Yazar "Tufan, Ali Evren" seçeneğine göre listele
Listeleniyor 1 - 20 / 20
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Altered serum levels of vascular endothelial growth factor and glial-derived neurotrophic factor but not fibroblast growth factor-2 in treatment-naive children with attention deficit/hyperactivity disorder(Taylor & Francis Ltd, 2019) Yurteri, Nihal; Şahin, İbrahim Ethem; Tufan, Ali EvrenBackground and aim: Recent evidence suggests that growth factors might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). The aim of this study was to determine whether serum levels of brain-derived neurotrophic factor (BDNF), glial-derived neurotrophic factor (GDNF), neurotrophin-3 (NT-3), nerve growth factor (NGF), fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) were altered in children with ADHD.Methods: Serum levels of BDNF, GDNF, NT-3, NGF, VEGF and FGF-2 were analyzed in 49 treatment- naive children with ADHD and age, gender matched 36 healthy controls using enzyme-linked immunosorbent assay. ADHD symptoms were scored by Du Paul ADHD Rating Scale and Strengths and Difficulties Questionnaire.Results: We found that serum VEGF levels were significantly lower (p<0.001) and GDNF levels were significantly higher in ADHD group compared to control group (p=0.003). However, we found no correlations between ADHD symptoms and serum VEGF or GDNF levels. Furthermore, we observed no significant alterations in serum BDNF, NT-3, NGF, FGF-2 levels in children with ADHD.Conclusion: To our knowledge, the present study is the first to examine serum VEGF and FGF-2 levels in children with ADHD. Our results indicate that VEGF and GDNF might be involved in the etiology of ADHD. Further studies are required to determine the role of growth factors in the etiology and consequently in the treatment of ADHD.Öğe Attention Deficit Hyperactivity Disorder Comorbidity in an Adolescent Diagnosed with L-2 Hydroxyglutaric Aciduria and Response to Atomoxetine Treatment: a Case Report(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2016) Yektaş, Çiğdem; Tufan, Ali EvrenL-2-hydroxyglutaric aciduria (L-2 HGA) is a rare, neurodegenerative, slowly progressing and autosomal recessively inherited metabolic disorder. The disease progresses with mental retardation, behavioral disorder, ataxia, extrapyramidal signs and epileptic seizures. Diagnosis is made by detection of increased levels of L-2-hydroxyglutaric acid in urine, plasma or cerebrospinal fluid. In this report, we presented a 13 year old male patient diagnosed with L-2 HGA and had seizures, intellectual disability, attention deficit hyperactivity disorder (ADHD) symptoms and failure in school performance. Here we discussed this rare disease with ADHD symptoms and the response to atomoxetine treatment.Öğe Attention Deficit Hyperactivity DisorderComorbidity in anAdolescent Diagnosed withL-2 Hydroxyglutaric Aciduriaand Response toAtomoxetine Treatment:a Case Report(2016) Yektaş, Çiğdem; Tufan, Ali EvrenL-2-hidroksi glutarik asidüri tanılı bir ergende dikkat eksikliği hiperaktivite bozukluğu eş tanısı ve atomoksetin tedavisine yanıt: Bir olgu sunumuL-2-hidroksi glutarik asidüri (L-2 HGA) nadir görülen, yavaş ilerleyen ve otozomal resesifkalıtılan nörodejeneratif metabolik bir hastalıktır. Hastalık mental retardasyon, davranış bozukluğu, ataksi, ekstrapiramidal bulgular ve epileptik nöbetlerle seyreder. Tanı; idrar, plazma ya da serebrospinal sıvıda L-2hidroksiglutarik asid yüksekliği ile konulur. Bu yazıda nöbetler, mental retardasyon, dikkat eksikliği hiperaktivite bozukluğu (DEHB) belirtileri, okul başarısında sorunlarla belirti veren ve L-2 HGA tanısı konulan 13 yaşında bir erkek hastadan bahsedilmiş olup nadir görülen bu hastalığa eşlik eden DEHB semptomlarına atomoksetin tedavi yanıtı tartışılmıştır.Öğe Cinsel istismar mağduru çocuk ve ergenlerde istismar ve istismarcıya ilişkin özelliklerin ve psikopataloji ile ilişkili risk etkenlerinin değerlendirilmesi(2018) Yektaş, Çiğdem; Tufan, Ali Evren; Büken, Bora; Çetin, Nihal Yurteri; Yazıcı, MerveAmaç: Bu çalışmada, bir çocuk ve ergen ruh sağlığı ve hastalıkları kliniğine adli mercilerce yönlendirilen istismar mağduru çocuk ve ergen olguların sosyodemografik özelliklerinin, istismar ve istismarcıların niteliğinin ve istismar sonrası klinik tanılarının değerlendirilmesi ile psikopatoloji gelişimini yordayan etkenlerin belirlenmesi amaçlan-mıştır. Yöntem: Adli mercilerce yönlendirilen 3-18 yaşları arasındaki 106 çocuk ve ergenin (83 kız, 23 erkek) sosyo-demografik ve klinik bilgileri dosyaları ve adli raporları incelenerek geriye dönük olarak değerlendirilmiştir. Bulgular: Örneklemin %63.2’si ergenlik dönemindeki kızlardan oluşuyordu. En sık bildirilen cinsel istismar tipi cinsel uyarılma için bedene dokunmaydı (%47.2). Çocukların %10.4’ünün birden fazla yolla cinsel istismara uğradığı belirlendi. Olguların %32.1’i cinsel istismar sırasında fiziksel şiddet görmüştü. Örneklemin %17.0’si başka istismar türlerine de uğramıştı. Tüm örneklemde yineleyen cinsel istismar oranı %69.8 olarak saptandı. Cinsel istismar edilen olgula-rın %50.0’ının aile içinde farklı tipte istismarlara da uğradığı bildiriliyordu. Cinsel istismara maruz kalan çocuklara en sık konulan klinik tanılar sırasıyla travma sonrası stres bozukluğu (%24.5), uyum bozukluğu (%16.0) ve akut stres bozu kluğu (%11.3) oldu. Sonuç: Çalışmamızdaki olguların önemli bir bölümünün kızlardan oluşması kız çocukların daha fazla istismara maruz kaldığı bilgisini desteklemektedir. İstismarcıların hepsi erkek cinsiyette olup çoğunlukla çocuğun tanıdığı kişilerdir. Zeka geriliği olan ve istismar sırasında fiziksel şiddet gören çocuk ve ergen-lerde ruhsal sorun gelişme riski daha yüksek bulunmuştur. (Anadolu Psikiyatri Derg 2018; 19(5):501-508)Öğe Clinical and Sociodemographic Characteristics of Institutionalized Children in Duzce(Duzce Univ, 2018) Yektaş, Çiğdem; Tufan, Ali Evren; Yazıcı, MerveObjective: In this study, it is aimed to investigate sociodemographic and clinical characteristics of children and adolescents who are under institutional care in Duzce city and the factors that may be related to mental problems. Methods: A total of 61 children and adolescents in institutional care were enrolled at the Duzce University Child and Adolescent Psychiatry Department during the period of 2016-2018 years. Clinical evaluations of the patients were made according to the DSM 5 diagnostic system and the patients were evaluated by the Depression Scale for Children, Beck Depression Scale, Scanning and Assessment Scale for Anxiety and Related Disorders, Beck Anxiety Scale, and also the Screening and Assessment Scale for Disruptive Behavioral Disorders Based on DSM-IV was filled by institutional staff and teachers. Results: The most common causes of institutional care were poverty, failure to provide basic care for the child, neglect and abuse. The median age for to be institutionalized was 96 months, and the median duration for the institution care was 36 months. At least one psychopathology was found to be diagnosed in 90.2% of 61 children. The most frequent clinical diagnoses were ADHD, MDD, DBD, MR and LD. The relationship between psychopathology presence and parental separation also between inattention, hyperactivity / impulsivity, oppositional behaviour and behavioral problems reported by both teachers and institutional officials was found to be significantly correlated. Conclusion: Our findings may suggest that even if even if the child remains in the institution, the parents' ability to continue living together may have a protective effect. On the other hand, the behavioral problems reported by the institutional staff and the attention problems that teachers observe may be stimulating for different psychopathologies in these children.Öğe Comparison of serum B12, folate and homocysteine concentrations in children with autism spectrum disorder or attention deficit hyperactivity disorder and healthy controls(Dove Medical Press Ltd, 2019) Yektaş, Çiğdem; Alpay, Merve; Tufan, Ali EvrenObjective: We aimed to investigate the serum concentrations of vitamin B12, folate and homocysteine in children diagnosed with attention deficit hyperactivity disorder (ADHD) or autism spectrum disorder (ASD) and healthy controls. Materials and methods: Serum vitamin B12, folate and homocysteine concentrations were measured in 118 children (48 children diagnosed with ADHD, 35 children diagnosed with ASD and 35 healthy controls). Symptom severity in the ADHD and ASD groups was evaluated by the Childhood Autism Rating Scale and Turgay-DSM-1V-Based Screening and Assessment Scale for Disruptive Behavior Disorders. Multivariate analysis of covariance was used to evaluate the effects of diagnosis and gender on biochemical parameters. Results: The ADHD and ASD groups and the healthy controls differed significantly regarding vitamin B12 and homocysteine concentrations, but not folate levels. Patients with ASD had the lowest vitamin B12 and the highest homocysteine levels. Vitamin B12 levels correlated negatively with hyperactivity and/orimpulsivity and oppositionality symptoms in children with ADHD. There were no relationships between psychometric evaluations and laboratory measurements in children with ASD. Gender did not affect vitamin concentrations. Conclusion: Previous studies found that vitamin B12 was reduced while homocysteine was elevated among patients with ADHD and ASDs. Our results also support those reported previously. Oppositionality and hyperactivity and/orimpulsivity may be related to vitamin B12 and homocysteine levels in children with ADHD. Further studies are required to define the role of these parameters and effects on the etiology and clinical manifestations of ASD and ADHD.Öğe Evaluating clonidine response in children and adolescents with attention-deficit/hyperactivity disorder(Amer Inst Mathematical Sciences-Aims, 2018) Kütük, Meryem Özlem; Güler, Gülen; Tufan, Ali Evren; Sungur, Mehmet Ali; Topal, Zehra; Kütük, ÖzgürAttention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood, which is generally treated with stimulant and non-stimulant medications. However, 10-30% of patients in clinical setting do not present with adequate response to initial stimulant treatment. Thereby, clonidine may be considered for those patients who have failed to respond to psychostimulant/atomoxetine monotherapy or as an augmentation for inadequate response/comorbidity. This observational study evaluated its effectiveness as a single drug in ADHD cases unresponsive to previous treatment trials. Seventeen ADHD cases that were non-responders to stimulant, non-stimulant and combination therapy for the primary symptoms of ADHD were included in the study. Four cases dropped out before follow up, leaving thirteen cases who were administered immediate release clonidine treatment alone with a mean dose of 0.2 +/- 0.05 mg/day at baseline. The trial lasted for 12 weeks, and treatment outcomes were evaluated by the Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale (T-DSM-IV-S) and the Clinical Global Impressions-Severity (CGI-S) and Improvement (CGI-I) scales. Mean age of the sample was 12.5 years (SD = 3.0) and eleven of the subjects had another comorbid psychopathology. Only two cases were evaluated as "very much improved", while another patient was judged to be "minimally improved" after 12 weeks of clonidine treatment. Attrition during follow-up was associated with higher median scores on the hyperactivity and impulsivity subscales (Mann-Whitney U test, p = 0.02). According to the T-DSM-IV-S, CGI-S, and CGI-I scales, clonidine treatment by itself had minimal benefits in this sample of treatment of refractory cases with ADHD evaluated at the study center. Clonidine is not available in Turkey pharmaceutical marketing system and patients' access to drug is limited. Our results provide first data regarding the use of clonidine in Turkish ADHD patients.Öğe Evaluation of abuse and abuser's features and risk factors associated with psychopathology in children and adolescents victimized by sexual abuse(Cumhuriyet Univ Tip Fak Psikiyatri Anabilim Dali, 2018) Yektaş, Çiğdem; Tufan, Ali Evren; Büken, Bora; Yurteri Çetin, Nihal; Yazıcı, MerveObjective: The aim of this study to determine sociodemographic variables, characteristics of abuses and abusers, clinical diagnosis after abuse and factors associated with the psychopathology of sexually abused children and adolescents who referred to the department of child and adolescent psychiatry with the request of criminal report. Methods: Sexually abused 106 children and adolescents (83 girls and 23 boys) aged 3-18 years who referred for criminal reports were evaluated. Case files and criminal reports were examined retrospectively. Results: Great majority of the group was consisted of adolescent girls (63.2%). Touching to the body for sexual arousal was the most reported type of the sexual abuse (47.2%). 10.4% of the children reported multiway abuse. 32.1% of the cases experienced physical violence during sexual abuse. Other victims were also present in 17.0% (n=18) Recurrent sexual abuse was found in 69.8% of cases. 50.0% of sexually abused cases were also exposed to different types of abuse within the family. The most common clinical diagnoses were post-traumatic stress disorder (24.5%) adjustment disorder (16.0%) and acute stress disorder (11.3%). Conclusion: Consistent with the literature, our finding, in which a significant proporiton of the cases were girls, shows that the girls are exposed to the sexual abuse more than boys. All abusers are male who were mostly familiar to the victims. Children and adolescents with mental retardation and experienced physical violence during abuse had a higher risk of developing psychopathology.Öğe Imipramine-induced mania in a child diagnosed with attention-deficit/hyperactivity disorder (ADHD): a case report(Taylor & Francis Ltd, 2018) Yektaş, Çiğdem; Tufan, Ali EvrenChildren and adolescents treated with antidepressants (ADs) are at higher risk for developing hypomania and mania compared with adults. It was suggested that AD-induced mania represent a predisposition to bipolar disorder (BD) so it may accelerate the course of BD in this risky population. According to the literature, susceptibility to manic conversion with the use of ADs is higher in BD patients treated with tricyclic ADs compared with selective serotonin reuptake inhibitors (SSRIs) and placebo. Here, we report a six-year-old girl who was diagnosed with attention-deficit/hyperactivity disorder (ADHD) and primary nocturnal enuresis who developed manic symptoms after imipramine treatment. While using tricyclic antidepressants or SSRIs for different indications in the paediatric population, clinicians should be alert for the manic switch or behavioural activation symptoms, which may show a bipolar predisposition.Öğe Increased Frequency of Encopresis in a Child Diagnosed With Attention Deficit/Hyperactivity Disorder and Encopresis After Atomoxetine Use: A Case Report(Lippincott Williams & Wilkins, 2016) Yektaş, Çiğdem; Cansız, Mehmet Akif; Tufan, Ali EvrenAttention deficit hyperactivity disorder (ADHD) is among the most frequently reported coexisting psychiatric conditions in children with encopresis. Some case reports state that atomoxetine-a selective presynaptic norepinephrine reuptake inhibitor-approved for treatment of ADHD is also effective in the treatment of coexisting encopresis. Contrasting those reports, here we present a case diagnosed with ADHD and secondary encopresis without constipation whose encopretic symptoms increased after atomoxetine treatment and discuss possible mechanisms.Öğe Increased Trichotillomania Symptoms in a Child With Fluoxetine Treatment(Lippincott Williams & Wilkins, 2017) Yektaş, Çiğdem; Tufan, Ali EvrenTrichotillomania (TTM) is a mental disorder characterized by uncontrolled and impulsive hair pulling leading to hair loss, distress, and disordered functioning. Treatment choices include behavioral therapy (especially habit reversal training) and selective serotonin reuptake inhibitors. However, randomized controlled trials conducted with selective serotonin reuptake inhibitors have led to controversial results of effectiveness for TTM. Here, we report a female patient whose TTM symptoms increased after fluoxetine use.Öğe Loss of Eyebrows (Madarosis) After Use of Long-Acting Methylphenidate: Case Report(Lippincott Williams & Wilkins, 2017) Yektaş, Çiğdem; Samurcu, Nuran Demir; Tufan, Ali Evren…Öğe Maculopapular Rash Related to Atomoxetine: Case Report(2020) Kasar, Nurdan; Yektaş, Çiğdem; Tufan, Ali EvrenExanthematous drug eruptions, also known as maculopapular drug eruptions, are the most common drug-induced hypersensitivity reactions. Pruritus, urticaria, exanthematous rash, fixed drug eruption, photosensitivity, pigmentation and alopecia are common skin reactions to psychotropic medications. Atomoxetine (ATX), a selective inhibitor of presynaptic norepinephrine transporters (SNRI), is classified as a non-stimulant and is commonly used in the treatment of attention deficit hyperactivity disorder (ADHD). It also binds to dopamine and serotonin transporters with a low affinity. Abdominal pain, loss of appetite, somnolence, irritability, fatigue, dizziness and dyspepsia are the most common side effects of ATX. Major cutaneous drug reactions with SNRIs are rarely reported in the literature. Here we present an eight-year-old girl diagnosed with ADHD who had a drug-induced skin reaction after an increase in the dosage of ATX treatment.Öğe Novel inflammatory targets for immunotherapies in pediatric patients with trichotillomania(Elsevier GmbH, 2020) Kütük, Meryem Özlem; Tufan, Ali Evren; Kılıçaslan, Fethiye; Mutluer, Tuba; Gökçen, Cem; Karadağ, Mehmet; Kütük, ÖzgürImmune dysregulation may be important in the etiology of obsessive-compulsive and related disordersandbody-focusedrepetitivebehaviors, such as Trichotillomania (TTM). The role of inflammation and inflammatory markers in TTM has received relatively little attention. This study was aimed to determine the expression levels of inflammatory markers (i.e. IL-1?, IL-1?, IL-4, IL-6, IL-17, TNF-? and TGF-?) in peripheral blood mononuclear cells of children with TTM and healthy controls and to evaluate their association with clinical variables. Seventy-seven patients with TTM and 107 healthy controls were enrolled in the study. Peripheral blood was collected in standardized conditions. The mean age of patients and controls did not differ significantly (10.8 ± 4.4 and 12.0 ± 3.2 years; respectively). The majority of patients with TTM and controls were females (n = 55, 71.4 % and n = 55, 51.4 %; respectively); with a greater preponderance of females among TTM. Patients with TTM had significantly elevated expression levels of TNF-?, IL-6 and IL-17 compared to controls. However, the expression level of IL-4 was significantly reduced in TTM patients compared to controls. Accordingly, we found a pro-inflammatory state in TTM and those findings may suggest novel treatment options for TTM and further, cross-disciplinary studies focusing on neuro- inflammation in TTM conducted on larger samples are needed. © 2020 Elsevier GmbHÖğe Predictors of Severe and Permanent Disability in Children Evaluated in Health Boards: A Single-Center Study(2020) Yıldırım, Didem Derici; Biçer, Ali; Kütük, Meryem Özlem; Toros, Fevziye; Tufan, Ali Evren; Aksu, Gülen Güler; Dağ, PelinAim: The aim of this study is to determine the severe and permanent disability of the childrenevaluated in the disabled health boards and to evaluate the predictors of severe and permanentdisability.Material and Methods: Records of 1482 children who were referred to a university hospitalhealth board for disability between the years 2013-2018 were screened retrospectively.Results: More than half (52.2%) of the children had a single psychopathology. 83.5% of thecases were severely disabled and 66.5% were permanently disabled. Severely disabled childrenwere significantly more likely to have psychiatric, pediatric, neurological, orthopedic andotorhinolaringologic disorders. Permanent disability was significantly more frequent amongpatients with pediatric, ophthalmologic and cardiac disorders while children withpsychopathologies were significantly less likely to have permanent disability. Mentalretardation/intellectual developmental disorder levels differed in rates of permanent disabilitywith pair-wise comparisons revealing that severe mental retardation/intellectualdevelopmental disorder was the main factor. Severe disability was significantly more commonamong children younger than 8 years while permanent disability was more common amongchildren >3 years. Children with psychopathology were 4.1 times more likely to have severedisability and this further increased to 15.3 for those with mental retardation/intellectualdevelopmental disorder.Conclusion: This is the first study to evaluate the factors that affecting the decisions ofpermanent and severe disabilities in disability health boards. Comprehensive results have beenachieved despite low generalizability. To provide consistent reports, further and multicenterstudies on factors associated with severe and permanent disabilities in children are needed.Öğe Prescribing Trends of Atypical Antipsychotic Drugs in an Outpatient Unit of a Child and Adolescent Clinic in Turkey(Lippincott Williams & Wilkins, 2018) Yektaş, Çiğdem; Tufan, Ali EvrenObjective Use of antipsychotic agents in the management of various psychopathologies in Child and Adolescent Psychiatric practice is gradually increasing. This study aimed to evaluate the sociodemographic and clinical features of children and adolescents who applied to an outpatient clinic of child and adolescent psychiatry department in Turkey and were prescribed atypical antipsychotics. Method Patients with prescription codes of ATC N05A (except N05AN lithium) were accepted to denote those with atypical antipsychotic treatment. Sociodemographic and clinical variables, pharmacological mechanisms and groups and use of multiple agents for 212 patients with atypical antipsychotic treatment were collected and recorded. Results Patients (6.6%) evaluated within a year were prescribed antipsychotic agents (APs). The majority of the sample consisted of adolescents and especially females. The most common diagnoses managed with atypical antipsychotic were attention-deficit/hyperactivity disorder, MDD, and mental retardation/intellectual disability in decreasing frequency. Males with attention-deficit/hyperactivity disorder, CD, and autism spectrum disorders and females with MDD and PTSD were more frequently prescribed APs. Most common indications were irritability, impulsivity, and self-harming behaviors. Most common agents were risperidone, aripiprazole, and quetiapine in decreasing order of frequency. Most common adverse effects were reported as sedation, increased appetite, and hyperprolactinemia. Conclusions Our results support the prevalence of off-label use of AP agents in managing various childhood psychopathologies also in Turkey. Further studies from multiple centers and using reliable and valid measurements are needed to determine the extent and predictors of AP use in outpatient samples from different child and adolescent centers.Öğe Sleep habits of children diagnosed with attention/ deficit/ hyperactivity disorder and effects of treatment on sleep related parameters(Elsevier, 2020) Yektas, Cigdem; Tufan, Ali Evren; Sarigedik, EnesThis study aimed to evaluate the baseline sleep habits of children with ADHD and the effects of treatment with methylphenidate (MPH) and atomoxetine (ATX) on sleep parameters. Treatment naive children with clinically normal intelligence diagnosed with ADHD were enrolled in the study. Children were treated naturalistically with MPH and ATX. Treatments were started at 0.5 mg/ kg/ day and titrated weekly to a maximum of 1.2 mg/ kg/ day. The daily equivalent dose was calculated according to clinician toolkits of Utah Academy of Child and Adolescent Psychiatry. DSM-IV Based Screening and Assessment Scale for Disruptive Behavior Disorders- Parent form (DBSASDBD) and Clinical Global Impression Scale were used to assess ADHD symptoms and Children's Sleep Habits Questionnaire (CSHQ)- Short Form was used to assess the sleep habits and problems before and after the treatment. Both MPH and ATX reduced symptom severity of ADHD in all domains and also reduced total CSHQ scores with similar effect sizes. (0.7 for MPH vs. 0.8 for ATX). The rate of clinically significant sleep problems at baseline was 93.5 %. At the end-point, 83.9 % of the sample still displayed clinically significant sleep problems while none of the children were judged to have moderate-severe sleep problems. Our results suggest that both ATX and MPH may selectively improve different sleep domains in children with ADHD. Studies using standardized dosing schemes for longer durations and evaluating sleep with objective measurements may clarify the differential effects of treatments on sleep among children with ADHD.Öğe Spontaneous Ejaculations in an Adolescent With Olanzapine Use: Case Report(Lippincott Williams & Wilkins, 2016) Yektaş, Çiğdem; Tufan, Ali EvrenOlanzapine (OLZ) is a second-generation atypical antipsychotic (AAP) frequently used in acute and maintenance treatment of children and adolescents with psychotic disorders. Most commonly reported sexual problems caused by AAPs are decreases in libido or arousal, erectile dysfunctions, reduced/abnormal ejaculations, and problems in achieving or maintaining orgasm. Olanzapine is less commonly implicated for those adverse effects, which may reflect its more selective affinity to dopaminergic receptors or more transient effects on prolactin levels. Sexual dysfunction with AAPs, including OLZ, is reported predominantly in adult patients and adverse sexual effects in prepubertal/peripubertal patients with psychosis received scant attention. Studies and reports of sexual adverse effects of AAPs in this special population may benefit clinicians. Therefore, in this study, we report an adolescent male patient with psychosis who developed spontaneous ejaculations with OLZ and whose complaints remitted with change in treatment.Öğe Treatment Related Adverse Events In Children With Attention-Deficit/Hyperactivity Disorder Using Atomoxetine(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2021) Kasar, Nurdan; Yektaş, Çiğdem; Tufan, Ali EvrenObjective: The aim of our study is to evaluate treatment related adverse events in children with attention-deficit/hyperactivity disorder (ADHD) using atomoxetine. Material and Methods: One hundred eleven patients receiving atomoxetine treatment were included in this study. Evaluations were conducted with all participants and their parents using Turgay DSM-IV-Based Child and Adolescent Behavioral Disorders Screening and Rating Scale, Clinic Global Impression Scale and Atomoxetine Side Effect List. Results: Decreased appetite, irritability, loss of weight, fatigue, abdominal pain, constipation, change in sleep patterns, dizziness were common adverse effects of atomoxetine in our study. Diarrhea, rash and skin picking were rare. Changes in sleep patterns were more frequent in patients with the inattentive subtype (chi 2= 5.7, p=0.06, Cramer's V=0.25, Likelihood ratio). Patients using atomoxetine as the only treatment had constipation significantly more frequently than those receiving multiple regimens (p=0.02). Conclusion: Atomoxetine is generally safe and well tolerated. Further studies with a larger sample size are required to investigate adverse effects of atomoxetine treatment.Öğe Vitamin D status in children with attention-deficit-hyperactivity disorder(Wiley, 2014) Göksügür, Sevil Bilir; Tufan, Ali Evren; Semiz, Murat; Güneş, Cemalettin; Bekdaş, Mervan; Tosun, Mehmet; Demircioğlu, FatihBackgroundAttention-deficit-hyperactivity disorder (ADHD), one of the most common psychiatric disorders of childhood, has an early onset, affecting 2-18% of children worldwide. The etiopathogenesis of ADHD is obscure. In recent studies, a low level of vitamin D has been found in association with many disorders as well as in neuropsychiatric diseases. The aim of this study was therefore to investigate serum vitamin D level in pediatric ADHD patients. MethodsA total of 60 ADHD patients and 30 healthy controls were included in the study. The age of both groups was in the 7-18-year-old range. Serum 25-OH-vitamin D, calcium, phosphorus and alkaline phosphatase were investigated. ResultsSerum 25-OH-vitamin D was found to be significantly lower in children and adolescents with ADHD compared to healthy controls, and no significant differences were found between the groups in terms of other variables. 25-OH-vitamin D level in the ADHD group and control group was, respectively, 20.9 19.4ng/mL and 34.9 +/- 15.4ng/mL (P = 0.001). ConclusionThere is an association between lower 25-OH-vitamin D concentration and ADHD in childhood and adolescence. To the authors' knowledge this is the first study to investigate the relationship between vitamin D and ADHD in children.
