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  • Küçük Resim
    Öğe
    Kalp Yetersizliği Olan Geriatrik Hastalarda Kemik Mineral Dansitometri ve Kalça Kırıklarının Değerlendirilmesi
    (Düzce Üniversitesi, 2019) Arslan, Arslan Kağan; Tolunay, Hatice
    Objectives: Osteoporosisdefined by low Bone Mineral Density (BMD), is a progressive disease affectingespecially older adults. Hip fracture is the important result of osteoporosis.  For the older adults, heart failure (HF) andosteoporosis are two common chronic conditions that are gaining importance forhealthcare. The aim of this study is to evaluate bone mineral density and hipfractures in geriatric aged patients with heart failureMethods: We retrospectively analyzed 157 geriatricpatients with heart failure and 155 geriatric control subjects without anycardiovascular disease and risk factors. All subjects underwent transthoracicechocardiography, biochemical analysis, and bone DEXA study. Osteoporoticfracture history and operation for fracture, list of current and prior use ofmedications were obtained from each center’s medical recordings.Results: Among the 157 patients, 45 (29%) had normalBMD, 14 (9%) had osteopenia, and 98 (62%) had osteoporosis.  In 155 control subjects,68 (44%) had normalBMD, 12 (8%) had osteopenia, and 75 (46%) had osteoporosis (P=0.019). Sixteensubjects (10.2%) in heart failure group and 6 subjects (3.9%) in controls hadhip fracture (p=0.029). Level of 25-hydroxyvitamin D was significantly lower inheart failure than in controls (15.1±10.2 vs. 29.1±20.4 ng/ml; p lt;0.001). Conclusion: Patients with heart failure have a lower bonemineral density, low vitamin D level and an increased rate of hip fractures.These findings can be explained by shared risk factors and pathogeneticmechanisms. Further prospective studies should be performed for evaluating therole of heart failure in osteoporotic hip fractures.  
  • Küçük Resim
    Öğe
    Triglyceride Glucose Index and The Triglyceride/HDL Ratio as Predictors of Coronary Artery Disease
    (2021) Fırtına, Serdar; Tolunay, Hatice
    Aim: Triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride-glucose (TyG) index are simple, reliable screening methods. It has been shown that the TyG index predicts mortality in cardiovascular diseases and the TG/HDL-C ratio predicts the severity of coronary artery disease (CAD). We planned a study to define the relationship between the SYNTAX score, which indicates the severity of CAD, and the TyG index and TG / HDL-C ratio.Material and Methods: A total of 408 patients who underwent coronary angiography were evaluated in this study. TyG index, TG/HDL-C ratio and SYNTAX scores were calculated. Patients were grouped according to their diagnosis and SYNTAX scores. Relationships between TyG index, TG / HDL-C ratio and SYNTAX score were examined.Results: There is a significant relationship between the TyG index and the presence of CAD (p<0.001). When the TyG index was evaluated in terms of the severity of CAD, there was a positive significant relationship between mild and severe CAD (p<0.040). While there was a significant positive correlation between TG/HDL-C ratio and the presence of CAD (p<0.001), there was no significant relationship between severity of CAD (p:0.814). There was a low level significant positive correlation in terms of TyG index between patients with unstable angina pectoris and ST-elevation myocardial infarction (p:0.046).Conclusion: The TyG index and TG/HDL-C ratio are predictors of the presence of CAD and the TyG index also provides guidance on the severity of CAD. Standard use may be considered in addition to risk scoring in the diagnosis of CAD and planning coronary angiography.