Yazar "Tokmak, Mehmet" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Effect of Taurine on Experimental Facial Paralysis and Dry Eye in Rats
    (Duzce University Medical School, 2025) Koc, Haci; Koçak, Ibrahim; Tokmak, Mehmet; Kale, Saim; Gök, Ali; Demir, Şerif
    Aim: This study aimed to evaluate dry eye development and the efficacy of taurine for dry eye treatment in a rat model with facial paralysis. Material and Methods: Thirty-two rats were divided into four groups with eight rats in each. The rats in groups 2, 3, and 4 underwent facial paralysis surgically, while the rats in group 1 remained as controls. The rats in group 2 did not receive any treatment. Group 3 was treated with 0.2% sodium hyaluronate, and group 4 was treated with 0.2% sodium hyaluronate and 0.5% taurine. The results of the first and last Schirmer’s tests were compared. Results: When the Schirmer’s tests were performed in rats with facial paralysis under general anesthesia to detect dry eye, the scores were low, indicating that general anesthesia increased dry eye in all groups. Thus, Schirmer’s tests were performed without general anesthesia. The final test results were significantly different between groups (p=0.001). Pairwise comparisons revealed that there was a significant decrease in groups 2 (p=0.001) and 3 (p=0.002) compared to the control group. Group 4 was similar to the control group (p=0.304) and had a significant improvement compared to group 2 (p=0.037). No statistically significant difference was found between groups 2 and 4 (p=0.566). Conclusion: Taurine seems to have the potential to be effective in relieving dry eye symptoms. This could be related to the dominantly antioxidant effect of taurine. These results warrant further studies with larger sample size to determine the effectiveness of taurine for dry eye treatment. © 2025 Elsevier B.V., All rights reserved.
  • Küçük Resim
    Öğe
    Effect of topical rifamycin application on epidural fibrosis in rats
    (Baycinar Medical Publ-Baycinar Tibbi Yayincilik, 2019) Dinç, Cem; Tuncer, Cengiz; Türkoğlu, Mehmet Erhan; Tokmak, Mehmet; Ocak, Pınar; Er, Uygur
    Objectives: This study aims to investigate the effects of topical rifamycin SV application on epidural fibrosis formation in a rat model. Materials and methods: Between March 2015 and April 2015, a total of 20 Wistar rats were equally and randomly divided into laminectomy only group (control group) and laminectomy and rifamycin SV group (treatment group). Laminectomy was performed between L3-L5 in all rats. Surgical field was irrigated with 1 mL rifamycin SV (1 mL). After four weeks, vertebral columns of the rats were removed en bloc between the L1 and L5 levels, and epidural fibrosis and arachnoid involvement were histopathologically evaluated and graded. Results: Grade 3 epidural fibrosis formation ratio was lower in the treatment group (40%) compared to the control group (80%). However, there was no statistically significant difference between the treatment and control groups in terms of epidural fibrosis (p=0.164) and arachnoid involvement (p=0.303). Conclusion: Intraoperative rifamycin irrigation tends to reduce epidural fibrosis formation risk, although not statistically significant.