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    Effects of Hypoxia on the Vestibular System in Obstructive Sleep Apnea Syndrome Observed on a Video Head Impulse Test
    (Aves, 2021) Topuz, Muhammet Fatih; Oghan, Fatih; Akdağ, Gönül; Gülhan, Pınar Yıldız; Erdogan, Onur; Arık, Özlem; Ceyhan, Aykut
    Objective: The aim of this research was to investigate the effects of hypoxia, observed in patients with obstructive sleep apnea (OSA) syndrome, on vestibular functions through the application of video head impulse test (v-HIT). Methods: Patients with sleep apnea/snoring complaints and who had undergone polysomnography (PSG) between January 10, 2019, and January 10, 2020, received a full otorhinolaryngological examination and v-HIT in this prospective cohort study. Polysomnography findings of 83 patients with appropriate criteria for the study (age, sex, body mass index (BMI), apnea-hypopnea index (AHI), and mean oxygen saturation) and v-HIT findings were compared. Results: Patients included in the study were divided into 4 groups according to the AHI scores. When age, gender, BMI, AHI, and mean oxygen saturation data were examined, only AHI scores showed statistically significant differences (P =.000). There was no statistically significant difference present between the groups in terms of mean vestibulo-ocular reflex (VOR) gains, mean asymmetry, overt and covert saccades in the right ear, and overt saccades in the left ear. There was a statistically significant difference between the groups in the covert saccade in the left ear (P =.014). Of all patients included in the study, 72 patients (86.5%) had pathological VOR gains and/or at least 1 overt/covert saccade. Conclusion: Our study with v-HIT concluded that the vestibular system is affected just as other systems in patients diagnosed with OSA syndrome. The literature review has proved that similar results were achieved in studies evaluating the vestibular system.
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    Evaluation of Chronic Otitis Media-Related Risk Factors in Low Social-Economic Levels
    (Düzce Üniversitesi, 2018) Güler, Yavuz; Güler, Rukiye; Şen, Alper; Topuz, Muhammet Fatih; Özdamar, Kadir; Üstyol, Esra Aycan
    Aim: To examine the role of some changeable risk factors thought to be associated with chronic otitis media (COM) in the low socioeconomic status population and to contribute to the health policies that can be developed in this respect.Material and Methods: Between 1 October 2017 and 1 May 2018, 759 patients with low socio-economic status were evaluated in Balıklıgöl State Hospital Otorhinolaryngology outpatient clinics. The anamnesis of the patients was obtained and otoscopic examination was done. Patients with perforated COM diagnosed with otoscopic examination were found to have perforation on the eardrum at least 3-month. Patients were divided into two groups according to whether they were perforated COM with at least one ear. All patients were interviewed in terms of age, gender, educational conditions and ages of the parents, the household conditions, the number of individuals living in the household, economic incomes, duration of breastfeeding, food use, bottle feeding and passive smokers.Results: 221 (29.1%) of 759 patients included in our study were diagnosed with perforated COM. When the two groups were compared; In COM (+), female sex ratio, passive smoking exposure and feeding with bottle were statistically significant according to COM (-) (p=0.035, p lt;0.001 and p=0.048). Maternal literacy was statistically significantly lower in COM (+) than in COM (-) (p=0.041). Perforated COM was statistically more frequent between 0-12 months of breastfeeding (p=0.013).Conclusion: Passive smoking exposure during infancy, bottle feeding, female sex, and maternal illiteracy increase the risk of perforated COM. Breastfeeding for at least 12 months has a protective effect against COM. The social distribution of common diseases in society such as COM varies according to socio-economic level. By increasing the socio-economic level of society, the prevalence of such diseases can be reduced.
  • Küçük Resim
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    The importance of systemic immune-inflammation index in obstructive sleep apnea syndrome
    (Springer, 2022) Topuz, Muhammet Fatih; Ture, Nurullah; Akdağ, Gönül; Arık, Özlem; Gülhan, Pınar Yıldız
    Objective This study aims to explore the importance of systemic immune-inflammation index (SII) in patients diagnosed with obstructive sleep apnea (OSA). Materials and method In this study planned as a retrospective cohort, the files of the patients who presented with sleep apnea/snoring complaint between 10.01.2017 and 10.01.2021 and underwent polysomnography (PSG) and complete blood count analyses were reviewed. PSG findings (age, sex, body mass index (BMI), apnea-hypopnea index (AHI), mean oxygen saturation) were compared with SII in 194 patients meeting study eligibility criteria. Results Patients included in this study were divided into 4 groups by AHI value. Statistical difference was detected between the groups in terms of age, sex, body mass index (BMI), and mean oxygen saturation (p < 0.05). There is an approximately 30% positive statistically significant correlation between the severity of OSA and SII (p < 0.001). As for the mean SII values of the AHI groups, it was observed that the more severe AHI is, the higher the mean SII value is. The correlation between SII and the severity of OSA was found to be more significant than the correlation with neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR). Conclusion There is a significant correlation between SII and the severity of OSA. This correlation is stronger compared to NLR and PLR. SII can be used to demonstrate the chronic systemic inflammation observed in OSA patients, and can be utilized as a simple and inexpensive biomarker as it can be easily calculated from the parameters present in routine blood analyses.