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  • Küçük Resim
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    D2-40 Immunreactivity In Colon Adenocarcinomas
    (Düzce Üniversitesi, 2011) Özardalı, Hasan İlyas; Yıldız, Fahrettin; Terzi, Alpaslan; Özgönül, Abdullah; Bitiren, Muharrem; Yıldırım, Levent; Metineren, Mehmet Hüseyin
    Aim: In the present study, the relationship between D2-40 immunoreactivity and tumor grade,clinic phase and lymph node metastase in colon adenocarcinomas were examined.Method: Sixty cases diagnosed with colon adenocarcinoma in our department between 2002and 2009 were included in the study. Sections from appropriate paraffin blocks belonging tothe cases were examined by D2-40 antibody immunohistochemical method.Findings: On the immunohistochemical examination, positive immunoreactivity with D2-40was found in 18 of 60 cases (30%). In the statistical analysis, no significant correlation wasdetermined between histologic grade (p:0,78), clinic phase (p:0,91), lymph node metastasis(p:0,56) and D2-40 immunoreactivity.Conclusion: No correlation was found between immunoreactivity with D2-40 and prognosticparameters. Yet, due to the fact that there are few studies in literature on immunoreactivity withD2-40 in tumor cells in colon adenocarcinomas, we believe that further studies are needed inthis subject
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    Diagnosis Of Asthma In A Misdiagnosed Hemorrhoid Patient With Inappropriate Steroid Use: A Case Report
    (Düzce Üniversitesi, 2010) Yıldız, Fahrettin; Çoban, Sacit; Gencer, Mehmet; Terzi, Alpaslan
    Hemorrhoid is a frequently seen benign anorectal disease. Although its diagnosis is simple, it isfrequently misdiagnosed. Our patient was 55 years old female who had been diagnosed ashemorrhoid and using steroid pomades and suppozituars for 5 years. The patient had alsodyspnea complaints and those medications had help to relieve the symptoms. The patient hadapplied to our clinic for the repetition of her hemorrhoid prescription. Anal examination wasperformed since it was thought from her story that she does not suffer from hemorrhoid. Therewas no sign of hemorrhoid in the anal examination. As the patient had dyspnea complains, shewas referred to Chest Diseases Clinic and she was diagnosed as asthma. The importance ofanorectal examination is well established. But it still sometimes neglected and wrong andunnecessary treatments are given to the patients. In our case, there was an unnecessary treatmentfor hemorrhoid, but the medication helped the treatment of asthma despite its late diagnosis.This case is presented as it has made an interesting contribution to the diagnosis of asthma
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    Protective Effect of Urtica dioica on Liver Injury Induced by Hepatic Ischemia Reperfusion Injury in Rats
    (Düzce Üniversitesi, 2010) Yıldız, Fahrettin; Çoban, Sacit; Taşkın, Abdullah; Bitiren, Muharrem; Aksoy, Nurten; Terzi, Alpaslan
    Background: This study was designed to investigate the effects of Urtica dioica on liverischemia reperfusion injury in rats. Methods: Thirty male Wistar-albino rats were used in this experimental study. Animals weredivided into three groups as sham operated (group 1), control (group 2), and Urtica dioicatreatment group (group 3). Urtica dioica 2ml/kg were administered intraperitoneally beforeischemia and immediately after the reperfusion. The levels of total antioxidant capacity, totalfree sulfidril group, Total oxidant status, Oxidative stress index, and myeloperoxidase in livertissues were measured. The serum levels of ALT, AST and LDH were also measuredResults: Total antioxidant capacity and total free sulfidril group in liver tissue were significantlyhigher in group 3 than in group 2. Oxidative stress index and myeloperoxidase in liver tissuewere significantly lower in group 3 than the group 2. The levels of liver enzymes in treatmentgroup were significantly lower than those in the control group. Histological tissue damage wasmilder in the treatment group than that in the control group.Conclusion: It is concluded that Urtica dioica increase the antioxidant capacity and decreaseoxidative stress and liver enzymes in the hepatic ischemi reperfusion injury of rats