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Öğe Auditory evaluation in Parkinsonian patients(Springer, 2009) Yılmaz, Süleyman; Karalı, Elif; Tokmak, Abdurrahman; Güçlü, Ender; Koçer, Abdulkadir; Öztürk, ÖzcanTwenty Parkinson's disease (PD) patients (mean age 69.9 years) and 24 normal individuals' (mean age 63.8) both ears were investigated by brainstem auditory evoked potentials (BAEPs) and pure tone audiometry (PTA). There were no statistically significant age differences between the patients and control subjects. PTA results were significantly elevated for PD patients in 4,000 and 8,000 Hz (P < 0.05). Parkinsonian patients showed significantly increased latencies in wave V and I-V interpeak latencies (P < 0.05). The results of this study suggest that PTA and BAEPs could be affected in parkinson disease.Öğe Branchio-ocuto-facial syndrome with the atresia of external ear(Elsevier Ireland Ltd, 2005) Öztürk, Özcan; Tokmak, Abdurrahman; Demirci, Levent; Sılan, Fatma; Güçlü, EnderWe report an 8-year-old child with branchio-oculo-facial syndrome. He showed atresia of external ear, preauricular pit, maxillar and mandibular hypoplasia, mild ptosis on the left side, Lacrimal duct obstruction, unilateral branchial cyst, hypertrichosis of the neck, left foot showed mild syndactily of fourth and fifth toes and dental abnormalities. His mother had pseudocleft of the lip which Led to the diagnosis. The importance of serial observations in patients with rare genetic disorders is emphasized. (c) 2005 Elsevier Iretand Ltd. All rights reserved.Öğe Does pregnancy-associated plasma protein A have a role in allergic rhinitis?(Ocean Side Publications Inc, 2008) Güçlü, Ender; Coşkun, Abdurrahman; Tokmak, Abdurrahman; Duran, Sadık; Öztürk, Özcan; Akkan, Nermin; Egeli, ErolBackground: Pregnancy-associated plasma protein A (PAPP-A), also known as insulin-like growth factor binding protein 4 protease, is postulated to be a new inflammatory marker in various clinical situations such as cardiovascular events, dialysis, renal transplantation, and asthma. PAPP-A also is produced in high concentrations by trophoblasts during pregnancy. Methods: We evaluated PAPP-A levels in allergic rhinitis patients and compared these with levels in healthy subjects. Thirty-one newly diagnosed allergic rhinitis patients and 29 healthy controls were included in the study. Serum PAPP-A, IgE, urea, creatinine, aspartate aminotransferase, creatine kinase (CK), CK-MB isoenzyme, total cholesterol, and triglyceride levels were determined. Results: The serum PAPP-A level was significantly higher (p = 0.013) in the allergic rhinitis group (6.1 +/- 2.9 mU/L) than in the control group (4.5 +/- 1.7 mU/L). The PAPP-A level in patients with allergic rhinitis and asthma (6.1 +/- 2.3 mU/L) was not significantly different (p = 0.959) from that in patients with allergic rhinitis alone (6.1 +/- 3.3 mU/L). The serum PAPP-A level in allergic rhinitis patients who had turbinate hypertrophy (6.9 +/- 2.2 mU/L) had a tendency to be higher than that in patients who had no turbinate hypertrophy (5.5 +/- 3.2 mU/L); however, this difference was not statistically significant (p = 0.151). Conclusion: Increased PAPP-A activity may be involved in the inflammation and tissue remodelling that occurs in allergic rhinitis.Öğe Evaluation of deaf children in a large series in Turkey(Elsevier Ireland Ltd, 2005) Öztürk, Özcan; Sılan, Fatma; Oğhan, Fatih; Egeli, Erol; Belli, Şeyda; Tokmak, Abdurrahman; Zafer, CansuObjective: Evaluation of the deafness etiology, ear examination findings and hearing levels of deaf children in a large series. Patients and methods: We studied 840 deaf primary school children (486 mate, 354 female, mean age 12.69 +/- 3.52, range 5-22). A questionaire investigating the prenatal, perinatal and postnatal etiological causes was prepared and pedigree analysis was performed. After ENT examination, odyologic tests were performed. Results: The etiological features of deafness were found for genetic causes as 429 cases (51.1%), 127 children (15.1%) for acquired group and 284 children (33.8%) for unknown group. We confirmed 136 (15.5%) syndromic deaf children and 19 of them (13.9%) were autosomal recessive (AR), 105 of them (77.2%) were autosomal dominant (AD), six (4.4%) of them were X-linked. Two hundred and ninety-three deaf (33.4%) children were in the familial nonsyndromic group. In this group, the inheritance of 255 (87%) were AR, 23 (7.8%) were AD and 15 (5.2%) were X-linked recessive. Febrile convulsion was identified as the most common etiology in 36 (4.3%) cases in the acquired group. Three hundred and twenty-two (67.7%) children had profound HL (above 91 dB), 111 (23.3%) had severe HL and 43 (9%) had moderately severe HL. Sensorineural. HL was found in 439 (92.2%) and mixed type hearing loss was seen 37 (7.8%) of 476 cases. We found many major and minor abnormalities and ocular, ear and dental pathologies. The prevalence of ear diseases was found in 203 (24.2%) of children. Impacted wax was found in 80 (9.5%) of 840 children with otoscopic examination and was the most common pathology, retraction in 70 (8.3%) and perforation in 15 (1.8%) followed it. Conclusion: Preventable ear disease are important health problems among school children for the deaf because these diseases can affect the real level and type of deafness, so determining early diagnostic criteria, ear diseases and minor abnormalities is important for early rehabilitation. Syndromes can be prevented in pregnancy, infections can be prevented in prenatal or postnatal period but unknown group cannot be prevented although the unknown etiology can be reduced by multidiciplinary approach. (c) 2004 Elsevier Ireland Ltd. All rights reserved.Öğe Frequency of migraine in patients with allergic rhinitis(Professional Medical Publications, 2013) Öztürk, Ayhan; Değirmenci, Yıldız; Tokmak, Burcu; Tokmak, AbdurrahmanObjectives: Allergic rhinitis (AR) is an IgE mediated disease which is released by activation of mast cells and basophils, and often leads to sinus headache. Histamine which is the key mediator in the pathogenesis of AR, also plays an important role in the pathogenesis of migraine with nitric oxide (NO). Aim of our study was to investigate the frequency of migraine in patients with AR. Methodology: Headache assessment and neurological examination was performed on patients diagnosed as AR in the outpatient ear nose and throat clinic with age-matched controls. Participants with headache were classified according to the International Headache Society criteria, and migraine frequency was investigated in the patients with AR and control groups. Results: Migraine headache was detected in 50% of the patients with AR. Among these, 95% were migraine without aura, and 5% were migraine with aura. Migraine frequency in the control group was 18.75% in the control group, and all was migraine without aura. Migraine frequency in the patients with AR was four times higher when compared with the control group. Conclusion: While a histamine and IgE associated common mechanism is responsible in the pathogenesis of AR and migraine, not only sinus headache but also migraine headache should be kept in mind. Headache assessment of the patients with AR, and in case of headache existence, referral of these patients to neurology outpatient clinics for differential diagnosis and, to maintain appropriate therapy should not be forgotten.Öğe Nasal carriage of pathogenic bacteria in medical students: effects of clinic exposure on prevalence and antibiotic susceptibility(Springer, 2007) Güçlü, Ender; Yavuz, Tevfik; Tokmak, Abdurrahman; Behçet, Mustafa; Karalı, Elif; Öztürk, Özcan; Egeli, ErolStaphylococcus aureus is a major cause of community-acquired and nosocomial infections worldwide. One important source of this pathogen for nosocomial infections is the nasal carriage of S. aureus among hospital personnel. There are only a few studies investigating the carriage of S. aureus in a community of medical students. Oral and nasal flora of 179 medical students with varying clinical exposures were determined. Oral cultures revealed no nosocomial pathogen and nasal cultures showed an increasing rate of S. aureus carriage with increasing clinical exposure. Methicillin resistance also demonstrated a tendency toward increasing with increasing clinical exposure.Öğe Obstrüktif uyku apnesi sendromlu hastalarda işitme yolaklarının değerlendirilmesi(Düzce Üniversitesi, 2007) Tokmak, Abdurrahman; Öztürk, ÖzcanObstrüktif uyku apne sendromu (OUAS), birçok hastalık tablosunun görülebildigi uyku hastalıkları spektrumu içinde en sık görülen patolojidir. OUAS hastalarının uykuya baslaması ile üst hava yolu dinamigini saglayan dilatör kasların aktivitesi azalır ve hava yolu daralıp, kollaps olur. Bunun sonucu apne ve hipopne gelisir. Bunun devamında hipoksi ve hiperkapni olur. Bu hipoksi ve hiperkapni, isitme yolaklarını çesitli sekillerde etkiler. BERA tetkiki santral ve periferik isitme yolaklarını degerlendirmemizi saglayan non invaziv, objektif bir testtir. Çalısmamızın amacı, OUAS'ın isitme yolaklarına bir etkisinin olup olmadıgını ortaya çıkarmaktı. Hasta ve kontrol grubuna isitme degerlendirilmesi için odyolojik ve BERA tetkiki yapıldı. Çalısmaya, Eylül 2006-Temmuz 2007 tarihleri arasında Düzce Üniversitesi Tıp Fakültesi Kulak Burun Bogaz Kliniginde OUAS tanısı almıs 30 hasta ile 20 kontrol grubu alındı. Sonuç olarak, OUAS'ın isitme üzerine etkisi olmadıgı tespit edildi.Öğe Skin Prick Test Results of Patients with Allergic Rhinitis in Düzce(Düzce Üniversitesi, 2005) Öztürk, Özcan; Tokmak, Abdurrahman; Güçlü, Ender; Yıldızbaş, Şahnur; Gültekin, ErolObjectives. To identify the responsible allergens in patients with allergic rhinitis and contribute to the establishment of allergen distribution specific to the region. Material and Methods. Skin prick test results and serum total IgE levels of 180 suspicous of allergic rhinitis patients who presented to Abant İzzet Baysal University Düzce Medical Faculty Department of Otolaryngology from February 2004 to March 2005 with symptoms like frequent sneezing, copious and serous rhinorrhea, nasal obstruction, itching of the eyes and nose were evaluated. Results. One hundred and two patients (56.7 %) was reactive to at least one allergen. Prick test positivity and hight total IgE levels were most frequent (30.4 %) in the age group of 21 to 30 years. Total IgE levels were elevated in 46 patients (% 45.1). Most common allergens were mites I (D. farinae), positive in 74 patients (72.5 %) and mites II (D. pteronyssinus), positive in 65 patients (63.7 %). After mites, grass pollens were the most common allergen seen in 29 patients (28.4 %), followed by barley, grasses-cereals, trees I, trees II and molds. Conclusion. Most common allergen in patients with allergic rhinitis in Düzce was house dust mites
