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    Correlation of perilipin 2 and lipid metabolism in elective cesarean section and vaginal delivery: a prospective study with oxidative and apoptotic pathways
    (Springer, 2021) Hacioglu, Ceyhan; Sahin, Ibrahim Ethem; Uyuk, Can
    Vaginal delivery (VD) and elective cesarean (CS) delivery modes may cause significant differences in maternal and fetal metabolism. In this study, we aimed to investigate changes in lipid metabolism, oxidative and apoptotic signaling pathways during VD and CS in maternal and cord blood and placenta tissue. The study included two groups of participants delivered via 90 CS and 90 VD. Maternal and cord blood samples were collected from the participants. In addition, placenta samples were also taken after delivery. Total oxidant (TOS), malondialdehyde (MDA), total antioxidant (TAS), glutathione (GSH), cleaved caspase 3 (CASP3) and perilipin 2 (PLIN2) levels were measured to determine oxidative stress, antioxidant levels and apoptosis status in the VD and CS groups. Besides, PLIN2 mRNA expressions in placental specimens were analyzed. We found no statistically significant difference in maternal age, body mass index, gestational age, birth weight and Apgar scores in both groups (P > 0.05). The increase in MDA, TOS, GSH and TAS levels was higher in the VD group compared to the CS group (P < 0.05). Similarly, PLIN2 levels and lipid profiles showed an increase in the VD group (P < 0.05 vs CS group). Likewise, PLIN2 expression enhanced in the VD group (P < 0.05 vs CS group). However, CASP3 activity reduced in maternal and cord blood in the VD group compared to the CS group. Our results support that the delivery mode may cause differences in lipid profile, oxidative and apoptotic status by affecting PLIN2 levels in both maternal and cord blood and placenta tissue.
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    An Investigation of Latex Sensitivity and Respiratory Complaints in Workers in a Rubber-Based Material Manufacturing Industry
    (Lippincott Williams & Wilkins, 2023) Elverisli, Mehmet Fatih; Gulhan, Pinar Yildiz; Mungan, Dilsad; Ercelik, Merve; Sahin, Ibrahim Ethem; Balbay, Ege Gulec; Coban, Seyit
    ObjectiveTo present study aimed to investigate the prevalence of latex sensitivity in a workplace that produced rubber-based vehicle seals.MethodThe serum latex-specific IgE levels, respiratory complaints, PFT, serum interleukin (IL)-4, IL-5, IL-8, IL-10, IL-13 levels of all male workers (n = 108) exposed to latex in the workplace, which produced rubber seals, were compared with the control group (n = 52).ResultsThe rates of latex-specific IgE >0.10 kU/L in the workers and control group were 12.3% and 4.1%, respectively (P = 0.147). There was no difference in IL-4, IL-5, IL-10, and IL-13 levels between latex-specific IgE-positive, and -negative participants.ConclusionLatex sensitivity was higher in workers who used rubber as a raw material than in the control group but it was not statistically significant.
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    A NEW MARKER PERILIPINE COUNTERWORK WITH VITAMIN D THROUGH REGULATION LIPID METABOLISM IN OBESES
    (Carbone Editore, 2020) Sahin, Ibrahim Ethem; Alpay, Merve; Sonmez, Cemil Isik
    Introduction: Vitamin D deficiency and obesity are common controversial health problems. Vit D supports lipolysiv from the outside, stimulates lipogenesis. Perilipine protein, which allows the use of lipids in the mitochondria in cell. Our main aim of this research was to control obesity prognosis monitoring Perilipine levels related by WO treatments. Methods: During winter months, patients that have admitted the hospital whose ages ranged from 18 to 65 years at 80 obese and normal BMI individuals were included the study. Blood samples from patients were taken and measured for VitD level. Experimental groups arranged again according to BMI and VitD results. Results: The mean age of the patients was +/- 34(18-65). After organized samples, vitamin D deficiency group which 25-OH D levels were < 20 nglml, were 37.75 +/- 4.79 higher Perilipine levels than normal VItD individuals. However, Perilipine levels were increased in obese patients display positive correlation with BMI. Discussion: These results were indicated that high frequency of vitamin D deficiency drives obesity relatively especially in winter months. The research findings suggest that Perilipine expression has direct correlation by vitamin D alteration. For this purpose, Perilipine can be a novel marker to prevent obesity and should he controlled previously identified obesity groups treated new methods of VitD uptake.
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    Short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes
    (Springer, 2021) Kabaklioglu, Murat; Kaya, Murat; Sahin, Ibrahim Ethem; Gamsizkan, Mehmet; Bahcivan, Atike; Eroz, Recep
    Rapamycin has antioxidant defense mechanisms and immune suppressive effects. To detect the short- and long-term effects of rapamycin on ischemic damage and apoptotic changes in torsion of rat testes, mature male albino Wistar rats (n = 48) were included in the study as control, sham, early torsion-detorsion (T/D), early rapamycin treatment, early rapamycin control, late T/D, late rapamycin treatment, and late rapamycin control. The right testis was rotated 720 degrees in a clockwise direction during 4 h in operation groups. Rapamycin was administered orally three times: 30 min before detorsion and 24 and 48 h after detorsion. The animals were killed on the third day in early groups and on the tenth day in late groups after detorsion. Statistically significant differences among all groups were detected for SOD and TBARS, mean seminiferous tubule diameter (MSTD) and Cosentino's histologic score (CHS), caspase 3, bax, average number of apoptotic cells per tubule (ANPCT), and percentage of apoptotic tubule (PAT) values. ANPCT values were 10% lower in the rapamycin treatment groups compared with the untreated T/D groups, and the PAT values were also approximately 1.3 times lower. Although short-term usage of rapamycin may reduce to the tubular injury caused by I/R conversely to apoptosis in the testicular tissue after testicular torsion, rapamycin may have the potential to increase the long-term apoptosis with/without testicular torsion and a subsequent regression in fertility.