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Öğe Can serum NSE and S100-beta protein levels predict central nervous system injury in patients with carbon dioxide retention?(Kuwait Medical Assoc, 2020) Gunes, Harun; Candar, Muhammed M.; Saritas, AyhanObjectives: To evaluate whether serum neuron specific enolase (NSE) or S100-beta protein levels are helpful in predicting central nervous system (CNS) injury in patients with carbon dioxide (CO2) retention Design: A case-control study Setting: This study was performed in the Emergency Department of a University Hospital which functions as the only tertiary center in the city. Subjects: One hundred patients who were admitted to the emergency department and seen to have an arterial partial carbon dioxide pressure above 45 mmHg were included as the study group and 48 healthy volunteers as the control group. Interventions: None Main outcome measures: Possible elevations in serum NSE and/or S100-beta protein levels in the study group were main outcome measures. The levels of these markers were measured using enzyme-linked immunoassay kits, and mean values of these parameters were compared between the study and the control groups. Results: Mean NSE level was found to be 69.45 +/- 36.39 ng/ml, and mean S100-beta level was 160.57 +/- 54.05 pg/ml in the study group. Mean NSE and S100-beta levels of the control group were 30.99 +/- 20.04 ng/ml and 129.31 +/- 415.17 pg/ml, respectively. Mean NSE levels differed significantly between the study and control groups; however, mean S100-beta levels did not. Conclusions: The results of the present study suggest that NSE can be used to predict CNS injury in patients with CO2 retention, but S100-beta protein cannot. New studies including larger number of patients are needed to obtain more accurate results on this topic.Öğe Does determination of drug level in intoxicated patients offer an advantage in diagnosis, treatment, and reducing complications?(Pakistan Medical Assoc, 2020) Tayfur, Ismail; Senel, Ahmet; Colak, Sahin; Ibrahim, Abdullah; Afacan, Mustafa Ahmet; Saritas, AyhanObjective: To investigate the effect of determining the drug type and level on emergency management in patients presenting with intoxication, and to identify the factors behind associated mortality. Methods: The retrospective, observational, cross-sectional and single -centre study was conducted at a large tertiary care teaching hospital in Istanbul, Turkey, between September and November 2016 using the hospital's toxicology registry. Data was extracted for patients who had presented to the emergency department from January 1, 2011, to February 28, 2013, and were found to have toxic doses of single active ingredients in the plasma. The patients were evaluated in terms of age, gender, demographic characteristics, time from ingestion to presentation, reason for drug ingestion, type of drug ingested, time elapsed before the emergency service was called, treatment given, drug level, hospitalisation and mortality. Data was analysed using SPSS 11.5. Results: Of the 224 patients, 145(64.8%) were women. The overall mean age was 30.8 +/- 15.4 years. Drug ingestion was more common in women aged 18-30 years (p<0.0001). Besides, 215(96%) patients had ingested drugs with the intent to commit suicide. The minimum education level of 163(72.8%) patients was high school. The most frequently ingested drug was paracetamol 90(40.2%). Overall mortality was 4(1.8%) and all of them were brought to the emergency department after a delay of more than five hours (p<0.0001). Conclusion: Drug type and quantity were found to be of great importance in taking timely decisions while attending to patients with intoxication in an emergency setting. Delay in presentation was associated with mortality.Öğe ECG Evaluation in Patients with Pneumothorax Admitted to the Emergency Department: A Three years Analysis(Duzce Univ, Fac Medicine, 2021) Karakoyun, Salih; Boran, Mertay; Saritas, Ayhan; Boran, ErtayObjective: Pneumothorax is one of the life-threatening differential diagnoses of patients presenting to emergency department (ED) with shortness of breath and chest pain. The place of dynamic electrocardiography (ECG) changes in diagnosis of pneumothorax was not well defined. The aim of our study was to reveal the clinical importance of ECG in pneumothorax. Methods: Between 01.04.2014 and 01.04.2017, 147 patients who applied to our ED and take a diagnosis of pneumothorax were retrospectively examined. The patients were divided as Group 1 (with pneumothorax volume <20%), and group 2 (with pneumothorax volume >= 20%). Patient demographics, mechanism of pneumothorax formation (traumatic or spontaneous), X-ray and tomographic findings, ECG findings, hospitalization-follow-up periods, treatment methods; were derived from the hospital's data recording system and compared between groups. Results: 109 (74.1 %) of 147 patients had a traumatic pneumothorax, and 38 (25.8%) had a spontaneous pneumothorax (p <0.001). 21 (55.2%) of the spontaneous pneumothorax cases are primary spontaneous pneumothorax. 64.6% (n=95) of the patients had chest pain. The two groups were similar in terms of age, hemoglobin level, GCS, number of days followed, gender and smoking status, (p> 0.05). When the ECG data was analyzed, a difference was found between the two groups. While 52.8% of the patients in group 1 had ECG changes, all of the patients in group-2 (100%) had unusual ECG findings (p = 0.004). Conclusions: Pneumothorax is a condition that should not be overlooked at ED. Pneumothorax especially with large volume size (size >= 20%) should be remembered in cases with abnormal findings in their ECG.Öğe Use of argyrophilic nucleolar-organizer region-associated protein synthesis in skeletal muscle cells for prediction of chronic carbon monoxide exposure(Taylor & Francis Inc, 2020) Gunes, Harun; Saritas, Ayhan; Eroz, Recep; Colakoglu, SerdarThis study aims to evaluate possible effects of chronic carbon monoxide (CO) exposure on argyrophilic nucleolar-organizer region (AgNOR)-associated protein synthesis in striated muscle cells. Eighteen rats were randomly divided into three groups. Rats in group II and group III were given CO gas (1000 and 3000 ppm, respectively) for 30 min a day for 7 d. Mean AgNOR number per nucleus and ratio of total AgNOR area to nuclear area (TAA/NA) were determined. Both TAA/NA ratio and mean AgNOR number provided information about the existence or absence of exposure. TAA/NA ratio was also an indicator of the level of exposure.
