-TNF agents. Methods: This was a placebo controlled, split-body (UVB-treated versus -untreated) study on mice. Treatment groups were infliximab (n = 11), etanercept (n = 11), cyclosporine (n = 11) and vehicle control (n = 11). Agents were introduced on the 10th week of phototherapy and continued through 24th week. The macroscopic, histological and immunohistochemical analysis of test sites were carried out. Results: Overall 132 tumors were detected on test sites. All of these tumors developed on UV-exposed sides. Histologic examination of these tumors was compatible with keratinocytic neoplasia in 128, mastocytosis in 3, epidermal cyst in 1. Median tumor burden in the UVB exposed areas for ETN, IFX, CYC, and control groups were 14.91, 10.20, 6.28, and 3.14 cm(2), respectively. ETN group demonstrated both higher tumor burden and keratinocytic neoplasia numbers than controls (p = .03, p = .025). Although there were 1.8 and 1.7 times more keratinocytic neoplasms in IFX and CYC groups compared to controls, these differences didn't reach statistically significant levels (p = .14; p = .19). Conclusion: This study points out to a significant photocarcinogenic potential of anti-TNF agent etanercept.
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    Cryosurgery to remove perichondrium for the rabbit ear hypertrophic scar model: a simplified method
    (Dermatovenerological Soc Slovenia, 2019) Tunca, Mustafa; Gamsızkan, Mehmet; Yürekli, Aslan; Göksel, Berk Alp; Çiçek, Ali Fuat; Çalışkan, Ercan
    Introduction: The rabbit ear hypertrophic scar model is a preferred animal model of excessive scarring for investigating the scarring process and novel treatment modalities. In this model, surgical removal of perichondrium can be challenging, and it is often insufficient or damages the underlying cartilage. It is hypothesized that cryosurgery would offer a more efficient alternative to conventional surgery. The objective of this study was to compare structural changes in scar tissues in two groups of the hypertrophic scar model: cryosurgery compared to standard conventional surgery. Methods: We introduced a novel technique to remove perichondrium using cryosurgery. Hypertrophic scars obtained with conventional surgery and cryosurgery were studied in a left-right comparison method. Comparative parameters included the histological structure of the scars and structural changes in the cartilage just beneath the scarring. Results: Cryosurgery produced similar scars in comparison to conventional surgery. Although statistically not significant (p = 0.16), the histological findings of cartilage damage were lower in the cryosurgery group (six out of 21) compared to the established model (10 out of 20). Conclusions: This study suggests that cryotherapy can be used for removal of perichondrium.