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Öğe Effect of isotretinoin use on hematological parameters and biochemical values(Bayrakol Medical Publisher, 2022) Karagöz, Yalçın; Tosun, MustafaAim: The aim of this study was to investigate the general effects of oral isotretinoin on hematological parameters and biochemical values, and to identify whether these values vary according to age and gender. Material and Methods: The study included 143 patients diagnosed with moderate or severe acne in the age range of 15-47 years. Patients were monitored retrospectively. Hematological parameters and biochemical values were recorded before treatment, then at the end of the first and third months of the treatment. Results: The serum lipid levels, creatinine, cholesterol, triglyceride and AST values of liver enzymes, and renal function values were found to increase after the onset of treatment. Hematological parameters including LYM, HGB, HCT, RDW, MCV, PLT, MPV and PCT parameters were seen to increase after the onset of treatment, while the NEU parameter decreased. The values of other hematological parameters did not change. Discussion: Although the use of oral isotretinoin has been shown to cause changes in hematological parameters and serum lipid levels, liver and renal function values, these changes usually remain within normal limits and continue with treatment.Öğe Effect of Tocilizumab Use on Mortality in COVID-19 Patients Admitted to Intensive Care Unit(2022) Tosun, Mustafa; Ölmez, HasanAim: Coronavirus disease 2019 (COVID-19) mostly proceeds with mild respiratory symptoms, but sometimes severe pneumonia, cytokine storm, and acute respiratory distress syndrome can develop. Anti-cytokine treatments are being tried for cytokine storm. In this study, we aimed to examine the effect of tocilizumab on mortality associated with COVID-19. Material and Methods: The study included 146 patients with moderate-to-severe acute respiratory distress syndrome diagnosed with COVID-19. The patients were divided into two groups, receiving only standard treatment (ST group, n=44), and tocilizumab treatment in addition to standard treatment (TCZ group, n=102). Groups were compared in terms of demographic, clinic, and laboratory data. Also, mortality rates were determined to detect the effect of tocilizumab on mortality. Results: Overall, 36.3% (n=53) of the patients were female, 63.7% (n=93) were male, and the mean age was 69.5±14.2 years. The mortality rate was 29.4% (n=30) in the TCZ group and 52.3% (n=23) in the ST group (p=0.009). While C-reactive protein, fibrinogen, and lactate levels on admission to the intensive care unit (ICU) were similar across the groups, the TCZ group had higher ferritin levels (p=0.006). On discharge from ICU, the TCZ group had a significant decrease in C-reactive protein (p<0.001), while their ferritin levels decreased to levels in the ST group (p=0.134). The absence of tocilizumab in the treatment regimen was associated with a 2.63-fold increase in the mortality risk. Conclusion: Tocilizumab reduces the mortality in COVID-19 patients in ICU. However, further studies are warranted to better elucidate the efficacy and side effects of tocilizumab.Öğe Rosacea-Specific Quality of Life Scale (RosaQoL): The Study of Adaptation and Validation for Turkish Rosacea Patients(Marmara Univ, Inst Health Sciences, 2022) Tosun, Mustafa; Karagoz, YalcinObjective: Rosacea-Specific Quality of Life Scale (RosaQoL) developed specifically for rosacea. The aim of the study was to adapt the RosaQoL Scale that is specific to Rosacea used in evaluating the quality of life of patients with Rosacea into Turkish, and evaluate its validity and reliability. Methods: The RosaQoL Scale is a 21-item index that is specific to Rosacea, and was developed originally in English. The Turkish Scale, which was created after the clinical examinations of the patients, was applied to the patients. A total of 285 people, 240 females (84.2%) and 45 males (15.8%), who were diagnosed with Rosacea, admitting to the dermatology clinic between May 2019 and August 2019 were included in the study. Results: The mean age of the patients was found to be 44.8 +/- 12.5 years in the study. The internal consistency of the scale (Cronbach's Alpha Coefficient) was found to be 0.952. The correlation coefficient was calculated as r=0.988 in the test-retest reliability. The total RosaQoL score was 62.4 +/- 11.5 (Mean +/- SD), and the total DLQI score was 7.85 +/- 5.04 (Mean +/- SD). For validity analysis, the correlation coefficient between RosaQoL and DLQI was calculated as r=0.411 (p<0.05). Conclusion: The Turkish version of the RosaQoL was valid and reliable for evaluating the quality of life of Turkish Rosacea patients.Öğe Rosacea-Specific Quality of Life Scale (RosaQoL): The Study of Adaptation and Validation for Turkish Rosacea Patients(2022) Tosun, Mustafa; Karagöz, YalçınObjective: Rosacea-Specific Quality of Life Scale (RosaQoL) developed specifically for rosacea. The aim of the study was to adapt the RosaQoL Scale that is specific to Rosacea used in evaluating the quality of life of patients with Rosacea into Turkish, and evaluate its validity and reliability. Methods: The RosaQoL Scale is a 21-item index that is specific to Rosacea, and was developed originally in English. The Turkish Scale, which was created after the clinical examinations of the patients, was applied to the patients. A total of 285 people, 240 females (84.2%) and 45 males (15.8%), who were diagnosed with Rosacea, admitting to the dermatology clinic between May 2019 and August 2019 were included in the study. Results: The mean age of the patients was found to be 44.8 ± 12.5 years in the study. The internal consistency of the scale (Cronbach’s Alpha Coefficient) was found to be 0.952. The correlation coefficient was calculated as r=0.988 in the test-retest reliability. The total RosaQoL score was 62.4 ± 11.5 (Mean ± SD), and the total DLQI score was 7.85 ± 5.04 (Mean ± SD). For validity analysis, the correlation coefficient between RosaQoL and DLQI was calculated as r=0.411 (p<0.05). Conclusion: The Turkish version of the RosaQoL was valid and reliable for evaluating the quality of life of Turkish Rosacea patients.