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    The Comparison of The Efficacy and The Confidence of The Vasodilator Therapy With Felodipine And Lisinopril in Chronic, Moderate to Severe Aortic Regurgitation
    (Düzce Üniversitesi, 2007) Taçoy, Gülten; Özdemır, Murat; Tavıl, Yusuf; Türkoglu, Sedat; Çengel, Atiye
    Purpose: Afterload reduction decreases volume overload on the left ventricle in chronic asymptomatic aortic regurgitation (AR). In this prospective, randomized trial, we aimed to compare the effects of a 6-months long treatment with lisinopril versus felodipine on left ventricular function and hemodynamic parameters. Methods: 41 asymptomatic patients with moderate to severe chronic, isolated AR were randomly assigned to treatment with either lisinopril (20 mg) or felodipin (10 mg). Echocardiographic ([ESV], [EDV], [EF], [FSV], [LVSV], [RV], [RF], [FCO], [LVCO], [SW], [CW], [LVWS]) and hemodynamic parameters [SBP], [DBP], [SVR]) at baseline and at 6 months were compared. Results: At 6 months, with lisinopril, SBP 8,9 %, DBP 5,9 %, SVR 16,7 %, RV 8,4 %, RF 11 %, SW 6 %, CW 7.2 % decreased and FSV 11,2 %, LVSV 3 % increased (p